TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 600.934 | Formula: C28H31BrClN5O3
H donors: 1 H acceptors: 4 LogP: 4.79 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: CCCCC(=O)N1CCN(CC1C(=O)Nc1onc(c1)C)C1c2ccc(cc2CCc2c1ncc(c2)Br)Cl
InChi: 1S/C28H31BrClN5O3/c1-3-4-5-25(36)35-11-10-34(16-23(35)28(37)32-24-12-17(2)33-38-24)27-22-9-8-21(30)14-18(22)6-7-19-13-20(29)15-31-26(19)27/h8-9,12-15,23,27H,3-7,10-11,16H2,1-2H3,(H,32,37)
InChiKey: CGLDQNAZWLLHQY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase Lyn	0.006	0.0671	0.0823
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0033	0.0175	0.0381
Brugia malayi	hypothetical protein	0.0131	0.1938	0.1938
Onchocerca volvulus		0.005	0.0489	0.0355
Echinococcus granulosus	twitchin	0.0063	0.0727	0.0892
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0489	0.1527
Schistosoma mansoni	tyrosine kinase	0.0058	0.0633	0.1377
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0116	0.1668	0.2046
Mycobacterium ulcerans	hypothetical protein	0.0033	0.0175	0.5
Wolbachia endosymbiont of Brugia malayi	Mg2+/Co2+ transporter	0.0033	0.0175	0.5
Wolbachia endosymbiont of Brugia malayi	hemolysin	0.0033	0.0175	0.5
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0033	0.0175	0.0487
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0054	0.0567	0.0896
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0033	0.0175	0.5
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0052	0.0532	0.1156
Schistosoma mansoni	tyrosine kinase	0.0024	0.0024	0.0053
Trypanosoma cruzi	chloride channel protein, putative	0.0033	0.0175	0.0487
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0489	0.1527
Trypanosoma cruzi	chloride channel protein, putative	0.0033	0.0175	0.0487
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0358	0.0439
Schistosoma mansoni	chloride channel protein	0.0033	0.0175	0.0381
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0633	0.0777
Schistosoma mansoni	protein kinase	0.016	0.2464	0.5356
Mycobacterium ulcerans	hypothetical protein	0.0033	0.0175	0.5
Echinococcus multilocularis	Immunoglobulin	0.0052	0.0532	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0532	0.0532
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.0489	0.06
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0247	0.4017	0.4929
Loa Loa (eye worm)	CAMK/CAMKL/AMPK protein kinase	0.0278	0.4571	0.4571
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0323	0.0323
Echinococcus granulosus	5' AMP activated protein kinase subunit gamma	0.0279	0.4601	0.5645
Trypanosoma brucei	AMP-activated protein kinase, gamma regulatory subunit	0.0033	0.0175	0.0487
Schistosoma mansoni	protein kinase subunit beta	0.0192	0.3043	0.6614
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0033	0.0175	0.0381
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0253	0.414	0.414
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0033	0.0175	0.0487
Echinococcus granulosus	SNF4:AMP activated protein kinase gamma subunit	0.0033	0.0175	0.0215
Schistosoma mansoni	protein kinase	0.0249	0.4055	0.8814
Treponema pallidum	Mg2+ transport protein (mgtE)	0.0033	0.0175	1
Schistosoma mansoni	vesicular amine transporter	0.0052	0.0532	0.1156
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.058	1	1
Echinococcus granulosus	TGF beta receptor type 1	0.0249	0.4055	0.4975
Trypanosoma cruzi	SNF1-related protein kinase regulatory subunit beta, putative	0.0192	0.3043	1
Echinococcus granulosus	5' AMP activated protein kinase subunit beta 1	0.0103	0.1443	0.1771
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0033	0.0175	0.5
Brugia malayi	CBS domain containing protein	0.0033	0.0175	0.0175
Trypanosoma cruzi	GMP reductase	0.0033	0.0175	0.0487
Schistosoma mansoni	protein kinase subunit beta	0.0103	0.1443	0.3137
Echinococcus granulosus	Immunoglobulin	0.0052	0.0532	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0175	0.0175
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.005	0.048	0.0589
Brugia malayi	chloride channel protein 7	0.0033	0.0175	0.0175
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0567	0.1233
Echinococcus granulosus	serine:threonine kinase SAD 1	0.0054	0.0567	0.0696
Brugia malayi	Voltage gated chloride channel family protein	0.0033	0.0175	0.0175
