Detailed information for compound 405590

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1105.28 | Formula: C45H76N20O11S
  • H donors: 17 H acceptors: 11 LogP: -5.11 Rotable bonds: 40
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(c2c1cccc2)N(C)C)C)C
  • InChi: 1S/C45H76N20O11S/c1-24(58-36(68)25(2)64-77(75,76)34-18-17-33(65(3)4)26-11-5-6-12-27(26)34)35(67)63-32(23-66)40(72)61-29(14-8-20-55-43(48)49)38(70)59-28(13-7-19-54-42(46)47)37(69)60-30(15-9-21-56-44(50)51)39(71)62-31(41(73)74)16-10-22-57-45(52)53/h5-6,11-12,17-18,24-25,28-32,64,66H,7-10,13-16,19-23H2,1-4H3,(H,58,68)(H,59,70)(H,60,69)(H,61,72)(H,62,71)(H,63,67)(H,73,74)(H4,46,47,54)(H4,48,49,55)(H4,50,51,56)(H4,52,53,57)/t24-,25-,28-,29-,30-,31-,32-/m0/s1
  • InChiKey: WWFPNGLDVJEFCF-WUCONBCXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0113 0.0552
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.0019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0013 0.0051
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0018 0.0076
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0028
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0028
Brugia malayi GnHR receptor homolog 0.0019 0.0018 0.0076
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0018 0.0039
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0011
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0041 0.0557
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Echinococcus granulosus microtubule associated protein 2 0.0716 0.1008 0.1007
Schistosoma mansoni biogenic amine receptor 0.0019 0.0018 0.0039
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0018 0.0017
Entamoeba histolytica hypothetical protein, conserved 0.0131 0.0177 1
Onchocerca volvulus 0.0019 0.0018 0.0715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Brugia malayi Zona pellucida-like domain containing protein 0.0131 0.0177 0.0868
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0131 0.0177 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0018 0.0017
Echinococcus granulosus voltage dependent calcium channel subunit 0.3207 0.4543 0.4543
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0015
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0012
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0003 0.0002
Echinococcus granulosus hypothetical protein 0.0019 0.0018 0.0017
Schistosoma mansoni lipoxygenase 0.0086 0.0112 0.0256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0005
Brugia malayi Dopamine receptor 0.0019 0.0018 0.0076
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni adenoreceptor 0.0019 0.0018 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0018 0.0017
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Mycobacterium ulcerans beta-lactamase 0.0036 0.0041 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0041 0.5
Entamoeba histolytica elongation factor-2 kinase, putative 0.0131 0.0177 1
Brugia malayi G-protein coupled receptor 0.0019 0.0018 0.0076
Onchocerca volvulus 0.0131 0.0177 1
Loa Loa (eye worm) CUTiclin family member 0.0131 0.0177 0.0868
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.002 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0061 0.0289
Onchocerca volvulus 0.0019 0.0018 0.0715
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0041 0.2341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus granulosus smad 0.0008 0.0003 0.0002
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0113 0.0258
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0005
Echinococcus granulosus serotonin receptor 0.0019 0.0018 0.0017
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1551 0.2192 0.503
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0018 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0002
Onchocerca volvulus 0.0019 0.0018 0.0715
Echinococcus granulosus cpg binding protein 0.003 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi Doublecortin family protein 0.002 0.002 0.0085
Schistosoma mansoni polycystin 1-related 0.002 0.002 0.0044
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0025 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.0019
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0018 0.0017
Echinococcus granulosus g protein coupled receptor 0.0019 0.0018 0.0017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0006 0.0005
Loa Loa (eye worm) acetyltransferase 0.0143 0.0194 0.0955
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0018 0.0076
Brugia malayi sulfakinin receptor protein 0.0019 0.0018 0.0076
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0018 0.0017
Schistosoma mansoni cpg binding protein 0.0028 0.0031 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0072 0.3094
Echinococcus granulosus neuropeptide receptor 0.0019 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.002 0.002 0.0044
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0006 0.0005
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi Serotonin receptor 0.0019 0.0018 0.0076
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0041 0.2341
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0018 0.0017
Schistosoma mansoni neuropeptide receptor 0.0019 0.0018 0.0039
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0018 0.0017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0086 0.0113 0.6293
Schistosoma mansoni hypothetical protein 0.0034 0.0039 0.0087
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0194 0.0955
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0028
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0018 0.0039
Brugia malayi hypothetical protein 0.002 0.002 0.0085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0075
Brugia malayi Dopamine receptor protein 1 0.0019 0.0018 0.0076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0006 0.0015
Brugia malayi ecdysteroid receptor 0.001 0.0006 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Schistosoma mansoni lipoxygenase 0.0122 0.0165 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0041 1
Onchocerca volvulus 0.0019 0.0018 0.0715
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0006 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0005
Schistosoma mansoni amine GPCR 0.0019 0.0018 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0055 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0055 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0041 0.2341
