Detailed information for compound 405037

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1218.8 | Formula: C60H91Cl3O17Si
  • H donors: 1 H acceptors: 4 LogP: 9.35 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1CC(OC(C1OC1CC(OC)C(C(O1)C)OC(=O)CCC(=O)OCC(Cl)(Cl)Cl)C)O[C@@H]1[C@@H](C)C=CC=C2CO[C@H]3[C@@]2(O)[C@@H](C=C([C@@H]3O[Si](C(C)(C)C)(C)C)C)C(=O)O[C@@H]2C[C@@H](CC=C1C)O[C@]1(C2)C=C[C@H]([C@@H](O1)[C@H](CC)C)C
  • InChi: 1S/C60H91Cl3O17Si/c1-16-33(2)51-36(5)24-25-58(79-51)30-42-27-41(78-58)21-20-35(4)50(34(3)18-17-19-40-31-70-55-52(80-81(14,15)57(9,10)11)37(6)26-43(56(66)74-42)60(40,55)67)76-48-29-45(69-13)54(39(8)73-48)77-49-28-44(68-12)53(38(7)72-49)75-47(65)23-22-46(64)71-32-59(61,62)63/h17-20,24-26,33-34,36,38-39,41-45,48-55,67H,16,21-23,27-32H2,1-15H3/b18-17+,35-20+,40-19+/t33-,34-,36-,38?,39?,41+,42-,43-,44?,45?,48?,49?,50-,51+,52+,53?,54?,55+,58+,60+/m0/s1
  • InChiKey: MRINOFRBRKOSGE-KWXQDSITSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cdc2-related kinase 1 0.0054 0.044 0.0494
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.1557
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0628
Loa Loa (eye worm) hypothetical protein 0.0051 0.0387 0.0476
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0054 0.0452 0.0556
Trypanosoma brucei developmentally regulated phosphoprotein 0.0125 0.1695 0.4098
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.03 0.03
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Loa Loa (eye worm) AGC/PKA protein kinase 0.0051 0.0387 0.0476
Brugia malayi serine/threonine protein kinase 6 0.0243 0.3749 0.461
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0069 0.0183
Echinococcus granulosus epidermal growth factor receptor 0.0237 0.3636 0.3636
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0158 0.2259 0.3665
Plasmodium falciparum cyclin 0.0033 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0086 0.1013 0.1245
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0051 0.0387 0.0958
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Brugia malayi hypothetical protein 0.003 0.0032 0.0039
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0125 0.1695 0.275
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.1389 0.3219
Brugia malayi Protein kinase domain containing protein 0.0046 0.03 0.0369
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0584 0.0907
Brugia malayi Blistered cuticle protein 3 0.0126 0.1706 0.2097
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.044 0.11
Echinococcus granulosus tyrosine protein kinase shark 0.027 0.4214 0.4214
Echinococcus multilocularis epidermal growth factor receptor 0.0164 0.2364 0.3837
Brugia malayi Immunoglobulin I-set domain containing protein 0.0131 0.1794 0.2206
Brugia malayi hypothetical protein 0.0046 0.03 0.0369
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0042 0.0235 0.0381
Echinococcus granulosus neuroglian 0.0047 0.0326 0.0326
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0051 0.039 0.0351
Brugia malayi Cyclin, N-terminal domain containing protein 0.0033 0.0074 0.0091
Trypanosoma brucei polo-like protein kinase 0.0108 0.1389 0.3219
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0584 0.0584
Schistosoma mansoni tyrosine kinase 0.0046 0.03 0.0486
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0064 0.0627 0.1018
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase 0.0095 0.1165 0.1432
Brugia malayi cell division control protein 2 homolog 0.0095 0.1165 0.1432
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0185 0.2729 0.3356
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0051 0.0387 0.0958
Brugia malayi p70 ribosomal S6 kinase beta 0.005 0.0378 0.0465
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1966 0.319
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0584 0.0907
Trypanosoma brucei rac serine-threonine kinase, putative 0.0052 0.0416 0.0424
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.053 0.1343
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0243 0.3749 1
Echinococcus multilocularis hemicentin 1 0.0039 0.0185 0.0301
Echinococcus granulosus protein kinase c iota type 0.0035 0.0111 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0036 0.0135 0.0165
Echinococcus granulosus protein kinase shaggy 0.0059 0.053 0.053
Onchocerca volvulus 0.0068 0.0694 0.0786
Echinococcus multilocularis protein kinase c epsilon type 0.0036 0.0135 0.0218
Loa Loa (eye worm) AGC/PKA protein kinase 0.0051 0.0387 0.0476
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0141 0.1966 0.4877
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0392 0.6346 0.7802
Giardia lamblia Kinase, CMGC CDK 0.0054 0.044 0.11