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Brugia malayi	ephrin receptor 1 precursor	0.0042	0.034	0.034
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0175	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.0054	0.0567	0.0886
Echinococcus granulosus	roundabout 2	0.0075	0.094	0.1154
Trypanosoma brucei	Voltage-gated Chloride channel Like 3	0.0033	0.0175	0.0487
Loa Loa (eye worm)	TK/EPH protein kinase	0.0101	0.1408	0.1408
Leishmania major	guanosine monophosphate reductase	0.0033	0.0175	0.0487
Trypanosoma brucei	5'-AMP-activated protein kinase catalytic subunit alpha, putative	0.0054	0.0567	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0529	0.0529
Schistosoma mansoni	ephrin receptor	0.0081	0.1044	0.2268
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0024	0.0024	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0489	0.1527
Mycobacterium leprae	Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450)	0.0033	0.0175	0.5
Loa Loa (eye worm)	5'-AMP-activated protein kinase	0.0192	0.3043	0.3043
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0582	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0733	0.0733
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0033	0.0175	0.5
Echinococcus multilocularis	SNF4:AMP activated protein kinase gamma subunit	0.0033	0.0175	0.0215
Treponema pallidum	hemolysin (tlyC)	0.0033	0.0175	1
Echinococcus multilocularis	roundabout 2	0.0075	0.094	0.1154
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0058	0.0633	0.0777
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0033	0.0175	0.0215
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0489	0.06
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0532	0.0532
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0633	0.0777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.005	0.048	0.0589
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.3052	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0024	0.0024	0.003
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0041	0.0323	0.0396
Onchocerca volvulus	Alicorn homolog	0.0168	0.2606	0.275
Brugia malayi	Fibronectin type III domain containing protein	0.0055	0.0582	0.0582
Loa Loa (eye worm)	TK protein kinase	0.005	0.048	0.048
Chlamydia trachomatis	GutQ/KpsF family sugar-phosphate isomerase	0.0033	0.0175	0.5
Giardia lamblia	Kinase, AGC AKT	0.0099	0.1376	0.2714
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0133	0.1975	0.1975
Brugia malayi	5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein	0.0192	0.3043	0.3043
Brugia malayi	protein-tyrosine kinase	0.005	0.048	0.048
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0033	0.0175	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Schistosoma mansoni	cell adhesion molecule	0.0066	0.0783	0.1702
Trypanosoma cruzi	AMP-activated protein kinase, gamma regulatory subunit	0.0033	0.0175	0.0487
Trypanosoma cruzi	chloride channel protein, putative	0.0033	0.0175	0.0487
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0033	0.0175	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0058	0.0633	0.0777
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0633	0.0777
Toxoplasma gondii	CBS family protein	0.0033	0.0175	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0529	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0567	0.0567
Echinococcus granulosus	ephrin type A receptor 4 A	0.0081	0.1044	0.128
Echinococcus granulosus	tyrosine protein kinase Blk	0.005	0.048	0.0589
Leishmania major	serine/threonine protein kinase, putative,protein kinase, putative	0.0054	0.0567	0.1788
Loa Loa (eye worm)	chloride channel protein 7	0.0033	0.0175	0.0175
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0052	0.0532	0.1156
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0567	0.1233
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0058	0.0633	0.0777
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.3052	0.65
Leishmania major	protein kinase, putative,SNF1-related protein kinases, putative	0.0054	0.0567	0.1788
Giardia lamblia	5-AMP-activated protein kinase, gamma-1 subunit	0.0279	0.4601	1
Schistosoma mansoni	chloride channel protein	0.0033	0.0175	0.0381
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0033	0.0175	0.0487
Brugia malayi	hypothetical protein	0.0052	0.0529	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0582	0.0582
