Detailed information for compound 372168

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.261 | Formula: C18H20BrNO2
  • H donors: 0 H acceptors: 1 LogP: 3.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)/C=C\1/CN2C3C1C(CC2CC3)c1ccc(cc1)Br
  • InChi: 1S/C18H20BrNO2/c1-22-17(21)8-12-10-20-14-6-7-16(20)18(12)15(9-14)11-2-4-13(19)5-3-11/h2-5,8,14-16,18H,6-7,9-10H2,1H3/b12-8-
  • InChiKey: ZMKPUZMPYBNAFS-WQLSENKSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.072
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0177 0.3649 0.5495
Plasmodium vivax hypothetical protein, conserved 0.005 0.0838 0.076
Loa Loa (eye worm) serotonin transporter b 0.0292 0.6188 1
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0493 0.1973
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1162
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0484 0.0404
Leishmania major protein kinase, putative 0.0034 0.0484 0.7919
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0484 0.1927
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0438 0.0581
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0283 0.0201
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0838 0.1235
Echinococcus granulosus serotonin transporter 0.0292 0.6188 1
Schistosoma mansoni glucose transport protein 0.011 0.216 0.3402
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0177 0.3649 0.3595
Leishmania major glucose transporter, lmgt3 0.0034 0.0493 0.8107
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0838 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0469 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0084 0.2954
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0838 0.1235
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.0884 0.1311
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Schistosoma mansoni glucose transport protein 0.011 0.216 0.3402
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0469 0.9253
Mycobacterium ulcerans sugar transporter 0.0015 0.0084 0.2954
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0469 0.0631
Plasmodium falciparum transporter, putative 0.005 0.0838 0.076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0589 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0283 0.395
Schistosoma mansoni glucose transport protein 0.011 0.216 0.3402
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0484 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Onchocerca volvulus 0.005 0.0838 0.1235
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0484 0.072
Plasmodium falciparum amino acid transporter, putative 0.005 0.0838 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0493 0.1973
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0838 0.1235
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Echinococcus granulosus General substrate transporter 0.0094 0.1821 0.2846
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0484 0.0617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0589 0.0779
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.0292 0.6188 1
Plasmodium falciparum hexose transporter 0.011 0.216 0.2094
Plasmodium vivax amine transporter, putative 0.005 0.0838 0.076
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0283 0.0961
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0838 0.1235
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0838 0.1235
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.6188 1
Plasmodium falciparum protein kinase 7 0.0309 0.6571 0.6542
Loa Loa (eye worm) sugar transporter 0.011 0.216 0.3448
Schistosoma mansoni protein kinase 0.0034 0.0484 0.0656
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0469 0.0631
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.216 0.3402
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0202 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.6188 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.6188 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0838 0.1235
Brugia malayi hypothetical protein 0.005 0.0838 0.1235
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0283 0.3046
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0484 0.0656
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0393
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0484 0.0617
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0484 0.0404
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0084 0.5
Trichomonas vaginalis conserved hypothetical protein 0.011 0.216 1
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.6188 1
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0493 0.1973
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1235
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1235
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0493 0.8107
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0027 0.0333 0.0474
Echinococcus multilocularis serotonin transporter 0.0292 0.6188 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0838 0.1235
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0217 0.0641
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0484 0.0404
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0838 0.1235
Echinococcus multilocularis General substrate transporter 0.0094 0.1821 0.2846
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.0327
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Brugia malayi Cam kinase protein 1 0.0034 0.0484 0.0656
Onchocerca volvulus 0.005 0.0838 0.1235
Loa Loa (eye worm) hypothetical protein 0.0292 0.6188 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0838 0.1235
Toxoplasma gondii protein kinase, putative 0.0309 0.6571 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1235
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0202 1
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0589 0.051
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.216 0.3201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0283 0.0327
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1162
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0469 0.0631
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0484 0.0404
Schistosoma mansoni hypothetical protein 0.011 0.216 0.3402
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0493 0.8107
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0484 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1973
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0283 0.395
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0589 0.051
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0069
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0484 0.0404
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 1
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0493 0.1973
Onchocerca volvulus 0.005 0.0838 0.1235
Plasmodium falciparum mitogen-activated protein kinase 2 0.0177 0.3649 0.3595
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1296
Entamoeba histolytica protein kinase, putative 0.0034 0.0484 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0469 0.0631
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0484 0.072
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0438 0.0581
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Trypanosoma cruzi hexose transporter 0.0034 0.0493 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0838 0.1235
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0283 0.0327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0154 0.1383
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0838 0.1235
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0283 0.0327
Trypanosoma brucei glucose transporter 2A 0.0034 0.0493 0.8107
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0084 0.2954
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0838 0.1235
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0484 0.0656
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0838 0.1235
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0469 0.1855
Schistosoma mansoni protein kinase 0.0034 0.0484 0.0656
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1296
Schistosoma mansoni protein kinase 0.0034 0.0484 0.0656
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0469 0.0631
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0493 0.1973
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.6188 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0493 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0484 0.0617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0484 0.7919
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0484 0.0656
Plasmodium vivax CDK-related protein kinase 6, putative 0.0465 1 1
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0283 0.0201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.216 0.3402
Loa Loa (eye worm) sugar transporter 0.0015 0.0084 0.0069
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0069
Onchocerca volvulus 0.0292 0.6188 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0838 0.1235
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0838 0.1235
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0838 0.1235
Plasmodium vivax hexose transporter 0.011 0.216 0.2094
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0283 0.5182
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0838 0.1235
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0493 0.8107
Brugia malayi Sugar transporter family protein 0.011 0.216 0.3402
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0838 0.1235
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0838 0.1162
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0838 0.1235
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0589 1
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0838 0.1235
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.1296
Entamoeba histolytica protein kinase, putative 0.0034 0.0484 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0838 0.1235
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0469 1
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0283 0.3382
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Toxoplasma gondii hypothetical protein 0.005 0.0838 0.1162
Leishmania major glucose transporter, lmgt1 0.0034 0.0493 0.8107
Trypanosoma brucei glucose transporter 1E 0.0034 0.0493 0.8107
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.6188 1
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0283 0.0308
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0469 0.0631
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.0695
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0283 0.0327
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.0695
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0484 0.0404
Leishmania major glucose transporter, lmgt2 0.0034 0.0493 0.8107
Toxoplasma gondii hypothetical protein 0.005 0.0838 0.1162
Trypanosoma brucei glucose transporter, putative 0.0034 0.0493 0.8107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0283 0.395
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0838 0.1235
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.6188 1
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0084 0.2954

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.94 nM Displacement of [125I]RTI-55 from human DAT transfected in HEK293 cells ChEMBL. 16784855
Ki (binding) = 2.94 nM Displacement of [125I]RTI-55 from human DAT transfected in HEK293 cells ChEMBL. 16784855
Ki (binding) = 5.63 nM Displacement of [3H]citalopram from human SERT transfected in HEK293 cells ChEMBL. 16784855
Ki (binding) = 5.63 nM Displacement of [3H]citalopram from human SERT transfected in HEK293 cells ChEMBL. 16784855
Ki (binding) = 12.53 nM Displacement of [3H]nisoxetine from human NET transfected in HEK293 cells ChEMBL. 16784855
Ki (binding) = 12.53 nM Displacement of [3H]nisoxetine from human NET transfected in HEK293 cells ChEMBL. 16784855

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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