TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 411.885 | Formula: C21H22ClN5O2
H donors: 2 H acceptors: 4 LogP: 1.95 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: NCCCC(=O)NCc1nnc(n1c1ccc(cc1C(=O)c1ccccc1)Cl)C
InChi: 1S/C21H22ClN5O2/c1-14-25-26-19(13-24-20(28)8-5-11-23)27(14)18-10-9-16(22)12-17(18)21(29)15-6-3-2-4-7-15/h2-4,6-7,9-10,12H,5,8,11,13,23H2,1H3,(H,24,28)
InChiKey: HYIWESLQPGAAHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tumor protein p63	0.0343	0.2393	0.553
Onchocerca volvulus		0.0142	0.084	0.5189
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Onchocerca volvulus		0.0142	0.084	0.5189
Giardia lamblia	Cathepsin B precursor	0.0207	0.1346	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0142	0.084	0.0825
Plasmodium vivax	vivapain-3	0.0066	0.0254	0.4054
Entamoeba histolytica	hypothetical protein	0.0035	0.002	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0593	0.4315	0.4305
Loa Loa (eye worm)	cysteine protease	0.0111	0.0604	0.0588
Brugia malayi	Dopamine receptor protein 2	0.0142	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	neuropeptides capa receptor	0.0142	0.084	0.1916
Schistosoma mansoni	hypothetical protein	0.0166	0.1031	0.2361
Onchocerca volvulus		0.0111	0.0604	0.3702
Echinococcus multilocularis	GPCR, family 2	0.0062	0.0227	0.0491
Brugia malayi	Pre-SET motif family protein	0.0212	0.1378	0.1378
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0062	0.0227	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Brugia malayi	neuropeptide F receptor	0.0142	0.084	0.084
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0142	0.084	0.1916
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0032	0.0099
Echinococcus multilocularis	cathepsin L cysteine protease	0.0111	0.0604	0.1367
Onchocerca volvulus		0.0111	0.0604	0.3702
Schistosoma mansoni	myosin xvIII	0.0142	0.084	0.1916
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0142	0.084	0.1916
Echinococcus granulosus	cysteine protease	0.0066	0.0254	0.0554
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0137	0.0802
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0111	0.0604	0.1367
Echinococcus granulosus	geminin	0.0166	0.1031	0.2361
Echinococcus multilocularis	neuropeptide receptor	0.0142	0.084	0.1916
Onchocerca volvulus		0.0142	0.084	0.5189
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0137	0.206
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0207	0.1346	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0196	0.1257	0.1257
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	cathepsin l1	0.008	0.0365	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Onchocerca volvulus		0.0142	0.084	0.5189
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0142	0.084	0.1916
Entamoeba histolytica	cysteine proteinase, putative	0.008	0.0365	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	neuropeptide s receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0016
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.0604	0.1367
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Brugia malayi	hypothetical protein	0.005	0.0137	0.0137
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0096	0.0186
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0142	0.084	0.1916
Echinococcus granulosus	cathepsin L	0.0066	0.0254	0.0554
Schistosoma mansoni	biogenic amine receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0196	0.1257	0.1243
Echinococcus granulosus	neuropeptide receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.0684	0.0669
Brugia malayi	Cathepsin L-like precursor	0.008	0.0365	0.0365
Echinococcus granulosus	GPCR family 2	0.0062	0.0227	0.0491
Entamoeba histolytica	hypothetical protein	0.0035	0.002	0.0069
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0111	0.0604	0.0588
Brugia malayi	cathepsin L precursor	0.0035	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Echinococcus multilocularis	cathepsin b	0.0593	0.4315	1
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0604	0.0604
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0032	0.0037
Onchocerca volvulus		0.008	0.0365	0.2201
Loa Loa (eye worm)	melatonin receptor type 1A	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0142	0.084	0.084
Schistosoma mansoni	neuropeptide receptor	0.0142	0.084	0.1916
Trypanosoma cruzi	cysteine protease, putative	0.0066	0.0254	0.0554
Plasmodium vivax	vivapain-1	0.0066	0.0254	0.4054
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0142	0.084	0.1916
Echinococcus granulosus	tm gpcr rhodopsin	0.0142	0.084	0.1916
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0111	0.0604	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0142	0.084	0.1916
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0137	0.206
