Detailed information for compound 369930

Basic information

Technical information
  • TDR Targets ID: 369930
  • Name: 2-[[(1S)-2-[[2-[(4-carbamimidoylphenyl)methyl carbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyc lohexyl-2-oxoethyl]amino]acetic acid
  • MW: 505.609 | Formula: C28H35N5O4
  • H donors: 5 H acceptors: 4 LogP: 0.51 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CN[C@H](C(=O)NC1(Cc2c(C1)cccc2)C(=O)NCc1ccc(cc1)C(=N)N)C1CCCCC1
  • InChi: 1S/C28H35N5O4/c29-25(30)20-12-10-18(11-13-20)16-32-27(37)28(14-21-8-4-5-9-22(21)15-28)33-26(36)24(31-17-23(34)35)19-6-2-1-3-7-19/h4-5,8-13,19,24,31H,1-3,6-7,14-17H2,(H3,29,30)(H,32,37)(H,33,36)(H,34,35)/t24-/m0/s1
  • InChiKey: UZAYUOPBAIRPKQ-DEOSSOPVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(1S)-2-[[2-[(4-carbamimidoylphenyl)methylcarbamoyl]indan-2-yl]amino]-1-cyclohexyl-2-oxo-ethyl]amino]acetic acid
  • 2-[[(1S)-2-[[2-[[(4-carbamimidoylphenyl)methylamino]-oxomethyl]-2-indanyl]amino]-1-cyclohexyl-2-oxoethyl]amino]acetic acid
  • 2-[[(1S)-2-[[2-[(4-carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyclohexyl-2-oxo-ethyl]amino]ethanoic acid
  • 2-[[(1S)-2-[[2-[(4-amidinobenzyl)carbamoyl]indan-2-yl]amino]-1-cyclohexyl-2-keto-ethyl]amino]acetic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0257 0.0257
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0037 0.0107
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.002 0.002
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus multilocularis G-protein coupled receptor, putative 0.0045 0.026 0.026
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0331 0.3172 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) TYRA-2 protein 0.0045 0.026 0.026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.013 0.013
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.002 0.002
Schistosoma mansoni growth hormone secretagogue receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Toxoplasma gondii PAN domain-containing protein 0.0356 0.343 1
Onchocerca volvulus 0.0021 0.002 0.0513
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Echinococcus granulosus protein jagged 2 0.002 0.0007 0.0007
Echinococcus granulosus Mastin 0.0063 0.0449 0.0449
Echinococcus multilocularis neuropeptide FF receptor 2 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.013 0.013
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.013 0.013
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus neurogenic locus notch protein 4 0.002 0.0007 0.0007
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0007 0.0007
Toxoplasma gondii EGF family domain-containing protein 0.002 0.0007 0.002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0045 0.026 0.026
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.026 0.026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0063 0.0449 0.0449
Schistosoma mansoni alpha-1 adrenergic receptor 0.0045 0.026 0.026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi Melatonin receptor type 1A 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0045 0.026 0.026
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1053 0.1053
Brugia malayi Cadherin domain containing protein 0.002 0.0007 0.0007
Brugia malayi Kringle domain containing protein 0.0021 0.002 0.002
Echinococcus multilocularis laminin 0.0032 0.0132 0.0132
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0021 0.0017 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.013 0.013
Echinococcus multilocularis g protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni neuropeptide f receptor 76f 0.0045 0.026 0.026
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1002 1 1
Brugia malayi steroid hormone receptor 0.0032 0.013 0.013
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0045 0.026 0.026
Loa Loa (eye worm) Notch2 0.002 0.0007 0.0007
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Schistosoma mansoni thyroid hormone receptor 0.0155 0.138 0.138
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.026 0.026
Brugia malayi RE15519p 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Entamoeba histolytica hypothetical protein 0.0021 0.0017 1
Echinococcus granulosus protein jagged 1 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.013 0.013
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0132 0.0132
Echinococcus granulosus protein jagged 1 0.002 0.0007 0.0007
Echinococcus granulosus G protein coupled receptor 139 0.0045 0.026 0.026
Schistosoma mansoni laminin gamma-3 chain 0.002 0.0007 0.0007
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.013 0.4861
Loa Loa (eye worm) notch protein 0.002 0.0007 0.0007
Toxoplasma gondii microneme protein, putative 0.0023 0.0037 0.0107
Toxoplasma gondii kringle domain-containing protein 0.0021 0.002 0.0058
Echinococcus granulosus delta-like protein 1 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0045 0.026 0.026
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.013 0.013
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.013 0.4861
Brugia malayi nuclear receptor NHR-88 0.0032 0.013 0.013
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis fmrfamide receptor 0.0045 0.026 0.026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0045 0.026 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.013 0.013
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus allatostatin A receptor 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Echinococcus granulosus hypothetical protein 0.0045 0.026 0.026
Brugia malayi Protein kinase domain containing protein 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.002 0.5