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0489	0.1527
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.0489	0.06
Trypanosoma cruzi	5'-AMP-activated protein kinase subunit beta, putative	0.0192	0.3043	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.0489	0.1527
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Brugia malayi	loechrig isoform VII	0.0279	0.4601	0.4601
Schistosoma mansoni	tyrosine kinase	0.0024	0.0024	0.0053
Echinococcus multilocularis	tyrosine protein kinase Blk	0.005	0.048	0.0589
Brugia malayi	hypothetical protein	0.0055	0.0582	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1938	0.1938
Toxoplasma gondii	CBS domain-containing protein	0.0033	0.0175	0.0691
Echinococcus multilocularis	tyrosine protein kinase Srms	0.005	0.048	0.0589
Echinococcus granulosus	tyrosine kinase	0.005	0.048	0.0589
Echinococcus multilocularis	5' AMP activated protein kinase subunit gamma	0.0279	0.4601	0.5645
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0633	0.0777
Schistosoma mansoni	serine/threonine protein kinase	0.0278	0.4571	0.9936
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0025	0.0038	0.0038
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.3052	0.3744
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0058	0.0633	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0582	0.0582
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.3052	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0268	0.0268
Toxoplasma gondii	hypothetical protein	0.005	0.0489	0.2165
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.0489	0.1062
Brugia malayi	Protein kinase domain containing protein	0.0133	0.1975	0.1975
Echinococcus granulosus	c src tyrosine kinase	0.0024	0.0024	0.003
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0033	0.0175	0.0175
Loa Loa (eye worm)	chloride channel 3	0.0033	0.0175	0.0175
Schistosoma mansoni	tyrosine kinase	0.0027	0.0072	0.0157
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0055	0.0582	0.0582
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.0489	0.1527
Onchocerca volvulus		0.051	0.8736	0.9684
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.3052	1
Echinococcus granulosus	TGF-beta receptor type-1	0.0249	0.4055	0.4975
Giardia lamblia	5-AMP-activated protein kinase, beta-1 subunit	0.0192	0.3043	0.648
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0532	0.0532
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.3052	0.3052
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0175	0.5
Brugia malayi	Protein kinase domain containing protein	0.0483	0.8261	0.8261
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.3052	1
Leishmania major	hypothetical protein, conserved	0.0192	0.3043	1
Echinococcus multilocularis	neuroglian	0.0061	0.0689	0.0846
Echinococcus granulosus	defective proboscis extension response	0.0052	0.0532	0.0653
Brugia malayi	EST embl\|AI107989\|AI107989 comes from the 3' UTR, putative	0.0278	0.4571	0.4571
Schistosoma mansoni	protein kinase subunit beta	0.0024	0.0028	0.0061
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0033	0.0175	0.0175
Brugia malayi	putative serine/threonine kinase SADA gamma	0.0054	0.0567	0.0567
Leishmania major	CBS domain protein, conserved	0.0033	0.0175	0.0487
Schistosoma mansoni	protein kinase subunit gamma	0.0279	0.4601	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.0633	0.1377
Trypanosoma brucei	Voltage-gated Chloride channel Like 1	0.0033	0.0175	0.0487
Mycobacterium ulcerans	cystathionine beta-synthase	0.0033	0.0175	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0033	0.0175	0.5
Chlamydia trachomatis	Mg++ transporter	0.0033	0.0175	0.5
Loa Loa (eye worm)	loechrig isoform VII	0.0279	0.4601	0.4601
Onchocerca volvulus	Tyrosine kinase homolog	0.0525	0.9016	1
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0483	0.8261	0.8261
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0116	0.1668	0.2046
Echinococcus granulosus	H:Cl exchange transporter 3	0.0033	0.0175	0.0215
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.0489	0.0489
Plasmodium falciparum	serine/threonine protein kinase KIN	0.0054	0.0567	0.1363
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0033	0.0175	0.0487
Brugia malayi	Tyrosine-protein kinase abl-1	0.0024	0.0024	0.0024