Brugia malayi	GnHR receptor homolog	0.0142	0.084	0.084
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0016	0.0016
Onchocerca volvulus		0.0037	0.0032	0.0099
Echinococcus multilocularis	dro:myosuppressin receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0096	0.0186
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0032	0.0099
Entamoeba histolytica	cysteine proteinase 2	0.0066	0.0254	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0066	0.0254	0.4054
Brugia malayi	G-protein coupled receptor	0.0142	0.084	0.084
Echinococcus granulosus	cathepsin b	0.0593	0.4315	1
Leishmania major	cysteine peptidase A (CPA)	0.0111	0.0604	0.4352
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Schistosoma mansoni	histamine h1 receptor	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1346	0.8378
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Loa Loa (eye worm)	hypothetical protein	0.008	0.0365	0.035
Echinococcus granulosus	g protein coupled receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.008	0.0365	0.035
Onchocerca volvulus	Cathepsin F homolog	0.0111	0.0604	0.3702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0365	0.2201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0254	0.1693
Schistosoma mansoni	amine GPCR	0.0142	0.084	0.1916
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0111	0.0604	0.3702
Schistosoma mansoni	adenoreceptor	0.0142	0.084	0.1916
Onchocerca volvulus		0.0142	0.084	0.5189
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Echinococcus multilocularis	neuropeptides capa receptor	0.0142	0.084	0.1916
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0137	0.0282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0016
Brugia malayi	Latrophilin receptor protein 2	0.0062	0.0227	0.0227
Brugia malayi	Papain family cysteine protease containing protein	0.0066	0.0254	0.0254
Echinococcus multilocularis	g protein coupled receptor	0.0142	0.084	0.1916
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	allatostatin A receptor	0.0142	0.084	0.1916
Schistosoma mansoni	neuropeptide F-like receptor	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0096	0.0186
Brugia malayi	Dopamine receptor	0.0142	0.084	0.084
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0137	0.0282
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Brugia malayi	G protein-coupled receptor F59B2.13	0.0142	0.084	0.084
Echinococcus granulosus	somatostatin receptor	0.0142	0.084	0.1916
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0035	0.0016	0.0016
Brugia malayi	fibroinase precursor	0.0035	0.0016	0.0016
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Echinococcus granulosus	sex peptide receptor	0.0142	0.084	0.1916
Schistosoma mansoni	amine GPCR	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.0604	0.3702
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0142	0.084	0.5189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Brugia malayi	neuropeptide F receptor	0.0142	0.084	0.084
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1346	0.3093
Schistosoma mansoni	hypothetical protein	0.0062	0.0227	0.0491
Schistosoma mansoni	neuropeptide receptor	0.0142	0.084	0.1916
Entamoeba histolytica	hypothetical protein	0.0035	0.002	0.0069
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0142	0.084	0.1916
Schistosoma mansoni	hypothetical protein	0.0142	0.084	0.1916
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0142	0.084	0.1916
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0254	0.0554
Schistosoma mansoni	hypothetical protein	0.0142	0.084	0.1916
Brugia malayi	Dopamine receptor protein 1	0.0142	0.084	0.084
Onchocerca volvulus		0.0142	0.084	0.5189
Echinococcus granulosus	7tm_1 domain containing protein	0.0142	0.084	0.1916
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0142	0.084	0.1916
Schistosoma mansoni	neuropeptide receptor	0.0142	0.084	0.1916
Onchocerca volvulus		0.0142	0.084	0.5189
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0062	0.0227	0.0211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0142	0.084	0.084
Mycobacterium ulcerans	lipase LipD	0.0037	0.0032	0.5
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0604	0.0604
Echinococcus granulosus	neuropeptide s receptor	0.0142	0.084	0.1916
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0032	0.5
Leishmania major	hypothetical protein, conserved	0.005	0.0137	0.0802
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	TYRA-2 protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0142	0.084	0.0825
Brugia malayi	Cathepsin L-like cysteine proteinase	0.008	0.0365	0.0365
Onchocerca volvulus		0.0142	0.084	0.5189
Echinococcus multilocularis	somatostatin receptor	0.0142	0.084	0.1916
Entamoeba histolytica	hypothetical protein	0.0035	0.002	0.0069