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0036 0.0129 0.0344
Echinococcus granulosus cyclin dependent kinase 1 0.0054 0.044 0.044
Plasmodium falciparum protein kinase 5 0.0054 0.044 0.11
Brugia malayi Protein kinase domain containing protein 0.0052 0.0416 0.0511
Giardia lamblia Kinase, CDC7 0.0068 0.0694 0.1784
Schistosoma mansoni vesicular amine transporter 0.0038 0.0173 0.0281
Echinococcus granulosus cyclin dependent kinase 5 0.0054 0.044 0.044
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0046 0.0304 0.0494
Loa Loa (eye worm) hypothetical protein 0.0079 0.0875 0.1075
Onchocerca volvulus 0.0126 0.1706 0.2039
Schistosoma mansoni tyrosine kinase 0.0237 0.3636 0.5901
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0584 0.1487
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0205 0.3081 0.5001
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0051 0.0387 0.0342
Onchocerca volvulus 0.0046 0.03 0.0298
Brugia malayi Variant SH3 domain containing protein 0.0046 0.0304 0.0374
Brugia malayi Tyrosine-protein kinase abl-1 0.0148 0.2081 0.2558
Brugia malayi serine/threonine-protein kinase 6 0.0243 0.3749 0.461
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0198 0.2964 0.2964
Toxoplasma gondii aurora kinase 0.0243 0.3749 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0628
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0861 0.1398
Brugia malayi Protein kinase domain containing protein 0.0094 0.114 0.1402
Loa Loa (eye worm) TK protein kinase 0.0046 0.03 0.0369
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Entamoeba histolytica protein kinase , putative 0.0243 0.3749 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0051 0.0387 0.0342
Onchocerca volvulus 0.0095 0.1165 0.1369
Onchocerca volvulus 0.0126 0.1706 0.2039
Schistosoma mansoni lipoxygenase 0.0123 0.1659 0.2693
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0158 0.2259 0.3665
Onchocerca volvulus 0.0059 0.053 0.0583
Echinococcus multilocularis protein kinase shaggy 0.0059 0.053 0.0861
Echinococcus granulosus hemicentin 1 0.0039 0.0185 0.0185
Loa Loa (eye worm) TK/INSR protein kinase 0.0205 0.3081 0.3789
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.1389 0.1707
Brugia malayi Protein kinase domain containing protein 0.0046 0.03 0.0369
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.1659 0.1659
Plasmodium falciparum protein kinase, putative 0.0116 0.1523 0.4012
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0034 0.0088 0.0109
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0243 0.3749 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0033 0.0074 0.0091
Echinococcus granulosus tyrosine protein kinase Src64B 0.0064 0.0627 0.0627
Echinococcus granulosus tyrosine protein kinase Srms 0.0046 0.03 0.03
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.053 0.1415
Onchocerca volvulus 0.0046 0.03 0.0298
Echinococcus multilocularis 0.0067 0.0667 0.1083
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0158 0.2259 0.2259
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0243 0.3749 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0046 0.0304 0.0494
Schistosoma mansoni lipoxygenase 0.0086 0.101 0.1639
Schistosoma mansoni tyrosine kinase 0.027 0.4214 0.6838
Trichomonas vaginalis cyclin B, putative 0.0079 0.0875 0.2333
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0064 0.0627 0.1018
Trichomonas vaginalis AGC family protein kinase 0.0243 0.3749 1
Loa Loa (eye worm) TK protein kinase 0.0131 0.1794 0.2206
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Brugia malayi serine/threonine kinase 12 0.0243 0.3749 0.461
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.053 0.0753
Echinococcus granulosus tyrosine kinase 0.0046 0.03 0.03
Schistosoma mansoni tyrosine kinase 0.0064 0.0627 0.1018
Loa Loa (eye worm) blistered cuticle protein 3 0.0126 0.1706 0.2097
Toxoplasma gondii AGC kinase 0.005 0.0378 0.0315
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.053 0.0861
Trichomonas vaginalis cyclin D, putative 0.0033 0.0074 0.0197
Echinococcus granulosus cyclin B3 1 0.0033 0.0074 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0392 0.6346 0.7802
Echinococcus granulosus tyrosine protein kinase ABL1 0.0263 0.4102 0.4102
Echinococcus granulosus Immunoglobulin 0.0038 0.0173 0.0173
Echinococcus granulosus insulin receptor 0.0205 0.3081 0.3081
Onchocerca volvulus Dual oxidase homolog 0.0126 0.1706 0.2039
Entamoeba histolytica protein kinase, putative 0.0052 0.0416 0.1109
Entamoeba histolytica cyclin, putative 0.0079 0.0875 0.2333
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0213
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0125 0.1695 0.1695
