Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adenylate cyclase 9 | 0.0693 | 0.8518 | 1 |
Onchocerca volvulus | 0.0693 | 0.8518 | 1 | |
Schistosoma mansoni | glucose transport protein | 0.0105 | 0.0146 | 0.5 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0693 | 0.8518 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0663 | 0.8099 | 0.8071 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0134 | 0.0559 | 0.0656 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0.0146 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0134 | 0.0559 | 0.0656 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Plasmodium vivax | hexose transporter | 0.0105 | 0.0146 | 0.5 |
Brugia malayi | Adenylyl cyclase protein | 0.0693 | 0.8518 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.0693 | 0.8518 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0105 | 0.0146 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0105 | 0.0146 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0105 | 0.0146 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0693 | 0.8518 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Schistosoma mansoni | glucose transport protein | 0.0105 | 0.0146 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0146 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 0.0146 | 0.0172 |
Loa Loa (eye worm) | hypothetical protein | 0.0693 | 0.8518 | 0.8496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 195 nM | Binding affinity against adenosine A2 receptor in rat brain using [3H]- CGS 21680 as radioligand | ChEMBL. | 8496902 |
Ki (binding) | = 195 nM | Binding affinity against adenosine A2 receptor in rat brain using [3H]- CGS 21680 as radioligand | ChEMBL. | 8496902 |
Ki (binding) | = 2140 nM | Affinity against Adenosine A1 receptor in rat brain using [3H]- PIA as radioligand | ChEMBL. | 8496902 |
Ki (binding) | = 2140 nM | Affinity against Adenosine A1 receptor in rat brain using [3H]- PIA as radioligand | ChEMBL. | 8496902 |
Ratio (binding) | = 11 | Ratio between Ki of adenosine A1 receptor to that of adenosine A2 receptor | ChEMBL. | 8496902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.