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Onchocerca volvulus Arrow homolog 0.0032 0.0132 0.4923
Brugia malayi putative neuropeptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0257 0.0257
Brugia malayi Cadherin domain containing protein 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Brugia malayi nuclear hormone receptor 0.0032 0.013 0.013
Toxoplasma gondii hypothetical protein 0.0023 0.0037 0.0107
Echinococcus granulosus 7TM GPCR rhodopsin 0.0045 0.026 0.026
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.013 0.013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Brugia malayi Fibulin-1 precursor 0.0032 0.0132 0.0132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.026 0.026
Brugia malayi GnHR receptor homolog 0.0045 0.026 0.026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0045 0.026 0.026
Echinococcus granulosus dro:myosuppressin receptor 0.0045 0.026 0.026
Echinococcus multilocularis protein jagged 1 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis serotonin receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.026 0.026
Brugia malayi Dopamine receptor 0.0045 0.026 0.026
Schistosoma mansoni myosin xvIII 0.0045 0.026 0.026
Echinococcus granulosus glycoprotein Antigen 5 0.0063 0.0449 0.0449
Onchocerca volvulus 0.0045 0.026 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus orexin receptor type 2 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni septate junction protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis sex peptide receptor 0.0045 0.026 0.026
Echinococcus granulosus neurogenic locus protein delta 0.002 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0037 0.1177
Onchocerca volvulus 0.0045 0.026 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Onchocerca volvulus 0.0045 0.026 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0111 0.0936 0.0936
Echinococcus granulosus serotonin receptor 0.0045 0.026 0.026
Toxoplasma gondii hypothetical protein 0.0023 0.0037 0.0107
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.013 0.013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0045 0.026 0.026
Echinococcus granulosus neuropeptide receptor A26 0.0045 0.026 0.026
Brugia malayi G protein-coupled receptor F59B2.13 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0045 0.026 1
Brugia malayi Dopamine receptor protein 2 0.0045 0.026 0.026
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0045 0.026 0.026
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0123 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.013 0.013
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus multilocularis somatostatin receptor 0.0045 0.026 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.026 0.026
Echinococcus multilocularis fibrillin 1 0.0032 0.0132 0.0132
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0007 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1002 1 1
Echinococcus multilocularis protein jagged 2 0.002 0.0007 0.0007
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0132 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0037 0.1177
Brugia malayi sulfakinin receptor protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0257 0.0257
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Schistosoma mansoni opsin-like receptor 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0045 0.026 0.026
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus notch 0.002 0.0007 0.0007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0045 0.026 0.026
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0132 0.0384
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni cell polarity protein 0.002 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0037 0.0107
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.026 0.026
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.013 0.013
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis fat cadherin tumor suppressor 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Brugia malayi AKH receptor 0.0045 0.026 0.026
Echinococcus multilocularis neurogenic locus notch protein 4 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Toxoplasma gondii microneme protein MIC4 0.0023 0.0037 0.0107
Echinococcus granulosus neural cadherin 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Echinococcus granulosus slit 2 protein 0.002 0.0007 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0128 0.1109 0.1109
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.013 0.013
Echinococcus multilocularis Tolloid protein 1 0.0032 0.0132 0.0132
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Schistosoma mansoni notch 0.002 0.0007 0.0007
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0032 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0331 0.3172 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Echinococcus granulosus protein jagged 2 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Giardia lamblia NADPH oxidoreductase, putative 0.0021 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Brugia malayi notch-like transmembrane receptor 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Onchocerca volvulus 0.0023 0.0037 0.1177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.013 0.013
Echinococcus granulosus laminin 0.0032 0.0132 0.0132
Echinococcus multilocularis serotonin receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0032 0.0132 0.0132
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0037 0.0107
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0021 0.0017 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni retinoic acid receptor RXR 0.0128 0.1109 0.1109
