TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 919.993 | Formula: C50H55F6N5O5
H donors: 2 H acceptors: 5 LogP: 10.17 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCOC(c1/c/2=C/C3=N/C(=C\c4[nH]c5/C(=C/6\N=C(/C=c(/c1C)\[nH]2)[C@@H](C)[C@@H]6CCC(=O)OC)/C(=O)N(C(=O)c5c4C)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)/C(=C3C)CC)C
InChi: 1S/C50H55F6N5O5/c1-9-11-12-13-14-17-66-29(7)42-27(5)37-21-36-26(4)34(15-16-41(62)65-8)45(59-36)44-46-43(28(6)38(60-46)22-39-33(10-2)25(3)35(57-39)23-40(42)58-37)47(63)61(48(44)64)24-30-18-31(49(51,52)53)20-32(19-30)50(54,55)56/h18-23,26,29,34,58,60H,9-17,24H2,1-8H3/b35-23-,36-21-,37-21-,38-22-,39-22-,40-23-,45-44+/t26-,29?,34-/m0/s1
InChiKey: IPEGFVFEVMIWAG-FXMPDQDHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0113	0.084	0.2427
Brugia malayi	ORL1-like opioid receptor	0.0113	0.084	0.2724
Brugia malayi	Methionine aminopeptidase protein type I	0.0042	0.0121	0.0391
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0042	0.0121	0.0121
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0113	0.084	0.2427
Echinococcus multilocularis	dro:myosuppressin receptor	0.0113	0.084	0.084
Echinococcus multilocularis	neuropeptide Y receptor	0.0113	0.084	0.084
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0408	0.1324
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0113	0.084	0.084
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0028	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Toxoplasma gondii	methionine aminopeptidase	0.0042	0.0121	0.0391
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus multilocularis	xaa pro aminopeptidase	0.0042	0.0121	0.0121
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0028	0.0028
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0042	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Loa Loa (eye worm)	melatonin receptor type 1A	0.0113	0.084	0.2724
Schistosoma mansoni	neuropeptide receptor	0.0113	0.084	0.2724
Echinococcus granulosus	FACT complex subunit SPT16	0.0042	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0113	0.084	0.2724
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0336	0.3083	1
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0042	0.0121	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0042	0.0121	0.0391
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0113	0.084	0.084
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0113	0.084	0.084
Schistosoma mansoni	amine GPCR	0.0113	0.084	0.2724
Schistosoma mansoni	myosin xvIII	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Plasmodium falciparum	aminopeptidase P	0.0042	0.0121	0.0391
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0113	0.084	0.2724
Onchocerca volvulus		0.0113	0.084	0.2427
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0336	0.3083	1
Echinococcus granulosus	allatostatin A receptor	0.0113	0.084	0.084
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0042	0.0121	0.0391
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0042	0.0121	0.0391
Echinococcus multilocularis	neuropeptide receptor	0.0113	0.084	0.084
Echinococcus granulosus	7TM GPCR rhodopsin	0.0113	0.084	0.084
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0042	0.0121	0.0391
Echinococcus multilocularis	serotonin receptor	0.0113	0.084	0.084
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0113	0.084	0.2724
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	g protein coupled receptor	0.0113	0.084	0.084
Echinococcus granulosus	g protein coupled receptor	0.0113	0.084	0.084
Echinococcus granulosus	xaa pro aminopeptidase	0.0042	0.0121	0.0121
Echinococcus granulosus	g-protein coupled receptor	0.0113	0.084	0.084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	DNA-binding protein	0.0042	0.0121	0.0391
Schistosoma mansoni	amine GPCR	0.0113	0.084	0.2724
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0113	0.084	0.2724
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0042	0.0121	0.0391
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0113	0.084	0.084
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	follicle stimulating hormone receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0121	0.0391
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0042	0.0121	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0121	0.0391
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0042	0.0121	0.0391
Schistosoma mansoni	neuropeptide receptor	0.0113	0.084	0.2724
Onchocerca volvulus		0.0113	0.084	0.2427
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0113	0.084	0.2724
Echinococcus multilocularis	FACT complex subunit SPT16	0.0042	0.0121	0.0121
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0042	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0113	0.084	0.2724
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0042	0.0121	0.0391
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0113	0.084	0.084
Loa Loa (eye worm)	G-protein coupled receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Trypanosoma brucei	methionine aminopeptidase, putative	0.0042	0.0121	0.0391
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0113	0.084	0.084
Echinococcus granulosus	Proliferation associated protein 2G4	0.0042	0.0121	0.0121
Onchocerca volvulus		0.0113	0.084	0.2427
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0113	0.084	0.084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Mycobacterium ulcerans	dipeptidase	0.0042	0.0121	0.5