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0032	0.0032
Brugia malayi	putative neuropeptide receptor	0.0142	0.084	0.084
Onchocerca volvulus		0.0142	0.084	0.5189
Loa Loa (eye worm)	cathepsin B	0.0207	0.1346	0.1332
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0032	0.0268
Echinococcus multilocularis	fmrfamide receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus granulosus	g-protein coupled receptor	0.0142	0.084	0.1916
Brugia malayi	cathepsin F-like cysteine proteinase	0.0035	0.0016	0.0016
Echinococcus multilocularis	serotonin receptor	0.0142	0.084	0.1916
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0032	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus granulosus	orexin receptor type 2	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0142	0.084	0.1916
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0142	0.084	0.1916
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Brugia malayi	hypothetical protein	0.0035	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0016	0.0016
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0593	0.4315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Echinococcus granulosus	serotonin receptor	0.0142	0.084	0.1916
Plasmodium vivax	unspecified product	0.0066	0.0254	0.4054
Brugia malayi	larval opioid receptor	0.0142	0.084	0.084
Echinococcus multilocularis	neuropeptide receptor A26	0.0142	0.084	0.1916
Onchocerca volvulus		0.0142	0.084	0.5189
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.1603	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0604	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Onchocerca volvulus		0.0142	0.084	0.5189
Echinococcus granulosus	7TM GPCR rhodopsin	0.0142	0.084	0.1916
Onchocerca volvulus		0.0111	0.0604	0.3702
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0066	0.0254	0.0554
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Onchocerca volvulus		0.005	0.0137	0.0762
Echinococcus granulosus	neuropeptides capa receptor	0.0142	0.084	0.1916
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0032	0.0037
Schistosoma mansoni	opsin-like receptor	0.0142	0.084	0.1916
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0593	0.4315	1
Onchocerca volvulus		0.0142	0.084	0.5189
Schistosoma mansoni	opsin-like receptor	0.0142	0.084	0.1916
Echinococcus multilocularis	cysteine protease	0.0111	0.0604	0.1367
Echinococcus multilocularis	orexin receptor type 2	0.0142	0.084	0.1916
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0142	0.084	0.1916
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Echinococcus multilocularis	cathepsin L cysteine protease	0.0111	0.0604	0.1367
Brugia malayi	beta-lactamase family protein	0.0037	0.0032	0.0032
Echinococcus granulosus	biogenic amine 5HT receptor	0.0142	0.084	0.1916
Brugia malayi	Cathepsin L-like precursor	0.008	0.0365	0.0365
Schistosoma mansoni	hypothetical protein	0.0062	0.0227	0.0491
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0142	0.084	0.1916
Echinococcus granulosus	g protein coupled receptor	0.0142	0.084	0.1916
Toxoplasma gondii	ABC1 family protein	0.0037	0.0032	0.0118
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0142	0.084	0.0825
Loa Loa (eye worm)	neuropeptide F receptor	0.0142	0.084	0.0825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0032	0.5
Onchocerca volvulus		0.0241	0.1603	1
Onchocerca volvulus		0.0142	0.084	0.5189
Brugia malayi	Serotonin receptor	0.0142	0.084	0.084
Schistosoma mansoni	hypothetical protein	0.0166	0.1031	0.2361
Echinococcus multilocularis	cathepsin L	0.0066	0.0254	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0016
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0593	0.4315	1
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0142	0.084	0.5189
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Loa Loa (eye worm)	G-protein coupled receptor	0.0142	0.084	0.0825
Onchocerca volvulus		0.0142	0.084	0.5189
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0016
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0604	0.1367
Entamoeba histolytica	cysteine proteinase, putative	0.0066	0.0254	0.4054
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0142	0.084	0.1916
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0142	0.084	0.1916
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0142	0.084	0.084
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0142	0.084	0.1916
Echinococcus multilocularis	cathepsin b	0.0593	0.4315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0066	0.0254	0.1501
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0066	0.0254	0.0554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Toxoplasma gondii	cathepsin B	0.0207	0.1346	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0032	0.0016
