Detailed information for compound 407807

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1399.41 | Formula: C62H86N12O25
  • H donors: 22 H acceptors: 19 LogP: -7.2 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](Oc2ccc(cc2)C[C@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC2=O)[C@H]([C@@H]2CN=C(N2)N)O)[C@H]([C@@H]2CN=C(N2[C@H]2O[C@H](CO)[C@H]([C@@H]([C@@H]2O)O)O)N)O)CO)[C@H](c2ccccc2)C)[C@H]([C@H]([C@@H]1O[C@H]1O[C@H](COCc2ccc(cc2)C)[C@H]([C@@H]([C@@H]1O)O)O)O)O
  • InChi: 1S/C62H86N12O25/c1-25-8-10-28(11-9-25)23-94-24-37-45(82)47(84)50(87)60(98-37)99-52-36(22-77)97-59(51(88)48(52)85)95-30-14-12-27(13-15-30)16-31-54(90)72-40(42(79)32-17-66-61(63)70-32)57(93)73-41(43(80)34-18-67-62(64)74(34)58-49(86)46(83)44(81)35(21-76)96-58)56(92)69-33(20-75)53(89)65-19-38(78)71-39(55(91)68-31)26(2)29-6-4-3-5-7-29/h3-15,26,31-37,39-52,58-60,75-77,79-88H,16-24H2,1-2H3,(H2,64,67)(H,65,89)(H,68,91)(H,69,92)(H,71,78)(H,72,90)(H,73,93)(H3,63,66,70)/t26-,31+,32-,33-,34-,35+,36+,37+,39-,40-,41+,42-,43-,44+,45+,46-,47-,48+,49-,50-,51-,52+,58-,59-,60+/m0/s1
  • InChiKey: RPGAVKOGZRQMJZ-ICCDQEKOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0123 0.1067 0.4791
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0276 0.4087
Echinococcus granulosus serine protein kinase ATM 0.004 0.0231 0.0134
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0274
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0031 0.014 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Schistosoma mansoni intermediate filament proteins 0.0027 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0098 0.0128
Brugia malayi FAT domain containing protein 0.0031 0.014 0.0325
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.1
Giardia lamblia GTOR 0.007 0.0539 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Onchocerca volvulus 0.0027 0.0103 0.033
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Echinococcus granulosus serine:threonine protein kinase SMG1 0.004 0.0231 0.0134
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Echinococcus multilocularis musashi 0.0027 0.0103 0.0005
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0098 0.0399
Schistosoma mansoni survival motor neuron protein 0.0048 0.0318 0.4979
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.007 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.007 0.0539 1
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0098 0.0399
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.007 0.0539 0.1352
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0539 0.24
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.007 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0103 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Onchocerca volvulus 0.0027 0.0098 0.0276
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0539 0.1359
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0044 0.0276 0.1478
Trypanosoma cruzi hypothetical protein, conserved 0.0354 0.3388 1
Onchocerca volvulus 0.0048 0.0318 0.2482
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0103 0.0423
Brugia malayi G protein-coupled receptor 0.0027 0.0098 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0231 0.0747
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.007 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.004 0.0231 0.0134
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Schistosoma mansoni cellular tumor antigen P53 0.005 0.033 0.5259
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0031 0.014 0.0043
Echinococcus multilocularis lamin dm0 0.0027 0.0103 0.0005
Onchocerca volvulus 0.0027 0.0098 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0098 0.0128
Brugia malayi sulfakinin receptor protein 0.0027 0.0098 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Echinococcus multilocularis tumor protein p63 0.0339 0.324 0.3174
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi putative neuropeptide receptor 0.0027 0.0098 0.0128
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.007 0.0539 0.1352
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0098 0.0128
Echinococcus multilocularis serine protein kinase ATM 0.004 0.0231 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.007 0.0539 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.004 0.0231 0.3007
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0098 0.0276
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.004 0.0231 0.0414
Brugia malayi Dopamine receptor protein 1 0.0027 0.0098 0.0128
Echinococcus granulosus lamin dm0 0.0027 0.0103 0.0005
Schistosoma mansoni fkbp-rapamycin associated protein 0.004 0.0231 0.3007
Brugia malayi hypothetical protein 0.0237 0.2217 1
Brugia malayi G-protein coupled receptor 0.0027 0.0098 0.0128
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0098 0.0128
Brugia malayi Dopamine receptor 0.0027 0.0098 0.0128
Schistosoma mansoni hypothetical protein 0.0048 0.0318 0.4979
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi larval opioid receptor 0.0027 0.0098 0.0128
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.8013 0.7994
Onchocerca volvulus 0.0027 0.0098 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Onchocerca volvulus 0.0027 0.0098 0.0276
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.007 0.0539 0.1359
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.001 0.5
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Leishmania major phosphatidylinositol 3-kinase, putative 0.007 0.0539 0.1359
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.04
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Brugia malayi hypothetical protein 0.0123 0.1067 0.4644
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Entamoeba histolytica hypothetical protein 0.004 0.0231 0.3417
Onchocerca volvulus Huntingtin homolog 0.0123 0.1067 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0098 0.0128
Brugia malayi RE15519p 0.0027 0.0098 0.0128
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.007 0.0539 0.0446
