TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.47 | Formula: C25H24N2O2
H donors: 1 H acceptors: 2 LogP: 4.58 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)c1cccc(c1)C(=O)C)Nc1ccc2c(c1)N(C)CCC2
InChi: 1S/C25H24N2O2/c1-17(28)21-5-3-6-22(15-21)18-8-10-20(11-9-18)25(29)26-23-13-12-19-7-4-14-27(2)24(19)16-23/h3,5-6,8-13,15-16H,4,7,14H2,1-2H3,(H,26,29)
InChiKey: FXBAKEKMXDSFRF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Schistosoma mansoni	cathepsin F (C01 family)	0.0424	0.3014	0.3014
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1045	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0176	0.1045	0.1045
Schistosoma mansoni	hypothetical protein	0.0165	0.0957	0.0957
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0143	0.0779	0.1357
Trypanosoma cruzi	cysteine peptidase, putative	0.0335	0.2303	0.2155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0143	0.0779	0.1357
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.1487	0.1487
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0143	0.0779	0.1357
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Loa Loa (eye worm)	cysteine protease	0.0616	0.4538	0.4538
Brugia malayi	cathepsin L-like precursor	0.0424	0.3014	0.3014
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0143	0.0779	0.1357
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0143	0.0779	0.1357
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Plasmodium vivax	vivapain-3	0.0335	0.2303	0.4861
Echinococcus multilocularis	cathepsin L cysteine protease	0.0616	0.4538	0.4538
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0143	0.0779	0.0779
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0424	0.3014	0.288
Plasmodium vivax	unspecified product	0.0192	0.1167	0.2249
Brugia malayi	SWIRM domain containing protein	0.0188	0.1135	0.1135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Schistosoma mansoni	amine oxidase	0.0069	0.0189	0.0189
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	Cathepsin L-like precursor	0.0424	0.3014	0.3014
Echinococcus multilocularis	cysteine protease	0.0616	0.4538	0.4538
Trypanosoma cruzi	cysteine proteinase, putative	0.0335	0.2303	0.2155
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0616	0.4538	0.4538
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0143	0.0779	0.0779
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0502	0.3631	0.3508
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0189	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0335	0.2303	0.2155
Plasmodium vivax	vivapain-1	0.0335	0.2303	0.4861
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0335	0.2303	0.4861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0424	0.3014	0.5946
Echinococcus multilocularis	cathepsin L	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Entamoeba histolytica	cysteine proteinase, putative	0.0616	0.4538	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0143	0.0779	0.0602
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0019	0.0019
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0176	0.1045	0.1045
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1304	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0143	0.0779	0.0779
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1304	1	1
Echinococcus multilocularis	cathepsin L	0.0335	0.2303	0.2303
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0612	0.4509	1
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Plasmodium vivax	vivapain-2	0.0616	0.4538	1
Brugia malayi	hypothetical protein	0.0069	0.0189	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Schistosoma mansoni	cathepsin s	0.0192	0.1167	0.1167
Giardia lamblia	Cathepsin B precursor	0.0502	0.3631	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Loa Loa (eye worm)	cathepsin B	0.0502	0.3631	0.3631
Toxoplasma gondii	cathepsin CPL	0.0616	0.4538	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine protease, putative	0.0616	0.4538	1
Schistosoma mansoni	cathepsin C	0.0143	0.0779	0.0779
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0616	0.4538	0.4538
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0424	0.3014	0.3014
Echinococcus multilocularis		0.0069	0.0189	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0335	0.2303	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0143	0.0779	0.1357
Plasmodium falciparum	serine repeat antigen 2	0.0143	0.0779	0.1357
Echinococcus granulosus	cathepsin l1	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Echinococcus multilocularis	cysteine protease	0.0616	0.4538	0.4538
Trypanosoma cruzi	cysteine protease, putative	0.0335	0.2303	0.2155
Entamoeba histolytica	cysteine proteinase, putative	0.0424	0.3014	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.1487	0.1487
Echinococcus multilocularis	geminin	0.0165	0.0957	0.0957
Onchocerca volvulus		0.0188	0.1135	0.247
Schistosoma mansoni	amine oxidase	0.0069	0.0189	0.0189
