TDR Targets

Basic information

Technical information

TDR Targets ID: 371230
Name: 2-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methyl carbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyc lohexyl-2-oxoethyl]amino]acetic acid
MW: 505.609 | Formula: C28H35N5O4
H donors: 5 H acceptors: 4 LogP: 0.51 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)CN[C@@H](C(=O)NC1(Cc2c(C1)cccc2)C(=O)NCc1ccc(cc1)C(=N)N)C1CCCCC1
InChi: 1S/C28H35N5O4/c29-25(30)20-12-10-18(11-13-20)16-32-27(37)28(14-21-8-4-5-9-22(21)15-28)33-26(36)24(31-17-23(34)35)19-6-2-1-3-7-19/h4-5,8-13,19,24,31H,1-3,6-7,14-17H2,(H3,29,30)(H,32,37)(H,33,36)(H,34,35)/t24-/m1/s1
InChiKey: UZAYUOPBAIRPKQ-XMMPIXPASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methylcarbamoyl]indan-2-yl]amino]-1-cyclohexyl-2-oxo-ethyl]amino]acetic acid
2-[[(1R)-2-[[2-[[(4-carbamimidoylphenyl)methylamino]-oxomethyl]-2-indanyl]amino]-1-cyclohexyl-2-oxoethyl]amino]acetic acid
2-[[(1R)-2-[[2-[(4-carbamimidoylphenyl)methylcarbamoyl]-1,3-dihydroinden-2-yl]amino]-1-cyclohexyl-2-oxo-ethyl]amino]ethanoic acid
2-[[(1R)-2-[[2-[(4-amidinobenzyl)carbamoyl]indan-2-yl]amino]-1-cyclohexyl-2-keto-ethyl]amino]acetic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	coagulation factor VII (serum prothrombin conversion accelerator)	Starlite/ChEMBL	References
Homo sapiens	protein C (inactivator of coagulation factors Va and VIIIa)	Starlite/ChEMBL	References
Homo sapiens	coagulation factor II (thrombin)	Starlite/ChEMBL	References
Homo sapiens	coagulation factor XI	Starlite/ChEMBL	References
Homo sapiens	coagulation factor X	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	PAN domain-containing protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Echinococcus granulosus	enteropeptidase	Get druggable targets OG5_136757	All targets in OG5_136757
Echinococcus multilocularis	Mastin	Get druggable targets OG5_136757	All targets in OG5_136757
Echinococcus multilocularis	enteropeptidase	Get druggable targets OG5_136757	All targets in OG5_136757
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Echinococcus multilocularis	glycoprotein Antigen 5	Get druggable targets OG5_136757	All targets in OG5_136757
Echinococcus granulosus	Mastin	Get druggable targets OG5_136757	All targets in OG5_136757
Schistosoma japonicum	ko:K01346 pancreatic elastase II [EC3.4.21.71], putative	Get druggable targets OG5_136757	All targets in OG5_136757
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	Get druggable targets OG5_136757	All targets in OG5_136757
Toxoplasma gondii	PAN domain-containing protein	Get druggable targets OG5_134971	All targets in OG5_134971
Neospora caninum	hypothetical protein	Get druggable targets OG5_134971	All targets in OG5_134971
Echinococcus granulosus	glycoprotein Antigen 5	Get druggable targets OG5_136757	All targets in OG5_136757

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	glycoprotein Antigen 5	coagulation factor VII (serum prothrombin conversion accelerator)	466 aa	384 aa	23.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0045	0.026	0.026
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.013	0.013
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.013	0.013
Echinococcus granulosus	allatostatin A receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Echinococcus granulosus	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	Protein kinase domain containing protein	0.0021	0.002	0.002
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0045	0.026	0.026
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0021	0.002	0.5
Schistosoma mansoni	hypothetical protein	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Onchocerca volvulus	Arrow homolog	0.0032	0.0132	0.4923
Brugia malayi	putative neuropeptide receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0021	0.002	0.002
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0257	0.0257
Brugia malayi	Cadherin domain containing protein	0.002	0.0007	0.0007
Brugia malayi	nuclear hormone receptor	0.0032	0.013	0.013
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Echinococcus granulosus	7TM GPCR rhodopsin	0.0045	0.026	0.026
Toxoplasma gondii	hypothetical protein	0.0023	0.0037	0.0107
Schistosoma mansoni	thyroid hormone receptor	0.0155	0.138	0.138
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.013	0.013
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.026	0.026
Brugia malayi	RE15519p	0.0045	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Entamoeba histolytica	hypothetical protein	0.0021	0.0017	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0032	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.013	0.013
Echinococcus granulosus	protein jagged 1	0.002	0.0007	0.0007
Echinococcus granulosus	protein jagged 1	0.002	0.0007	0.0007
Echinococcus granulosus	G protein coupled receptor 139	0.0045	0.026	0.026
Schistosoma mansoni	laminin gamma-3 chain	0.002	0.0007	0.0007