Onchocerca volvulus 0.0019 0.0018 0.0715
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0006 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0041 0.0093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0085
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0041 0.0557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0015
Loa Loa (eye worm) beta-lactamase 0.0036 0.0041 0.0192
Brugia malayi hypothetical protein 0.002 0.002 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0192
Brugia malayi Dopamine receptor protein 2 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0003 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0076 0.0173
Loa Loa (eye worm) doublecortin family protein 0.002 0.002 0.0085
Schistosoma mansoni histamine h1 receptor 0.0019 0.0018 0.0039
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0041 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Mycobacterium tuberculosis Conserved protein 0.0036 0.0041 0.0557
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0018 0.0017
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0003 0.0002
Brugia malayi beta-lactamase family protein 0.0036 0.0041 0.0192
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0018 0.0076
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0018 0.0017
Schistosoma mansoni neuropeptide receptor 0.0019 0.0018 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0061 0.0289
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0018 0.0039
Echinococcus granulosus fmrfamide receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Brugia malayi Zona pellucida-like domain containing protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0013 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0041 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0041 0.5
Onchocerca volvulus 0.002 0.002 0.0828
Schistosoma mansoni myosin xvIII 0.0019 0.0018 0.0039
Brugia malayi CXXC zinc finger family protein 0.0028 0.0031 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0018 0.0039
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0046 0.1344
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0019 0.0018 0.0715
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0018 0.0017
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0018 0.0039
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0036 0.0041 0.2083
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0018 0.0017
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0018 0.0715
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0018 0.0039
Echinococcus granulosus GPCR family 2 0.0016 0.0013 0.0012
Brugia malayi AKH receptor 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Schistosoma mansoni amine GPCR 0.0019 0.0018 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi larval opioid receptor 0.0019 0.0018 0.0076
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi steroid hormone receptor 0.001 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi MH2 domain containing protein 0.0124 0.0167 0.0818
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis GPCR, family 2 0.0016 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) CUTiclin-Like family member 0.0131 0.0177 0.0868
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Trichomonas vaginalis esterase, putative 0.0036 0.0041 0.2341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0192
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0061 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0131 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0051 0.1673
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0018 0.0039
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0131 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0018 0.0076
Echinococcus multilocularis somatostatin receptor 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0036 0.0041 0.2083
Echinococcus granulosus g protein coupled receptor 0.0019 0.0018 0.0017
Toxoplasma gondii microneme protein MIC2 0.0131 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0006 0.0011
Mycobacterium ulcerans hypothetical protein 0.0036 0.0041 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0041 0.0557
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0018 0.0017
Schistosoma mansoni opsin-like receptor 0.0019 0.0018 0.0039
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0018 0.0017
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0131 0.0177 0.0868
Onchocerca volvulus 0.0131 0.0177 1
Echinococcus granulosus sex peptide receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0041 0.0192
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0131 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0041 0.0192
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0025 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0041 0.0557
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0018 0.0039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0018 0.0017
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0018 0.0076
Schistosoma mansoni neuropeptide receptor 0.0019 0.0018 0.0039
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0131 0.0177 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0003 0.0005
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0194 0.0193
Echinococcus granulosus FTZ F1 alpha 0.001 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0055 0.0124
Onchocerca volvulus 0.0019 0.0018 0.0715
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0018 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0041 0.2341
Echinococcus granulosus Smad4 0.0008 0.0003 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0041 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0018 0.0076
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0006 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0018 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0041 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0018 0.0039
Schistosoma mansoni amine GPCR 0.0019 0.0018 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.1008 0.2311
Onchocerca volvulus 0.0019 0.0018 0.0715
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Onchocerca volvulus 0.0019 0.0018 0.0715
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0018 0.0039
Echinococcus granulosus allatostatin A receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0015
