TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 221.726 | Formula: C13H16ClN
H donors: 1 H acceptors: 0 LogP: 2.93 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: CC1[C@@H]2CNC[C@@H]2c2c1cc(C)c(c2)Cl
InChi: 1S/C13H16ClN/c1-7-3-9-8(2)11-5-15-6-12(11)10(9)4-13(7)14/h3-4,8,11-12,15H,5-6H2,1-2H3/t8?,11-,12+/m0/s1
InChiKey: LKSWCKLOGNAERN-DAPPQGSGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Echinococcus granulosus	sodium and chloride dependent glycine	0.0046	0.0547	0.0741
Brugia malayi	Pre-SET motif family protein	0.0031	0.0339	0.035
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0004
Schistosoma mansoni	hypothetical protein	0.0048	0.0585	0.1249
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0238	0.07
Echinococcus granulosus	G protein coupled receptor 139	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0195	0.2657	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Brugia malayi	AKH receptor	0.0048	0.0585	0.0642
Plasmodium vivax	importin-beta 2, putative	0.003	0.0317	0.1044
Schistosoma mansoni	opsin-like receptor	0.0048	0.0585	0.1249
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0044	0.006
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0044	0.013
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0238	0.0128
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0585	0.1249
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0046	0.0547	0.0741
Brugia malayi	Pre-SET motif family protein	0.0217	0.2971	0.3479
Onchocerca volvulus		0.0048	0.0585	0.0543
Echinococcus multilocularis	somatostatin receptor	0.0048	0.0585	0.0792
Plasmodium vivax	amine transporter, putative	0.0046	0.0547	0.1924
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0048	0.0585	0.1252
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Brugia malayi	Importin beta-1 subunit	0.003	0.0317	0.0324
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.1165
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0044	0.006
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0048	0.0585	0.1249
Leishmania major	telomerase reverse transcriptase, putative	0.0195	0.2657	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0048	0.0585	0.0792
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0206	0.0621
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0339	0.0681
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0585	0.0792
Trichomonas vaginalis	ran, putative	0.0022	0.0206	0.0608
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0048	0.0585	0.1249
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0585	0.1249
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0048	0.0585	0.0792
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0046	0.0547	0.0741
Schistosoma mansoni	amine GPCR	0.0048	0.0585	0.1249
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.027	0.3721	0.437
Schistosoma mansoni	growth hormone secretagogue receptor	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.2971	0.6766
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	hypothetical protein	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0046	0.0547	0.1162
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0585	0.0792
Schistosoma mansoni	myosin xvIII	0.0048	0.0585	0.1249
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.001	0.0044	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0048	0.0585	0.0792
Echinococcus multilocularis	serotonin transporter	0.027	0.3721	0.5043
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0046	0.0547	0.0741
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0044	0.006
Onchocerca volvulus		0.0048	0.0585	0.0543
Echinococcus granulosus	neuropeptide s receptor	0.0528	0.7378	1
Brugia malayi	Dopamine receptor protein 2	0.0048	0.0585	0.0642
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0044	0.006
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0046	0.0547	0.0741
Echinococcus granulosus	neuropeptide receptor A26	0.0528	0.7378	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0048	0.0585	0.0642
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Schistosoma mansoni	hypothetical protein	0.0048	0.0585	0.1249
Schistosoma mansoni	amine GPCR	0.0048	0.0585	0.1249
Onchocerca volvulus		0.0247	0.3396	0.3367
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0585	0.1249
Treponema pallidum	sodium- and chloride- dependent transporter	0.027	0.3721	0.5
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0323	0.0437
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0585	0.1249
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	neuropeptide receptor	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus granulosus	importin subunit beta 1	0.003	0.0317	0.043
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0046	0.0547	0.0741
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0046	0.0547	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	neuropeptide F receptor	0.0048	0.0585	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.0585	0.0792
Onchocerca volvulus		0.0046	0.0547	0.0505
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus granulosus	7tm_1 domain containing protein	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0585	0.1249
Onchocerca volvulus		0.0048	0.0585	0.0543
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0339	0.0459
Schistosoma mansoni	sodium/chloride dependent transporter	0.027	0.3721	0.8497
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0585	0.0792
Echinococcus multilocularis	serotonin receptor	0.0048	0.0585	0.0792
Brugia malayi	G protein-coupled receptor F59B2.13	0.0048	0.0585	0.0642
Onchocerca volvulus		0.0048	0.0585	0.0543
Trichomonas vaginalis	taga, putative	0.001	0.0044	0.013
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.0585	0.0792
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.0598
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.0043	0.0058
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0206	0.0378
Schistosoma mansoni	neuropeptide f receptor 76f	0.0048	0.0585	0.1249
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0048	0.0585	0.1249
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0585	0.1249
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0585	0.0792
Echinococcus multilocularis	dro:myosuppressin receptor	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0048	0.0585	0.0792
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0048	0.0585	0.0792
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0044	0.006
Loa Loa (eye worm)	melatonin receptor type 1A	0.0048	0.0585	0.1252
Loa Loa (eye worm)	hypothetical protein	0.003	0.0317	0.0634
Onchocerca volvulus		0.0031	0.0339	0.0296
Entamoeba histolytica	hypothetical protein	0.0024	0.0238	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0043	0.0058
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0048	0.0585	0.0792
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Trichomonas vaginalis	abcb9, putative	0.001	0.0044	0.013
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0206	0.028
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0238	0.07
