Detailed information for compound 415397

Basic information

Technical information
  • TDR Targets ID: 415397
  • Name: (1S,3S,4S,4aS,9aS)-1,4,8-trihydroxy-6-methoxy -3,4a-dimethyl-2,3,4,9a-tetrahydro-1H-xanthen -9-one
  • MW: 308.326 | Formula: C16H20O6
  • H donors: 3 H acceptors: 4 LogP: 1.52 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2O[C@]3(C)[C@@H](O)[C@@H](C)C[C@@H]([C@@H]3C(=O)c2c(c1)O)O
  • InChi: 1S/C16H20O6/c1-7-4-10(18)13-14(19)12-9(17)5-8(21-3)6-11(12)22-16(13,2)15(7)20/h5-7,10,13,15,17-18,20H,4H2,1-3H3/t7-,10-,13+,15-,16-/m0/s1
  • InChiKey: PIJNYABFKNAKHE-YZKPXJPOSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0153 0.1671 0.1671
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1067 0.5109
Loa Loa (eye worm) TYRA-2 protein 0.0153 0.1671 0.3617
Onchocerca volvulus Prolyl endopeptidase homolog 0.0385 0.4609 1
Echinococcus multilocularis allatostatin A receptor 0.0153 0.1671 0.1671
Leishmania major beta tubulin 0.0185 0.2076 0.449
Leishmania major beta tubulin 0.0185 0.2076 0.449
Echinococcus granulosus peptide allatostatin:somatostatin 0.0153 0.1671 0.1671
Echinococcus granulosus Dipeptidyl peptidase 9 0.004 0.0236 0.0236
Schistosoma mansoni ran 0.0023 0.0012 0.0012
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.004 0.0236 0.1086
Leishmania major beta tubulin 0.0185 0.2076 0.449
Onchocerca volvulus 0.0153 0.1671 0.3397
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0236 0.0488
Entamoeba histolytica prolyl oligopeptidase family protein 0.004 0.0236 0.1086
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Entamoeba histolytica dipeptidyl-peptidase, putative 0.004 0.0236 0.1086
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Echinococcus granulosus tubulin beta 1 chain 0.0185 0.2076 0.2076
Echinococcus granulosus neuropeptides capa receptor 0.0153 0.1671 0.1671
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0708 0.1525
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0708 0.0708
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0708 0.3373
Echinococcus multilocularis neuropeptide receptor A26 0.0153 0.1671 0.1671
Echinococcus granulosus dna polymerase kappa 0.0062 0.0505 0.0505
Echinococcus granulosus snurportin 1 0.0329 0.3905 0.3905
Entamoeba histolytica aminopeptidase, putative 0.0034 0.0159 0.0714
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Giardia lamblia Beta tubulin 0.0185 0.2076 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0159 0.0333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0363 0.0775
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0068 0.0068
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0505 0.1072
Echinococcus granulosus tm gpcr rhodopsin 0.0153 0.1671 0.1671
Echinococcus granulosus fmrfamide receptor 0.0153 0.1671 0.1671
Plasmodium falciparum tubulin beta chain 0.0185 0.2076 1
Onchocerca volvulus 0.0153 0.1671 0.3397
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0153 0.1671 0.1671
Schistosoma mansoni tubulin subunit beta 0.0185 0.2076 0.2076
Loa Loa (eye worm) prolyl oligopeptidase 0.004 0.0236 0.05
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1476 0.1476
Trypanosoma brucei unspecified product 0.0042 0.0262 0.0545
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Toxoplasma gondii prolyl endopeptidase 0.0385 0.4609 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.004 0.0236 0.05
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0505 0.1083
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0153 0.1667 0.149
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1476 0.1476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Trichomonas vaginalis tubulin, putative 0.0185 0.2076 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0505 0.1083
Brugia malayi prolyl oligopeptidase family protein 0.0385 0.4609 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni neuropeptide F-like receptor 0.0153 0.1671 0.1671
Echinococcus granulosus Tubulin beta 2C chain 0.0185 0.2076 0.2076
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.1067 0.1067
Echinococcus multilocularis cpg binding protein 0.0093 0.0899 0.0899
Echinococcus granulosus prolyl endopeptidase 0.0385 0.4609 0.4609
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0505 0.1072
Giardia lamblia Beta tubulin 0.0185 0.2076 1
Leishmania major beta tubulin 0.0185 0.2076 0.449
Echinococcus granulosus neuropeptides capa receptor 0.0153 0.1671 0.1671
Brugia malayi AKH receptor 0.0153 0.1671 0.3609
Echinococcus multilocularis tubulin beta 1 chain 0.0185 0.2076 0.2076
Loa Loa (eye worm) peptidase family M1 containing protein 0.0094 0.0921 0.1988
Trypanosoma brucei beta tubulin 0.0185 0.2076 0.449
Echinococcus granulosus neuropeptide receptor 0.0153 0.1671 0.1671
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0505 0.2292
