Detailed information for compound 375870

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.47 | Formula: C19H23N3O2S
  • H donors: 2 H acceptors: 1 LogP: 4.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(C)[nH]c2c1/C(=N/OC(=O)Nc1ccccc1SC)/CCC2
  • InChi: 1S/C19H23N3O2S/c1-4-13-12(2)20-15-9-7-10-16(18(13)15)22-24-19(23)21-14-8-5-6-11-17(14)25-3/h5-6,8,11,20H,4,7,9-10H2,1-3H3,(H,21,23)/b22-16+
  • InChiKey: OFRSYFPUDWBCAS-CJLVFECKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Plasmodium falciparum protein kinase 7 0.033 0.658 0.6542
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0092 0.029
Echinococcus granulosus bloom syndrome protein 0.0073 0.1272 0.3996
Brugia malayi Carboxylesterase family protein 0.0066 0.1135 0.5208
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0092 0.029
Echinococcus multilocularis General substrate transporter 0.0101 0.1841 0.5782
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.037 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0486 0.5617
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0206 0.0647
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0092 0.029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0103 0.0337
Schistosoma mansoni protein kinase 0.0036 0.0507 0.1594
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni biogenic amine receptor 0.0016 0.0092 0.029
Trypanosoma cruzi hexose transporter, putative 0.002 0.0178 0.1097
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1135 0.3566
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0043 0.0658 0.0556
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Echinococcus granulosus serotonin receptor 0.0016 0.0092 0.029
Schistosoma mansoni opsin-like receptor 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Onchocerca volvulus 0.0016 0.0092 0.4473
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0517 0.0794
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0307 0.0966
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0492 0.0939
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0785 1
Echinococcus granulosus neuropeptide receptor 0.0016 0.0092 0.029
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0092 0.4473
Onchocerca volvulus 0.0016 0.0092 0.4473
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0241 0.037
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0092 0.029
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0716 0.2339
Schistosoma mansoni amine GPCR 0.0016 0.0092 0.029
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0307 0.0201
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0103 0.0324
Onchocerca volvulus 0.0016 0.0092 0.4473
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Onchocerca volvulus 0.0016 0.0092 0.4473
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0092 0.029
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus General substrate transporter 0.0101 0.1841 0.5782
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0226 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0206 0.0647
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0517 0.6066
Echinococcus granulosus dna polymerase eta 0.0016 0.0103 0.0324
Onchocerca volvulus 0.0016 0.0092 0.4473
Treponema pallidum ATP-dependent DNA helicase 0.0022 0.0222 0.0305
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0206 0.0647
Echinococcus multilocularis bloom syndrome protein 0.0073 0.1272 0.3996
Trypanosoma brucei glucose transporter 1E 0.0036 0.0517 0.6066
Trypanosoma brucei unspecified product 0.0039 0.0564 0.6762
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0152 0.0712
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0206 0.0945
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0206 0.0647
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0108 0.0166
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Brugia malayi GnHR receptor homolog 0.0016 0.0092 0.0423
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0108 0.034
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0785 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0152 0.0712
Echinococcus granulosus geminin 0.0166 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Mycobacterium ulcerans sugar transporter 0.0016 0.0108 0.0353
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0255 0.2231
Schistosoma mansoni glucose transport protein 0.0117 0.218 0.6847
Onchocerca volvulus 0.0016 0.0092 0.4473
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0206 0.0945
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0612 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Brugia malayi Serotonin receptor 0.0016 0.0092 0.0423
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1135 0.3566
Plasmodium vivax hexose transporter 0.0117 0.218 0.2094
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0108 0.0075
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0043 0.0658 0.2067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0658 0.3019
Brugia malayi hypothetical protein 0.0016 0.0108 0.0496
Schistosoma mansoni glucose transport protein 0.0117 0.218 0.6847
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0092 0.029
Schistosoma mansoni protein kinase 0.0036 0.0507 0.1594
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0092 0.029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0206 0.0647
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0517 0.0794
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0785 0.1206
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0612 0.7465
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0222 0.0698
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0092 0.029
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0206 0.0647
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Loa Loa (eye worm) hypothetical protein 0.0035 0.0492 0.1548
Trichomonas vaginalis DNA helicase recq1, putative 0.0073 0.1272 0.1954
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.3062 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0517 0.6066
Trypanosoma cruzi hexose transporter 0.0036 0.0517 0.6066
Onchocerca volvulus 0.0021 0.0206 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0716 0.11
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0307 0.2994
Onchocerca volvulus 0.0016 0.0108 0.5251
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0067 0.1145 0.1048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0206 0.0647
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Brugia malayi Sugar transporter family protein 0.0016 0.0108 0.0496
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0092 0.029
Echinococcus multilocularis dna polymerase eta 0.0016 0.0103 0.0324
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0508 0.0404
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0092 0.029
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0092 0.029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0255 0.2231
Onchocerca volvulus 0.0016 0.0092 0.4473
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0508 0.0404