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0037	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.013	0.4861
Loa Loa (eye worm)	notch protein	0.002	0.0007	0.0007
Toxoplasma gondii	microneme protein, putative	0.0023	0.0037	0.0107
Echinococcus granulosus	delta-like protein 1	0.002	0.0007	0.0007
Toxoplasma gondii	kringle domain-containing protein	0.0021	0.002	0.0058
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.013	0.4861
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Brugia malayi	nuclear receptor NHR-88	0.0032	0.013	0.013
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.013	0.013
Schistosoma mansoni	neuropeptide receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Echinococcus granulosus	neurogenic locus notch protein 4	0.002	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	Calcium binding EGF domain containing protein	0.002	0.0007	0.0007
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0045	0.026	0.026
Toxoplasma gondii	EGF family domain-containing protein	0.002	0.0007	0.002
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0045	0.026	0.026
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0063	0.0449	0.0449
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.026	0.026
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.026	0.026
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Brugia malayi	Melatonin receptor type 1A	0.0045	0.026	0.026
Onchocerca volvulus		0.0023	0.0037	0.1177
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0045	0.026	0.026
Echinococcus multilocularis	laminin	0.0032	0.0132	0.0132
Brugia malayi	Kringle domain containing protein	0.0021	0.002	0.002
Brugia malayi	Cadherin domain containing protein	0.002	0.0007	0.0007
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.1053	0.1053
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0021	0.0017	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.013	0.013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.013	0.013
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	Notch2	0.002	0.0007	0.0007
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0045	0.026	0.026
Brugia malayi	steroid hormone receptor	0.0032	0.013	0.013
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.1002	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0257	0.0257
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0023	0.0037	0.0107
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	TK/ROR protein kinase	0.0021	0.002	0.002
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0045	0.026	0.026
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0331	0.3172	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	TYRA-2 protein	0.0045	0.026	0.026
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.013	0.013
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.013	0.013
Echinococcus granulosus	tissue type plasminogen activator	0.0021	0.002	0.002
Schistosoma mansoni	growth hormone secretagogue receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Onchocerca volvulus		0.0045	0.026	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Toxoplasma gondii	PAN domain-containing protein	0.0356	0.343	1
Onchocerca volvulus		0.0021	0.002	0.0513
Echinococcus granulosus	Mastin	0.0063	0.0449	0.0449
Echinococcus granulosus	protein jagged 2	0.002	0.0007	0.0007
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0045	0.026	0.026
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.013	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0331	0.3172	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.013	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.013	0.013
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0132	0.0132
Echinococcus granulosus	protein jagged 2	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Giardia lamblia	NADPH oxidoreductase, putative	0.0021	0.0017	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0132	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	notch-like transmembrane receptor	0.002	0.0007	0.0007
Onchocerca volvulus		0.0023	0.0037	0.1177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.013	0.013
Echinococcus multilocularis	serotonin receptor	0.0045	0.026	0.026
Echinococcus granulosus	laminin	0.0032	0.0132	0.0132
Schistosoma mansoni	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0032	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0021	0.0017	1
Toxoplasma gondii	microneme protein MIC17B	0.0023	0.0037	0.0107
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	retinoic acid receptor RXR	0.0128	0.1109	0.1109
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0021	0.0017	0.0055
Onchocerca volvulus		0.0045	0.026	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	opsin-like receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0132	0.0132
Schistosoma mansoni	neuropeptide receptor	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Toxoplasma gondii	microneme protein MIC17A	0.0023	0.0037	0.0107