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0153 0.1671 0.3617
Trichomonas vaginalis tubulin epsilon chain, putative 0.0185 0.2076 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0012 0.0013
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0385 0.4609 0.4609
Leishmania major beta tubulin 0.0185 0.2076 0.449
Loa Loa (eye worm) G-protein coupled receptor 0.0153 0.1671 0.3617
Echinococcus multilocularis beta tubulin 0.0185 0.2076 0.2076
Entamoeba histolytica hypothetical protein 0.0025 0.0041 0.0142
Brugia malayi neuropeptide F receptor 0.0153 0.1671 0.3609
Giardia lamblia Beta tubulin 0.0185 0.2076 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Brugia malayi sulfakinin receptor protein 0.0153 0.1671 0.3609
Schistosoma mansoni amine GPCR 0.0153 0.1671 0.1671
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0505 0.0505
Schistosoma mansoni ap endonuclease 0.0078 0.0708 0.0708
Mycobacterium tuberculosis Conserved protein 0.0106 0.1067 0.072
Leishmania major beta tubulin 0.0185 0.2076 0.449
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0159 0.0321
Toxoplasma gondii ABC1 family protein 0.0106 0.1067 0.2294
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0553 0.0553
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0153 0.1671 0.1671
Echinococcus granulosus sex peptide receptor 0.0153 0.1671 0.1671
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1067 0.1067
Echinococcus granulosus Tubulin beta 2C chain 0.0185 0.2076 0.2076
Trypanosoma brucei unspecified product 0.0042 0.0262 0.0545
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.004 0.0236 0.0236
Leishmania major beta tubulin 0.0185 0.2076 0.449
Onchocerca volvulus 0.0106 0.1067 0.2039
Onchocerca volvulus 0.0153 0.1671 0.3397
Echinococcus multilocularis fmrfamide receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) RNA binding protein 0.0065 0.0553 0.1187
Schistosoma mansoni tubulin subunit beta 0.0185 0.2076 0.2076
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Entamoeba histolytica hypothetical protein 0.0038 0.0212 0.0971
Echinococcus multilocularis Tubulin beta 2C chain 0.0185 0.2076 0.2076
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Loa Loa (eye worm) beta-lactamase 0.0106 0.1067 0.2304
Plasmodium falciparum importin beta, putative 0.0031 0.0115 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0708 0.1515
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0153 0.1671 0.1671
Mycobacterium ulcerans lipase LipD 0.0106 0.1067 0.602
Entamoeba histolytica prolyl oligopeptidase family protein 0.004 0.0236 0.1086
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0153 0.1671 0.1671
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0153 0.1671 0.1671
Echinococcus multilocularis aminopeptidase N 0.0117 0.1204 0.1204
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0505 0.1083
Echinococcus multilocularis sex peptide receptor 0.0153 0.1671 0.1671
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0159 0.0159
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0708 0.1515
Schistosoma mansoni neuropeptide receptor 0.0153 0.1671 0.1671
Echinococcus granulosus g-protein coupled receptor 0.0153 0.1671 0.1671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0505 0.2387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0505 0.2387
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0212 0.0212
Echinococcus granulosus Tubulin beta 2C chain 0.0185 0.2076 0.2076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0708 0.1525
Echinococcus granulosus Tubulin beta 2C chain 0.0185 0.2076 0.2076
Echinococcus granulosus dro:myosuppressin receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) BEN-1 protein 0.0185 0.2076 0.4497
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.1067 0.072
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0363 0.0764
Schistosoma mansoni growth hormone secretagogue receptor 0.0153 0.1671 0.1671
Onchocerca volvulus Neuropeptide F receptor homolog 0.0153 0.1671 0.3397
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0505 0.1072
Loa Loa (eye worm) BEN-1 protein 0.0185 0.2076 0.4497
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0153 0.1667 0.3607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0708 0.0708
Echinococcus multilocularis orexin receptor type 2 0.0153 0.1671 0.1671
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0332 0.0332
Echinococcus multilocularis neuropeptides capa receptor 0.0153 0.1671 0.1671
Leishmania major beta tubulin 0.0185 0.2076 0.449
Loa Loa (eye worm) melatonin receptor type 1A 0.0153 0.1671 0.3617
Leishmania major beta tubulin 0.0185 0.2076 0.449
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0153 0.1671 0.1671
Schistosoma mansoni neuropeptide f receptor 76f 0.0153 0.1671 0.1671
