TDR Targets

Basic information

Technical information

TDR Targets ID: 416783
Name: 2,4-dibromo-6-(3,6-dibromo-2-hydroxyphenoxy)p henol
MW: 517.79 | Formula: C12H6Br4O3
H donors: 2 H acceptors: 2 LogP: 5.51 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: Brc1cc(Br)c(c(c1)Oc1c(Br)ccc(c1O)Br)O
InChi: 1S/C12H6Br4O3/c13-5-3-8(16)10(17)9(4-5)19-12-7(15)2-1-6(14)11(12)18/h1-4,17-18H
InChiKey: SFRUBLKYXLNPMS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,4-dibromo-6-(3,6-dibromo-2-hydroxy-phenoxy)phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0078	0.0081
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0078	0.0029
Leishmania major	acetyl-CoA synthetase, putative	0.0093	0.0618	0.0598
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0098	0.0668	0.0621
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0093	0.0618	0.0628
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0078	0.0031
Brugia malayi	AMP-binding enzyme family protein	0.0093	0.0618	0.0618
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0709	0.0709
Onchocerca volvulus	Fatty acid synthase homolog	0.0092	0.0611	0.3816
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0098	0.0668	0.0621
Mycobacterium leprae	Polyketide synthase Pks13	0.0077	0.0459	0.0452
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0093	0.0618	0.0674
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0078	0.0046
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0054	0.0247	0.0267
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0398	0.0398
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.0134
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0093	0.0618	0.0571
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0093	0.0618	0.0571
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0093	0.0618	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0618	0.0618
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0074	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0618	0.0618
Loa Loa (eye worm)	hypothetical protein	0.007	0.0398	0.0397
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0078	0.0046
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0051	0.0216	0.0167
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.005	0.0201	0.0216
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.099	0.9231	1
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0054	0.0247	0.0218
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0054	0.0247	0.0218
Echinococcus granulosus	muscleblind protein	0.0148	0.1145	0.1206
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0074	0.0041
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0051	0.0216	0.0233
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0098	0.0668	0.0621
Echinococcus multilocularis	muscleblind protein	0.0148	0.1145	0.1206
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0098	0.0668	0.0682
Loa Loa (eye worm)	oxidoreductase	0.0093	0.0618	0.0618
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.005	0.0201	0.0216
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.1071	1	1
Toxoplasma gondii	propionate-CoA ligase	0.0093	0.0618	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0093	0.0618	0.0633
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0043	0.0134	0.0093
Brugia malayi	hypothetical protein	0.0051	0.0216	0.0216
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1145	0.1145
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0093	0.0618	0.0628
Brugia malayi	AMP-binding enzyme family protein	0.0141	0.1077	0.1077
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0618	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0618	0.0618
Mycobacterium ulcerans	thioesterase	0.0043	0.0134	0.0085
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.1145	0.1206
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0709	0.0709
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.0977	0.9107	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0051	0.0216	0.0184
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0078	0.0078
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0093	0.0618	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0054	0.0247	0.0267
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0093	0.0618	0.059
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.016	0.0134
Brugia malayi	Muscleblind-like protein	0.0148	0.1145	0.1145
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0078	0.0081
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0036	0.0036
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0077	0.0459	0.05
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0041	0.012	0.0071
Toxoplasma gondii	type I fatty acid synthase, putative	0.0067	0.0371	0.5698
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0078	0.0078
Brugia malayi	hypothetical protein	0.0036	0.0074	0.0074
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0078	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0078	0.0078
Leishmania major	4-coumarate:coa ligase-like protein	0.0093	0.0618	0.0598
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0141	0.1077	0.1077
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0078	0.0081
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0074	0.0041
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0093	0.0618	0.0571
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.0134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.016	0.0134
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.0134
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0036	0.0036
Onchocerca volvulus		0.0182	0.1474	1
Leishmania major	fatty acid transporter protein-like protein	0.0977	0.9107	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0093	0.0618	0.0674
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0054	0.0247	0.0218
Mycobacterium ulcerans	polyketide synthase Pks13	0.0077	0.0459	0.0412
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0216	0.2549
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.008	0.0494	0.0538
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0078	0.0078
Mycobacterium ulcerans	thioesterase TesA	0.0043	0.0134	0.0085
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0078	0.0029
Schistosoma mansoni	FFA transport protein	0.099	0.9231	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0977	0.9107	1
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.1071	1	1
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0098	0.0668	0.0621
Echinococcus granulosus	long chain fatty acid transport protein 4	0.099	0.9231	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0093	0.0618	0.059
Onchocerca volvulus		0.0141	0.1077	0.716
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0098	0.0668	0.0729
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0042	0.0127	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0675	0.0674
Leishmania major	4-coumarate:coa ligase-like protein	0.0093	0.0618	0.0598
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0093	0.0618	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.016	0.0134
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0093	0.0618	0.0674
Trichomonas vaginalis	antibiotic synthetase, putative	0.0093	0.0618	1
Brugia malayi	beta-lactamase	0.0037	0.0078	0.0078
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0093	0.0618	0.0598
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0098	0.0668	0.0668
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.099	0.9231	1
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0097	0.0656	0.0656
Schistosoma mansoni	acetyl-CoA synthetase	0.0093	0.0618	0.0633
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0078	0.0081
