Detailed information for compound 369527

Basic information

Technical information
  • TDR Targets ID: 369527
  • Name: 2-[[(2R)-1-[[2-[(4-carbamimidoylphenyl)methyl carbamoyl]-1,3-dihydroinden-2-yl]amino]-3-cyc lohexyl-1-oxopropan-2-yl]amino]acetic acid
  • MW: 519.635 | Formula: C29H37N5O4
  • H donors: 5 H acceptors: 4 LogP: 1.24 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CN[C@@H](C(=O)NC1(Cc2c(C1)cccc2)C(=O)NCc1ccc(cc1)C(=N)N)CC1CCCCC1
  • InChi: 1S/C29H37N5O4/c30-26(31)21-12-10-20(11-13-21)17-33-28(38)29(15-22-8-4-5-9-23(22)16-29)34-27(37)24(32-18-25(35)36)14-19-6-2-1-3-7-19/h4-5,8-13,19,24,32H,1-3,6-7,14-18H2,(H3,30,31)(H,33,38)(H,34,37)(H,35,36)/t24-/m1/s1
  • InChiKey: UEWOKJCHBKCJBO-XMMPIXPASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methylcarbamoyl]indan-2-yl]amino]-1-(cyclohexylmethyl)-2-oxo-ethyl]amino]acetic acid
  • 2-[[(1R)-2-[[2-[[(4-carbamimidoylphenyl)methylamino]-oxomethyl]-2-indanyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]amino]acetic acid
  • 2-[[(2R)-1-[[2-[(4-carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-3-cyclohexyl-1-oxo-propan-2-yl]amino]ethanoic acid
  • 2-[[(1R)-2-[[2-[(4-amidinobenzyl)carbamoyl]indan-2-yl]amino]-1-(cyclohexylmethyl)-2-keto-ethyl]amino]acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glycoprotein Antigen 5 Get druggable targets OG5_136757 All targets in OG5_136757
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus granulosus Mastin Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus multilocularis enteropeptidase Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus multilocularis glycoprotein Antigen 5 Get druggable targets OG5_136757 All targets in OG5_136757
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus granulosus enteropeptidase Get druggable targets OG5_136757 All targets in OG5_136757
Echinococcus multilocularis Mastin Get druggable targets OG5_136757 All targets in OG5_136757
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G-protein coupled receptor, putative 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0331 0.3172 1
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0037 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0257 0.0257
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0045 0.026 0.026
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) TYRA-2 protein 0.0045 0.026 0.026
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.002 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus 0.0021 0.002 0.0513
Toxoplasma gondii PAN domain-containing protein 0.0356 0.343 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.013 0.013
Echinococcus multilocularis neuropeptide FF receptor 2 0.0045 0.026 0.026
Echinococcus granulosus Mastin 0.0063 0.0449 0.0449
Echinococcus granulosus protein jagged 2 0.002 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Echinococcus granulosus neurogenic locus notch protein 4 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.013 0.013
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0045 0.026 0.026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0063 0.0449 0.0449
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.026 0.026
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0045 0.026 0.026
Toxoplasma gondii EGF family domain-containing protein 0.002 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.026 0.026
Schistosoma mansoni alpha-1 adrenergic receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Brugia malayi Melatonin receptor type 1A 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.013 0.013
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0045 0.026 0.026
Loa Loa (eye worm) Notch2 0.002 0.0007 0.0007
Brugia malayi steroid hormone receptor 0.0032 0.013 0.013
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1002 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0045 0.026 0.026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0045 0.026 0.026
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0021 0.0017 1
Echinococcus multilocularis laminin 0.0032 0.0132 0.0132
Brugia malayi Kringle domain containing protein 0.0021 0.002 0.002
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1053 0.1053
Brugia malayi Cadherin domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Brugia malayi RE15519p 0.0045 0.026 0.026
Schistosoma mansoni thyroid hormone receptor 0.0155 0.138 0.138
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Schistosoma mansoni laminin gamma-3 chain 0.002 0.0007 0.0007
Echinococcus granulosus G protein coupled receptor 139 0.0045 0.026 0.026
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.013 0.013
Echinococcus granulosus protein jagged 1 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Entamoeba histolytica hypothetical protein 0.0021 0.0017 1
Echinococcus granulosus protein jagged 1 0.002 0.0007 0.0007
Toxoplasma gondii microneme protein, putative 0.0023 0.0037 0.0107
Loa Loa (eye worm) notch protein 0.002 0.0007 0.0007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Toxoplasma gondii kringle domain-containing protein 0.0021 0.002 0.0058
Echinococcus granulosus delta-like protein 1 0.002 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.013 0.4861
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.013 0.4861
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Brugia malayi nuclear receptor NHR-88 0.0032 0.013 0.013
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.013 0.013
Echinococcus granulosus allatostatin A receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0045 0.026 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Echinococcus multilocularis fmrfamide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi Protein kinase domain containing protein 0.0021 0.002 0.002
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Echinococcus granulosus hypothetical protein 0.0045 0.026 0.026
Brugia malayi putative neuropeptide receptor 0.0045 0.026 0.026
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.002 0.5
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus Arrow homolog 0.0032 0.0132 0.4923
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi nuclear hormone receptor 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus 7TM GPCR rhodopsin 0.0045 0.026 0.026
Toxoplasma gondii hypothetical protein 0.0023 0.0037 0.0107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.002
Brugia malayi Cadherin domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Brugia malayi GnHR receptor homolog 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.026 0.026
Brugia malayi Fibulin-1 precursor 0.0032 0.0132 0.0132
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.013 0.013
Brugia malayi Dopamine receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis protein jagged 1 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus dro:myosuppressin receptor 0.0045 0.026 0.026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0045 0.026 0.026