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0158 0.2259 0.2777
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0243 0.3749 0.6084
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0116 0.1523 0.4012
Brugia malayi Protein kinase domain containing protein 0.0205 0.3081 0.3789
Brugia malayi Peroxidasin 0.0142 0.1987 0.2443
Echinococcus granulosus c src tyrosine kinase 0.0064 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0215
Onchocerca volvulus 0.0079 0.0875 0.101
Echinococcus granulosus mitogen activated protein kinase 14 0.0141 0.1966 0.1966
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0243 0.3749 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0584 0.1487
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0213
Onchocerca volvulus 0.0046 0.03 0.0298
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0381 0.6162 0.7576
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0387 0.1032
Onchocerca volvulus 0.0327 0.5225 0.6398
Schistosoma mansoni tyrosine kinase 0.0145 0.2041 0.3313
Trichomonas vaginalis cyclins, putative 0.0079 0.0875 0.2333
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0158 0.2259 0.3665
Entamoeba histolytica protein kinase, putative 0.0036 0.0129 0.0344
Schistosoma mansoni tyrosine kinase 0.0242 0.3738 0.6066
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0628
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0046 0.0304 0.0374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0213
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1706 0.2097
Brugia malayi Protein kinase domain containing protein 0.0185 0.2729 0.3356
Trypanosoma cruzi cyclin, putative 0.0079 0.0875 0.2269
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0198 0.2964 0.3644
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.053 0.0652
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0584 0.0947
Loa Loa (eye worm) hypothetical protein 0.0075 0.0817 0.1005
Echinococcus granulosus epidermal growth factor receptor 0.0164 0.2364 0.2364
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.2729 0.4429
Echinococcus granulosus cyclins 0.0033 0.0074 0.0074
Echinococcus granulosus cyclins 0.0033 0.0074 0.0074
Schistosoma mansoni pyruvate dehydrogenase 0.0118 0.1573 0.2552
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.053 0.0753
Trichomonas vaginalis cyclin B, putative 0.0079 0.0875 0.2333
Loa Loa (eye worm) TK/ABL protein kinase 0.0263 0.4102 0.5043
Echinococcus multilocularis neuroglian 0.0047 0.0326 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Trypanosoma cruzi cyclin, putative 0.0079 0.0875 0.2269
Schistosoma mansoni tyrosine kinase 0.0236 0.3626 0.5885
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0057 0.0093
Entamoeba histolytica protein kinase, putative 0.0059 0.053 0.1415
Schistosoma mansoni cell adhesion molecule 0.0046 0.0299 0.0485
Echinococcus multilocularis tyrosine kinase 0.0046 0.03 0.0486
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0046 0.03 0.0486
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1966 0.319
Trichomonas vaginalis cyclins, putative 0.0079 0.0875 0.2333
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Echinococcus multilocularis cyclin dependent kinase 5 0.0054 0.044 0.0714
Echinococcus granulosus peroxidasin 0.0142 0.1987 0.1987
Schistosoma mansoni tyrosine kinase 0.0205 0.3081 0.5001
Leishmania major developmentally regulated phosphoprotein-like protein 0.0125 0.1695 0.4098
Echinococcus multilocularis serine threonine protein kinase 0.0116 0.1523 0.2471
Brugia malayi protein kinase C II. 0.0036 0.0135 0.0165
Echinococcus multilocularis protein kinase c iota type 0.0035 0.0111 0.0181
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0079 0.0875 0.1742
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0694 0.1852
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0135 0.0218
Loa Loa (eye worm) AUR protein kinase 0.0243 0.3749 0.461
Schistosoma mansoni cyclin B3 0.0033 0.0074 0.012
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0205 0.3081 0.3081
Echinococcus granulosus contactin 0.0039 0.0185 0.0185
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0034 0.0088 0.0088
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0381 0.6162 1
Echinococcus granulosus protein kinase C gamma type 0.0071 0.075 0.075
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Brugia malayi RhoGAP domain containing protein 0.0034 0.0088 0.0109
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.053 0.1343
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0141 0.1966 0.2417
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0064 0.0627 0.0627
Giardia lamblia Kinase, CMGC CDK 0.0054 0.044 0.11