Brugia malayi	beta-lactamase family protein	0.0037	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0078	0.0078
Leishmania major	hypothetical protein, conserved	0.0051	0.0216	0.0152
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Brugia malayi	beta-lactamase family protein	0.0037	0.0078	0.0078
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0078	0.0081
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0078	0.0046
Brugia malayi	AMP-binding enzyme family protein	0.0093	0.0618	0.0618
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0051	0.0216	0.0184
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0093	0.0618	1
Onchocerca volvulus		0.0093	0.0618	0.3869
Echinococcus granulosus	geminin	0.0505	0.457	0.4931
Brugia malayi	AMP-binding enzyme family protein	0.0093	0.0618	0.0618
Toxoplasma gondii	ABC1 family protein	0.0037	0.0078	0.0603
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0093	0.0618	0.9164
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0078	0.0078
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0054	0.0247	0.0198
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0093	0.0618	0.0674
Echinococcus multilocularis	geminin	0.0505	0.457	0.4931
Leishmania major	4-coumarate:coa ligase-like protein	0.0093	0.0618	0.0598
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0141	0.1077	0.1179
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0078	0.0078
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0093	0.0618	0.0628
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0098	0.0668	0.0729
Mycobacterium ulcerans	acyl-CoA synthetase	0.0098	0.0668	0.0621
Brugia malayi	AMP-binding enzyme family protein	0.0093	0.0618	0.0618
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0043	0.0134	0.0143
Mycobacterium ulcerans	polyketide synthase	0.0054	0.0247	0.0198
Schistosoma mansoni	hypothetical protein	0.0505	0.457	0.4931
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0078	0.0031
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0078	0.0081
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0093	0.0618	0.0674
Brugia malayi	AMP-binding enzyme family protein	0.0093	0.0618	0.0618
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0051	0.0216	0.0216
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.016	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0709	0.0709
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Leishmania major	acetyl-CoA synthetase, putative	0.0093	0.0618	0.0598
Schistosoma mansoni	hypothetical protein	0.0036	0.0074	0.0041
Schistosoma mansoni	hypothetical protein	0.007	0.0398	0.0393
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0093	0.0618	0.0618
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0098	0.0668	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0216	0.0216
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0051	0.0216	0.0167
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0077	0.0459	0.05
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0051	0.0216	0.0167
Schistosoma mansoni	hypothetical protein	0.0505	0.457	0.4931
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0054	0.0247	0.0198
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0093	0.0618	0.0674
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0078	0.0081
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0078	0.0029
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0093	0.0618	0.0633
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0093	0.0618	0.059
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.016	0.0159
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0051	0.0216	0.0167
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0093	0.0618	0.9164
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0216	0.2998
Onchocerca volvulus		0.0098	0.0668	0.4225
Entamoeba histolytica	acyl-coA synthetase, putative	0.0093	0.0618	0.9164
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0078	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0078	0.0078
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Trichomonas vaginalis	antibiotic synthetase, putative	0.0093	0.0618	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0093	0.0618	0.0571
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0078	0.0029
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0051	0.0216	0.0233
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0093	0.0618	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0216	0.2549
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0098	0.0668	0.0729
Brugia malayi	hypothetical protein	0.0033	0.0042	0.0042
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0093	0.0618	0.0571
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0093	0.0618	1
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0037	0.0078	0.0081
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0216	0.015
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0093	0.0618	0.0674
Toxoplasma gondii	type I fatty acid synthase, putative	0.0036	0.0075	0.054
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.099	0.9231	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1145	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0078	0.0078
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0093	0.0618	0.0674
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0041	0.012	0.0078
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0709	0.0709
Mycobacterium ulcerans	lipase LipD	0.0037	0.0078	0.0029
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0078	0.0081
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0093	0.0618	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0093	0.0618	0.0628
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0093	0.0618	0.0571
Loa Loa (eye worm)	fatty acid synthase	0.0051	0.021	0.021
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.1983	0.2174
Mycobacterium ulcerans	acyl-CoA synthetase	0.0093	0.0618	0.0571
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0041	0.012	0.0071
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0216	0.015
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0093	0.0618	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0618	0.0618
Mycobacterium ulcerans	polyketide synthase	0.0051	0.0216	0.0167
Onchocerca volvulus		0.0093	0.0618	0.3869
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0078	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0036	0.0036
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0051	0.0216	0.0233
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0054	0.0247	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0618	0.0618
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0098	0.0668	1
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0039	0.0097	0.0935
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.016	0.016
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0093	0.0618	0.059

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	> 15 ug ml-1	Cytotoxicity against rat NBT-T2 cells by MTT method	ChEMBL.	17311456
IZ (functional)	= 7 mm	Antibacterial activity against Bacillus subtilis at 0.1ug/disk after 24 hrs by agar-plate diffusion assay	ChEMBL.	17311456
IZ (functional)	= 13 mm	Antibacterial activity against Bacillus subtilis at 1 ug/disk after 24 hrs hrs by agar-plate diffusion assay	ChEMBL.	17311456
IZ (functional)	= 20 mm	Antibacterial activity against Bacillus subtilis at 5 ug/disk after 24 hrs hrs by agar-plate diffusion assay	ChEMBL.	17311456
IZ (functional)	= 20 mm	Antibacterial activity against Bacillus subtilis at 10 ug/disk after 24 hrs hrs by agar-plate diffusion assay	ChEMBL.	17311456

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL374039
PubChem: 16115952

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 416783