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0017 0.0055
Onchocerca volvulus 0.0045 0.026 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni opsin-like receptor 0.0045 0.026 0.026
Echinococcus granulosus Tolloid protein 1 0.0032 0.0132 0.0132
Echinococcus granulosus c-Jun N-terminal kinases 0.1002 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.013 0.013
Onchocerca volvulus 0.0023 0.0037 0.1177
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0045 0.026 0.026
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi putative neuropeptide receptor NPR1 0.0045 0.026 0.026
Echinococcus granulosus neurogenic locus notch protein 0.002 0.0007 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0045 0.026 0.026
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0021 0.0017 0.0055
Brugia malayi Muscle positioning protein 4 0.002 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.026 0.026
Loa Loa (eye worm) melatonin receptor type 1A 0.0045 0.026 0.026
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus g-protein coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis notch 0.002 0.0007 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni coup transcription factor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Brugia malayi neuropeptide F receptor 0.0045 0.026 0.026
Leishmania major hypothetical protein, conserved 0.0021 0.002 1
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni notch 0.002 0.0007 0.0007
Echinococcus granulosus enteropeptidase 0.0063 0.0449 0.0449
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.013 0.013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Brugia malayi Delta serrate ligand family protein 0.002 0.0007 0.0007
Brugia malayi Dopamine receptor protein 1 0.0045 0.026 0.026
Schistosoma mansoni biogenic amine receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Brugia malayi Serotonin receptor 0.0045 0.026 0.026
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0257 0.0257
Echinococcus granulosus neuropeptide FF receptor 2 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis G protein coupled receptor 139 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide receptor 0.0045 0.026 0.026
Giardia lamblia High cysteine protein 0.002 0.0007 0.3938
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni notch 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Schistosoma mansoni notch 0.002 0.0007 0.0007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0045 0.026 0.026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.002 0.0007 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus multilocularis orexin receptor type 2 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Schistosoma mansoni biogenic amine receptor 0.0045 0.026 0.026
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0045 0.026 0.026
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0037 0.0107
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0037 0.0107
Echinococcus granulosus g protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.026 0.026
Schistosoma mansoni neuropeptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni notch 0.002 0.0007 0.0007
Echinococcus multilocularis neuropeptide receptor A26 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi ORL1-like opioid receptor 0.0045 0.026 0.026
Schistosoma mansoni adenoreceptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.0045 0.026 0.026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0045 0.026 0.026
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Brugia malayi G-protein coupled receptor 0.0045 0.026 0.026
Echinococcus granulosus alpha 1A adrenergic receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0155 0.138 0.138
Echinococcus granulosus g protein coupled receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.013 0.013
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Echinococcus granulosus fmrfamide receptor 0.0045 0.026 0.026
Echinococcus granulosus neuropeptide s receptor 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis g-protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni notch 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.002 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Echinococcus multilocularis glycoprotein Antigen 5 0.0063 0.0449 0.0449
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0032 0.0132 0.0132
Echinococcus granulosus neuropeptide receptor 0.0045 0.026 0.026
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Echinococcus granulosus sex peptide receptor 0.0045 0.026 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Schistosoma mansoni opsin-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0021 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis fibropellin Ia 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni nuclear hormone receptor 0.0032 0.013 0.013
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.002 0.0007 0.0007
Brugia malayi G protein-coupled receptor 0.0045 0.026 0.026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.013 0.013
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.013 0.013
Toxoplasma gondii subtilisin SUB12 0.0023 0.0037 0.0107
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0037
Onchocerca volvulus 0.0023 0.0037 0.1177
Schistosoma mansoni slit 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0132 0.0384
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0023 0.0037 0.1177
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0257 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.013 0.013
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.013 0.013