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.013	0.013
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	fat cadherin tumor suppressor	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	AKH receptor	0.0045	0.026	0.026
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	neurogenic locus notch protein 4	0.002	0.0007	0.0007
Echinococcus granulosus	neural cadherin	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Toxoplasma gondii	microneme protein MIC4	0.0023	0.0037	0.0107
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Schistosoma mansoni	amine GPCR	0.0045	0.026	0.026
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0128	0.1109	0.1109
Echinococcus granulosus	slit 2 protein	0.002	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Echinococcus multilocularis	Tolloid protein 1	0.0032	0.0132	0.0132
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.013	0.013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	notch	0.002	0.0007	0.0007
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0032	0.0132	0.0132
Echinococcus granulosus	serotonin receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.026	0.026
Toxoplasma gondii	hypothetical protein	0.0023	0.0037	0.0107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.013	0.013
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0045	0.026	0.026
Echinococcus granulosus	neuropeptide receptor A26	0.0045	0.026	0.026
Brugia malayi	G protein-coupled receptor F59B2.13	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.026	0.026
Brugia malayi	Dopamine receptor protein 2	0.0045	0.026	0.026
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0045	0.026	0.026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0123	0.1053	0.1053
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.013	0.013
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Echinococcus multilocularis	somatostatin receptor	0.0045	0.026	0.026
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0037	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.026	0.026
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.026	0.026
Echinococcus multilocularis	fibrillin 1	0.0032	0.0132	0.0132
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0037	0.0107
Brugia malayi	Calcium binding EGF domain containing protein	0.002	0.0007	0.0007
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.026	0.026
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.1002	1	1
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0032	0.0132	0.0132
Echinococcus multilocularis	protein jagged 2	0.002	0.0007	0.0007
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Brugia malayi	sulfakinin receptor protein	0.0045	0.026	0.026
Onchocerca volvulus		0.0023	0.0037	0.1177
Schistosoma mansoni	neuropeptide receptor	0.0045	0.026	0.026
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0045	0.026	0.026
Schistosoma mansoni	opsin-like receptor	0.0045	0.026	0.026
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0045	0.026	0.026
Echinococcus granulosus	notch	0.002	0.0007	0.0007
Schistosoma mansoni	cell polarity protein	0.002	0.0007	0.0007
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0032	0.0132	0.0384
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.013	0.013
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Brugia malayi	Fibulin-1 precursor	0.0032	0.0132	0.0132
Brugia malayi	GnHR receptor homolog	0.0045	0.026	0.026
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.026	0.026
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	protein jagged 1	0.002	0.0007	0.0007
Echinococcus granulosus	dro:myosuppressin receptor	0.0045	0.026	0.026
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0045	0.026	0.026
Echinococcus multilocularis	serotonin receptor	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	Dopamine receptor	0.0045	0.026	0.026
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.026	0.026
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.013	0.013
Onchocerca volvulus		0.0045	0.026	1
Echinococcus granulosus	glycoprotein Antigen 5	0.0063	0.0449	0.0449
Schistosoma mansoni	myosin xvIII	0.0045	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0045	0.026	0.026
Echinococcus granulosus	orexin receptor type 2	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	septate junction protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0132	0.0132
Echinococcus multilocularis	sex peptide receptor	0.0045	0.026	0.026
Echinococcus granulosus	neurogenic locus protein delta	0.002	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Onchocerca volvulus		0.0045	0.026	1
Onchocerca volvulus		0.0023	0.0037	0.1177
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.013	0.013
Schistosoma mansoni	amine GPCR	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0111	0.0936	0.0936
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0257	0.0257
Plasmodium falciparum	cysteine repeat modular protein 1	0.0021	0.002	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Echinococcus multilocularis	glycoprotein Antigen 5	0.0063	0.0449	0.0449