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0192	0.1167	0.1167
Trypanosoma cruzi	cysteine peptidase, putative	0.0192	0.1167	0.0997
Onchocerca volvulus		0.0616	0.4538	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0502	0.3631	0.5942
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0335	0.2303	0.4054
Loa Loa (eye worm)	ctsf protein	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0502	0.3631	0.3631
Plasmodium falciparum	serine repeat antigen 6	0.0143	0.0779	0.1357
Giardia lamblia	Cathepsin B precursor	0.0502	0.3631	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.003	0.003
Plasmodium falciparum	serine repeat antigen 7	0.0143	0.0779	0.1357
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.003	0.003
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0069	0.0189	0.0189
Toxoplasma gondii	cathepsin CPC2	0.0143	0.0779	0.1357
Schistosoma mansoni	hypothetical protein	0.0165	0.0957	0.0957
Schistosoma mansoni	cathepsin B (C01 family)	0.0143	0.0779	0.0779
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.1304	1	1
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Brugia malayi	Papain family cysteine protease containing protein	0.0335	0.2303	0.2303
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0069	0.0189	0.0189
Trypanosoma cruzi	major cysteine proteinase, putative	0.0143	0.0779	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Trypanosoma cruzi	cysteine peptidase, putative	0.0616	0.4538	0.4433
Plasmodium vivax	unspecified product	0.0335	0.2303	0.4861
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0335	0.2303	0.2155
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0544	0.3964	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	fibroinase precursor	0.0143	0.0779	0.0779
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0192	0.1167	0.1167
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0424	0.3014	0.3014
Loa Loa (eye worm)	hypothetical protein	0.008	0.028	0.028
Brugia malayi	cathepsin F-like cysteine proteinase	0.0143	0.0779	0.0779
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Toxoplasma gondii	cathepsin B	0.0502	0.3631	0.7914
Plasmodium vivax	serine-repeat antigen (SERA)	0.0143	0.0779	0.1357
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0189	0.0189
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0779	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1167	0.1167
Schistosoma mansoni	cathepsin F (C01 family)	0.0616	0.4538	0.4538
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0069	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0424	0.3014	0.3014
Loa Loa (eye worm)	hypothetical protein	0.0424	0.3014	0.3014
Onchocerca volvulus	Cathepsin L homolog	0.0143	0.0779	0.1682
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0143	0.0779	0.0779
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0143	0.0779	0.1357
Onchocerca volvulus	Cathepsin L homolog	0.0616	0.4538	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0069	0.0189	0.5
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0616	0.4538	0.4538
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Trypanosoma cruzi	cruzipain precursor, putative	0.0616	0.4538	0.4433
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0176	0.1045	0.1045
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0143	0.0779	0.1357
Plasmodium vivax	vivapain-2	0.0616	0.4538	1
Brugia malayi	Cathepsin L-like precursor	0.0424	0.3014	0.3014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Echinococcus granulosus	geminin	0.0165	0.0957	0.0957
Plasmodium falciparum	serine repeat antigen 4	0.0143	0.0779	0.1357
Onchocerca volvulus		0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0143	0.0779	0.0779
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0616	0.4538	0.4538
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1487	0.1487
Brugia malayi	Cathepsin L-like precursor	0.0192	0.1167	0.1167
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1304	1	1
Plasmodium falciparum	serine repeat antigen 3	0.0143	0.0779	0.1357
Echinococcus multilocularis	cathepsin b	0.1304	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0616	0.4538	1
Onchocerca volvulus	Cathepsin L homolog	0.0616	0.4538	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Toxoplasma gondii	cathepsin CPC1	0.0143	0.0779	0.1357
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.003	0.003
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0335	0.2303	0.2303
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Onchocerca volvulus		0.0424	0.3014	0.6628
Entamoeba histolytica	cysteine proteinase, putative	0.0335	0.2303	0.4054
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0019	0.0019
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0335	0.2303	0.2303
Brugia malayi	cathepsin L precursor	0.0143	0.0779	0.0779
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0502	0.3631	0.7914