Echinococcus multilocularis serotonin receptor 0.0153 0.1671 0.1671
Onchocerca volvulus 0.0106 0.1067 0.2039
Schistosoma mansoni adenoreceptor 0.0153 0.1671 0.1671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.004 0.0236 0.0236
Echinococcus multilocularis Tubulin beta 2C chain 0.0185 0.2076 0.2076
Echinococcus multilocularis fmrfamide receptor 0.0153 0.1671 0.1671
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0159 0.0321
Schistosoma mansoni tubulin subunit beta 0.0185 0.2076 0.2076
Echinococcus multilocularis Dipeptidyl peptidase 9 0.004 0.0236 0.0236
Echinococcus multilocularis tubulin subunit beta 0.0185 0.2076 0.2076
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Leishmania major beta tubulin 0.0185 0.2076 0.449
Onchocerca volvulus 0.0153 0.1671 0.3397
Brugia malayi Peptidase family M1 containing protein 0.0117 0.1204 0.2592
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Leishmania major beta tubulin 0.0185 0.2076 0.449
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.1067 0.602
Plasmodium vivax hypothetical protein, conserved 0.0106 0.1067 0.5109
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0153 0.1671 0.1671
Trypanosoma cruzi beta tubulin, putative 0.0185 0.2076 0.4497
Echinococcus granulosus tm gpcr rhodopsin 0.0153 0.1671 0.1671
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Brugia malayi putative neuropeptide receptor NPR1 0.0153 0.1671 0.3609
Toxoplasma gondii hypothetical protein 0.004 0.0236 0.0488
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Onchocerca volvulus 0.0153 0.1671 0.3397
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0553 0.0553
Loa Loa (eye worm) neuropeptide F receptor 0.0153 0.1671 0.3617
Onchocerca volvulus 0.0048 0.0332 0.0387
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0115 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0153 0.1671 0.3609
Loa Loa (eye worm) hypothetical protein 0.005 0.0363 0.0775
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0363 0.0764
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Onchocerca volvulus 0.0117 0.1204 0.2347
Schistosoma mansoni biogenic amine (5HT) receptor 0.0153 0.1671 0.1671
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0529 0.6438 0.6438
Mycobacterium tuberculosis Probable peptidase 0.0153 0.1667 0.149
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0068 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0505 0.1072
Brugia malayi beta-lactamase family protein 0.0106 0.1067 0.2294
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.1831 0.3956
Echinococcus granulosus tumor protein p63 0.0327 0.3878 0.3878
Loa Loa (eye worm) hypothetical protein 0.0106 0.1067 0.2304
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1476 0.3185
Entamoeba histolytica tubulin family protein 0.0185 0.2076 1
Brugia malayi hypothetical protein 0.0038 0.0212 0.0436
Loa Loa (eye worm) hypothetical protein 0.0106 0.1067 0.2304
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0153 0.1667 0.3607
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.1067 0.072
Schistosoma mansoni hypothetical protein 0.0153 0.1671 0.1671
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0836 0.1802
Echinococcus multilocularis serotonin receptor 0.0153 0.1671 0.1671
Schistosoma mansoni neuropeptide F-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) G-protein coupled receptor 0.0153 0.1671 0.3617
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0153 0.1671 0.1671
Echinococcus granulosus aminopeptidase N 0.0117 0.1204 0.1204
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0159 0.0321
Trypanosoma brucei beta tubulin 0.0185 0.2076 0.449
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1067 0.2304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.004 0.0236 0.0488
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Echinococcus granulosus g protein coupled receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0505 0.1072
Mycobacterium ulcerans hypothetical protein 0.0106 0.1067 0.602
Giardia lamblia Alanyl dipeptidyl peptidase 0.004 0.0236 0.1086
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1067 0.5109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.1067 0.2294
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0505 0.0505
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0153 0.1671 0.1671
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0385 0.4609 0.4609
Onchocerca volvulus 0.0153 0.1671 0.3397
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Leishmania major beta tubulin 0.0185 0.2076 0.449
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Trichomonas vaginalis tubulin beta chain, putative 0.0185 0.2076 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0708 0.3373
Trypanosoma brucei beta tubulin 0.0185 0.2076 0.449