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.026	0.026
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0032	0.0132	0.0132
Echinococcus granulosus	neuropeptide receptor	0.0045	0.026	0.026
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0045	0.026	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.013	0.013
Echinococcus granulosus	sex peptide receptor	0.0045	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	opsin-like receptor	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Echinococcus multilocularis	fibropellin Ia	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.013	0.013
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Brugia malayi	G protein-coupled receptor	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.026	0.026
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.013	0.013
Toxoplasma gondii	subtilisin SUB12	0.0023	0.0037	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.013	0.013
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.026	0.026
Toxoplasma gondii	PAN domain-containing protein	0.0023	0.0037	0.0107
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0045	0.026	0.026
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0023	0.0037	0.0107
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Echinococcus granulosus	g protein coupled receptor	0.0045	0.026	0.026
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Schistosoma mansoni	neuropeptide receptor	0.0045	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.0021	0.002	0.002
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0045	0.026	0.026
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	neuropeptide receptor A26	0.0045	0.026	0.026
Schistosoma mansoni	notch	0.002	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Brugia malayi	ORL1-like opioid receptor	0.0045	0.026	0.026
Schistosoma mansoni	adenoreceptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Echinococcus multilocularis	dro:myosuppressin receptor	0.0045	0.026	0.026
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0045	0.026	0.026
Brugia malayi	G-protein coupled receptor	0.0045	0.026	0.026
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0045	0.026	0.026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	EGF-like domain containing protein	0.002	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Schistosoma mansoni	thyroid hormone receptor	0.0155	0.138	0.138
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Echinococcus granulosus	g protein coupled receptor	0.0045	0.026	0.026
Echinococcus granulosus	fmrfamide receptor	0.0045	0.026	0.026
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.013	0.013
Schistosoma mansoni	amine GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Echinococcus granulosus	neuropeptide s receptor	0.0045	0.026	0.026
Schistosoma mansoni	notch	0.002	0.0007	0.0007
Echinococcus multilocularis	g-protein coupled receptor	0.0045	0.026	0.026
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Echinococcus granulosus	enteropeptidase	0.0063	0.0449	0.0449
Schistosoma mansoni	notch	0.002	0.0007	0.0007
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.013	0.013
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Brugia malayi	Dopamine receptor protein 1	0.0045	0.026	0.026
Brugia malayi	Delta serrate ligand family protein	0.002	0.0007	0.0007
Schistosoma mansoni	biogenic amine receptor	0.0045	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Brugia malayi	Serotonin receptor	0.0045	0.026	0.026
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0257	0.0257
Echinococcus granulosus	neuropeptide FF receptor 2	0.0045	0.026	0.026
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.026	0.026
Echinococcus multilocularis	G protein coupled receptor 139	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Giardia lamblia	High cysteine protein	0.002	0.0007	0.3938
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Schistosoma mansoni	notch	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Schistosoma mansoni	notch	0.002	0.0007	0.0007
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.026	0.026
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.002	0.0007	0.0007
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0045	0.026	0.026
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.013	0.013
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Echinococcus multilocularis	orexin receptor type 2	0.0045	0.026	0.026
Schistosoma mansoni	biogenic amine receptor	0.0045	0.026	0.026
Onchocerca volvulus		0.0023	0.0037	0.1177
Echinococcus granulosus	c-Jun N-terminal kinases	0.1002	1	1
Echinococcus granulosus	Tolloid protein 1	0.0032	0.0132	0.0132
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.013	0.013
Onchocerca volvulus		0.0023	0.0037	0.1177
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0045	0.026	0.026
