Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | endoplasmin | 0.0079 | 0.655 | 0.655 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0079 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0061 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0099 | 1 | 1 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0099 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.655 | 0.655 |
Echinococcus multilocularis | heat shock protein 90 | 0.0079 | 0.655 | 0.655 |
Schistosoma mansoni | endoplasmin | 0.0099 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0079 | 0.655 | 0.655 |
Echinococcus multilocularis | heat shock protein | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0079 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0061 | 0.345 | 0.345 |
Brugia malayi | heat shock protein 90 | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0099 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0059 | 0.3058 | 0.3058 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0079 | 0.655 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0099 | 1 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0099 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0099 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.0099 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0079 | 0.655 | 0.655 |
Trichomonas vaginalis | heat shock protein, putative | 0.0061 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0099 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0099 | 1 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0041 | 0 | 0.5 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0099 | 1 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0079 | 0.655 | 0.5 |
Echinococcus granulosus | heat shock protein 90 | 0.0099 | 1 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0079 | 0.655 | 0.5 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0099 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 1 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0079 | 0.655 | 0.655 |
Echinococcus granulosus | heat shock protein 90 | 0.0079 | 0.655 | 0.655 |
Schistosoma mansoni | heat shock protein | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Treponema pallidum | heat shock protein 90 | 0.0079 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.655 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0099 | 1 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0099 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.0079 | 0.655 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0099 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0099 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0099 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 47 nM | Displacement of [3H]ZM241385 from adenosine A2A receptor in rat brain membrane | ChEMBL. | 15566292 |
Ki (binding) | > 1000 nM | Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane | ChEMBL. | 15566292 |
Ki (binding) | > 1000 nM | Displacement of [3h]DPCPX from adenosine A receptor in rat cerebral cortex membrane | ChEMBL. | 15566292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.