Loa Loa (eye worm) hypothetical protein 0.0062 0.0505 0.1083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0012 0.0013
Trypanosoma brucei prolyl oligopeptidase, putative 0.0153 0.1667 0.3599
Brugia malayi G protein-coupled receptor F59B2.13 0.0153 0.1671 0.3609
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0115 0.0225
Trypanosoma brucei beta tubulin 0.0185 0.2076 0.449
Echinococcus multilocularis neuropeptide Y receptor 0.0153 0.1671 0.1671
Echinococcus granulosus cpg binding protein 0.0093 0.0899 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.0545
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0153 0.1671 0.1671
Echinococcus multilocularis g protein coupled receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0104 0.1051 0.2269
Onchocerca volvulus 0.0153 0.1671 0.3397
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0553 0.0553
Brugia malayi GnHR receptor homolog 0.0153 0.1671 0.3609
Loa Loa (eye worm) tubulin beta-4 chain 0.0185 0.2076 0.4497
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0236 0.0488
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0385 0.4609 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0153 0.1671 0.3617
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0153 0.1671 0.1671
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0153 0.1671 0.1671
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0708 0.3373
Echinococcus multilocularis tumor protein p63 0.0327 0.3878 0.3878
Trichomonas vaginalis esterase, putative 0.0106 0.1067 0.5109
Echinococcus granulosus orexin receptor type 2 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus granulosus geminin 0.0529 0.6438 0.6438
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.004 0.0236 0.0173
Entamoeba histolytica hypothetical protein, conserved 0.004 0.0236 0.1086
Onchocerca volvulus 0.0153 0.1671 0.3397
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus granulosus tm gpcr rhodopsin 0.0153 0.1671 0.1671
Echinococcus granulosus beta tubulin 0.0185 0.2076 0.2076
Brugia malayi neuropeptide F receptor 0.0153 0.1671 0.3609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0708 0.0261
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Schistosoma mansoni hypothetical protein 0.0329 0.3905 0.3905
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0336
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0153 0.1671 0.1671
Plasmodium vivax tubulin beta chain, putative 0.0185 0.2076 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0041 0.0064
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Echinococcus multilocularis neuropeptide receptor 0.0153 0.1671 0.1671
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0153 0.1671 0.3617
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1476 0.3193
Schistosoma mansoni biogenic amine (5HT) receptor 0.0153 0.1671 0.1671
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0237
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0708 0.5
Schistosoma mansoni amine GPCR 0.0153 0.1671 0.1671
Leishmania major beta tubulin 0.0185 0.2076 0.449
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1067 0.5109
Echinococcus granulosus beta tubulin 0.0185 0.2076 0.2076
Loa Loa (eye worm) tubulin beta chain 0.0185 0.2076 0.4497
Schistosoma mansoni tubulin subunit beta 0.0185 0.2076 0.2076
Onchocerca volvulus 0.0153 0.1671 0.3397
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0708 0.1515
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0068 0.0134
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.1067 0.602
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0553 0.0553
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0153 0.1671 0.1671
Entamoeba histolytica tubulin family protein 0.0185 0.2076 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Leishmania major hypothetical protein, conserved 0.0106 0.1067 0.2294
Echinococcus granulosus Tubulin beta 2C chain 0.0185 0.2076 0.2076
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.1067 0.072
Echinococcus granulosus neuropeptide receptor A26 0.0153 0.1671 0.1671
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0153 0.1667 1
Echinococcus granulosus serotonin receptor 0.0153 0.1671 0.1671
Mycobacterium tuberculosis Conserved protein 0.0106 0.1067 0.072
Toxoplasma gondii beta-1 tubulin, putative 0.0185 0.2076 0.449
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0505 0.2292
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0159 0.0714
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.1067 0.072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1476 0.1476
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0708 0.3642
Echinococcus granulosus tubulin subunit beta 0.0185 0.2076 0.2076
Onchocerca volvulus 0.0106 0.1067 0.2039