Brugia malayi Carboxylesterase family protein 0.0066 0.1135 0.5208
Schistosoma mansoni hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0092 0.029
Schistosoma mansoni flap endonuclease-1 0.0026 0.0312 0.0981
Brugia malayi nuclear receptor NHR-88 0.0021 0.0206 0.0945
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Brugia malayi steroid hormone receptor 0.0021 0.0206 0.0945
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0103 0.0324
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Echinococcus multilocularis solute carrier family 22 0.0016 0.0108 0.034
Schistosoma mansoni hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0206 0.0647
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0043 0.0658 0.2067
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0092 0.029
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0092 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0108 0.0166
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0206 0.0647
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0092 0.029
Brugia malayi G protein-coupled receptor 0.0016 0.0092 0.0423
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0092 0.029
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0517 0.6066
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0716 0.2339
Plasmodium falciparum mitogen-activated protein kinase 2 0.0189 0.3664 0.3595
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0092 0.029
Echinococcus granulosus flap endonuclease 1 0.0029 0.037 0.1162
Schistosoma mansoni myosin xvIII 0.0016 0.0092 0.029
Schistosoma mansoni DNA helicase recq5 0.0043 0.0658 0.2067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0206 0.0945
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0103 0.0473
Toxoplasma gondii sugar transporter ST2 0.0016 0.0108 0.0127
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0307 0.0965
Schistosoma mansoni amine GPCR 0.0016 0.0092 0.029
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0462 0.145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0206 0.0945
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0517 0.6066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0206 0.0647
Echinococcus granulosus acetylcholinesterase 0.0066 0.1135 0.3566
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0206 0.0647
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0508 0.0404
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0205 0.0159
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0049 0.0785 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0492 0.1547
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0206 0.0647
Entamoeba histolytica protein kinase, putative 0.0036 0.0507 0.0631
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0092 0.0423
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.3062 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0108 0.0166
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0092 0.029
Brugia malayi G-protein coupled receptor 0.0016 0.0092 0.0423
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0507 0.1595
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Entamoeba histolytica protein kinase, putative 0.0036 0.0507 0.0631
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0307 0.0965
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Schistosoma mansoni hypothetical protein 0.0166 0.3184 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0092 0.029
Echinococcus granulosus allatostatin A receptor 0.0016 0.0092 0.029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0206 0.0647
Schistosoma mansoni amine GPCR 0.0016 0.0092 0.029
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0092 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0108 0.0166
Brugia malayi major facilitator superfamily protein 0.0016 0.0108 0.0496
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0108 0.0127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0517 0.6066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0092 0.029
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0222 0.1748
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0108 0.0353
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0492 0.0608
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0092 0.4473
Brugia malayi G-protein coupled receptor 0.0016 0.0092 0.0423
Schistosoma mansoni neuropeptide receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) sugar transporter 0.0117 0.218 0.685
Echinococcus granulosus neuropeptide receptor 0.0016 0.0092 0.029
Toxoplasma gondii protein kinase, putative 0.033 0.658 1
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0517 0.0794
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0206 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0189 0.3664 0.5552
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0307 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0108 0.0166
Onchocerca volvulus 0.0016 0.0108 0.5251
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0108 0.0075
Schistosoma mansoni hypothetical protein 0.0117 0.218 0.6847
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Onchocerca volvulus 0.0016 0.0108 0.5251
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0103 0.0324
Brugia malayi Flap endonuclease-1 0.0029 0.037 0.1697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0206 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Brugia malayi neuropeptide F receptor 0.0016 0.0092 0.0423
Onchocerca volvulus 0.0016 0.0108 0.5251
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0092 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0036 0.0507 0.1595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0206 0.0647
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.218 0.3287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus solute carrier family 22 0.0016 0.0108 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0092 0.029
Echinococcus granulosus orexin receptor type 2 0.0016 0.0092 0.029
Echinococcus multilocularis flap endonuclease 1 0.0029 0.037 0.1162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0206 0.0647
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0108 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Onchocerca volvulus 0.0016 0.0108 0.5251
Echinococcus multilocularis solute carrier family 22 0.0016 0.0108 0.034
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0043 0.0658 0.2068
Onchocerca volvulus 0.0016 0.0092 0.4473
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0092 0.0423
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0092 0.029
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0222 0.0301
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.037 0.0265
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0307 0.0201
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0108 0.034
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0092 0.029
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1135 0.3566
Brugia malayi Cam kinase protein 1 0.0036 0.0507 0.2328