Onchocerca volvulus		0.0113	0.084	0.2427
Schistosoma mansoni	opsin-like receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	neuropeptide F receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0336	0.3083	0.3083
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	xaa Pro dipeptidase	0.0042	0.0121	0.0121
Schistosoma mansoni	neuropeptide receptor	0.0113	0.084	0.2724
Onchocerca volvulus		0.0113	0.084	0.2427
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.2896	0.9393
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	neuropeptide receptor A26	0.0113	0.084	0.084
Schistosoma mansoni	neuropeptide F-like receptor	0.0113	0.084	0.2724
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0042	0.0121	0.0391
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0113	0.084	0.084
Echinococcus multilocularis	sex peptide receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0113	0.084	0.084
Brugia malayi	metallopeptidase family M24 containing protein	0.0042	0.0121	0.0391
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0042	0.0121	0.0391
Brugia malayi	Dopamine receptor	0.0113	0.084	0.2724
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0113	0.084	0.2724
Echinococcus granulosus	neuropeptide s receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	neuropeptide F receptor	0.0113	0.084	0.2724
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	tm gpcr rhodopsin	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	xaa Pro dipeptidase	0.0042	0.0121	0.0121
Echinococcus multilocularis	neuropeptides capa receptor	0.0113	0.084	0.084
Schistosoma mansoni	growth hormone secretagogue receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	xaa Pro dipeptidase	0.0042	0.0121	0.0121
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus granulosus	serotonin receptor	0.0113	0.084	0.084
Echinococcus multilocularis	xaa Pro dipeptidase	0.0042	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	MH2 domain containing protein	0.0251	0.2229	0.7228
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0113	0.084	0.2724
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Echinococcus granulosus	neuropeptide Y receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	transcription factor SMAD2	0.0251	0.2229	0.7228
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0736	0.2386
Echinococcus granulosus	G protein coupled receptor 139	0.0113	0.084	0.084
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	TYRA-2 protein	0.0113	0.084	0.2724
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0113	0.084	0.2724
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0113	0.084	0.2724
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0336	0.3083	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0042	0.0121	0.0391
Echinococcus granulosus	g protein coupled receptor	0.0113	0.084	0.084
Toxoplasma gondii	peptidase D, putative	0.0042	0.0121	0.0391
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0042	0.0121	0.0391
Schistosoma mansoni	hypothetical protein	0.0033	0.0028	0.0091
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0042	0.0121	0.0391
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0042	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0042	0.0121	0.0391
Brugia malayi	metallopeptidase family M24 containing protein	0.0042	0.0121	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Mycobacterium leprae	Probable cytoplasmic peptidase PepQ	0.0042	0.0121	0.5
Echinococcus granulosus	GPCR family 2	0.0033	0.0028	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0336	0.3083	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0042	0.0121	0.0121
Schistosoma mansoni	biogenic amine receptor	0.0113	0.084	0.2724
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0113	0.084	0.2427
Echinococcus granulosus	snurportin 1	0.0317	0.2896	0.2896
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0736	0.2386
Echinococcus granulosus	neuropeptide receptor	0.0113	0.084	0.084
Echinococcus multilocularis	snurportin 1	0.0317	0.2896	0.2896
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	fmrfamide receptor	0.0113	0.084	0.084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0113	0.084	0.084
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0042	0.0121	0.5
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0042	0.0121	0.0391
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0042	0.0121	0.0391
Treponema pallidum	methionine aminopeptidase (map)	0.0042	0.0121	0.5
Onchocerca volvulus		0.0113	0.084	0.2427
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0336	0.3083	1
Onchocerca volvulus		0.0113	0.084	0.2427
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0028	0.0028
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0336	0.3083	1
Brugia malayi	larval opioid receptor	0.0113	0.084	0.2724
Mycobacterium ulcerans	cytoplasmic peptidase PepQ	0.0042	0.0121	0.5
Mycobacterium tuberculosis	Probable cytoplasmic peptidase PepQ	0.0042	0.0121	0.5
Brugia malayi	Serotonin receptor	0.0113	0.084	0.2724
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0336	0.3083	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0042	0.0121	0.0391
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0113	0.084	0.2724
Schistosoma mansoni	hypothetical protein	0.0033	0.0028	0.0091