Echinococcus multilocularis RNA directed DNA polymerase 0.0042 0.0228 0.037
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.044 0.0541
Echinococcus granulosus serine threonine protein kinase 0.0116 0.1523 0.1523
Schistosoma mansoni growth factor receptor-bound protein 0.0046 0.0304 0.0494
Echinococcus granulosus serine threonine protein kinase nrc 0.003 0.0031 0.0031
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0628
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1165 0.189
Brugia malayi Tyrosine-protein kinase abl-1 0.0134 0.185 0.2274
Schistosoma mansoni protein kinase 0.0243 0.3749 0.6084
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0038 0.0173 0.0281
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1389 0.3651
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.1557
Schistosoma mansoni vav2 0.0036 0.0126 0.0205
Brugia malayi Furin-like cysteine rich region family protein 0.0237 0.3636 0.4471
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0069 0.0112
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0038 0.0173 0.0281
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0198 0.2964 0.481
Loa Loa (eye worm) hypothetical protein 0.0046 0.03 0.0369
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.044 0.0714
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0141 0.1966 0.4877
Echinococcus multilocularis serine threonine protein kinase 0.0071 0.075 0.1217
Brugia malayi Cyclin, N-terminal domain containing protein 0.0079 0.0875 0.1075
Schistosoma mansoni tyrosine kinase 0.0164 0.2364 0.3837
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1706 0.2097
Echinococcus granulosus cyclin b3 0.0033 0.0074 0.0074
Brugia malayi MAP kinase sur-1 0.0062 0.0584 0.0718
Entamoeba histolytica protein kinase, putative 0.005 0.0378 0.1008
Trichomonas vaginalis cyclin A, putative 0.0079 0.0875 0.2333
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.044 0.1173
Schistosoma mansoni adapter molecule crk 0.0046 0.0304 0.0494
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.053 0.1415
Echinococcus granulosus aurora kinase A 0.0243 0.3749 0.3749
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.1389 0.1646
Schistosoma mansoni atypical protein kinase C 0.0035 0.0111 0.0181
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0694 0.1852
Trichomonas vaginalis AGC family protein kinase 0.0243 0.3749 1
Entamoeba histolytica cyclin family protein 0.0033 0.0074 0.0197
Loa Loa (eye worm) TK/EGFR protein kinase 0.0237 0.3636 0.4471
Schistosoma mansoni tyrosine kinase 0.0145 0.2041 0.3313
Echinococcus multilocularis serine:threonine protein kinase NIM1 0.0095 0.1165 0.189
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0064 0.0627 0.1018
Giardia lamblia G2/mitotic-specific cyclin B 0.0079 0.0875 0.2269
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0185 0.2728 0.4428
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1706 0.2097
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0046 0.03 0.03
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0051 0.0387 0.0958
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0086 0.1013 0.1245
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0158 0.2259 0.2777
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0088 0.0143
Entamoeba histolytica cyclin family protein 0.0033 0.0074 0.0197
Schistosoma mansoni tyrosine kinase 0.0205 0.3081 0.5001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0304 0.0374
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0051 0.0387 0.0958
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0057 0.0093
Schistosoma mansoni tyrosine kinase 0.0164 0.2364 0.3837
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.003 0.0031 0.005
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0158 0.2259 0.2259
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0387
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.1389 0.1389
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1706 0.2097
Onchocerca volvulus Chorion peroxidase homolog 0.0126 0.1706 0.2039
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0033 0.0074 0.012
Giardia lamblia Kinase, AGC PKA 0.0051 0.0387 0.0958
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.1557
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.0627 0.1018
Schistosoma mansoni tyrosine kinase 0.0122 0.1641 0.2663
Brugia malayi Variant SH3 domain containing protein 0.0046 0.0304 0.0374
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.03 0.0486
Echinococcus multilocularis Immunoglobulin 0.0038 0.0173 0.0281
Brugia malayi intracellular kinase 0.0059 0.053 0.0652
