Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidine phosphorylase | 0.2616 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0118 | 0.2046 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0021 | 0.0021 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.008 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0244 | 0.2945 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0387 | 0.4664 |
Brugia malayi | bZIP transcription factor family protein | 0.0083 | 0.0253 | 0.2792 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0031 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0118 | 0.1102 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0387 | 0.4664 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0031 | 0.0014 |
Echinococcus granulosus | jun protein | 0.0083 | 0.0253 | 0.0253 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0031 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0576 | 0.0576 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.05 | 0.5883 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.009 | 0.1079 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0021 | 0.036 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.001 | 0.001 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0002 | 0.0028 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.083 | 0.083 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0576 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.0175 | 0.3033 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0014 | 0.0235 |
Onchocerca volvulus | 0.0065 | 0.0185 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0083 | 0.0253 | 0.0253 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.05 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0081 | 0.0972 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0021 | 0.0021 |
Schistosoma mansoni | jun-related protein | 0.0067 | 0.0194 | 0.3359 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0194 | 0.3359 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0014 | 0.0163 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0071 | 0.0071 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0083 | 0.0253 | 0.0253 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0161 | 0.0161 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.2616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.083 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0161 | 0.0161 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0071 | 0.0071 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0118 | 0.2046 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.05 | 0.6031 |
Echinococcus granulosus | geminin | 0.0167 | 0.0576 | 0.0576 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0203 | 0.2446 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.05 | 0.05 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.001 | 0.0166 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0738 | 0.2776 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.2616 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0031 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.083 | 0.083 |
Brugia malayi | hypothetical protein | 0.0065 | 0.0185 | 0.194 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0031 | 0.0372 |
Brugia malayi | hypothetical protein | 0.0232 | 0.083 | 1 |
Echinococcus multilocularis | jun protein | 0.0083 | 0.0253 | 0.0253 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0031 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.05 | 0.6031 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0031 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.0219 | 0.2368 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0576 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.05 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0097 | 0.1166 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0387 | 0.4466 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0031 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 500 uM | Displacement of [3H]BTX-B from voltage gated sodium channel in rat cerebral cortex synaptoneurosomes | ChEMBL. | 15588087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.