TDR Targets

Basic information

Technical information

TDR Targets ID: 349407
Name: N-[(5Z)-4-oxo-2-sulfanylidene-5-[(3,4,5-trifl uorophenyl)methylidene]-1,3-thiazolidin-3-yl] benzenesulfonamide
MW: 430.444 | Formula: C16H9F3N2O3S3
H donors: 1 H acceptors: 3 LogP: 4.13 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: S=C1S/C(=C\c2cc(F)c(c(c2)F)F)/C(=O)N1NS(=O)(=O)c1ccccc1
InChi: 1S/C16H9F3N2O3S3/c17-11-6-9(7-12(18)14(11)19)8-13-15(22)21(16(25)26-13)20-27(23,24)10-4-2-1-3-5-10/h1-8,20H/b13-8-
InChiKey: RTJZGZDMOCVJOP-JYRVWZFOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(5Z)-4-oxo-2-thioxo-5-[(3,4,5-trifluorophenyl)methylene]thiazolidin-3-yl]benzenesulfonamide
N-[(5Z)-4-oxo-2-thioxo-5-[(3,4,5-trifluorophenyl)methylene]-3-thiazolidinyl]benzenesulfonamide
N-[(5Z)-4-keto-2-thioxo-5-(3,4,5-trifluorobenzylidene)thiazolidin-3-yl]benzenesulfonamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS5B RNA-dependent RNA polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Rrm3p helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus granulosus	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	DNA repair and recombination protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to PIF1 DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma japonicum	ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0069	0.0572	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0209	0.238	0.4539
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1265	0.1265
Onchocerca volvulus	Cell death protein 3 homolog	0.006	0.0451	0.086
Loa Loa (eye worm)	hypothetical protein	0.006	0.0451	0.0451
Brugia malayi	Fli-1 protein	0.0213	0.2432	0.2432
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0114	0.0423
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.2697	1
Schistosoma mansoni	inhibitor of apoptosis protein	0.0131	0.1366	0.1366
Loa Loa (eye worm)	hypothetical protein	0.006	0.0451	0.0451
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0209	0.238	0.4539
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0209	0.238	0.4539
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0061	0.0061
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0188	0.21	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0047	0.009
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0572	0.0572
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0156	0.1687	0.3217
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0131	0.1366	0.1366
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0069	0.0572	0.2122
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0134	0.0308
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0134	0.0134
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0069	0.0572	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1366	0.1366
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0069	0.0572	1
Mycobacterium tuberculosis	Probable peptidase	0.0188	0.21	0.4826
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0134	0.0496
Brugia malayi	prolyl oligopeptidase family protein	0.0069	0.0572	0.0572
Plasmodium vivax	SET domain protein, putative	0.0029	0.0061	0.1073
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0134	0.0637
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0134	0.0255
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0061	0.0117
Echinococcus granulosus	apoptotic protease activating factor 1	0.006	0.0451	0.086
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0061	0.0117
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.03	0.3545	0.6762
Trypanosoma cruzi	oligopeptidase b	0.0188	0.21	0.4006
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0134	0.2339
Onchocerca volvulus		0.0029	0.0061	0.0117
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.2331	0.2331
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0069	0.0572	0.0572
Leishmania major	hypothetical protein, conserved	0.016	0.1738	0.3315
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0114	0.0218
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0134	0.0637
Loa Loa (eye worm)	hypothetical protein	0.006	0.0456	0.0456
Trypanosoma brucei	oligopeptidase b	0.0188	0.21	0.4006
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.007	0.0587	0.0587
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0365	0.4387	0.8368
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0209	0.238	0.4539
Echinococcus granulosus	acylamino acid releasing enzyme	0.0069	0.0572	0.1092
Onchocerca volvulus		0.0131	0.1366	0.2605
Schistosoma mansoni	ets-related	0.0213	0.2432	0.2432
Echinococcus granulosus	inhibitor of apoptosis protein	0.0131	0.1366	0.2605
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0801	1	1
Brugia malayi	Ets-domain containing protein	0.007	0.0587	0.0587
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0134	0.0308
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0061	0.0061
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0131	0.1366	0.1366