Entamoeba histolytica protein kinase domain containing protein 0.0243 0.3749 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0054 0.044 0.0494
Trichomonas vaginalis cyclins, putative 0.0079 0.0875 0.2333
Echinococcus multilocularis tyrosine protein kinase Abl 0.0148 0.2081 0.3377
Onchocerca volvulus Tyrosine kinase homolog 0.0378 0.6106 0.7489
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0299 0.0299
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0064 0.0627 0.1018
Onchocerca volvulus Peroxidase homolog 0.0126 0.1706 0.2039
Brugia malayi Protein kinase domain containing protein 0.0068 0.0694 0.0854
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0069 0.0112
Giardia lamblia Aurora kinase 0.0243 0.3749 1
Loa Loa (eye worm) animal heme peroxidase 0.0135 0.1859 0.2286
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0054 0.044 0.0494
Trypanosoma cruzi Protein kinase B 0.0032 0.0069 0.0102
Trichomonas vaginalis cyclin B3, putative 0.0033 0.0074 0.0197
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0051 0.0387 0.0342
Trypanosoma brucei cdc2-related kinase 3 0.0054 0.044 0.0494
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.044 0.1173
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Brugia malayi map kinase activated protein kinase protein 2 0.0198 0.2964 0.3644
Leishmania major protein kinase A catalytic subunit isoform 1 0.0051 0.0387 0.0342
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0088 0.0109
Entamoeba histolytica protein kinase, putative 0.0052 0.0416 0.1109
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0051 0.0387 0.0342
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0044 0.0268 0.0638
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Schistosoma mansoni tyrosine kinase 0.0035 0.0112 0.0181
Brugia malayi Protein kinase domain containing protein 0.0046 0.03 0.0369
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0064 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0102 0.1278 0.1571
Trichomonas vaginalis STE family protein kinase 0.0116 0.1523 0.4062
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0125 0.1695 0.4475
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.053 0.1415
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0122 0.1641 0.2663
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0088 0.0143
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Schistosoma mansoni cyclin B 0.0079 0.0875 0.1419
Onchocerca volvulus Peroxidase homolog 0.0126 0.1706 0.2039
Echinococcus granulosus tyrosine kinase 0.0046 0.03 0.03
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.053 0.0861
Onchocerca volvulus 0.0068 0.0694 0.0786
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0387 0.0628
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0584 0.1487
Leishmania major protein kinase, putative 0.0243 0.3749 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0064 0.0627 0.1018
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Onchocerca volvulus Peroxidasin homolog 0.0135 0.1861 0.2232
Echinococcus multilocularis cyclin b3 0.0033 0.0074 0.012
Toxoplasma gondii AGC kinase 0.0051 0.0387 0.0342
Echinococcus granulosus serine:threonine protein kinase NIM1 0.0095 0.1165 0.1165
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0694 0.1852
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.044 0.1173
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Schistosoma mansoni tyrosine kinase 0.0064 0.0627 0.1018
Echinococcus granulosus tyrosine protein kinase Src42A 0.0064 0.0627 0.0627
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.053 0.1343
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.003 0.0032 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0213
Echinococcus granulosus defective proboscis extension response 0.0038 0.0173 0.0173
Trichomonas vaginalis AGC family protein kinase 0.0243 0.3749 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.03 0.0486
Loa Loa (eye worm) hypothetical protein 0.0125 0.1695 0.2084
Brugia malayi protein-tyrosine kinase 0.0046 0.03 0.0369
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0054 0.044 0.044
Echinococcus multilocularis cyclin dependent kinase 0.0054 0.044 0.0714
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Schistosoma mansoni tyrosine kinase 0.0034 0.0103 0.0167
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0054 0.044 0.0541
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.005 0.0378 0.0465
Schistosoma mansoni cyclins 0.0033 0.0074 0.012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0018
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0122 0.1641 0.2663
Giardia lamblia Kinase, PLK 0.0108 0.1389 0.3651
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0057 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1389 0.2254