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0339	0.0681
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0046	0.0547	0.1162
Onchocerca volvulus		0.027	0.3721	0.3693
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.1924
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0048	0.0585	0.1252
Brugia malayi	Dopamine receptor protein 1	0.0048	0.0585	0.0642
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0317	0.1044
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0048	0.0585	0.1249
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0044	0.013
Loa Loa (eye worm)	hypothetical protein	0.027	0.3721	0.8498
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0206	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.3396	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0048	0.0585	0.0642
Onchocerca volvulus		0.0048	0.0585	0.0543
Echinococcus granulosus	7TM GPCR rhodopsin	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0585	0.1252
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0048	0.0585	0.0792
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0044	0.006
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0046	0.0547	0.1162
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0339	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	neuropeptide receptor A26	0.0528	0.7378	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0238	0.07
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0044	0.006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0339	0.0681
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0046	0.0547	0.1162
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0044	0.013
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0046	0.0547	0.0741
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Toxoplasma gondii	RNA-directed DNA polymerase	0.0195	0.2657	1
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0044	0.013
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0048	0.0585	0.1249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0206	0.028
Brugia malayi	GnHR receptor homolog	0.0048	0.0585	0.0642
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Echinococcus granulosus	sex peptide receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	sodium and chloride dependent glycine	0.0046	0.0547	0.0741
Brugia malayi	larval opioid receptor	0.0048	0.0585	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus granulosus	fmrfamide receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0046	0.0547	0.0741
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.1924
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0044	0.006
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0585	0.1249
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0048	0.0585	0.1249
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Echinococcus granulosus	somatostatin receptor	0.0048	0.0585	0.0792
Trichomonas vaginalis	abcb9, putative	0.001	0.0044	0.013
Echinococcus multilocularis	g-protein coupled receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0048	0.0585	0.1249
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0044	0.006
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.0598
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0048	0.0585	0.0792
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0046	0.0547	0.1162
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Schistosoma mansoni	hypothetical protein	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0585	0.1249
Echinococcus granulosus	g-protein coupled receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.0585	0.0792
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0048	0.0585	0.0543
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.0585	0.0792
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0317	0.0451
Brugia malayi	G-protein coupled receptor	0.0048	0.0585	0.0642
Echinococcus granulosus	orexin receptor type 2	0.0048	0.0585	0.0792
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0044	0.006
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0044	0.006
Toxoplasma gondii	hypothetical protein	0.0046	0.0547	0.1924
Onchocerca volvulus		0.0048	0.0585	0.0543
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0048	0.0585	0.0792
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0238	0.0741
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0317	0.043
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0585	0.1249
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.0585	0.0792
Trypanosoma brucei	telomerase reverse transcriptase	0.0195	0.2657	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.0585	0.0792
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0046	0.0547	0.0598
Schistosoma mansoni	importin beta-1	0.003	0.0317	0.063
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0046	0.0547	0.1162
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	amine GPCR	0.0048	0.0585	0.1249
Schistosoma mansoni	amine GPCR	0.0048	0.0585	0.1249
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0585	0.0792
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0044	0.013
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0206	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0048	0.0585	0.1249
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0044	0.013
Schistosoma mansoni	adenoreceptor	0.0048	0.0585	0.1249
Onchocerca volvulus		0.0048	0.0585	0.0543
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0048	0.0585	0.0543
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.027	0.3721	0.8497
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0195	0.2657	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0585	0.0792
Plasmodium falciparum	importin beta, putative	0.003	0.0317	0.1044
Schistosoma mansoni	sodium/chloride dependent transporter	0.0046	0.0547	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0585	0.0792
Echinococcus multilocularis	allatostatin A receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	opsin-like receptor	0.0048	0.0585	0.1249
Brugia malayi	RE15519p	0.0048	0.0585	0.0642
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0585	0.1252
Echinococcus granulosus	serotonin receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0044	0.006
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0044	0.013
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.0585	0.0792
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0585	0.0792
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0048	0.0585	0.1252
Plasmodium vivax	SET domain protein, putative	0.0031	0.0339	0.1127
Onchocerca volvulus		0.0048	0.0585	0.0543
Brugia malayi	Dopamine receptor	0.0048	0.0585	0.0642
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	Serotonin receptor	0.0604	0.8457	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0048	0.0585	0.0792
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0046	0.0547	1
Echinococcus multilocularis	neuropeptide s receptor	0.0528	0.7378	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0044	0.0004
Toxoplasma gondii	hypothetical protein	0.0046	0.0547	0.1924
