Detailed information for compound 416918

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.618 | Formula: C30H36N2O3
  • H donors: 1 H acceptors: 2 LogP: 5.21 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CCN(CC1)c1ccccc1C)COc1ccccc1C(=O)CCc1ccc(cc1)C
  • InChi: 1S/C30H36N2O3/c1-23-11-13-25(14-12-23)15-16-29(34)27-8-4-6-10-30(27)35-22-26(33)21-31-17-19-32(20-18-31)28-9-5-3-7-24(28)2/h3-14,26,33H,15-22H2,1-2H3
  • InChiKey: XZQUTKGLNDRNRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0028 0.0512 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0028 0.0512 0.1135
Echinococcus granulosus transferase 0.0028 0.0512 0.1135
Mycobacterium ulcerans hypothetical protein 0.0028 0.0512 0.5
Schistosoma mansoni hypothetical protein 0.0028 0.0512 0.0415
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0512 0.1135
Onchocerca volvulus 0.018 0.4507 0.4451
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Echinococcus multilocularis transferase 0.0028 0.0512 0.1135
Schistosoma mansoni hypothetical protein 0.0028 0.0512 0.0415
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0389 1 1
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0028 0.0512 0.1135
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Brugia malayi endonuclease G, mitochondrial precursor 0.0108 0.2614 0.2539
Trypanosoma brucei endonuclease G, putative 0.0108 0.2614 1
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0028 0.0512 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0004
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0101 0.0225
Schistosoma mansoni endonuclease related 0.0108 0.2614 0.2539
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Echinococcus multilocularis Endonuclease G 0.0108 0.2614 0.58
Brugia malayi AEL166Cp 0.0028 0.0512 0.0415
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0101 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0101 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0512 0.1135
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0028 0.0512 0.0415
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0101 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0108 0.2614 0.5
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0028 0.0512 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.018 0.4507 0.4451
Onchocerca volvulus 0.0389 1 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0101 0.0004
Onchocerca volvulus 0.018 0.4507 0.4451
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0101 0.0004
Loa Loa (eye worm) hypothetical protein 0.018 0.4507 0.4453
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0101 0.5
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0108 0.2614 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0512 0.0418
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0028 0.0512 1
Echinococcus granulosus Endonuclease G 0.0108 0.2614 0.58
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0101 0.0225
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0028 0.0512 0.0415
Loa Loa (eye worm) hypothetical protein 0.0028 0.0512 0.0418
Schistosoma mansoni hypothetical protein 0.0389 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0101 0.0225
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.018 0.4507 0.4451
Leishmania major endonuclease G, putative 0.0108 0.2614 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0098 0.0217
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.018 0.4507 0.4451
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0028 0.0512 0.0415
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0101 0.0225
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Echinococcus granulosus ectonucleotide 0.0152 0.3761 0.8346
Loa Loa (eye worm) hypothetical protein 0.018 0.4507 0.4453
Loa Loa (eye worm) hypothetical protein 0.0152 0.3761 0.37
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0028 0.0512 0.0415
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0101 0.0225
Trichomonas vaginalis taga, putative 0.0013 0.0101 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0101 0.0004
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0101 0.0225
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0101 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0101 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0108 0.2614 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0101 0.0225
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0101 1
Trichomonas vaginalis abcb9, putative 0.0013 0.0101 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.018 0.4507 0.4451
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0101 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0101 1
Trypanosoma brucei endonuclease G, putative 0.0108 0.2614 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0152 0.3761 0.8346
Schistosoma mansoni hypothetical protein 0.0028 0.0512 0.0415
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0101 0.0225
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0028 0.0512 0.0418
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0101 1
Brugia malayi hypothetical protein 0.0028 0.0512 0.0415
Mycobacterium leprae hypothetical protein 0.0028 0.0512 0.5
Trypanosoma cruzi endonuclease G, putative 0.0108 0.2614 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0101 0.5
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0101 0.0225
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0152 0.3761 0.8346
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0101 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0098 0.0217
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0101 0.0225
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0028 0.0512 0.0415
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0028 0.0512 0.0415
Leishmania major ethanolamine phosphotransferase, putative 0.0028 0.0512 0.1633
Loa Loa (eye worm) hypothetical protein 0.0028 0.0512 0.0418
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.018 0.4507 1
Echinococcus multilocularis ectonucleotide 0.0152 0.3761 0.8346
Trichomonas vaginalis abcb9, putative 0.0013 0.0101 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0101 0.0225
Trypanosoma brucei endonuclease G, putative 0.0108 0.2614 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0101 1
Schistosoma mansoni hypothetical protein 0.0028 0.0512 0.0415
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0028 0.0512 0.0415
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0101 1
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0108 0.2614 0.5
Brugia malayi hypothetical protein 0.0028 0.0512 0.0415
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0101 0.0225
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0101 0.0225
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.018 0.4507 0.4451
Loa Loa (eye worm) hypothetical protein 0.018 0.4507 0.4453
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0101 1
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0028 0.0512 0.1135
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0101 1
Trypanosoma cruzi endonuclease G, putative 0.0108 0.2614 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0101 0.0225
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0028 0.0512 0.1135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0512 0.0418
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0512 0.1135

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.018 uM Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay ChEMBL. 17352460
EC50 (binding) = 0.018 uM Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay ChEMBL. 17352460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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