Echinococcus granulosus	g protein coupled receptor	0.0142	0.084	0.1916
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0032	0.0037
Schistosoma mansoni	hypothetical protein	0.0035	0.002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0604	0.0588
Brugia malayi	G protein-coupled receptor	0.0142	0.084	0.084
Loa Loa (eye worm)	G-protein coupled receptor	0.0142	0.084	0.0825
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0096	0.0186
Echinococcus multilocularis	G protein coupled receptor 139	0.0142	0.084	0.1916
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0096	0.0096
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0062	0.0227	0.0227
Onchocerca volvulus		0.0037	0.0032	0.0099
Brugia malayi	MH2 domain containing protein	0.0121	0.0684	0.0684
Echinococcus granulosus	fmrfamide receptor	0.0142	0.084	0.1916
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0604	0.1367
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0096	0.0186
Trichomonas vaginalis	esterase, putative	0.0037	0.0032	0.0099
Echinococcus multilocularis	allatostatin A receptor	0.0142	0.084	0.1916
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0604	0.0604
Schistosoma mansoni	cathepsin F (C01 family)	0.008	0.0365	0.0813
Echinococcus multilocularis	neuropeptide Y receptor	0.0142	0.084	0.1916
Plasmodium vivax	vivapain-2	0.0111	0.0604	1
Schistosoma mansoni	hypothetical protein	0.0062	0.0227	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0066	0.0254	0.1501
Entamoeba histolytica	cysteine proteinase, putative	0.0066	0.0254	0.4054
Loa Loa (eye worm)	hypothetical protein	0.005	0.0137	0.0121
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0032	0.0099
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0111	0.0604	0.1367
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0234	0.1549	1
Onchocerca volvulus		0.0111	0.0604	0.3702
Echinococcus granulosus	neuropeptides capa receptor	0.0142	0.084	0.1916
Brugia malayi	follicle stimulating hormone receptor	0.0142	0.084	0.084
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0142	0.084	0.084
Loa Loa (eye worm)	neuropeptide F receptor	0.0142	0.084	0.0825
Onchocerca volvulus	Cathepsin L homolog	0.0111	0.0604	0.3702
Brugia malayi	cathepsin L-like cysteine proteinase	0.0035	0.0016	0.0016
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0137	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0142	0.084	0.1916
Trypanosoma cruzi	cruzipain precursor, putative	0.0111	0.0604	0.1367
Brugia malayi	beta-lactamase	0.0037	0.0032	0.0032
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0032	0.5
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0196	0.1257	0.1257
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.002	0.0009
Schistosoma mansoni	cathepsin F (C01 family)	0.0111	0.0604	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0604	0.0604
Echinococcus granulosus	hypothetical protein	0.0142	0.084	0.1916
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Toxoplasma gondii	cathepsin CPL	0.0111	0.0604	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.008	0.0365	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0134	0.078	0.0766
Schistosoma mansoni	hypothetical protein	0.0142	0.084	0.1916
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0142	0.084	0.1916
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0137	0.091
Schistosoma mansoni	hypothetical protein	0.0142	0.084	0.1916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0111	0.0604	0.3702
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Onchocerca volvulus		0.0142	0.084	0.5189
Trypanosoma cruzi	cysteine proteinase, putative	0.0066	0.0254	0.0554
Schistosoma mansoni	hypothetical protein	0.0062	0.0227	0.0491
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	ctsf protein	0.0111	0.0604	0.0588
Echinococcus granulosus	neuropeptide Y receptor	0.0142	0.084	0.1916
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0142	0.084	0.1916
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.002	0.0009
Echinococcus granulosus	neuropeptide FF receptor 2	0.0142	0.084	0.1916
Brugia malayi	RE15519p	0.0142	0.084	0.084
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0035	0.0016	0.0016
Trypanosoma cruzi	cysteine proteinase, putative	0.0066	0.0254	0.0554
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0032	0.0037
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0142	0.084	0.1916
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0142	0.084	0.1916
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0062	0.0227	0.0491
Loa Loa (eye worm)	hypothetical protein	0.005	0.0137	0.0121
Onchocerca volvulus		0.0111	0.0604	0.3702
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0142	0.084	0.1916