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus granulosus	neurogenic locus notch protein	0.002	0.0007	0.0007
Brugia malayi	putative neuropeptide receptor NPR1	0.0045	0.026	0.026
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0045	0.026	0.026
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0021	0.0017	0.0055
Brugia malayi	Muscle positioning protein 4	0.002	0.0007	0.0007
Loa Loa (eye worm)	melatonin receptor type 1A	0.0045	0.026	0.026
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.026	0.026
Schistosoma mansoni	amine GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	notch	0.002	0.0007	0.0007
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.026	0.026
Echinococcus granulosus	g-protein coupled receptor	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.026	0.026
Schistosoma mansoni	coup transcription factor	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	neuropeptide F receptor	0.0045	0.026	0.026
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Leishmania major	hypothetical protein, conserved	0.0021	0.002	1
Echinococcus multilocularis	slit 2 protein	0.002	0.0007	0.0007
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.026	0.026
Schistosoma mansoni	amine GPCR	0.0045	0.026	0.026
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.026	0.026
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Echinococcus multilocularis	allatostatin A receptor	0.0045	0.026	0.026
Echinococcus granulosus	g protein coupled receptor	0.0045	0.026	0.026
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Onchocerca volvulus		0.0045	0.026	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.013	0.013
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0037	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.013	0.013
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0032	0.013	0.013
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0132	0.0132
Giardia lamblia	NADPH oxidoreductase, putative	0.0021	0.0017	1
Brugia malayi	neuropeptide F receptor	0.0045	0.026	0.026
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.013	0.013
Onchocerca volvulus		0.0023	0.0037	0.1177
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.013	0.013
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0045	0.026	0.026
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0045	0.026	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Brugia malayi	G-protein coupled receptor	0.0045	0.026	0.026
Schistosoma mansoni	serine/threonine protein kinase	0.1002	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	neurogenic locus notch protein	0.002	0.0007	0.0007
Echinococcus granulosus	neuropeptide receptor	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Schistosoma mansoni	biogenic amine receptor	0.0045	0.026	0.026
Echinococcus multilocularis	neural cadherin	0.002	0.0007	0.0007
Echinococcus multilocularis	enteropeptidase	0.0063	0.0449	0.0449
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.013	0.013
Trichomonas vaginalis	modulator of drug activity B, putative	0.0021	0.0017	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	tissue type plasminogen activator	0.0021	0.002	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.013	0.013
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Onchocerca volvulus		0.0045	0.026	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.1053	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.002	0.0007	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.013	0.013
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus granulosus	neurogenic locus notch protein	0.002	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	Mastin	0.0063	0.0449	0.0449
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.013	0.013
Echinococcus multilocularis	neurogenic locus protein delta	0.002	0.0007	0.0007
Toxoplasma gondii	microneme protein MIC17C	0.0023	0.0037	0.0107
Trypanosoma cruzi	hypothetical protein, conserved	0.0021	0.002	1
Echinococcus granulosus	somatostatin receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0037	0.0037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.026	0.026
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.013	0.4861
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.026	0.026
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.013	0.013
Echinococcus multilocularis	neurogenic locus notch protein	0.002	0.0007	0.0007
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0155	0.138	0.138
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Onchocerca volvulus		0.0023	0.0037	0.1177
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.026	0.026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.026	0.026
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0032	0.0132	0.0132
Echinococcus granulosus	fibropellin Ia	0.002	0.0007	0.0007
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Echinococcus multilocularis	neuropeptide s receptor	0.0045	0.026	0.026