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0206 0.0647
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0206 0.0647
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0108 0.0075
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1135 0.3566
Onchocerca volvulus 0.0016 0.0108 0.5251
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0226 0.0739
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0103 0.0324
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0206 0.0647
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0092 0.029
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0108 0.034
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0092 0.029
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0517 0.6066
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.037 0.3912
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0092 0.029
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0092 0.029
Schistosoma mansoni opsin-like receptor 0.0016 0.0092 0.029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0103 0.0324
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0307 0.0431
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0716 0.225
Onchocerca volvulus 0.0016 0.0108 0.5251
Entamoeba histolytica recQ family DNA helicase 0.0022 0.0222 0.0186
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0716 0.11
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0486 0.5617
Schistosoma mansoni glucose transport protein 0.0117 0.218 0.6847
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Schistosoma mansoni DNA polymerase eta 0.0016 0.0103 0.0324
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Brugia malayi Sugar transporter family protein 0.0016 0.0108 0.0496
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0612 0.7465
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Brugia malayi Dopamine receptor 0.0016 0.0092 0.0423
Schistosoma mansoni amine GPCR 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0103 0.0324
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0206 0.0647
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0612 0.7465
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0092 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0517 0.0794
Echinococcus multilocularis serotonin receptor 0.0016 0.0092 0.029
Schistosoma mansoni hypothetical protein 0.0016 0.0092 0.029
Onchocerca volvulus Putative transporter 0.0016 0.0108 0.5251
Brugia malayi polk-prov protein 0.0035 0.0486 0.2231
Schistosoma mansoni neuropeptide receptor 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0206 0.0647
Trichomonas vaginalis DNA helicase recq, putative 0.0073 0.1272 0.1954
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1135 0.3566
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0206 0.0945
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0092 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0108 0.0166
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0492 0.06
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0612 0.7465
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0092 0.4473
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0092 0.029
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0092 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0092 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0092 0.029
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.037 0.0568
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0021 0.0205 0.0098
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1135 0.3567
Echinococcus multilocularis geminin 0.0166 0.3184 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Schistosoma mansoni coup transcription factor 0.0021 0.0206 0.0647
Onchocerca volvulus 0.0016 0.0092 0.4473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0108 0.0353
Onchocerca volvulus 0.0016 0.0092 0.4473
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.218 0.6847
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0092 0.029
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0108 0.034
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0307 0.141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0206 0.0945
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0092 0.029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0206 0.0647
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0092 0.029
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0492 0.1547
Brugia malayi putative neuropeptide receptor 0.0016 0.0092 0.0423
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0092 0.029
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.6511 1
Onchocerca volvulus 0.0016 0.0108 0.5251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0206 0.0647
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0092 0.029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0206 0.0647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni neuropeptide receptor 0.0016 0.0092 0.029
Echinococcus multilocularis serotonin receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) carboxylesterase 0.0066 0.1135 0.3567
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0658 0.0966
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Giardia lamblia Fructose-bisphosphate aldolase 0.0327 0.6511 1
Schistosoma mansoni protein kinase 0.0036 0.0507 0.1594
Brugia malayi Serotonin receptor 0.0016 0.0092 0.0423
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0307 0.0472
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0564 0.6762
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0206 0.0647
Schistosoma mansoni sugar transporter 0.0016 0.0108 0.034
Brugia malayi ORL1-like opioid receptor 0.0016 0.0092 0.0423
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0092 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0092 0.029
Schistosoma mansoni blooms syndrome DNA helicase 0.0051 0.0819 0.2573
Treponema pallidum fructose-bisphosphate aldolase 0.0327 0.6511 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0206 0.0945
Schistosoma mansoni glucose transporter 0.0016 0.0108 0.034
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0658 0.3019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0206 0.0945
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Onchocerca volvulus 0.0016 0.0092 0.4473
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0517 0.6066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0612 0.0896
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0507 0.1595
Echinococcus granulosus somatostatin receptor 0.0016 0.0092 0.029
Echinococcus granulosus fmrfamide receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0166 0.3182 1
Schistosoma mansoni hypothetical protein 0.0166 0.3184 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0206 0.0647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni biogenic amine receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0092 0.029
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0046 0.0709 0.0608
