Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Beta-2 adrenergic receptor | Starlite/ChEMBL | References |
Cavia porcellus | Beta-1 adrenergic receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 7.3 | In vitro ability to block beta-2 adrenergic receptor in guinea pig trachea. | ChEMBL. | 6130153 |
Kd (binding) | = 7.4 | In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria. | ChEMBL. | 6130153 |
Kd (functional) | = 17 | In vivo inihibtion of Beta-1 adrenergic receptor in guinea pig right atria after 40 min | ChEMBL. | 6130153 |
pA2 (binding) | = 7.3 | In vitro ability to block beta-2 adrenergic receptor in guinea pig trachea. | ChEMBL. | 6130153 |
pA2 (binding) | = 7.4 | In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria. | ChEMBL. | 6130153 |
pA2 (functional) | = 17 | In vivo inihibtion of Beta-1 adrenergic receptor in guinea pig right atria after 40 min | ChEMBL. | 6130153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.