Giardia lamblia	NADPH oxidoreductase, putative	0.0021	0.0017	1
Schistosoma mansoni	histamine h1 receptor	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0257	0.0257
Brugia malayi	larval opioid receptor	0.0045	0.026	0.026
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0045	0.026	0.026
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Onchocerca volvulus		0.0023	0.0037	0.1177
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.026	0.026
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0045	0.026	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.013	0.013
Brugia malayi	GCC2 and GCC3 family protein	0.002	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.002	0.0007	0.0007
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.026	0.026
Echinococcus multilocularis	neurogenic locus protein delta	0.002	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Brugia malayi	follicle stimulating hormone receptor	0.0045	0.026	0.026
Echinococcus granulosus	7tm_1 domain containing protein	0.0045	0.026	0.026
Echinococcus multilocularis	protein jagged 1	0.002	0.0007	0.0007
Brugia malayi	Serotonin receptor	0.0045	0.026	0.026
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.013	0.013
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0037	0.0037
Onchocerca volvulus		0.0045	0.026	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0037	0.0037
Onchocerca volvulus		0.0023	0.0037	0.1177
Schistosoma mansoni	slit	0.002	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.026	0.026
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.026	0.026
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0032	0.0132	0.0384
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.026	0.026
Onchocerca volvulus		0.0023	0.0037	0.1177
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.013	0.013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0257	0.0257
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Onchocerca volvulus		0.0032	0.013	0.4861
Loa Loa (eye worm)	hypothetical protein	0.002	0.0007	0.0007
Brugia malayi	ecdysteroid receptor	0.0032	0.013	0.013
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0045	0.026	0.026
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.013	0.013
Schistosoma mansoni	egf-like domain protein	0.0032	0.0132	0.0132
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0017	0.0055
Brugia malayi	Calcium binding EGF domain containing protein	0.002	0.0007	0.0007
Brugia malayi	PAN domain containing protein	0.0023	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Onchocerca volvulus		0.0045	0.026	1
Toxoplasma gondii	PAN domain-containing protein	0.0356	0.343	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0045	0.026	0.026
Loa Loa (eye worm)	PAN domain-containing protein	0.0023	0.0037	0.0037

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 6.5 nM	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as concentration required to reach peak effect at 125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 34 nM)	ChEMBL.	24418773
Activity (binding)	= 7 nM	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as concentration required to reach peak effect at 12.5 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 34 nM)	ChEMBL.	24418773
Activity (binding)	= 23 nM	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as concentration required to reach peak effect at 1.25 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 34 nM)	ChEMBL.	24418773
Activity (binding)	= 34 nM	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as concentration required to reach peak effect at 0.125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 34 nM)	ChEMBL.	24418773
Activity (binding)	= 36 nM	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as concentration required to reach peak effect at 0.0125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 34 nM)	ChEMBL.	24418773
Activity (functional)	= 160 nM	Increase in thrombin generation in human moderate hemophilia A pooled poor platelet plasma by thrombogram assay at 20 uM	ChEMBL.	16913694
Activity (functional)	= 160 nM	Increase in thrombin generation in human moderate hemophilia A platelet poor plasma by thrombogram assay at 10 uM	ChEMBL.	16913694
Activity (functional)	= 160 nM	Increase in thrombin generation in human moderate hemophilia A pooled poor platelet plasma by thrombogram assay at 20 uM	ChEMBL.	16913694
Activity (functional)	= 160 nM	Increase in thrombin generation in human moderate hemophilia A platelet poor plasma by thrombogram assay at 10 uM	ChEMBL.	16913694
Activity (functional)	= 201 nM	Increase in thrombin generation in human severe hemophilia A pooled poor platelet plasma at 20 uM relative to control by thrombogram assay	ChEMBL.	16913694
Activity (functional)	= 201 nM	Increase in thrombin generation in human severe hemophilia A pooled poor platelet plasma at 20 uM relative to control by thrombogram assay	ChEMBL.	16913694