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0236 0.1086
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0041 0.0142
Echinococcus multilocularis neuropeptides capa receptor 0.0153 0.1671 0.1671
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0185 0.2076 0.2076
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.004 0.0236 0.0488
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0153 0.1671 0.3609
Brugia malayi RNA, U transporter 1 0.0088 0.0837 0.1796
Schistosoma mansoni importin beta-1 0.0031 0.0115 0.0115
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0159 0.0321
Loa Loa (eye worm) hypothetical protein 0.0106 0.1067 0.2304
Leishmania major beta tubulin 0.0185 0.2076 0.449
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0012 0.0012
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Onchocerca volvulus 0.0153 0.1671 0.3397
Echinococcus multilocularis geminin 0.0529 0.6438 0.6438
Brugia malayi Serotonin receptor 0.0153 0.1671 0.3609
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0153 0.1671 0.1671
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0153 0.1671 0.3609
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0012 0.0012
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0159 0.0333
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0153 0.1671 0.1671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1476 0.1476
Trichomonas vaginalis tubulin gamma chain, putative 0.0185 0.2076 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Schistosoma mansoni hypothetical protein 0.0529 0.6438 0.6438
Echinococcus multilocularis neuropeptide FF receptor 2 0.0153 0.1671 0.1671
Trypanosoma brucei prolyl endopeptidase 0.0385 0.4609 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.004 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0106 0.1067 0.2304
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.0006 0.0006
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Onchocerca volvulus 0.0153 0.1671 0.3397
Trypanosoma cruzi oligopeptidase b 0.0153 0.1667 0.3607
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0159 0.0321
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0153 0.1671 0.1671
Schistosoma mansoni biogenic amine receptor 0.0153 0.1671 0.1671
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0159 0.0714
Brugia malayi G-protein coupled receptor 0.0153 0.1671 0.3609
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0153 0.1671 0.3617
Echinococcus granulosus biogenic amine 5HT receptor 0.0153 0.1671 0.1671
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni opsin-like receptor 0.0153 0.1671 0.1671
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.05
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Brugia malayi beta-tubulin, identical 0.0185 0.2076 0.449
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0505 0.1083
Echinococcus multilocularis dro:myosuppressin receptor 0.0153 0.1671 0.1671
Schistosoma mansoni opsin-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.05
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0553 0.0553
Echinococcus multilocularis neuropeptide Y receptor 0.0153 0.1671 0.1671
Echinococcus granulosus 7tm_1 domain containing protein 0.0153 0.1671 0.1671
Echinococcus multilocularis neuropeptide s receptor 0.0153 0.1671 0.1671
Schistosoma mansoni ap endonuclease 0.0078 0.0708 0.0708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.004 0.0236 0.0488
Echinococcus multilocularis snurportin 1 0.0329 0.3905 0.3905
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0153 0.1671 0.1671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1476 0.1476
Echinococcus granulosus biogenic amine 5HT receptor 0.0153 0.1671 0.1671
Echinococcus multilocularis neuropeptide receptor 0.0153 0.1671 0.1671
Brugia malayi Serotonin receptor 0.0153 0.1671 0.3609
Echinococcus granulosus allatostatin A receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni cpg binding protein 0.0093 0.0899 0.0899
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0505 0.1083
Onchocerca volvulus 0.0153 0.1671 0.3397
Schistosoma mansoni myosin xvIII 0.0153 0.1671 0.1671
Brugia malayi hypothetical protein 0.0034 0.0159 0.0321
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0505 0.0505
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0212 0.0212
Echinococcus granulosus g protein coupled receptor 0.0153 0.1671 0.1671
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0344 0.4097 0.4606
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus granulosus tubulin beta 4A class IVa 0.0185 0.2076 0.2076
Schistosoma mansoni biogenic amine receptor 0.0153 0.1671 0.1671
Leishmania major DNA polymerase eta, putative 0.0062 0.0505 0.1072
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) prolyl oligopeptidase 0.004 0.0236 0.05