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0018 0.0076
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Entamoeba histolytica hypothetical protein 0.0131 0.0177 1
Brugia malayi Serotonin receptor 0.0019 0.0018 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0192
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0122 0.0165 0.0164
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0055 0.026
Loa Loa (eye worm) hypothetical protein 0.0086 0.0113 0.0552
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0131 0.0177 0.0176
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0003 0.0002
Schistosoma mansoni biogenic amine receptor 0.0019 0.0018 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0006 0.0015
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi RE15519p 0.0019 0.0018 0.0076
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0018 0.0076
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0018 0.0076
Brugia malayi ORL1-like opioid receptor 0.0019 0.0018 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Schistosoma mansoni neuropeptide receptor 0.0019 0.0018 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0006 0.0011
Schistosoma mansoni Smad4 0.0008 0.0003 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Schistosoma mansoni smad 0.0008 0.0003 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0006 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0006 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0018 0.0017
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0044
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0314 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0055 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0131 0.0177 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0018 0.0017
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0404 0.0565 0.1294
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0018 0.0017
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0018 0.0715
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0018 0.0039
Onchocerca volvulus 0.0028 0.0031 0.1485
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0556 0.0781 0.078
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0018 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0018 0.0017
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0018 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3207 0.4543 0.4543
Brugia malayi Immunoglobulin I-set domain containing protein 0.0131 0.0177 0.0868
Echinococcus granulosus g protein coupled receptor 0.0019 0.0018 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0041 0.2341
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0131 0.0177 1
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0025 0.0345
Plasmodium vivax thrombospondin-related anonymous protein 0.0131 0.0177 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0055 0.0054
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0018 0.0076
Mycobacterium ulcerans lipase LipD 0.0036 0.0041 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0018 0.0039
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0018 0.0017
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0113 0.0113
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0167 0.0818
Loa Loa (eye worm) hypothetical protein 0.142 0.2006 1
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.0565 0.0564
Brugia malayi von Willebrand Factor 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0179
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0131 0.0177 1
Onchocerca volvulus 0.0131 0.0177 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0041 0.106
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0018 0.0076
Treponema pallidum 76K protein 0.0131 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Onchocerca volvulus 0.0019 0.0018 0.0715
Mycobacterium tuberculosis Conserved protein 0.0036 0.0041 0.0557
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0018 0.0017
Schistosoma mansoni biogenic amine receptor 0.0019 0.0018 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0013 0.0012
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0051 0.1673
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0031 0.0141
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0005
Brugia malayi Cache domain containing protein 0.142 0.2006 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Echinococcus multilocularis serotonin receptor 0.0019 0.0018 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0006 0.0011
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0019 0.0018 0.0715
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0018 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0015
Onchocerca volvulus 0.002 0.002 0.0828
Onchocerca volvulus 0.0019 0.0018 0.0715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0051 0.2866
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0015
Mycobacterium leprae Probable lipase LipE 0.0036 0.0041 1
Brugia malayi putative neuropeptide receptor 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0018 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0018 0.0076
Schistosoma mansoni amine GPCR 0.0019 0.0018 0.0039
Echinococcus multilocularis voltage dependent calcium channel subunit 0.7051 1 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0003 0.0005
Entamoeba histolytica hypothetical protein, conserved 0.0131 0.0177 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0006 0.0015
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0018 0.0039
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0044
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0018 0.0039
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0131 0.0177 0.0868
Echinococcus multilocularis smad 0.0008 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0006 0.0011
Brugia malayi beta-lactamase 0.0036 0.0041 0.0192
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0041 0.0557
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0006 0.0011
Brugia malayi G-protein coupled receptor 0.0019 0.0018 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0018 0.0039
Brugia malayi G protein-coupled receptor 0.0019 0.0018 0.0076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0041 0.0557
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0018 0.0076