Activity (binding)	= 93 nM.min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as endogenous thrombin potential at 12.5 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid relative to control	ChEMBL.	24418773
Activity (binding)	= 117 nM.min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as endogenous thrombin potential at 125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid relative to control	ChEMBL.	24418773
Activity (binding)	= 161 nM.min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as endogenous thrombin potential at 1.25 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid relative to control	ChEMBL.	24418773
Activity (binding)	= 202 nM.min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as endogenous thrombin potential at 0.0125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid relative to control	ChEMBL.	24418773
Activity (binding)	= 203 nM.min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as endogenous thrombin potential at 0.125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid relative to control	ChEMBL.	24418773
IC50 (binding)	= 0.82 uM	Inhibition of human aPC	ChEMBL.	16913694
IC50 (binding)	= 0.82 uM	Inhibition of human aPC	ChEMBL.	16913694
IC50 (binding)	= 1.7 uM	Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	ChEMBL.	24418773
IC50 (binding)	= 8.9 uM	Inhibition of human coagulation factor 7a using spectrozyme as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis in presence of tissue factor	ChEMBL.	24418773
IC50 (binding)	= 36 uM	Inhibition of human thrombin using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	ChEMBL.	24418773
IC50 (binding)	> 44 uM	Inhibition of human coagulation factor 11a using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	ChEMBL.	24418773
IC50 (binding)	= 47 uM	Inhibition of human thrombin activity	ChEMBL.	16913694
IC50 (binding)	= 47 uM	Inhibition of human thrombin activity	ChEMBL.	16913694
IC50 (binding)	= 48 uM	Inhibition of human coagulation factor 10a using S-2765 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotometric analysis	ChEMBL.	24418773
Inhibition (binding)	= 40 %	Inhibition of coagulation factor 9a (unknown origin)-mediated hydrolysis of Z-D-Arg-Gly-Arg-pNA at 100 uM relative to control	ChEMBL.	24418773
Ki (binding)	= 0.5 uM	Competitive inhibition of human APC using S-2366 as substrate	ChEMBL.	24418773
Ki (binding)	= 7 uM	Competitive inhibition of human coagulation factor 7a using spectrozyme as substrate	ChEMBL.	24418773
Ki (binding)	= 16 uM	Competitive inhibition of human coagulation factor 10a using S-2765 as substrate	ChEMBL.	24418773
Ki (binding)	> 19 uM	Competitive inhibition of human coagulation factor 11a using S-2366 as substrate	ChEMBL.	24418773
Ki (binding)	= 19 uM	Competitive inhibition of human thrombin using S-2366 as substrate	ChEMBL.	24418773
Time (binding)	= 2.7 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as lag-time at 0.0125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 2.7 mins)	ChEMBL.	24418773
Time (binding)	= 2.8 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as lag-time at 0.125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 2.7 mins)	ChEMBL.	24418773
Time (binding)	= 3 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as lag-time at 1.25 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 2.7 mins)	ChEMBL.	24418773
Time (binding)	= 4.6 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as lag-time at 12.5 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 2.7 mins)	ChEMBL.	24418773
Time (binding)	= 5.9 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as time required to reach peak effect at 0.0125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 6 mins)	ChEMBL.	24418773
Time (binding)	= 6.3 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as time required to reach peak effect at 0.125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 6 mins)	ChEMBL.	24418773
Time (binding)	= 7 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as time required to reach peak effect at 1.25 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 6 mins)	ChEMBL.	24418773
Time (binding)	= 12 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as time required to reach peak effect at 12.5 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 6 mins)	ChEMBL.	24418773
Time (binding)	= 17 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as lag-time at 125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 2.7 mins)	ChEMBL.	24418773
Time (binding)	= 29 min	Inhibition of APC in human plasma assessed as effect on thrombin generation measured as time required to reach peak effect at 125 uM by calibrated automated thrombogram method in presence of coagulation factor 8-deficient plasma, tissue factor, rabbit lung thrombomodulin and ellagic acid (Rvb = 6 mins)	ChEMBL.	24418773

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL215295
PubChem: 9892392

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 371230