Schistosoma mansoni kinase 0.0059 0.0532 0.0864
Trichomonas vaginalis cyclins, putative 0.0033 0.0074 0.0197
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0263 0.4102 0.6657
Brugia malayi Cyclin, N-terminal domain containing protein 0.0079 0.0875 0.1075
Entamoeba histolytica protein kinase, putative 0.0116 0.1523 0.4062
Giardia lamblia Hypothetical protein 0.0033 0.0074 0.0115
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.044 0.11
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.053 0.0652
Schistosoma mansoni hypothetical protein 0.0032 0.0059 0.0096
Schistosoma mansoni tyrosine kinase 0.0064 0.0627 0.1018
Echinococcus granulosus N chimaerin 0.0034 0.0088 0.0088
Schistosoma mansoni growth factor receptor-bound protein 0.0046 0.0304 0.0494
Echinococcus granulosus serine/threonine protein kinase 0.0032 0.0069 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0439 0.0712
Loa Loa (eye worm) CDC7 protein kinase 0.0068 0.0694 0.0854
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0584 0.1487
Plasmodium vivax protein kinase Crk2 0.0054 0.044 0.11
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0057 0.0057
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0032 0.0057 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0387 0.0628
Entamoeba histolytica protein kinase 2, putative 0.003 0.0031 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.053 0.1415
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0032 0.0069 0.0102
Echinococcus granulosus cyclin dependent kinase 0.0054 0.044 0.044
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0042 0.0228 0.037
Brugia malayi Protein kinase domain containing protein 0.0046 0.03 0.0369
Brugia malayi Sex muscle abnormal protein 5 0.0046 0.0304 0.0374
Loa Loa (eye worm) hypothetical protein 0.0042 0.0228 0.028
Giardia lamblia Kinase, CMGC GSK 0.0059 0.053 0.1343
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.03 0.0486
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.044 0.0541
Brugia malayi SH2 domain containing protein 0.0046 0.03 0.0369
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0033 0.0074 0.0074
Brugia malayi cell division control protein 2 homolog 0.0054 0.044 0.0541
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1966 0.319
Brugia malayi kinase, mitochondrial precursor 0.0125 0.1695 0.2084
Onchocerca volvulus 0.0126 0.1706 0.2039
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0509 0.1359
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0064 0.0627 0.1018
Schistosoma mansoni tyrosine kinase 0.0145 0.2041 0.3313
Trypanosoma brucei aurora B kinase 0.0243 0.3749 1
Echinococcus multilocularis Immunoglobulin 0.0038 0.0173 0.0281
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0034 0.0088 0.0143
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0042 0.0235 0.0235
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.1389 0.3704
Loa Loa (eye worm) hypothetical protein 0.0046 0.0299 0.0367
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.003 0.0031 0.0031
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0038 0.0047
Brugia malayi Protein kinase domain containing protein 0.0054 0.044 0.0541
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0122 0.1641 0.1641
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.03 0.0369
Brugia malayi Animal haem peroxidase family protein 0.0135 0.1859 0.2286
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0584 0.0718
Echinococcus granulosus growth factor receptor bound protein 2 0.0046 0.0304 0.0304
Schistosoma mansoni titin 0.0039 0.0185 0.0301
Leishmania major cyclin 0.0079 0.0875 0.1742
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Echinococcus multilocularis c src tyrosine kinase 0.0064 0.0627 0.1018
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.1389 0.2254
Echinococcus granulosus cyclins 0.0033 0.0074 0.0074
Trichomonas vaginalis cyclins, putative 0.0054 0.044 0.1174
Echinococcus multilocularis NCK adaptor protein 0.0046 0.0304 0.0494
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0243 0.3749 0.3749
Echinococcus multilocularis peroxidasin 0.0142 0.1987 0.3225
Echinococcus multilocularis aurora kinase A 0.0243 0.3749 0.6084
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0584 0.0584
Trichomonas vaginalis cyclin D, putative 0.0033 0.0074 0.0197
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1966 0.5204
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0051 0.0387 0.0958
Onchocerca volvulus 0.0046 0.03 0.0298
Loa Loa (eye worm) IKK protein kinase 0.0494 0.8133 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0339 0.0417