Echinococcus multilocularis serotonin receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus orexin receptor type 2 0.0045 0.026 0.026
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Onchocerca volvulus 0.0045 0.026 1
Echinococcus granulosus glycoprotein Antigen 5 0.0063 0.0449 0.0449
Schistosoma mansoni myosin xvIII 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Onchocerca volvulus 0.0045 0.026 1
Onchocerca volvulus 0.0023 0.0037 0.1177
Echinococcus granulosus neurogenic locus protein delta 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0111 0.0936 0.0936
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni septate junction protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis sex peptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Onchocerca volvulus 0.0045 0.026 1
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.0045 0.026 0.026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0045 0.026 0.026
Brugia malayi G protein-coupled receptor F59B2.13 0.0045 0.026 0.026
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0045 0.026 0.026
Brugia malayi Dopamine receptor protein 2 0.0045 0.026 0.026
Toxoplasma gondii hypothetical protein 0.0023 0.0037 0.0107
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.026 0.026
Echinococcus granulosus serotonin receptor 0.0045 0.026 0.026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Echinococcus multilocularis somatostatin receptor 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0045 0.026 0.026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0123 0.1053 0.1053
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0132 0.0132
Echinococcus multilocularis protein jagged 2 0.002 0.0007 0.0007
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1002 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0007 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.026 0.026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.026 0.026
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Echinococcus multilocularis fibrillin 1 0.0032 0.0132 0.0132
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni opsin-like receptor 0.0045 0.026 0.026
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni cell polarity protein 0.002 0.0007 0.0007
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0132 0.0384
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0045 0.026 0.026
Echinococcus granulosus notch 0.002 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0037 0.1177
Brugia malayi sulfakinin receptor protein 0.0045 0.026 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.013 0.013
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0037 0.0107
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Echinococcus multilocularis fat cadherin tumor suppressor 0.002 0.0007 0.0007
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus neural cadherin 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Toxoplasma gondii microneme protein MIC4 0.0023 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis neurogenic locus notch protein 4 0.002 0.0007 0.0007
Brugia malayi AKH receptor 0.0045 0.026 0.026
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.013 0.013
Echinococcus multilocularis Tolloid protein 1 0.0032 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0032 0.0132 0.0132
Schistosoma mansoni notch 0.002 0.0007 0.0007
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus slit 2 protein 0.002 0.0007 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0128 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Echinococcus granulosus protein jagged 2 0.002 0.0007 0.0007
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0331 0.3172 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Onchocerca volvulus 0.0023 0.0037 0.1177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis serotonin receptor 0.0045 0.026 0.026
Echinococcus granulosus laminin 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Giardia lamblia NADPH oxidoreductase, putative 0.0021 0.0017 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi notch-like transmembrane receptor 0.002 0.0007 0.0007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni retinoic acid receptor RXR 0.0128 0.1109 0.1109
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0021 0.0017 1
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni opsin-like receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0017 0.0055
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0045 0.026 0.026
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0045 0.026 0.026
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0 0.5
Echinococcus granulosus c-Jun N-terminal kinases 0.1002 1 1
Echinococcus granulosus Tolloid protein 1 0.0032 0.0132 0.0132
Onchocerca volvulus 0.0023 0.0037 0.1177
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.013 0.013
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0021 0.0017 0.0055
Brugia malayi Muscle positioning protein 4 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0045 0.026 0.026
Echinococcus granulosus neurogenic locus notch protein 0.002 0.0007 0.0007
Brugia malayi putative neuropeptide receptor NPR1 0.0045 0.026 0.026
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis notch 0.002 0.0007 0.0007
Echinococcus granulosus g-protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni coup transcription factor 0.0032 0.013 0.013
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.026 0.026
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) melatonin receptor type 1A 0.0045 0.026 0.026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Leishmania major hypothetical protein, conserved 0.0021 0.002 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi neuropeptide F receptor 0.0045 0.026 0.026
Brugia malayi Dopamine receptor protein 1 0.0045 0.026 0.026
Brugia malayi Delta serrate ligand family protein 0.002 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Schistosoma mansoni notch 0.002 0.0007 0.0007
Echinococcus granulosus enteropeptidase 0.0063 0.0449 0.0449
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0257 0.0257
Echinococcus granulosus neuropeptide FF receptor 2 0.0045 0.026 0.026
Brugia malayi Serotonin receptor 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0045 0.026 0.026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Schistosoma mansoni notch 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni notch 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Giardia lamblia High cysteine protein 0.002 0.0007 0.3938
Echinococcus multilocularis neuropeptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis G protein coupled receptor 139 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0045 0.026 0.026
