Detailed information for compound 377134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 3236.42 | Formula: C128H203N69O33
  • H donors: 48 H acceptors: 35 LogP: -23.53 Rotable bonds: 136
    Rule of 5 violations (Lipinski): 4
  • SMILES: NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N)CCCNC(=N)N)CCC(=O)N)CCCNC(=N)N)CCC(=O)O)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N)CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN(C(=O)Cn1ccc(nc1=O)N)CCNC(=O)CN(C(=O)Cn1cnc2c1nc(N)[nH]c2=O)CCNC(=O)CN(C(=O)Cn1ccc(nc1=O)N)CCNC(=O)CN(C(=O)Cn1cnc2c1nc(N)[nH]c2=O)CCNC(=O)CCC(=O)O)C)CCCNC(=N)N
  • InChi: 1S/C128H203N69O33/c1-64(170-89(204)57-193(91(206)59-195-46-31-82(130)185-128(195)230)50-44-157-88(203)56-192(93(208)61-197-63-169-97-100(197)187-126(153)189-115(97)228)49-43-156-86(201)54-190(90(205)58-194-45-30-81(129)184-127(194)229)48-42-155-87(202)55-191(47-41-154-85(200)27-29-95(211)212)92(207)60-196-62-168-96-99(196)186-125(152)188-114(96)227)101(214)172-69(16-5-33-159-117(136)137)102(215)175-76(23-12-40-166-124(150)151)109(222)183-80(52-84(132)199)113(226)179-73(20-9-37-163-121(144)145)105(218)174-70(17-6-34-160-118(138)139)103(216)173-71(18-7-35-161-119(140)141)104(217)176-75(22-11-39-165-123(148)149)108(221)182-79(51-65-53-167-67-14-3-2-13-66(65)67)112(225)178-74(21-10-38-164-122(146)147)107(220)181-78(25-28-94(209)210)111(224)177-72(19-8-36-162-120(142)143)106(219)180-77(24-26-83(131)198)110(223)171-68(98(133)213)15-4-32-158-116(134)135/h2-3,13-14,30-31,45-46,53,62-64,68-80,167H,4-12,15-29,32-44,47-52,54-61H2,1H3,(H2,131,198)(H2,132,199)(H2,133,213)(H,154,200)(H,155,202)(H,156,201)(H,157,203)(H,170,204)(H,171,223)(H,172,214)(H,173,216)(H,174,218)(H,175,215)(H,176,217)(H,177,224)(H,178,225)(H,179,226)(H,180,219)(H,181,220)(H,182,221)(H,183,222)(H,209,210)(H,211,212)(H2,129,184,229)(H2,130,185,230)(H4,134,135,158)(H4,136,137,159)(H4,138,139,160)(H4,140,141,161)(H4,142,143,162)(H4,144,145,163)(H4,146,147,164)(H4,148,149,165)(H4,150,151,166)(H3,152,186,188,227)(H3,153,187,189,228)/t64-,68+,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-/m0/s1
  • InChiKey: JJPZODNIPIBSJT-OTEKFNBLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0029 0.003 0.0236
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.127 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0148 0.1164
Echinococcus granulosus expressed protein 0.0363 0.0678 0.5341
Trichomonas vaginalis lipase containing protein, putative 0.0144 0.0253 0.2839
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0019 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0133
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0024 0.0311
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0086 0.0675
Echinococcus multilocularis regulator of G protein signaling 7 0.0036 0.0043 0.0337
Schistosoma mansoni rab6-interacting 0.0019 0.001 0.0083
Echinococcus granulosus fatty acid amide hydrolase 1 0.0024 0.0021 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.0253 0.0906
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0074
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0009 0.0074
Loa Loa (eye worm) hypothetical protein 0.0158 0.028 0.3692
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0009 0.0074
Brugia malayi Disco-interacting protein 2 homolog 0.0027 0.0025 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0086 0.0675
Brugia malayi hypothetical protein 0.0018 0.0007 0.001
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0074
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.085 0.669
Echinococcus granulosus single minded 2 0.0035 0.0041 0.0322
Echinococcus granulosus regulator of G protein signaling 7 0.0036 0.0043 0.0337
Echinococcus multilocularis transfer RNA-Gly 0.0172 0.0308 0.2423
Loa Loa (eye worm) amidase 0.0024 0.0021 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0086 0.0675
Loa Loa (eye worm) doublecortin family protein 0.0019 0.001 0.0133
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0074
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0035 1
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0144 0.0253 0.1989
Echinococcus multilocularis non capsid protein NS 1 0.0083 0.0135 0.1061
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.001 0.0083
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0009 0.0012
Onchocerca volvulus 0.0027 0.0025 0.0019
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0024 0.0021 0.0076
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0059 0.0088 0.0324
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0203 0.0366 0.2883
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0074
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0203 0.0366 0.2883
Trypanosoma brucei telomerase reverse transcriptase 0.1412 0.2712 1
Schistosoma mansoni lipoxygenase 0.0019 0.001 0.0083
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0043 0.0388
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0043 1
Brugia malayi hypothetical protein 0.0019 0.001 0.0014
Toxoplasma gondii RNA-directed DNA polymerase 0.1412 0.2712 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0331
Brugia malayi hypothetical protein 0.0019 0.001 0.0014
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0007 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0082 0.0642
Schistosoma mansoni regulator of G protein signaling 0.0036 0.0043 0.0337