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0062	0.0227	0.0491
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	biogenic amine 5HT receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Brugia malayi	AKH receptor	0.0142	0.084	0.084
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0142	0.084	0.1916
Schistosoma mansoni	amine GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	cathepsin b	0.0593	0.4315	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0066	0.0254	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	fibroinase	0.0111	0.0604	0.0588
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0207	0.1346	0.3093
Echinococcus granulosus	cathepsin l1	0.0111	0.0604	0.1367
Onchocerca volvulus		0.0142	0.084	0.5189
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0604	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.002	0.0009
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0111	0.0604	0.3702
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0111	0.0604	1
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0604	0.0604
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Entamoeba histolytica	cysteine proteinase, putative	0.0066	0.0254	0.4054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Echinococcus multilocularis	fmrfamide receptor	0.0142	0.084	0.1916
Entamoeba histolytica	cysteine protease, putative	0.0066	0.0254	0.4054
Echinococcus multilocularis	g protein coupled receptor	0.0142	0.084	0.1916
Brugia malayi	sulfakinin receptor protein	0.1332	1	1
Echinococcus multilocularis	sex peptide receptor	0.0142	0.084	0.1916
Schistosoma mansoni	hypothetical protein	0.0134	0.078	0.1778
Loa Loa (eye worm)	hypothetical protein	0.1332	1	1
Brugia malayi	Cathepsin L-like precursor	0.0111	0.0604	0.0604
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0032	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0604	0.1367
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0142	0.084	0.1916
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0142	0.084	0.1916
Onchocerca volvulus		0.0037	0.0032	0.0099
Brugia malayi	cathepsin L-like precursor	0.008	0.0365	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	serotonin receptor	0.0142	0.084	0.1916
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0032	0.5
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0212	0.1378	0.1364
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0142	0.084	0.1916
Giardia lamblia	Cathepsin B precursor	0.0207	0.1346	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0604	0.1367
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0032	0.0016
Echinococcus multilocularis	g protein coupled receptor	0.0142	0.084	0.1916
Brugia malayi	G-protein coupled receptor	0.0142	0.084	0.084
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0142	0.084	0.1916
Brugia malayi	beta-lactamase family protein	0.0037	0.0032	0.0032
Onchocerca volvulus		0.0111	0.0604	0.3702
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0111	0.0604	1
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0137	0.206
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.008	0.0365	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Schistosoma mansoni	neuropeptide receptor	0.0142	0.084	0.1916
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0142	0.084	0.1916
Schistosoma mansoni	amine GPCR	0.0142	0.084	0.1916
Brugia malayi	Melatonin receptor type 1A	0.0142	0.084	0.084
Echinococcus granulosus	neuropeptide receptor	0.0142	0.084	0.1916
Schistosoma mansoni	biogenic amine receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0196	0.1257	0.1243
Echinococcus multilocularis	tumor protein p63	0.0343	0.2393	0.553
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0096	0.0186
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0032	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0254	0.1693
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0142	0.084	0.1916
Echinococcus granulosus	neuropeptide Y receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0066	0.0254	0.0554
Echinococcus multilocularis	g-protein coupled receptor	0.0142	0.084	0.1916
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.0604	0.0604
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0142	0.084	0.0825
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.0684	0.0669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	tm gpcr rhodopsin	0.0142	0.084	0.1916
Echinococcus granulosus	dro:myosuppressin receptor	0.0142	0.084	0.1916
Echinococcus multilocularis	neuropeptide receptor	0.0142	0.084	0.1916
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0593	0.4315	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0066	0.0254	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0035	0.0016	0.0016