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0153 0.1671 0.1671
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1067 0.5109
Echinococcus multilocularis dnaJ subfamily B 0.0809 1 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0159 0.0333
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni hypothetical protein 0.0809 1 1
Schistosoma mansoni hypothetical protein 0.0153 0.1671 0.1671
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Schistosoma mansoni amine GPCR 0.0153 0.1671 0.1671
Schistosoma mansoni DNA polymerase eta 0.0062 0.0505 0.0505
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus granulosus rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.1067 0.072
Echinococcus multilocularis dna polymerase eta 0.0062 0.0505 0.0505
Echinococcus granulosus 7TM GPCR rhodopsin 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0153 0.1671 0.3617
Brugia malayi Dopamine receptor protein 1 0.0153 0.1671 0.3609
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.004 0.0236 0.05
Schistosoma mansoni hypothetical protein 0.0153 0.1671 0.1671
Leishmania major beta tubulin 0.0185 0.2076 0.449
Loa Loa (eye worm) hypothetical protein 0.0385 0.4609 1
Brugia malayi Tubulin beta-1 chain 0.0185 0.2076 0.449
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0553 0.0553
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0161 0.0324
Brugia malayi CXXC zinc finger family protein 0.0088 0.0836 0.1792
Echinococcus multilocularis g-protein coupled receptor 0.0153 0.1671 0.1671
Echinococcus granulosus dna polymerase eta 0.0062 0.0505 0.0505
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0153 0.1671 0.1671
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Echinococcus granulosus hypothetical protein 0.0153 0.1671 0.1671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Mycobacterium ulcerans beta-lactamase 0.0106 0.1067 0.602
Brugia malayi larval opioid receptor 0.0153 0.1671 0.3609
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.004 0.0236 0.0488
Entamoeba histolytica dipeptidyl-peptidase, putative 0.004 0.0236 0.1086
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Schistosoma mansoni biogenic amine receptor 0.0153 0.1671 0.1671
Brugia malayi G protein-coupled receptor 0.0153 0.1671 0.3609
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0153 0.1671 0.3609
Toxoplasma gondii beta tubulin 0.0185 0.2076 0.449
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0505 0.1072
Onchocerca volvulus 0.0153 0.1671 0.3397
Echinococcus granulosus tar DNA binding protein 0.0065 0.0553 0.0553
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.05
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.1067 0.072
Echinococcus granulosus alpha 1A adrenergic receptor 0.0153 0.1671 0.1671
Echinococcus granulosus neuropeptide FF receptor 2 0.0153 0.1671 0.1671
Toxoplasma gondii beta-tubulin, putative 0.0185 0.2076 0.449
Loa Loa (eye worm) beta-tubulin 0.0185 0.2076 0.4497
Echinococcus multilocularis Tubulin beta 2C chain 0.0185 0.2076 0.2076
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0115 0.0115
Echinococcus multilocularis Tubulin beta 2C chain 0.0185 0.2076 0.2076
Schistosoma mansoni amine GPCR 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus multilocularis beta tubulin 0.0185 0.2076 0.2076
Schistosoma mansoni ran 0.0023 0.0012 0.0012
Schistosoma mansoni histamine h1 receptor 0.0153 0.1671 0.1671
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.004 0.0236 0.0488
Schistosoma mansoni tubulin subunit beta 0.0185 0.2076 0.2076
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Onchocerca volvulus 0.0153 0.1671 0.3397
Loa Loa (eye worm) hypothetical protein 0.0106 0.1067 0.2304
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0553 0.1176
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0153 0.1667 0.3599
Brugia malayi RE15519p 0.0153 0.1671 0.3609
Loa Loa (eye worm) neuropeptide F receptor 0.0153 0.1671 0.3617
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.1067 0.2304
Echinococcus multilocularis somatostatin receptor 0.0153 0.1671 0.1671
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0708 0.3373
Schistosoma mansoni neuropeptide receptor 0.0153 0.1671 0.1671
Trypanosoma brucei unspecified product 0.0062 0.0505 0.1072
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0505 0.2387
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Onchocerca volvulus 0.0088 0.0836 0.152
Loa Loa (eye worm) tubulin beta-2A chain 0.0185 0.2076 0.4497
Echinococcus granulosus importin subunit beta 1 0.0031 0.0115 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.0545
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0159 0.0321
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.1067 0.072
Schistosoma mansoni hypothetical protein 0.0153 0.1671 0.1671