Onchocerca volvulus 0.0032 0.013 0.4861
Brugia malayi ecdysteroid receptor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0045 0.026 0.026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.013 0.013
Schistosoma mansoni egf-like domain protein 0.0032 0.0132 0.0132
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi Calcium binding EGF domain containing protein 0.002 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Toxoplasma gondii PAN domain-containing protein 0.0356 0.343 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.026 0.026
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Onchocerca volvulus 0.0023 0.0037 0.1177
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0132 0.0132
Echinococcus granulosus fibropellin Ia 0.002 0.0007 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.026 0.026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptide s receptor 0.0045 0.026 0.026
Giardia lamblia NADPH oxidoreductase, putative 0.0021 0.0017 1
Brugia malayi larval opioid receptor 0.0045 0.026 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0257 0.0257
Schistosoma mansoni histamine h1 receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0045 0.026 0.026
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0023 0.0037 0.1177
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.026 0.026
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Brugia malayi GCC2 and GCC3 family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.013 0.013
Echinococcus multilocularis g protein coupled receptor 0.0045 0.026 0.026
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus 7tm_1 domain containing protein 0.0045 0.026 0.026
Brugia malayi follicle stimulating hormone receptor 0.0045 0.026 0.026
Echinococcus multilocularis protein jagged 1 0.002 0.0007 0.0007
Brugia malayi Serotonin receptor 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.013 0.013
Schistosoma mansoni biogenic amine receptor 0.0045 0.026 0.026
Echinococcus multilocularis neural cadherin 0.002 0.0007 0.0007
Echinococcus multilocularis enteropeptidase 0.0063 0.0449 0.0449
Echinococcus granulosus FTZ F1 alpha 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.026 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1053 0.1053
Onchocerca volvulus 0.0045 0.026 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.002 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus neurogenic locus notch protein 0.002 0.0007 0.0007
Echinococcus multilocularis Mastin 0.0063 0.0449 0.0449
Brugia malayi hypothetical protein 0.0045 0.026 0.026
Echinococcus granulosus somatostatin receptor 0.0045 0.026 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.002 1
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0037 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.013 0.013
Echinococcus multilocularis neurogenic locus protein delta 0.002 0.0007 0.0007
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.013 0.4861
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Echinococcus multilocularis g protein coupled receptor 0.0045 0.026 0.026
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.013 0.013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.138 0.138
Schistosoma mansoni hypothetical protein 0.002 0.0007 0.0007
Echinococcus multilocularis slit 2 protein 0.002 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0045 0.026 0.026
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.026 0.026
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.026 0.026
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.026 0.026
Echinococcus multilocularis fmrfamide receptor 0.0045 0.026 0.026
Echinococcus multilocularis allatostatin A receptor 0.0045 0.026 0.026
Echinococcus granulosus g protein coupled receptor 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.013 0.013
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.026 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.026 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0017 0.0055
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0037 0.0037
Trichomonas vaginalis modulator of drug activity B, putative 0.0021 0.0017 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.013
Giardia lamblia NADPH oxidoreductase, putative 0.0021 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0132
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.026 0.026
Brugia malayi neuropeptide F receptor 0.0045 0.026 0.026
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.013 0.013
Onchocerca volvulus 0.0023 0.0037 0.1177
Brugia malayi Tachykinin-like peptides receptor 99D 0.0045 0.026 0.026
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.0023 0.0037 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.026 0.026
Onchocerca volvulus Neuropeptide F receptor homolog 0.0045 0.026 1
Schistosoma mansoni serine/threonine protein kinase 0.1002 1 1
Brugia malayi G-protein coupled receptor 0.0045 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.026
Onchocerca volvulus 0.0045 0.026 1
Echinococcus granulosus neuropeptide receptor 0.0045 0.026 0.026
Echinococcus multilocularis neurogenic locus notch protein 0.002 0.0007 0.0007

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 33 uM Inhibition of human thrombin activity ChEMBL. 16913694
IC50 (binding) > 33 uM Inhibition of human aPC ChEMBL. 16913694
IC50 (binding) > 33 uM Inhibition of human thrombin activity ChEMBL. 16913694
IC50 (binding) > 33 uM Inhibition of human aPC ChEMBL. 16913694

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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