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0131 0.0177 0.0404
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0041 0.1368
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0556 0.0781 0.078
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0006 0.0015
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0018 0.0076
Echinococcus granulosus somatostatin receptor 0.0019 0.0018 0.0017
Onchocerca volvulus 0.0019 0.0018 0.0715
Brugia malayi Melatonin receptor type 1A 0.0019 0.0018 0.0076
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0028
Schistosoma mansoni hypothetical protein 0.1656 0.2342 0.5374
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0131 0.0177 1
Echinococcus granulosus orexin receptor type 2 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0051 0.196
Onchocerca volvulus 0.0019 0.0018 0.0715
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0041 0.0192
Schistosoma mansoni coup transcription factor 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0055 0.0054
Treponema pallidum hypothetical protein 0.0131 0.0177 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0039 0.0179
Leishmania major hypothetical protein, conserved 0.0036 0.0041 1
Echinococcus multilocularis Smad4 0.0008 0.0003 0.0002
Schistosoma mansoni loxhd1 0.002 0.002 0.0044
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0025 0.0345
Onchocerca volvulus 0.0019 0.0018 0.0715
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0018 0.0076
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0046 0.5
Onchocerca volvulus 0.0019 0.0018 0.0715
Schistosoma mansoni amine GPCR 0.0019 0.0018 0.0039
Echinococcus granulosus RUN 0.002 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0131 0.0177 0.0404
Onchocerca volvulus 0.0131 0.0177 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0167 0.0818
Onchocerca volvulus 0.0036 0.0041 0.2083
Echinococcus multilocularis cpg binding protein 0.003 0.0033 0.0033
Echinococcus granulosus neuropeptide receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0046 0.1643
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0018 0.0039
Echinococcus granulosus collagen alpha 1VII chain 0.0131 0.0177 0.0176
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.1008 0.1007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0018 0.0039
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0188 0.0188
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0131 0.0177 0.0868
Onchocerca volvulus 0.0019 0.0018 0.0715
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0006 0.0005
Echinococcus multilocularis RUN 0.002 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi beta-lactamase family protein 0.0036 0.0041 0.0192
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0018 0.0017
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0122 0.0165 0.0164
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0041 0.0557
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0018 0.0076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0018 0.0017
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0018 0.0017
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0013 0.0051
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0018 0.0017
Plasmodium falciparum thrombospondin-related anonymous protein 0.0131 0.0177 1
Onchocerca volvulus 0.0131 0.0177 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0018 0.0017
Echinococcus multilocularis sex peptide receptor 0.0019 0.0018 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0005
Mycobacterium tuberculosis Conserved protein 0.0036 0.0041 0.0557
Brugia malayi neuropeptide F receptor 0.0019 0.0018 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0015
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0018 0.0017
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0015
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0006 0.0015
Echinococcus granulosus dnaJ subfamily B 0.0404 0.0565 0.0564
Schistosoma mansoni opsin-like receptor 0.0019 0.0018 0.0039
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0039
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0018 0.0017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0006 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0018 0.0017
Brugia malayi neuropeptide F receptor 0.0019 0.0018 0.0076
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Schistosoma mansoni opsin-like receptor 0.0019 0.0018 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0006 0.0015
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0018 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0061 0.0289
Onchocerca volvulus 0.0131 0.0177 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0018 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0055 0.026
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0018 0.0076
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0194 0.0444
Brugia malayi von Willebrand factor type A domain containing protein 0.0131 0.0177 0.0868
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0075
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0018 0.0017
Brugia malayi hypothetical protein 0.0131 0.0177 0.0868
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0015
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0131 0.0177 0.0868
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0039
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0018 0.0039
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0051 0.2866
Brugia malayi hypothetical protein 0.0019 0.0018 0.0076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0041 0.0093
Schistosoma mansoni serine-rich repeat protein 0.1656 0.2342 0.5374
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0039
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.3076 0.4357 1
Echinococcus multilocularis serotonin receptor 0.0019 0.0018 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 75 uM Inhibition of protein kinase C (PKC) ChEMBL. 1992155
IC50 (binding) > 75 uM Inhibition of cAMP-dependent protein kinase (PKA). ChEMBL. 1992155
IC50 (binding) > 75 uM Inhibition of protein kinase C (PKC) ChEMBL. 1992155
IC50 (binding) > 75 uM Inhibition of cAMP-dependent protein kinase (PKA). ChEMBL. 1992155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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