Schistosoma mansoni pyruvate dehydrogenase 0.0125 0.1695 0.275
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Echinococcus granulosus RNA directed DNA polymerase 0.0042 0.0228 0.0228
Brugia malayi Protein kinase domain containing protein 0.0046 0.03 0.0369
Schistosoma mansoni peroxidasin 0.0133 0.1834 0.2976
Trypanosoma brucei protein kinase, putative 0.0062 0.0584 0.0907
Echinococcus granulosus CDC7 cell division cycle 7 0.0068 0.0694 0.0694
Echinococcus multilocularis cyclin B3 1 0.0033 0.0074 0.012
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.044 0.0714
Echinococcus granulosus Protein kinase C brain isozyme 0.0078 0.0861 0.0861
Brugia malayi SH2 domain containing protein 0.0046 0.03 0.0369
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.3749 0.6084
Echinococcus granulosus protein kinase c epsilon type 0.0036 0.0135 0.0135
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0064 0.0627 0.1018
Schistosoma mansoni pyruvate dehydrogenase 0.0118 0.1573 0.2552
Entamoeba histolytica protein kinase, putative 0.0243 0.3749 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0074 0.0197
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0584 0.0907
Schistosoma mansoni nck2/grb4 0.0046 0.0304 0.0494
Mycobacterium ulcerans hypothetical protein 0.0114 0.1488 0.5
Loa Loa (eye worm) SRC-1 0.0064 0.0627 0.0771
Echinococcus granulosus mitogen activated protein kinase 11 0.0141 0.1966 0.1966
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.0627 0.1018
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0425 0.1133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.1557
Trichomonas vaginalis cyclin B, putative 0.0079 0.0875 0.2333
Onchocerca volvulus 0.0046 0.03 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0861 0.1398
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0416 0.1109
Onchocerca volvulus Peroxidasin homolog 0.0135 0.1859 0.2229
Trichomonas vaginalis STE family protein kinase 0.0116 0.1523 0.4062
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0051 0.0387 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0694 0.1127
Echinococcus multilocularis epidermal growth factor receptor 0.0237 0.3636 0.5901
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0052 0.0403 0.0496
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0046 0.03 0.0799
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0039 0.0185 0.0156
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0425 0.1133
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0064 0.0627 0.1018
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0078 0.0861 0.1398
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0201 0.3016 0.3708
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0381 0.6162 0.6162
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.044 0.0714
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0584 0.0947
Trypanosoma brucei protein kinase, putative 0.0059 0.053 0.0753
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0051 0.0387 0.0342
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0164 0.2364 0.2364
Loa Loa (eye worm) AUR protein kinase 0.0243 0.3749 0.461
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0125 0.1695 0.275
Toxoplasma gondii AGC kinase 0.0051 0.0387 0.0342
Echinococcus granulosus cyclins 0.0033 0.0074 0.0074
Onchocerca volvulus 0.0046 0.03 0.0298
Brugia malayi Protein kinase c protein 2 0.0058 0.0515 0.0633
Echinococcus multilocularis cyclins 0.0033 0.0074 0.012
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Trypanosoma cruzi CYC2-like cyclin, putative 0.0079 0.0875 0.2269
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0381 0.6162 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.044 0.0714
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0584 0.0907
Brugia malayi hypothetical protein 0.0126 0.1706 0.2097
Loa Loa (eye worm) AGC/AKT protein kinase 0.0052 0.0416 0.0511
Echinococcus multilocularis insulin receptor 0.0205 0.3081 0.5001
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.044 0.11
Loa Loa (eye worm) hypothetical protein 0.0078 0.0857 0.1054
Trypanosoma cruzi cyclin 6, putative 0.0079 0.0875 0.2269
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.1389 0.3704
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0116 0.1523 0.1872
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.1389 0.3651
Echinococcus granulosus twitchin 0.0056 0.0478 0.0478
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0038 0.0101
Echinococcus multilocularis N chimaerin 0.0034 0.0088 0.0143
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0051 0.0387 0.0958
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0381 0.6162 0.7576