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0593	0.4315	1
Onchocerca volvulus		0.0111	0.0604	0.3702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Echinococcus granulosus	tm gpcr rhodopsin	0.0142	0.084	0.1916
Schistosoma mansoni	opsin-like receptor	0.0142	0.084	0.1916
Plasmodium vivax	vivapain-2	0.0111	0.0604	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0604	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0142	0.084	0.1916
Echinococcus multilocularis	neuropeptide Y receptor	0.0142	0.084	0.1916
Brugia malayi	ORL1-like opioid receptor	0.0142	0.084	0.084
Schistosoma mansoni	amine GPCR	0.0142	0.084	0.1916
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0032	0.0037
Schistosoma mansoni	neuropeptide F-like receptor	0.0142	0.084	0.1916
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.008	0.0365	0.035
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0227	0.0211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Brugia malayi	Papain family cysteine protease containing protein	0.0066	0.0254	0.0254
Giardia lamblia	Cathepsin B precursor	0.0207	0.1346	1
Echinococcus granulosus	G protein coupled receptor 139	0.0142	0.084	0.1916
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0066	0.0254	0.0554
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0111	0.0604	0.0588
Echinococcus multilocularis	cysteine protease	0.0111	0.0604	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0604	0.3702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0111	0.0604	0.4352
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0142	0.084	0.1916
Brugia malayi	cathepsin B-like cysteine proteinase	0.0593	0.4315	0.4315
Schistosoma mansoni	neuropeptide f receptor 76f	0.0142	0.084	0.1916
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Brugia malayi	Serotonin receptor	0.0142	0.084	0.084
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0062	0.0227	0.0491
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0207	0.1346	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0142	0.084	0.1916
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0111	0.0604	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0142	0.084	0.084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0142	0.084	0.1916
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0142	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0032	0.0099
Brugia malayi	latrophilin 2 splice variant baaae	0.0134	0.078	0.078
Onchocerca volvulus		0.0142	0.084	0.5189
Echinococcus granulosus	cathepsin L cysteine protease	0.0066	0.0254	0.0554
Leishmania major	cathepsin L-like protease	0.0111	0.0604	0.4352
Loa Loa (eye worm)	hypothetical protein	0.0142	0.084	0.0825
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0096	0.0186
Schistosoma mansoni	biogenic amine receptor	0.0142	0.084	0.1916
Brugia malayi	putative neuropeptide receptor NPR1	0.0142	0.084	0.084
Echinococcus granulosus	neuropeptide receptor A26	0.0142	0.084	0.1916
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0032	0.0099
Echinococcus multilocularis	geminin	0.0166	0.1031	0.2361
Brugia malayi	hypothetical protein	0.0142	0.084	0.084
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0032	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0142	0.084	0.1916
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0111	0.0604	0.1367
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0096	0.008

Activities

Activity type	Activity value	Assay description	Source	Reference
Control (binding)	= 10 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 30 uM/kg iv dose (Range 5-10%)	ChEMBL.	3016261
Control (binding)	= 10 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 30 uM/kg iv dose (Range 5-10%)	ChEMBL.	3016261
Control (binding)	= 20 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 10 uM/kg iv dose	ChEMBL.	3016261
Control (binding)	= 20 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 10 uM/kg iv dose	ChEMBL.	3016261
Control (binding)	= 51 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 3 uM/kg iv dose	ChEMBL.	3016261
Control (binding)	= 51 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 3 uM/kg iv dose	ChEMBL.	3016261
Control (binding)	= 80 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 1 uM/kg iv dose	ChEMBL.	3016261
Control (binding)	= 80 %	Ex vivo displacement of [3H]-flunitrazepam from mouse GABA-A benzodiazepine receptor at 1 uM/kg iv dose	ChEMBL.	3016261
ED50 (functional)	= 320 uM kg-1	Ex vivo inhibition of [3H]-flunitrazepam binding to mouse GABA-A benzodiazepine receptor	ChEMBL.	3016261
ED50 (functional)	= 320 uM kg-1	Ex vivo inhibition of [3H]-flunitrazepam binding to mouse GABA-A benzodiazepine receptor	ChEMBL.	3016261

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 35780