Echinococcus multilocularis sex peptide receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0092 0.029
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0492 0.0756
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0206 0.0945
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0307 0.0965
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0092 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0716 0.8993
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0658 0.0966
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0658 0.2068
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0206 0.0647
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0307 0.0965
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0108 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0206 0.0647
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0206 0.0647
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0092 0.029
Echinococcus granulosus acetylcholinesterase 0.0066 0.1135 0.3566
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0462 0.145
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus solute carrier family 22 0.0016 0.0108 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0206 0.0647
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0092 0.029
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0092 0.029
Brugia malayi Dopamine receptor protein 1 0.0016 0.0092 0.0423
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0092 0.0423
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0517 0.0794
Loa Loa (eye worm) hypothetical protein 0.0029 0.0357 0.1121
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0492 0.2259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0206 0.0647
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0612 0.051
Loa Loa (eye worm) hypothetical protein 0.0066 0.1135 0.3567
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.218 0.3348
Brugia malayi neuropeptide F receptor 0.0016 0.0092 0.0423
Loa Loa (eye worm) sugar transporter 0.0016 0.0108 0.034
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0507 0.1594
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.037 0.0526
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0206 0.0647
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0508 0.0737
Onchocerca volvulus 0.0016 0.0108 0.5251
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0108 0.5251
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0206 0.0945
Plasmodium falciparum flap endonuclease 1 0.0029 0.037 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0206 0.0945
Schistosoma mansoni sugar transporter 0.0016 0.0108 0.034
Brugia malayi larval opioid receptor 0.0016 0.0092 0.0423
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0092 0.0423
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0092 0.029
Giardia lamblia Sgs1 DNA helicase, putative 0.0043 0.0658 0.0859
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0507 0.0779
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0508 0.0737
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0508 0.0404
Onchocerca volvulus 0.0016 0.0092 0.4473
Onchocerca volvulus 0.0016 0.0092 0.4473
Leishmania major hypothetical protein, conserved 0.0016 0.0108 0.0075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0092 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0152 0.0712
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Brugia malayi major facilitator superfamily protein 0.0016 0.0108 0.0496
Schistosoma mansoni DNA helicase recq1 0.0043 0.0658 0.2067
Toxoplasma gondii sugar transporter ST3 0.0016 0.0108 0.0127
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0092 0.029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0092 0.029
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0092 0.029
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0612 0.7465
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0066 0.0208
Brugia malayi hypothetical protein 0.0016 0.0108 0.0496
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0092 0.029
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0092 0.0423
Leishmania major DNA polymerase kappa, putative 0.0024 0.0255 0.2231
Echinococcus granulosus solute carrier family 22 0.0016 0.0108 0.034
Schistosoma mansoni opsin-like receptor 0.0016 0.0092 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Echinococcus multilocularis somatostatin receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0492 0.1547
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0307 0.1003
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0508 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0507 0.1594
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0206 0.0945
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0043 0.0658 0.2067
Schistosoma mansoni amine GPCR 0.0016 0.0092 0.029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0092 0.4473
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0092 0.029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0092 0.029
Echinococcus granulosus sex peptide receptor 0.0016 0.0092 0.029
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0108 0.0496
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0092 0.029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0092 0.0423
Schistosoma mansoni sugar transporter 0.0016 0.0108 0.034
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.218 0.6847
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0492 0.1548
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0206 0.0647
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.6511 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0043 0.0658 0.2067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0108 0.0496
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0508 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0206 0.0945
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.037 0.3912
Onchocerca volvulus 0.0016 0.0108 0.5251
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0517 0.0794
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0206 0.0647
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Brugia malayi hypothetical protein 0.0016 0.0108 0.0496
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.037 0.1163
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus g protein coupled receptor 0.0016 0.0092 0.029
Schistosoma mansoni adenoreceptor 0.0016 0.0092 0.029
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Echinococcus multilocularis solute carrier family 22 0.0016 0.0108 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0092 0.029
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0092 0.029
Schistosoma mansoni histamine h1 receptor 0.0016 0.0092 0.029
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus g protein coupled receptor 0.0016 0.0092 0.029
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0092 0.029
Brugia malayi RE15519p 0.0016 0.0092 0.0423
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0092 0.029