Trypanosoma cruzi	GMP reductase	0.0033	0.0175	0.0487
Echinococcus granulosus	H:Cl exchange transporter 4	0.0033	0.0175	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0175	0.0175
Brugia malayi	ancient conserved domain protein 4	0.0033	0.0175	0.0175
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0033	0.0175	0.0215
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.0489	0.109
Toxoplasma gondii	chloride transporter, chloride channel (ClC) family protein	0.0033	0.0175	0.0691
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0358	0.0439
Mycobacterium tuberculosis	Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)	0.0033	0.0175	0.5
Leishmania major	chloride channel protein, putative	0.0033	0.0175	0.0487
Echinococcus multilocularis	Immunoglobulin	0.0052	0.0532	0.0653
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0033	0.0175	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3052	0.3052
Toxoplasma gondii	IMP dehydrogenas	0.0033	0.0175	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0921	0.0921
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0058	0.0633	0.0777
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0052	0.0532	0.0653
Echinococcus multilocularis	AMPK beta subunit	0.0192	0.3043	0.3733
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0024	0.0024	0.003
Echinococcus multilocularis	5' AMP activated protein kinase subunit beta 1	0.0103	0.1443	0.1771
Echinococcus granulosus	AMPK beta subunit	0.0192	0.3043	0.3733
Echinococcus multilocularis	TGF beta receptor type 1	0.0249	0.4055	0.4975
Toxoplasma gondii	histone kinase SNF1, putative	0.0054	0.0567	0.2534
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0033	0.0175	0.5
Wolbachia endosymbiont of Brugia malayi	Mg/Co/Ni transporter MgtE	0.0033	0.0175	0.5
Brugia malayi	protein C17H12.11	0.0131	0.1938	0.1938
Schistosoma mansoni	chloride channel protein	0.0033	0.0175	0.0381
Brugia malayi	5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein	0.0192	0.3043	0.3043
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.0489	0.0708
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0253	0.414	0.414
Mycobacterium ulcerans	hypothetical protein	0.0033	0.0175	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0567	0.1233
Toxoplasma gondii	5'-AMP-activated protein kinase subunit beta-1 family protein, putative	0.0113	0.1628	0.7522
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0116	0.1668	0.1668
Schistosoma mansoni	serine/threonine protein kinase	0.0116	0.1668	0.3624
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0133	0.1975	0.1975
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Echinococcus multilocularis	H(+):Cl() exchange transporter 7	0.0033	0.0175	0.0215
Trypanosoma cruzi	SNF1-related protein kinases, putative	0.0054	0.0567	0.1788
Brugia malayi	ancient conserved domain protein 2	0.0033	0.0175	0.0175
Echinococcus multilocularis	H(+):Cl() exchange transporter 3	0.0033	0.0175	0.0215
Echinococcus granulosus	activin receptor type	0.0477	0.8151	1
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.3052	0.6633
Toxoplasma gondii	CBS domain-containing protein	0.0033	0.0175	0.0691
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0058	0.0633	0.0777
Brugia malayi	CLC chloride channel protein	0.0033	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0175	0.0175
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0175	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0058	0.0633	0.0777
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0489	0.1527
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.3052	0.3052
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0489	0.1527
Mycobacterium tuberculosis	Hypoxic response protein 1 Hrp1	0.0033	0.0175	0.5
Chlamydia trachomatis	CBS domain-containing protein	0.0033	0.0175	0.5
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.0489	0.0489
Echinococcus multilocularis	serine:threonine kinase SAD 1	0.0054	0.0567	0.0696
Brugia malayi	ribosomal protein S6 kinase alpha 3	0.0099	0.1376	0.1376
Giardia lamblia	Kinase, CAMK CAMKL	0.0054	0.0567	0.0886
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.3052	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0058	0.0633	0.0777
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.0489	0.0608