Brugia malayi	prolyl oligopeptidase family protein	0.0268	0.3134	0.3134
Loa Loa (eye worm)	subtilase	0.0801	1	1
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0365	0.4387	0.8368
Schistosoma mansoni	hypothetical protein	0.006	0.0451	0.0451
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0134	0.0496
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0034	0.0114	0.0218
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0134	0.0637
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0209	0.238	0.4539
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0188	0.21	0.4006
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0134	0.0308
Onchocerca volvulus		0.0234	0.2697	0.5145
Entamoeba histolytica	hypothetical protein, conserved	0.0069	0.0572	1
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0114	0.0218
Echinococcus granulosus	caspase 2	0.006	0.0451	0.086
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0069	0.0572	1
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0268	0.3134	0.5978
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0134	0.0255
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0134	0.0134
Onchocerca volvulus		0.0035	0.0134	0.0255
Echinococcus granulosus	prolyl endopeptidase	0.0432	0.5242	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0134	0.0637
Echinococcus multilocularis	prolyl endopeptidase	0.0432	0.5242	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0134	0.0308
Echinococcus multilocularis	GA binding protein alpha chain	0.007	0.0587	0.112
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0134	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0134	0.0134
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0061	0.0117
Onchocerca volvulus		0.006	0.0451	0.086
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.03	0.3545	0.6762
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0069	0.0572	0.1092
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0188	0.21	0.4006
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0034	0.0114	0.0218
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0114	0.0218
Trypanosoma cruzi	hypothetical protein, conserved	0.016	0.1738	0.3315
Brugia malayi	hypothetical protein	0.006	0.0451	0.0451
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.2573	0.5912
Toxoplasma gondii	ABC1 family protein	0.0035	0.0134	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0134	0.0134
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0209	0.238	0.4539
Brugia malayi	beta-lactamase family protein	0.0035	0.0134	0.0134
Brugia malayi	MH2 domain containing protein	0.0121	0.1242	0.1242
Mycobacterium tuberculosis	Conserved protein	0.016	0.1738	0.3994
Plasmodium vivax	hypothetical protein, conserved	0.0069	0.0572	1
Echinococcus granulosus	GA binding protein alpha chain	0.007	0.0587	0.112
Brugia malayi	beta-lactamase	0.0035	0.0134	0.0134
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0432	0.5242	0.5242
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0069	0.0572	0.2122
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0114	0.0218
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0268	0.3134	0.5978
Brugia malayi	hypothetical protein	0.0086	0.0796	0.0796
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0034	0.0114	0.0218
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0061	0.0117
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0134	0.0496
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0134	0.0496
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0134	0.0255
Trypanosoma cruzi	oligopeptidase b	0.0188	0.21	0.4006
Brugia malayi	beta-lactamase family protein	0.0035	0.0134	0.0134
Echinococcus multilocularis	caspase 2	0.006	0.0451	0.086
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0069	0.0572	0.0572
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0134	0.0637
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0432	0.5242	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0134	0.0134
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.1242	0.1242
Brugia malayi	prolyl oligopeptidase family protein	0.0069	0.0572	0.0572
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0131	0.1366	0.2605
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0134	0.0255
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0131	0.1366	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0134	0.0134
Trypanosoma cruzi	hypothetical protein, conserved	0.0069	0.0572	0.1092
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0034	0.0114	0.0218
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0365	0.4387	0.4387
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0134	0.0308
Loa Loa (eye worm)	prolyl oligopeptidase	0.0268	0.3134	0.3134
Echinococcus multilocularis	apoptotic protease activating factor 1	0.006	0.0451	0.086
Treponema pallidum	mcbG protein	0.016	0.1738	0.5
Leishmania major	hypothetical protein, conserved	0.0035	0.0134	0.0255