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0143	0.0779	0.1357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Echinococcus granulosus	cathepsin L	0.0335	0.2303	0.2303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0424	0.3014	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1304	1	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0069	0.0189	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Entamoeba histolytica	cysteine proteinase, putative	0.0616	0.4538	1
Plasmodium falciparum	serine repeat antigen 5	0.0143	0.0779	0.1357
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0616	0.4538	1
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Brugia malayi	hypothetical protein	0.0232	0.1487	0.1487
Brugia malayi	amine oxidase, flavin-containing family protein	0.008	0.028	0.028
Echinococcus multilocularis	cathepsin L cysteine protease	0.0616	0.4538	0.4538
Plasmodium falciparum	serine repeat antigen 8	0.0143	0.0779	0.1357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0616	0.4538	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0192	0.1167	0.0997
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0143	0.0779	0.0779
Schistosoma mansoni	cathepsin F (C01 family)	0.0616	0.4538	0.4538
Loa Loa (eye worm)	fibroinase	0.0616	0.4538	0.4538
Onchocerca volvulus		0.0616	0.4538	1
Plasmodium falciparum	serine repeat antigen 9	0.0143	0.0779	0.1357
Brugia malayi	Papain family cysteine protease containing protein	0.0335	0.2303	0.2303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Onchocerca volvulus	Cathepsin F homolog	0.0616	0.4538	1
Plasmodium vivax	unspecified product	0.0143	0.0779	0.1357
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0143	0.0779	0.1357
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Echinococcus granulosus	cathepsin L	0.0143	0.0779	0.0779
Brugia malayi	cathepsin F-like cysteine proteinase	0.0192	0.1167	0.1167
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0502	0.3631	0.7587
Onchocerca volvulus		0.0616	0.4538	1
Onchocerca volvulus		0.0143	0.0779	0.1682
Giardia lamblia	Cathepsin B precursor	0.0502	0.3631	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.003	0.003
Entamoeba histolytica	cysteine proteinase 2	0.0335	0.2303	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0616	0.4538	0.4538
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0143	0.0779	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1135	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0143	0.0779	0.1357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Echinococcus granulosus	cysteine protease	0.0335	0.2303	0.2303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0616	0.4538	1
Onchocerca volvulus		0.0616	0.4538	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0143	0.0779	0.0779
Onchocerca volvulus		0.0616	0.4538	1
Plasmodium falciparum	serine repeat antigen 1	0.0143	0.0779	0.1357
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0616	0.4538	0.4538
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0616	0.4538	0.4538
Echinococcus granulosus	cathepsin b	0.1304	1	1
Onchocerca volvulus		0.0616	0.4538	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0612	0.4509	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0616	0.4538	1
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0143	0.0779	0.1357
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0616	0.4538	0.4538
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0143	0.0779	0.1357
Echinococcus granulosus	cathepsin l1	0.0424	0.3014	0.3014
Plasmodium vivax	serine-repeat antigen (SERA)	0.0143	0.0779	0.1357
Echinococcus granulosus	cathepsin b	0.1304	1	1
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1167	0.1167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0616	0.4538	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0335	0.2303	0.2303
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Schistosoma mansoni	hypothetical protein	0.0047	0.0019	0.0019
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0335	0.2303	0.2303
Entamoeba histolytica	cysteine protease, putative	0.0335	0.2303	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1304	1	1
Leishmania major	cathepsin L-like protease	0.0616	0.4538	1
Loa Loa (eye worm)	hypothetical protein	0.0192	0.1167	0.1167
Echinococcus multilocularis	cathepsin b	0.1304	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0143	0.0779	0.0779
Schistosoma mansoni	cathepsin S (C01 family)	0.0143	0.0779	0.0779
Entamoeba histolytica	cysteine proteinase 1, putative	0.0335	0.2303	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1045	0.1045
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0143	0.0779	0.0779
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0616	0.4538	1

Activities

Activity type	Activity value	Assay description	Source	Reference
pKb (functional)	= 7	Antagonist activity against human TRPV1 assessed as inhibition of capsaicin-induced calcium influx by FLIPR assay	ChEMBL.	16806913

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 368987