Schistosoma mansoni polycystin 1-related 0.0019 0.001 0.0083
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus multilocularis expressed protein 0.0363 0.0678 0.5341
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Brugia malayi hypothetical protein 0.0019 0.0009 0.0012
Onchocerca volvulus 0.0026 0.0024 0.0017
Echinococcus granulosus microtubule associated protein 2 0.0668 0.127 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0012
Onchocerca volvulus 0.0026 0.0024 0.0017
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0029 0.003 0.011
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.001 0.0039
Schistosoma mansoni dep domain containing protein 0.0017 0.0007 0.0052
Plasmodium vivax telomerase reverse transcriptase, putative 0.1412 0.2712 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0043 0.0388
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0127 0.0997
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0074
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0029 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0082
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0144 0.0253 0.1989
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0009 0.0074
Trypanosoma brucei lipase domain protein, putative 0.0144 0.0253 0.0931
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0029 0.003 0.0083
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0009 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0043 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0082
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus granulosus neuropeptide s receptor 0.0452 0.085 0.669
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0024 0.0021 0.5
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0009 0.0012
Echinococcus granulosus intermediate filament protein 0.0026 0.0024 0.0188
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Giardia lamblia Telomerase catalytic subunit 0.1412 0.2712 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0074
Toxoplasma gondii hypothetical protein 0.0059 0.0088 0.0324
Brugia malayi Lipase family protein 0.0144 0.0253 0.0347
Echinococcus granulosus Pleckstrin G protein interacting region 0.0017 0.0007 0.0052
Brugia malayi Inositol-1 0.0036 0.0043 0.0058
Schistosoma mansoni amidase 0.0203 0.0366 0.2883
Brugia malayi CXXC zinc finger family protein 0.0023 0.0019 0.0025
Echinococcus multilocularis non capsid protein NS 1 0.0083 0.0135 0.1061
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0012
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0127 0.1667
Echinococcus multilocularis RUN 0.0019 0.001 0.0083
Loa Loa (eye worm) lipase 0.0144 0.0253 0.3331
Schistosoma mansoni single-minded 0.0047 0.0065 0.0509
Schistosoma mansoni lipoxygenase 0.0054 0.0078 0.061
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0009 0.012
Echinococcus granulosus cpg binding protein 0.0023 0.0019 0.0147
Schistosoma mansoni cpg binding protein 0.0023 0.0019 0.0147
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0009 0.0074
Echinococcus granulosus fatty acid amide hydrolase 1 0.0203 0.0366 0.2883
Echinococcus multilocularis lamin 0.0026 0.0024 0.0188
Toxoplasma gondii hypothetical protein 0.0017 0.0007 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.001 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0007 0.0027
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.2217
Brugia malayi hypothetical protein 0.0158 0.028 0.0385
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Brugia malayi intermediate filament protein 0.0026 0.0024 0.0032
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0009 0.0074
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0024 0.0021 0.0163
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0148 0.1164
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0024 0.0021 0.0163
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.0074
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Trichomonas vaginalis lipase containing protein, putative 0.0144 0.0253 0.2839
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0127 0.0174
Echinococcus multilocularis non capsid protein NS 1 0.0083 0.0135 0.1061
Leishmania major hypothetical protein, conserved 0.0144 0.0253 0.0931
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Schistosoma mansoni hypothetical protein 0.0083 0.0135 0.1061
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0029 0.003 0.0236
Entamoeba histolytica DNA repair and recombination protein, putative 0.0029 0.003 0.7025
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0009 0.0074
Brugia malayi Doublecortin family protein 0.0019 0.001 0.0014
Schistosoma mansoni hypothetical protein 0.0019 0.001 0.0083
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0009 0.0074
Brugia malayi Amidase family protein 0.0024 0.0021 0.0028
Echinococcus multilocularis transfer RNA-Gly 0.0172 0.0308 0.2423
Brugia malayi Pre-SET motif family protein 0.0058 0.0086 0.0118
Onchocerca volvulus 0.0023 0.0019 0.0012
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0024 0.0311
Echinococcus granulosus regulator of G protein signaling 7 0.0036 0.0043 0.0337
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0561
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.001 0.0039