Brugia malayi ORL1-like opioid receptor 0.0153 0.1671 0.3609
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1067 0.5109
Echinococcus granulosus neuropeptide s receptor 0.0153 0.1671 0.1671
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0041 0.0076
Plasmodium vivax hypothetical protein, conserved 0.004 0.0236 0.1086
Onchocerca volvulus 0.0153 0.1671 0.3397
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus granulosus neuropeptide Y receptor 0.0153 0.1671 0.1671
Brugia malayi Dopamine receptor 0.0153 0.1671 0.3609
Schistosoma mansoni cpg binding protein 0.0088 0.0836 0.0836
Leishmania major beta tubulin 0.0185 0.2076 0.449
Echinococcus multilocularis prolyl endopeptidase 0.0385 0.4609 0.4609
Echinococcus granulosus neuropeptide Y receptor 0.0153 0.1671 0.1671
Entamoeba histolytica prolyl oligopeptidase family protein 0.004 0.0236 0.1086
Schistosoma mansoni tubulin subunit beta 0.0185 0.2076 0.2076
Plasmodium vivax importin-beta 2, putative 0.0031 0.0115 0.0501
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3905 0.8469
Brugia malayi putative neuropeptide receptor 0.0153 0.1671 0.3609
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1067 0.2294
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0262 0.0545
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1476 0.1476
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0153 0.1671 0.1671
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0153 0.1671 0.1671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1067 0.2304
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.004 0.0236 0.0236
Entamoeba histolytica hypothetical protein 0.0038 0.0212 0.0971
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0153 0.1671 0.1671
Trichomonas vaginalis tubulin alpha chain, putative 0.0185 0.2076 1
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0236 0.0488
Brugia malayi follicle stimulating hormone receptor 0.0153 0.1671 0.3609
Echinococcus granulosus g protein coupled receptor 0.0153 0.1671 0.1671
Echinococcus granulosus tachykinin peptides receptor 99D 0.0153 0.1671 0.1671
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.004 0.0236 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0048 0.0332 0.0707
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0153 0.1671 0.1671
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0505 0.0505
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1476 0.1476
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1067 0.1067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0153 0.1671 0.1671
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0153 0.1671 0.3397
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.1067 0.1067
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0708 0.5
Brugia malayi RNA binding protein 0.0065 0.0553 0.1176
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0153 0.1667 0.3599
Echinococcus granulosus neuropeptide receptor 0.0153 0.1671 0.1671
Schistosoma mansoni opsin-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Toxoplasma gondii exonuclease III APE 0.0078 0.0708 0.1515
Plasmodium falciparum peptidase, putative 0.004 0.0236 0.1086
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Trichomonas vaginalis tubulin epsilon chain, putative 0.0185 0.2076 1
Giardia lamblia DINP protein human, muc B family 0.0062 0.0505 0.2387
Brugia malayi Dopamine receptor protein 2 0.0153 0.1671 0.3609
Leishmania major beta tubulin 0.0185 0.2076 0.449
Brugia malayi hypothetical protein 0.0153 0.1671 0.3609
Leishmania major DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Brugia malayi Tachykinin-like peptides receptor 99D 0.0153 0.1671 0.3609
Echinococcus granulosus G protein coupled receptor 139 0.0153 0.1671 0.1671
Echinococcus multilocularis g protein coupled receptor 0.0153 0.1671 0.1671
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0505 0.1083
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0505 0.1072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0708 0.3373
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0153 0.1667 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0159 0.0159
Echinococcus multilocularis G protein coupled receptor 139 0.0153 0.1671 0.1671
Schistosoma mansoni neuropeptide receptor 0.0153 0.1671 0.1671
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0063 0.0112
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0708 0.1525
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0153 0.1671 0.1671
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0153 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Brugia malayi Importin beta-1 subunit 0.0031 0.0115 0.0225
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Echinococcus multilocularis acylamino acid releasing enzyme 0.004 0.0236 0.0236