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.0585	0.0792
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0044	0.013
Echinococcus multilocularis	serotonin receptor	0.0048	0.0585	0.0792
Brugia malayi	hypothetical protein	0.0046	0.0547	0.0598
Giardia lamblia	Telomerase catalytic subunit	0.0195	0.2657	1
Schistosoma mansoni	opsin-like receptor	0.0048	0.0585	0.1249
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0339	0.0459
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0044	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0585	0.1252
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0044	0.013
Brugia malayi	putative neuropeptide receptor	0.0048	0.0585	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0585	0.1249
Echinococcus granulosus	serotonin transporter	0.027	0.3721	0.5043
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0044	0.013
Onchocerca volvulus		0.0048	0.0585	0.0543
Echinococcus multilocularis	sex peptide receptor	0.0048	0.0585	0.0792
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Onchocerca volvulus		0.0048	0.0585	0.0543
Schistosoma mansoni	histamine h1 receptor	0.0048	0.0585	0.1249
Schistosoma mansoni	ran	0.0022	0.0206	0.0375
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0048	0.0585	0.0642
Echinococcus granulosus	neuropeptide receptor	0.0048	0.0585	0.0792
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0585	0.0792
Leishmania major	GTP-binding protein, putative	0.0022	0.0206	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0547	0.1924
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0048	0.0585	0.0642
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.027	0.3721	0.8498
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0048	0.0585	0.1252
Loa Loa (eye worm)	serotonin transporter b	0.027	0.3721	0.8498
Echinococcus granulosus	hypothetical protein	0.0048	0.0585	0.0792
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0585	0.1249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0048	0.0585	0.0642
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0048	0.0585	0.0792
Brugia malayi	ORL1-like opioid receptor	0.0048	0.0585	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0339	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0048	0.0585	0.1252
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0585	0.1249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0195	0.2657	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.1924
Brugia malayi	RNA, U transporter 1	0.0084	0.109	0.1243
Echinococcus granulosus	snurportin 1	0.0316	0.4371	0.5925
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0044	0.013
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0585	0.0792
Loa Loa (eye worm)	hypothetical protein	0.027	0.3721	0.8498
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0585	0.1252
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0044	0.013
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0585	0.1249
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0046	0.0547	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	G protein-coupled receptor	0.0048	0.0585	0.0642
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0339	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0048	0.0585	0.0642
Echinococcus multilocularis	snurportin 1	0.0316	0.4371	0.5925
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.0585	0.0792
Brugia malayi	follicle stimulating hormone receptor	0.0048	0.0585	0.0642
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0206	0.0193
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0585	0.1249
Plasmodium falciparum	amino acid transporter, putative	0.0046	0.0547	0.1924
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0316	0.4371	1
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0044	0.006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Loa Loa (eye worm)	TYRA-2 protein	0.0048	0.0585	0.1252
Onchocerca volvulus		0.0046	0.0547	0.0505
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0046	0.0547	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Onchocerca volvulus		0.0048	0.0585	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	hypothetical protein	0.0316	0.4371	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0048	0.0585	0.0642
Brugia malayi	neuropeptide F receptor	0.0048	0.0585	0.0642
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0046	0.0547	0.1162
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0046	0.0547	0.1162
Brugia malayi	Serotonin receptor	0.0048	0.0585	0.0642
Echinococcus multilocularis	G protein coupled receptor 139	0.0048	0.0585	0.0792
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0044	0.006
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Loa Loa (eye worm)	solute carrier family 6 member 4	0.027	0.3721	0.8498
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0547	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Brugia malayi	Telomerase reverse transcriptase	0.0518	0.7241	0.8554
Onchocerca volvulus		0.0046	0.0547	0.0505
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0317	0.0451
Loa Loa (eye worm)	hypothetical protein	0.001	0.0044	0.0004
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.0585	0.0792
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.0585	0.0792
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0046	0.0547	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Plasmodium falciparum	telomerase reverse transcriptase	0.0195	0.2657	1
Trichomonas vaginalis	abcb9, putative	0.001	0.0044	0.013
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0585	0.1249
Schistosoma mansoni	sodium/chloride dependent transporter	0.0046	0.0547	0.1162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0339	0.0459
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0048	0.0585	0.0792
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Brugia malayi	Melatonin receptor type 1A	0.0048	0.0585	0.0642
Echinococcus granulosus	allatostatin A receptor	0.0048	0.0585	0.0792
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Schistosoma mansoni	ran	0.0022	0.0206	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0585	0.1252
Entamoeba histolytica	Ran family GTPase	0.0022	0.0206	0.8379
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0585	0.0792
Brugia malayi	hypothetical protein	0.0048	0.0585	0.0642
Brugia malayi	G-protein coupled receptor	0.0048	0.0585	0.0642
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0585	0.0792
Plasmodium falciparum	transporter, putative	0.0046	0.0547	0.1924
Loa Loa (eye worm)	norepinephrine transporter	0.027	0.3721	0.8498
Schistosoma mansoni	amine GPCR	0.0048	0.0585	0.1249
Brugia malayi	sulfakinin receptor protein	0.0048	0.0585	0.0642
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0044	0.013
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0585	0.1249

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 465 nM	Binding affinity to 5HT2C	ChEMBL.	16750364
Ki (binding)	= 465 nM	Binding affinity to 5HT2C	ChEMBL.	16750364

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369812