Schistosoma mansoni	gabp alpha	0.007	0.0587	0.0587
Trypanosoma brucei	prolyl endopeptidase	0.0432	0.5242	1
Toxoplasma gondii	hypothetical protein	0.0069	0.0572	0.1092
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0268	0.3134	0.3134
Schistosoma mansoni	caspase-7 (C14 family)	0.006	0.0451	0.0451
Brugia malayi	Pre-SET motif family protein	0.0206	0.2331	0.2331
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0188	0.21	0.4006
Loa Loa (eye worm)	prolyl oligopeptidase	0.0069	0.0572	0.0572
Trichomonas vaginalis	esterase, putative	0.0035	0.0134	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0796	0.0796
Brugia malayi	Ets-domain containing protein	0.007	0.0587	0.0587
Trypanosoma cruzi	hypothetical protein, conserved	0.0069	0.0572	0.1092
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0134	0.0134
Trypanosoma cruzi	hypothetical protein, conserved	0.016	0.1738	0.3315
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0188	0.21	1
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0572	0.2122
Schistosoma mansoni	hypothetical protein	0.0131	0.1366	0.1366
Brugia malayi	prolyl oligopeptidase family protein	0.0209	0.238	0.238
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0209	0.238	0.4539
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0134	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0432	0.5242	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0134	0.0134
Leishmania major	hypothetical protein, conserved	0.016	0.1738	0.3315
Onchocerca volvulus		0.0035	0.0134	0.0255
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0134	0.0255
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0134	0.0134
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0432	0.5242	1
Brugia malayi	Cell death protein 3 precursor	0.006	0.0451	0.0451
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0134	0.0308
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.016	0.1738	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0209	0.238	0.238
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0268	0.3134	0.5978
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0134	0.0134
Mycobacterium ulcerans	hypothetical protein	0.016	0.1738	0.8276
Schistosoma mansoni	hypothetical protein	0.0034	0.0114	0.0114
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0432	0.5242	0.5242
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0069	0.0572	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0061
Brugia malayi	prolyl oligopeptidase family protein	0.0432	0.5242	0.5242
Trypanosoma cruzi	prolyl endopeptidase	0.0432	0.5242	1
Mycobacterium ulcerans	lipase LipD	0.0035	0.0134	0.0637
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0069	0.0572	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0134	0.0496
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.1242	0.1242
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0188	0.21	0.4826
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0131	0.1366	0.2605
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0134	0.0637
Brugia malayi	Pre-SET motif family protein	0.0029	0.0061	0.0061
Leishmania major	oligopeptidase b	0.0188	0.21	0.4006
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1366	0.1366
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0134	0.0308
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0069	0.0572	0.1092
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0061	0.0061
Onchocerca volvulus	Deterin homolog	0.0131	0.1366	0.2605
Plasmodium falciparum	peptidase, putative	0.0069	0.0572	0.3293
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0362	0.4351	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0134	0.0308
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0034	0.0114	0.0218
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0188	0.21	0.4006
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0188	0.21	0.4006
Toxoplasma gondii	prolyl endopeptidase	0.0432	0.5242	1
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0069	0.0572	0.1092
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0131	0.1366	0.1366
Onchocerca volvulus		0.0035	0.0134	0.0255
Loa Loa (eye worm)	fli-1 protein	0.0213	0.2432	0.2432
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0061	0.0061
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0069	0.0572	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 uM	Inhibitory activity against HCV delta 21 NS5b RNA polymerase	ChEMBL.	16451069
IC50 (binding)	= 1 uM	Inhibitory activity against HCV delta 21 NS5b RNA polymerase	ChEMBL.	16451069
IC50 (functional)	> 50 uM	Cytotoxicity in E304 cells	ChEMBL.	16451069
IC50 (functional)	> 50 uM	Cytotoxicity in E304 cells	ChEMBL.	16451069
IC50 (functional)	> 100 uM	Cytotoxicity in HFF cells	ChEMBL.	16451069
IC50 (functional)	> 100 uM	Cytotoxicity in HFF cells	ChEMBL.	16451069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL199809
PubChem: 11669161

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 349407