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0028	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0121	0.0391
Echinococcus granulosus	neuropeptide FF receptor 2	0.0113	0.084	0.084
Onchocerca volvulus		0.0113	0.084	0.2427
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0113	0.084	0.084
Echinococcus granulosus	orexin receptor type 2	0.0113	0.084	0.084
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0042	0.0121	0.0391
Schistosoma mansoni	peptidase	0.0042	0.0121	0.0391
Brugia malayi	initiation factor 2-associated protein.	0.0336	0.3083	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Brugia malayi	Dopamine receptor protein 1	0.0113	0.084	0.2724
Wolbachia endosymbiont of Brugia malayi	Xaa-Pro aminopeptidase	0.0042	0.0121	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.0028	0.0091
Schistosoma mansoni	opsin-like receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0028	0.0028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0113	0.084	0.084
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0028	0.0091
Loa Loa (eye worm)	G-protein coupled receptor	0.0113	0.084	0.2724
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0113	0.084	0.2724
Leishmania major	methionine aminopeptidase 2, putative	0.0336	0.3083	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Chlamydia trachomatis	methionine aminopeptidase	0.0042	0.0121	0.5
Schistosoma mansoni	amine GPCR	0.0113	0.084	0.2724
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0042	0.0121	0.0391
Echinococcus granulosus	g protein coupled receptor	0.0113	0.084	0.084
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0736	0.2386
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	Melatonin receptor type 1A	0.0113	0.084	0.2724
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0042	0.0121	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0113	0.084	0.2724
Brugia malayi	AKH receptor	0.0113	0.084	0.2724
Mycobacterium ulcerans	dipeptidase PepE	0.0042	0.0121	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0113	0.084	0.084
Onchocerca volvulus		0.0113	0.084	0.2427
Onchocerca volvulus		0.0113	0.084	0.2427
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0042	0.0121	0.0391
Chlamydia trachomatis	aminopeptidase P	0.0042	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0042	0.0121	0.0121
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0042	0.0121	0.0391
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus granulosus	biogenic amine 5HT receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Toxoplasma gondii	creatinase domain-containing protein	0.0042	0.0121	0.0391
Echinococcus granulosus	7tm_1 domain containing protein	0.0113	0.084	0.084
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0336	0.3083	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0113	0.084	0.084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus granulosus	fmrfamide receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0113	0.084	0.2724
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0113	0.084	0.084
Echinococcus multilocularis	G protein coupled receptor 139	0.0113	0.084	0.084
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0042	0.0121	0.0391
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0336	0.3083	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Echinococcus granulosus	dro:myosuppressin receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0042	0.0121	0.0391
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0042	0.0121	0.0391
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0336	0.3083	1
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Plasmodium falciparum	methionine aminopeptidase 2	0.0336	0.3083	1
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0042	0.0121	0.5
Brugia malayi	Serotonin receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0113	0.084	0.084
Brugia malayi	RNA, U transporter 1	0.0085	0.0552	0.179
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0042	0.0121	0.0121
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0113	0.084	0.2724
Echinococcus granulosus	neuropeptides capa receptor	0.0113	0.084	0.084
Schistosoma mansoni	hypothetical protein	0.007	0.0408	0.1324
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0336	0.3083	1
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0042	0.0121	0.0391
Echinococcus granulosus	tm gpcr rhodopsin	0.0113	0.084	0.084
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0113	0.084	0.2724
Brugia malayi	G-protein coupled receptor	0.0113	0.084	0.2724
Echinococcus granulosus	tm gpcr rhodopsin	0.0113	0.084	0.084
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Onchocerca volvulus		0.0113	0.084	0.2427
Schistosoma mansoni	neuropeptide f receptor 76f	0.0113	0.084	0.2724
Echinococcus granulosus	methionine aminopeptidase type I	0.0042	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.007	0.0408	0.1324
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0113	0.084	0.084
Brugia malayi	sulfakinin receptor protein	0.0113	0.084	0.2724
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0042	0.0121	0.0391
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0042	0.0121	0.0391
Toxoplasma gondii	methionine aminopeptidase	0.0042	0.0121	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0028	0.0091
Onchocerca volvulus		0.0113	0.084	0.2427
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	neuropeptides capa receptor	0.0113	0.084	0.084