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Trichomonas vaginalis set domain proteins, putative 0.046 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.0366 0.4832
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0086 0.0675
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Leishmania major protein kinase, putative 0.002 0.0012 0.0043
Brugia malayi Telomerase reverse transcriptase 0.3757 0.7261 1
Brugia malayi hypothetical protein 0.0119 0.0203 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0144 0.0253 0.0906
Plasmodium falciparum telomerase reverse transcriptase 0.1412 0.2712 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0009 0.0012
Onchocerca volvulus 0.0019 0.001 0.0004
Echinococcus multilocularis disco interacting protein 2 0.0027 0.0025 0.02
Schistosoma mansoni lamin 0.0026 0.0024 0.0188
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0043 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0043 0.0336
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0009 0.012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0009 0.0074
Brugia malayi PXA domain containing protein 0.0019 0.0009 0.0012
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0029 0.003 0.0083
Brugia malayi regulator of G-protein signaling egl-10 0.0036 0.0043 0.0058
Schistosoma mansoni z-protein (S1r protein) 0.0036 0.0043 0.0337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0043 0.013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0043 0.013
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0024 0.0021 0.0163
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0404 0.0757 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0043 0.0336
Schistosoma mansoni dishevelled 0.0017 0.0007 0.0052
Brugia malayi follicle stimulating hormone receptor 0.0229 0.0417 0.0574
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0024 0.0021 0.0076
Onchocerca volvulus 0.0144 0.0253 0.0246
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Brugia malayi hypothetical protein 0.0019 0.0009 0.0012
Echinococcus multilocularis lamin dm0 0.0026 0.0024 0.0188
Echinococcus granulosus lamin dm0 0.0026 0.0024 0.0188
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0024 0.0021 0.0076
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0133
Echinococcus granulosus disco interacting protein 2 0.0027 0.0025 0.02
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0041 0.9205
Brugia malayi hypothetical protein 0.0017 0.0007 0.0009
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0029 0.003 0.011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0078 0.061
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0043 0.0157
Onchocerca volvulus 0.046 0.0866 0.086
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0086 0.0316
Trypanosoma brucei lipase domain protein, putative 0.0144 0.0253 0.0931
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0009 0.0074
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0036 0.0043 0.0561
Echinococcus granulosus lamin 0.0026 0.0024 0.0188
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0007 0.0082
Loa Loa (eye worm) hypothetical protein 0.035 0.0652 0.8603
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0007 0.0027
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0041 0.0056
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0009 0.012
Schistosoma mansoni cpg binding protein 0.0023 0.0019 0.0147
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.127 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0148 0.1164
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.035 0.0652 0.0645
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0009 0.0074
Loa Loa (eye worm) inositol-1 0.0036 0.0043 0.0558
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0009 0.0074
Echinococcus multilocularis transfer RNA-Gly 0.0172 0.0308 0.2423
Plasmodium vivax SET domain protein, putative 0.0058 0.0086 0.0316
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.0148 0.1164
Leishmania major hypothetical protein, conserved 0.0024 0.0021 0.0076
Echinococcus multilocularis transfer RNA-Trp 0.0172 0.0308 0.2423
Schistosoma mansoni inositol monophosphatase 0.0036 0.0043 0.0336
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0041 0.0322
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0007 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0074
Schistosoma mansoni fatty-acid amide hydrolase 0.0203 0.0366 0.2883
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0035 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0127 0.0997
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1412 0.2712 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0074
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Schistosoma mansoni loxhd1 0.0019 0.001 0.0083
Leishmania major hypothetical protein, conserved 0.0018 0.0007 0.0027
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0009 0.0012
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0009 0.012
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0024 0.0021 0.0163
Brugia malayi hypoxia-induced factor 1 0.0146 0.0256 0.0352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0086 0.0675
Loa Loa (eye worm) amidase 0.0024 0.0021 0.0267
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0017 0.0007 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0086 0.0675
Echinococcus multilocularis regulator of G protein signaling 7 0.0036 0.0043 0.0337