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.1659 0.2693
Giardia lamblia Kinase, CMGC GSK 0.0059 0.053 0.1343
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0509 0.1359
Loa Loa (eye worm) hypothetical protein 0.0142 0.1987 0.2443
Echinococcus granulosus fibroblast growth factor receptor 4 0.0122 0.1641 0.1641
Trypanosoma brucei mitotic cyclin 6 0.0079 0.0875 0.1742
Echinococcus granulosus cyclin B 0.0079 0.0875 0.0875
Echinococcus multilocularis rac serine:threonine kinase 0.0032 0.0069 0.0112
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0064 0.0627 0.0627
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 0.0627 0.0627
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.044 0.1173
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0051 0.0387 0.0476
Echinococcus multilocularis cyclin B 0.0079 0.0875 0.1419
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1706 0.2097
Loa Loa (eye worm) hypothetical protein 0.0046 0.0302 0.0371
Plasmodium falciparum serine/threonine protein kinase, putative 0.0243 0.3749 1
Echinococcus multilocularis tyrosine protein kinase shark 0.027 0.4214 0.6838
Brugia malayi Fibronectin type III domain containing protein 0.0038 0.0173 0.0213
Brugia malayi P38 map kinase family protein 2 0.0141 0.1966 0.2417
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.03 0.03
Echinococcus granulosus NCK adaptor protein 0.0046 0.0304 0.0304
Brugia malayi Animal haem peroxidase family protein 0.0126 0.1706 0.2097
Leishmania major protein kinase A catalytic subunit 0.0051 0.0387 0.0342
Echinococcus granulosus cyclins 0.0033 0.0074 0.0074
Trichomonas vaginalis cyclin B, putative 0.0079 0.0875 0.2333
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.044 0.11
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0064 0.0627 0.1018
Trichomonas vaginalis cyclin B, putative 0.0033 0.0074 0.0197
Giardia lamblia Cyclin A 0.0033 0.0074 0.0115
Echinococcus granulosus tyrosine protein kinase Fyn 0.0064 0.0627 0.0627
Echinococcus granulosus roundabout 2 0.0054 0.0452 0.0452
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.2964 0.481
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0173 0.0213
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0584 0.0947
Brugia malayi SRC-1 0.0064 0.0627 0.0771
Trichomonas vaginalis AGC family protein kinase 0.0243 0.3749 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.1389 0.1707
Brugia malayi serine/threonine-protein kinase PAK 7 0.0201 0.3016 0.3708
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1966 0.5204
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1966 0.319
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0185 0.2728 0.2728
Trypanosoma cruzi aurora B kinase, putative 0.0243 0.3749 1
Loa Loa (eye worm) animal heme peroxidase 0.0126 0.1706 0.2097
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0069 0.0183
Entamoeba histolytica protein kinase, putative 0.0243 0.3749 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0038 0.0173 0.0281
Schistosoma mansoni peroxidasin 0.0126 0.1706 0.2768
Loa Loa (eye worm) AUR protein kinase 0.0243 0.3749 0.461
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0046 0.0304 0.0374
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0054 0.044 0.0494
Trichomonas vaginalis cyclins, putative 0.0079 0.0875 0.2333
Loa Loa (eye worm) hypothetical protein 0.0079 0.0875 0.1075
Onchocerca volvulus 0.0494 0.8133 1
Brugia malayi hypothetical protein 0.0038 0.0173 0.0213
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0584 0.1487
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0038 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.044 0.1173
Brugia malayi Protein kinase domain containing protein 0.0494 0.8133 1
Entamoeba histolytica cyclin, putative 0.0033 0.0074 0.0197
Echinococcus granulosus tyrosine protein kinase Lyn 0.0073 0.0779 0.0779
Schistosoma mansoni nephrin 0.0047 0.0326 0.0529
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.1523 0.2471
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0354
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0387 0.0628
Echinococcus multilocularis CDC7 cell division cycle 7 0.0068 0.0694 0.1127
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Echinococcus multilocularis roundabout 2 0.0054 0.0452 0.0734
Loa Loa (eye worm) hypothetical protein 0.0126 0.1706 0.2097
Schistosoma mansoni tyrosine kinase 0.0064 0.0627 0.1018

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) 0 mg kg-1 Minimal dose necessary to eliminate > 83% of Trichostrongylus colubriformis infection in gerbils; No data ChEMBL. 7097720

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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