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0108 0.034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0092 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus granulosus g protein coupled receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Echinococcus multilocularis solute carrier family 22 0.0016 0.0108 0.034
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0108 0.0353
Brugia malayi hypothetical protein 0.0016 0.0092 0.0423
Trypanosoma brucei sugar transporter, putative 0.0016 0.0108 0.0075
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0092 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0716 0.8993
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0108 0.5251
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0206 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Schistosoma mansoni neuropeptide receptor 0.0016 0.0092 0.029
Leishmania major glucose transporter, lmgt3 0.0036 0.0517 0.6066
Brugia malayi Dopamine receptor protein 2 0.0016 0.0092 0.0423
Trypanosoma brucei glucose transporter 2A 0.0036 0.0517 0.6066
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0092 0.029
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0206 0.0647
Loa Loa (eye worm) RecQ helicase 0.0073 0.1272 0.3998
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.037 0.3912
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0108 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Leishmania major glucose transporter, lmgt1 0.0036 0.0517 0.6066
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0507 0.5928
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0092 0.029
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0092 0.029
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0092 0.029
Brugia malayi ecdysteroid receptor 0.0021 0.0206 0.0945
Brugia malayi Sugar transporter family protein 0.0117 0.218 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0108 0.0075
Schistosoma mansoni biogenic amine receptor 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0108 0.5251
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0517 0.0794
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0092 0.0423
Plasmodium falciparum hexose transporter 0.0117 0.218 0.2094
Loa Loa (eye worm) hypothetical protein 0.0066 0.1135 0.3567
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0222 0.1748
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0206 0.0945
Onchocerca volvulus 0.0016 0.0108 0.5251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0222 0.0699
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0092 0.0423
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0508 0.0404
Onchocerca volvulus 0.0016 0.0108 0.5251
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0206 0.0945
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0255 0.0833
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.6511 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0508 0.0404
Plasmodium vivax CDK-related protein kinase 6, putative 0.0496 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.034
Entamoeba histolytica Flap nuclease, putative 0.0029 0.037 0.0416
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.3062 1
Brugia malayi Melatonin receptor type 1A 0.0016 0.0092 0.0423
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus granulosus dna polymerase kappa 0.0046 0.0716 0.225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0206 0.0647
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0092 0.029
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0189 0.3664 0.3595
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0206 0.0647
Schistosoma mansoni sugar transporter 0.0016 0.0108 0.034
Giardia lamblia DINP protein human, muc B family 0.0024 0.0255 0.023
Toxoplasma gondii sugar transporter ST1 0.0016 0.0108 0.0127
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0307 0.2994
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0307 0.2994
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0092 0.029
Brugia malayi nuclear hormone receptor 0.0021 0.0206 0.0945
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0508 0.0737
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0108 0.0353
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0092 0.4473
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0092 0.029
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0492 0.2259
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0507 0.2328
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0021 0.0206 0.0647
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0092 0.029
Entamoeba histolytica hypothetical protein 0.0026 0.0307 0.0319
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0092 0.029
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0092 0.029
Onchocerca volvulus 0.0016 0.0108 0.5251
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0108 0.0353
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0092 0.0423
Onchocerca volvulus 0.0016 0.0092 0.4473
Echinococcus granulosus solute carrier family 22 0.0016 0.0108 0.034
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0307 0.0311
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0692 0.1018
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0025 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0716 0.8993
Brugia malayi AKH receptor 0.0016 0.0092 0.0423
Leishmania major protein kinase, putative 0.0036 0.0507 0.5928
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0108 0.0496
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0206 0.0647
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Brugia malayi sulfakinin receptor protein 0.0016 0.0092 0.0423
Entamoeba histolytica recQ family helicase, putative 0.0049 0.0785 0.1064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0307 0.1003
Leishmania major glucose transporter, lmgt2 0.0036 0.0517 0.6066
Brugia malayi Bloom's syndrome protein homolog 0.0073 0.1272 0.5837
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0508 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0108 0.0166
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0108 0.034
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0103 0.0473
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0492 0.1547
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0507 0.1594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0486 0.1528
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0206 0.0945
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0307 1
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.029
Trypanosoma brucei glucose transporter, putative 0.0036 0.0517 0.6066
Echinococcus granulosus hypothetical protein 0.0016 0.0092 0.029

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 41 % Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay at 1uM ChEMBL. 16942878
Inhibition (functional) = 41 % Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assay at 1uM ChEMBL. 16942878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.