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0115 0.0225
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0676 0.8304 1
Schistosoma mansoni cpg binding protein 0.0093 0.0899 0.0899
Mycobacterium tuberculosis Conserved protein 0.0106 0.1067 0.072
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.05
Trypanosoma cruzi oligopeptidase b 0.0153 0.1667 0.3607
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.2083 0.2083
Loa Loa (eye worm) tubulin beta-1 chain 0.0185 0.2076 0.4497
Leishmania major beta tubulin 0.0185 0.2076 0.449
Echinococcus granulosus somatostatin receptor 0.0153 0.1671 0.1671
Brugia malayi beta-lactamase 0.0106 0.1067 0.2294
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0159 0.0333
Trypanosoma cruzi prolyl endopeptidase 0.0385 0.4609 1
Echinococcus granulosus acylamino acid releasing enzyme 0.004 0.0236 0.0236
Trypanosoma brucei oligopeptidase b 0.0153 0.1667 0.3599
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0159 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0153 0.1671 0.1671
Giardia lamblia Alanyl dipeptidyl peptidase 0.004 0.0236 0.1086
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0041 0.0142
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Brugia malayi Melatonin receptor type 1A 0.0153 0.1671 0.3609
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0212 0.0212
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0153 0.1671 0.3609
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.004 0.0236 0.0236
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0553 0.1187
Echinococcus multilocularis G-protein coupled receptor, putative 0.0153 0.1671 0.1671
Echinococcus multilocularis g protein coupled receptor 0.0153 0.1671 0.1671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0153 0.1671 0.1671
Brugia malayi prolyl oligopeptidase family protein 0.004 0.0236 0.0488
Entamoeba histolytica hypothetical protein 0.0038 0.0212 0.0971
Schistosoma mansoni alpha-1 adrenergic receptor 0.0153 0.1671 0.1671
Onchocerca volvulus 0.0153 0.1671 0.3397
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0161
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0505 0.0505
Brugia malayi TAR-binding protein 0.0065 0.0553 0.1176
Loa Loa (eye worm) hypothetical protein 0.0153 0.1671 0.3617
Brugia malayi G-protein coupled receptor 0.0153 0.1671 0.3609
Entamoeba histolytica hypothetical protein 0.0038 0.0212 0.0971
Loa Loa (eye worm) hypothetical protein 0.0106 0.1067 0.2304
Schistosoma mansoni hypothetical protein 0.0038 0.0212 0.0212
Schistosoma mansoni amine GPCR 0.0153 0.1671 0.1671
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0236 0.1086
Schistosoma mansoni neuropeptide receptor 0.0153 0.1671 0.1671
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0708 0.3373
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0041 0.0142
Echinococcus multilocularis Tubulin beta 2C chain 0.0185 0.2076 0.2076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0153 0.1671 0.1671
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.004 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0082 0.0768 0.1655
Leishmania major oligopeptidase b 0.0153 0.1667 0.3599
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0505 0.1072
Brugia malayi beta-lactamase family protein 0.0106 0.1067 0.2294
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0553 0.1187
Onchocerca volvulus 0.0153 0.1671 0.3397

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) 0 Cytotoxicity against mouse Hepa 1c1c7 cells upto 50 uM ChEMBL. 17291041
Activity (functional) 0 DPPH radical scavenging activity upto 250 uM ChEMBL. 17291041
Activity (functional) 0 Superoxide anion radical scavenging activity upto 50 uM ChEMBL. 17291041
Activity (binding) = 12.8 uM Induction of NAD(P)H:quinone reductase in mouse Hepa 1c1c7 cells assessed as concentration required to double the specific activity ChEMBL. 17291041
Activity (binding) = 12.8 uM Induction of NAD(P)H:quinone reductase in mouse Hepa 1c1c7 cells assessed as concentration required to double the specific activity ChEMBL. 17291041
IC50 (binding) = 3 uM Inhibition of beta-napthoflavone-induced Cyp1A in rat H4II7 cell ChEMBL. 17291041
IC50 (binding) = 28.3 uM Inhibition of human recombinant aromatase ChEMBL. 17291041
IC50 (binding) = 28.3 uM Inhibition of human recombinant aromatase ChEMBL. 17291041
IC50 (binding) > 50 uM Induction of NAD(P)H:quinone reductase in mouse Hepa 1c1c7 cells ChEMBL. 17291041
IC50 (binding) > 50 uM Induction of NAD(P)H:quinone reductase in mouse Hepa 1c1c7 cells ChEMBL. 17291041
Inhibition (binding) < 50 % Inhibition of COX1 at 100 uM ChEMBL. 17291041
Inhibition (binding) < 50 % Inhibition of COX1 at 100 uM ChEMBL. 17291041

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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