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.002 0.0007 0.0007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0045 0.026 0.026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Echinococcus multilocularis orexin receptor type 2 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.026 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0257 0.0257
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0037 0.0107
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus g protein coupled receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni adenoreceptor 0.0045 0.026 0.026
Brugia malayi ORL1-like opioid receptor 0.0045 0.026 0.026
Echinococcus multilocularis dro:myosuppressin receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni notch 0.002 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor A26 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus alpha 1A adrenergic receptor 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Brugia malayi G-protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0045 0.026 0.026
Echinococcus granulosus fmrfamide receptor 0.0045 0.026 0.026
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus g protein coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis g-protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni notch 0.002 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor 0.0045 0.026 0.026
Echinococcus granulosus neuropeptide s receptor 0.0045 0.026 0.026
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0155 0.138 0.138
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0257 0.0257
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.002 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Echinococcus multilocularis glycoprotein Antigen 5 0.0063 0.0449 0.0449
Echinococcus granulosus sex peptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni opsin-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Echinococcus granulosus neuropeptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis fibropellin Ia 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Toxoplasma gondii subtilisin SUB12 0.0023 0.0037 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.013 0.013
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0032 0.013 0.013
Brugia malayi G protein-coupled receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni slit 0.002 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0257 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.013 0.013
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Onchocerca volvulus 0.0032 0.013 0.4861
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.026 0.026
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0132 0.0384
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni egf-like domain protein 0.0032 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.0032 0.013 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0045 0.026 0.026
Toxoplasma gondii PAN domain-containing protein 0.0356 0.343 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0007 0.0007
Echinococcus granulosus fibropellin Ia 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0045 0.026 0.026
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.026 0.026
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0132 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Giardia lamblia NADPH oxidoreductase, putative 0.0021 0.0017 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni histamine h1 receptor 0.0045 0.026 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0257 0.0257
Brugia malayi larval opioid receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide s receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0045 0.026 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.013 0.013
Brugia malayi GCC2 and GCC3 family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Echinococcus multilocularis protein jagged 1 0.002 0.0007 0.0007
Brugia malayi Serotonin receptor 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.0007 0.0007
Brugia malayi follicle stimulating hormone receptor 0.0045 0.026 0.026
Echinococcus granulosus 7tm_1 domain containing protein 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus FTZ F1 alpha 0.0032 0.013 0.013
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.002 0.002
Echinococcus multilocularis neural cadherin 0.002 0.0007 0.0007
Schistosoma mansoni biogenic amine receptor 0.0045 0.026 0.026
Echinococcus multilocularis enteropeptidase 0.0063 0.0449 0.0449
Echinococcus granulosus neurogenic locus notch protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1053 0.1053
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.002 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.013 0.013
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.013 0.4861
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis Mastin 0.0063 0.0449 0.0449
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0037 0.0107
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.0007 0.0007
Echinococcus granulosus somatostatin receptor 0.0045 0.026 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.002 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.138 0.138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.013 0.013
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0045 0.026 0.026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Echinococcus multilocularis g protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus granulosus g protein coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis allatostatin A receptor 0.0045 0.026 0.026
Echinococcus multilocularis fmrfamide receptor 0.0045 0.026 0.026
Echinococcus multilocularis slit 2 protein 0.002 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.026 0.026
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0037 0.1177
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.013 0.013
Brugia malayi Tachykinin-like peptides receptor 99D 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.013 0.013
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi neuropeptide F receptor 0.0045 0.026 0.026
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Giardia lamblia NADPH oxidoreductase, putative 0.0021 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus neuropeptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0045 0.026 1
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi G-protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni serine/threonine protein kinase 0.1002 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0045 0.026 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 uM Inhibition of human aPC ChEMBL. 16913694
IC50 (binding) = 0.1 uM Inhibition of human aPC ChEMBL. 16913694
IC50 (binding) = 1.25 uM Inhibition of human thrombin activity ChEMBL. 16913694
IC50 (binding) = 1.25 uM Inhibition of human thrombin activity ChEMBL. 16913694

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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