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.004 0.0231 0.3417
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.007 0.0539 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0274
Loa Loa (eye worm) hypothetical protein 0.005 0.033 0.1451
Entamoeba histolytica protein kinase rad3, putative 0.004 0.0231 0.3417
Onchocerca volvulus 0.0027 0.0098 0.0276
Loa Loa (eye worm) hypothetical protein 0.0123 0.1067 0.4791
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.007 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Onchocerca volvulus 0.0027 0.0098 0.0276
Loa Loa (eye worm) hypothetical protein 0.0237 0.2217 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.001 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0098 0.0128
Brugia malayi Serotonin receptor 0.0027 0.0098 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Schistosoma mansoni hypothetical protein 0.0031 0.014 0.0955
Schistosoma mansoni lamin 0.0027 0.0103 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.007 0.0539 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0044 0.0276 0.1478
Echinococcus granulosus intermediate filament protein 0.0027 0.0103 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.007 0.0539 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1012 1 1
Brugia malayi Melatonin receptor type 1A 0.0027 0.0098 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0539 0.24
Leishmania major phosphatidylinositol 3-related kinase, putative 0.007 0.0539 0.1359
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0098 0.0399
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0098 0.0399
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0539 0.2186
Onchocerca volvulus 0.0027 0.0098 0.0276
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0539 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi ORL1-like opioid receptor 0.0027 0.0098 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Onchocerca volvulus 0.0027 0.0098 0.0276
Onchocerca volvulus 0.0027 0.0098 0.0276
Schistosoma mansoni lamin 0.0027 0.0103 0.0122
Leishmania major hypothetical protein, conserved 0.0367 0.3524 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.007 1
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.2217 0.214
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0539 0.2186
Mycobacterium ulcerans hypothetical protein 0.0024 0.007 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.007 1
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0024 0.007 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.007 0.0539 0.1352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0044 0.0276 0.1207
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Echinococcus granulosus tumor protein p63 0.0339 0.324 0.3174
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0098 0.0399
Echinococcus multilocularis lamin 0.0027 0.0103 0.0005
Onchocerca volvulus 0.005 0.033 0.2606
Onchocerca volvulus 0.0027 0.0098 0.0276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0231 0.0747
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.007 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0098 0.0399
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0318 0.1153
Brugia malayi intermediate filament protein 0.0027 0.0103 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0098 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0098 0.0276
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.007 0.0539 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0276 0.4087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.007 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.007 0.0539 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0098 0.0399
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0098 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.007 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Onchocerca volvulus 0.0027 0.0098 0.0276
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0098 0.0128
Brugia malayi neuropeptide F receptor 0.0027 0.0098 0.0128
Onchocerca volvulus 0.0027 0.0103 0.033
Brugia malayi Dopamine receptor protein 2 0.0027 0.0098 0.0128
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.007 0.0539 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0103 0.0153
Onchocerca volvulus Huntingtin homolog 0.0123 0.1067 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Loa Loa (eye worm) hypothetical protein 0.0031 0.014 0.059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi AKH receptor 0.0027 0.0098 0.0128
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.001 0.139
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.004 0.0231 0.0414
Echinococcus granulosus lamin 0.0027 0.0103 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.007 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.2217 0.214
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Brugia malayi neuropeptide F receptor 0.0027 0.0098 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.014 0.1025
Brugia malayi G-protein coupled receptor 0.0027 0.0098 0.0128
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.007 0.0539 0.1359
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.007 0.0539 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Brugia malayi hypothetical protein 0.0027 0.0098 0.0128
Brugia malayi Serotonin receptor 0.0027 0.0098 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0098 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0231 0.3062
Brugia malayi GnHR receptor homolog 0.0027 0.0098 0.0128

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.12 ug ml-1 In vitro minimum inhibitory concentration of the compound against Streptococcus species; 0.12-0.5 ChEMBL. 12873519
MIC (functional) = 2 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus aureus ChEMBL. 12873519
MIC (functional) = 2 ug ml-1 In vitro minimum inhibitory concentration of the compound against Enterococcus species; 2-4 ChEMBL. 12873519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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