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0024 0.0021 0.5
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.2217
Trypanosoma cruzi amidase, putative 0.0024 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.012
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0074
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0017 0.0007 0.0052
Echinococcus granulosus fatty acid amide hydrolase 1 0.0203 0.0366 0.2883
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.001 0.0083
Echinococcus granulosus RUN 0.0019 0.001 0.0083
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.001 0.0083
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0007 0.0052
Brugia malayi putative amidase 0.0024 0.0021 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.0417 0.5509
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0043 0.0336
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0007 0.0009
Schistosoma mansoni fatty-acid amide hydrolase 0.0024 0.0021 0.0163
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0043 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0029 0.003 0.011
Echinococcus granulosus 5'partial|3'partial|non capsid protein NS 1 0.0083 0.0135 0.1061
Entamoeba histolytica hypothetical protein 0.0019 0.0009 0.2217
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0029 0.003 0.0083
Schistosoma mansoni lamin 0.0026 0.0024 0.0188
Brugia malayi Amidase family protein 0.0024 0.0021 0.0028
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0078 0.061
Brugia malayi hypothetical protein 0.0017 0.0007 0.0009
Schistosoma mansoni cpg binding protein 0.0023 0.0019 0.0147
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0299
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.085 0.669
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0007 0.0027
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0027 0.0025 0.02
Onchocerca volvulus 0.0019 0.001 0.0004
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Loa Loa (eye worm) hypothetical protein 0.009 0.0148 0.1948
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0009 0.0074
Brugia malayi amidase 0.0203 0.0366 0.0504
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0256 0.3379
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.001 0.0083
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0043 0.0157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0024 0.0311
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0009 0.0074
Brugia malayi N-terminal motif family protein 0.035 0.0652 0.0897
Trypanosoma cruzi amidase, putative 0.0024 0.0021 0.0049
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.085 0.669
Echinococcus multilocularis cpg binding protein 0.0023 0.0019 0.0147
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0065 0.0509
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Loa Loa (eye worm) hypothetical protein 0.0309 0.0572 0.7557
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.001 0.0083
Echinococcus multilocularis non capsid protein NS 1 0.0083 0.0135 0.1061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0092
Loa Loa (eye worm) hypothetical protein 0.0058 0.0086 0.1127
Schistosoma mansoni intermediate filament proteins 0.0026 0.0024 0.0188
Onchocerca volvulus 0.0058 0.0086 0.0079
Brugia malayi Pre-SET motif family protein 0.0404 0.0757 0.1043
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0007 0.0052
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0043 0.0388
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.012
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1412 0.2712 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0007 0.0009
Leishmania major telomerase reverse transcriptase, putative 0.1412 0.2712 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.0148 0.044
Onchocerca volvulus 0.0035 0.0041 0.0034
Schistosoma mansoni dishevelled 0.0017 0.0007 0.0052
Brugia malayi PAS domain containing protein 0.0047 0.0065 0.0088
Brugia malayi DIX domain containing protein 0.0017 0.0007 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.009 0.0148 0.0545
Schistosoma mansoni rab6-interacting 0.0019 0.001 0.0083
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus multilocularis musashi 0.0026 0.0024 0.0188
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0024 0.0032
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.003 0.7025
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0029 0.003 0.011
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0009 0.0074
Echinococcus multilocularis non capsid protein NS 1 0.0172 0.0308 0.2423
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0007 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.003 0.0239
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0086 0.0675
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0007 0.0027
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0148 0.1164
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0009 0.0074

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 5.7 nM Dissociation constant of compound with Rev-responsive element (RRE) IIB RNA was determined by the competition assay ChEMBL. 11354369
Ratio (binding) = 15 Ratio of the dissociation constant between Rev37-50 and the PNA-peptide ChEMBL. 11354369

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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