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0336	0.3083	1
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0042	0.0121	0.0121
Echinococcus multilocularis	somatostatin receptor	0.0113	0.084	0.084
Echinococcus multilocularis	g-protein coupled receptor	0.0113	0.084	0.084
Schistosoma mansoni	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Entamoeba histolytica	methionine aminopeptidase, putative	0.0336	0.3083	1
Echinococcus granulosus	methionyl aminopeptidase 2	0.0336	0.3083	0.3083
Echinococcus granulosus	neuropeptide Y receptor	0.0113	0.084	0.084
Echinococcus granulosus	somatostatin receptor	0.0113	0.084	0.084
Schistosoma mansoni	hypothetical protein	0.0033	0.0028	0.0091
Echinococcus multilocularis	allatostatin A receptor	0.0113	0.084	0.084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	neuropeptide receptor A26	0.0113	0.084	0.084
Echinococcus granulosus	neuropeptides capa receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0042	0.0121	0.0391
Echinococcus granulosus	biogenic amine 5HT receptor	0.0113	0.084	0.084
Schistosoma mansoni	histamine h1 receptor	0.0113	0.084	0.2724
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0042	0.0121	0.0391
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0113	0.084	0.2724
Brugia malayi	Dopamine receptor protein 2	0.0113	0.084	0.2724
Brugia malayi	neuropeptide F receptor	0.0113	0.084	0.2724
Schistosoma mansoni	opsin-like receptor	0.0113	0.084	0.2724
Brugia malayi	neuropeptide F receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0336	0.3083	1
Mycobacterium ulcerans	aminopeptidase	0.0042	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Echinococcus multilocularis	serotonin receptor	0.0113	0.084	0.084
Schistosoma mansoni	biogenic amine receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	g protein coupled receptor	0.0113	0.084	0.084
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0113	0.084	0.084
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0042	0.0121	0.5
Schistosoma mansoni	neuropeptide receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0113	0.084	0.084
Brugia malayi	G protein-coupled receptor F59B2.13	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Treponema pallidum	aminopeptidase P	0.0042	0.0121	0.5
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Giardia lamblia	Methionine aminopeptidase	0.0336	0.3083	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Schistosoma mansoni	amine GPCR	0.0113	0.084	0.2724
Brugia malayi	G-protein coupled receptor	0.0113	0.084	0.2724
Mycobacterium tuberculosis	Dipeptidase PepE	0.0042	0.0121	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0113	0.084	0.084
Loa Loa (eye worm)	MH2 domain-containing protein	0.0251	0.2229	0.7228
Brugia malayi	metallopeptidase family M24 containing protein	0.0042	0.0121	0.0391
Onchocerca volvulus		0.0113	0.084	0.2427
Brugia malayi	GnHR receptor homolog	0.0113	0.084	0.2724
Plasmodium vivax	peptidase, putative	0.0042	0.0121	0.0391
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0042	0.0121	0.0391
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0113	0.084	0.2724
Brugia malayi	putative neuropeptide receptor NPR1	0.0113	0.084	0.2724
Schistosoma mansoni	amine GPCR	0.0113	0.084	0.2724
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0736	0.2386
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0113	0.084	0.084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0113	0.084	0.2724
Schistosoma mansoni	adenoreceptor	0.0113	0.084	0.2724
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	g protein coupled receptor	0.0113	0.084	0.084
Onchocerca volvulus		0.0113	0.084	0.2427
Echinococcus granulosus	neuropeptide receptor	0.0113	0.084	0.084
Schistosoma mansoni	hypothetical protein	0.0317	0.2896	0.9393
Echinococcus multilocularis	neuropeptide Y receptor	0.0113	0.084	0.084
Brugia malayi	RE15519p	0.0113	0.084	0.2724
Echinococcus granulosus	sex peptide receptor	0.0113	0.084	0.084
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0028	0.0028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0113	0.084	0.084
Echinococcus multilocularis	fmrfamide receptor	0.0113	0.084	0.084
Brugia malayi	hypothetical protein	0.0113	0.084	0.2724
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0028	0.0028
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0042	0.0121	0.0121
Schistosoma mansoni	biogenic amine receptor	0.0113	0.084	0.2724
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.1023	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0113	0.084	0.084
Brugia malayi	G protein-coupled receptor	0.0113	0.084	0.2724
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Onchocerca volvulus		0.0113	0.084	0.2427
Onchocerca volvulus		0.0113	0.084	0.2427
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0113	0.084	0.2724
Brugia malayi	putative neuropeptide receptor	0.0113	0.084	0.2724
Echinococcus granulosus	hypothetical protein	0.0113	0.084	0.084
Mycobacterium ulcerans	methionine aminopeptidase	0.0042	0.0121	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.084	0.2724
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0113	0.084	0.2724

Activities

Activity type	Activity value	Assay description	Source	Reference
Ratio (ADMET)	= 1.97	Ratio of drug level in tumor to skin of C3H mouse bearing RIF tumors after 24 hrs by IRS	ChEMBL.	17371002

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 416292