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0033	0.0175	0.5
Echinococcus granulosus	5' AMP activated protein kinase catalytic	0.0278	0.4571	0.5609
Trypanosoma brucei	SNF1-related protein kinases, putative	0.0054	0.0567	0.1788
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0099	0.1376	0.4472
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.2155	0.65
Echinococcus multilocularis	H(+):Cl() exchange transporter 4	0.0033	0.0175	0.0215
Leishmania major	chloride channel protein, putative	0.0033	0.0175	0.0487
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.3052	0.3744
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0054	0.0567	0.0306
Echinococcus granulosus	H:Cl exchange transporter 7	0.0033	0.0175	0.0215
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0058	0.0633	0.0777
Mycobacterium tuberculosis	Probable conserved transmembrane alanine and leucine rich protein	0.0033	0.0175	0.5
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0155	0.238	0.292
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.0489	0.1527
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0033	0.0175	0.0487
Echinococcus multilocularis	5' AMP activated protein kinase catalytic	0.0278	0.4571	0.5609
Echinococcus granulosus	tyrosine protein kinase HCK	0.0041	0.0323	0.0396
Trypanosoma cruzi	Domain of unknown function DUF21, putative	0.0033	0.0175	0.0487
Echinococcus multilocularis	activin receptor type	0.0477	0.8151	1
Echinococcus multilocularis	c src tyrosine kinase	0.0024	0.0024	0.003
Brugia malayi	SRC-1	0.0058	0.0633	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0072	0.089	0.089
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0058	0.0633	0.0777
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0567	0.1233
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0033	0.0175	0.5
Echinococcus granulosus	AMP activated protein kinase gamma regulatory	0.0033	0.0175	0.0215
Trypanosoma brucei	5'-AMP-activated protein kinase subunit beta	0.0192	0.3043	1
Trypanosoma cruzi	chloride channel protein, putative	0.0033	0.0175	0.0487
Schistosoma mansoni	nephrin	0.0064	0.0739	0.1607
Toxoplasma gondii	hypothetical protein	0.0143	0.2155	1
Onchocerca volvulus		0.0074	0.0921	0.0844
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.3052	1
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Trypanosoma cruzi	5'-AMP-activated protein kinase catalytic subunit alpha, putative	0.0054	0.0567	0.1788
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0024	0.0024	0.0053
Loa Loa (eye worm)	SRC-1	0.0058	0.0633	0.0633
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0489	0.06
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0058	0.0633	0.0777
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0033	0.0175	0.5
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0064	0.0733	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0072	0.089	0.089
Trypanosoma brucei	GMP reductase	0.0033	0.0175	0.0487
Echinococcus granulosus	neuroglian	0.0061	0.0689	0.0846
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0058	0.0633	0.0777
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Mycobacterium ulcerans	transcriptional regulator	0.0033	0.0175	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0567	0.0306
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0081	0.1044	0.128
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0028	0.0028
Schistosoma mansoni	AMP-activated protein kinase gamma regulatory subunit	0.0033	0.0175	0.0381
Leishmania major	hypothetical protein, conserved	0.0033	0.0175	0.0487
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0489	0.1527
Loa Loa (eye worm)	CAMK/CAMKL/BRSK protein kinase	0.0054	0.0567	0.0567
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0033	0.0175	0.0487

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 560 nM	Inhibitory activity against farnesyltransferase quantified by SPA assay	ChEMBL.	16289818
IC50 (binding)	= 560 nM	Inhibitory activity against farnesyltransferase quantified by SPA assay	ChEMBL.	16289818
IC50 (functional)	> 4500 nM	Inhibitory activity against Ha-Ras processing in COS7 cells	ChEMBL.	16289818
IC50 (functional)	> 4500 nM	Inhibitory activity against Ha-Ras processing in COS7 cells	ChEMBL.	16289818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 352115