Detailed information for compound 423552

Basic information

Technical information
  • TDR Targets ID: 423552
  • Name: (2S)-2-[(2R)-5,8-dimethyl-7-propoxy-1,2,3,4-t etrahydronaphthalen-2-yl]-N-(pyridin-3-ylmeth yl)propanamide
  • MW: 380.523 | Formula: C24H32N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1cc(C)c2c(c1C)C[C@@H](CC2)[C@@H](C(=O)NCc1cccnc1)C
  • InChi: 1S/C24H32N2O2/c1-5-11-28-23-12-16(2)21-9-8-20(13-22(21)18(23)4)17(3)24(27)26-15-19-7-6-10-25-14-19/h6-7,10,12,14,17,20H,5,8-9,11,13,15H2,1-4H3,(H,26,27)/t17-,20+/m0/s1
  • InChiKey: MIJIJQNXQZCKIO-FXAWDEMLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[(2R)-5,8-dimethyl-7-propoxy-tetralin-2-yl]-N-(3-pyridylmethyl)propanamide
  • (2S)-2-[(2R)-5,8-dimethyl-7-propoxy-2-tetralinyl]-N-(3-pyridylmethyl)propanamide
  • (2S)-2-[(2R)-5,8-dimethyl-7-propoxy-tetralin-2-yl]-N-(3-pyridylmethyl)propionamide
  • ZINC03841688

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.167 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.167 0.167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.002 0.0642 0.0642
Onchocerca volvulus Netrin receptor homolog 0.0011 0.0144 0.0579
Onchocerca volvulus 0.0013 0.0251 0.1011
Brugia malayi hypothetical protein 0.0018 0.0519 0.0519
Schistosoma mansoni nuclear receptor 0.0018 0.0519 0.0703
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.167 0.2262
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0045 0.2135 0.8925
Schistosoma mansoni nuclear receptor 0.0018 0.0519 0.0703
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0066 0.3302 0.4363
Loa Loa (eye worm) DR-78 0.0018 0.0519 0.0519
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0251 0.034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0144 0.0144
Brugia malayi hypothetical protein 0.0018 0.0519 0.0519
Brugia malayi Cathepsin L-like precursor 0.0013 0.0251 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.167 0.2108
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.167 0.2108
Brugia malayi Cathepsin L-like precursor 0.0013 0.0251 0.0251
Plasmodium falciparum cysteine proteinase falcipain 3 0.0013 0.0251 0.5
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0251 0.1011
Leishmania major cathepsin L-like protease 0.005 0.2386 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0519 0.0703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Onchocerca volvulus 0.0018 0.0519 0.2089
Brugia malayi Cathepsin L-like precursor 0.0013 0.0251 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0519 0.0518
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.167 0.167
Onchocerca volvulus 0.0013 0.0251 0.1011
Echinococcus granulosus nuclear factor of activated T cells 5 0.0057 0.2833 0.4612
Onchocerca volvulus 0.0051 0.2483 1
Echinococcus multilocularis cysteine protease 0.0013 0.0251 0.0148
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0519 0.0845
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0251 0.0251
Echinococcus multilocularis jun protein 0.0066 0.3302 0.4363
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.167 0.6723
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0519 0.0703
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0013 0.0251 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.001 0.005 0.5
Leishmania major cysteine peptidase A (CPA) 0.0013 0.0251 0.0863
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.7381 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.167 0.2718
Loa Loa (eye worm) fibroinase 0.0013 0.0251 0.0251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.167 0.167
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0251 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0013 0.0251 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0251 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0519 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.167 0.167
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0519 0.0845
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Schistosoma mansoni hypothetical protein 0.0098 0.5203 0.7049
Leishmania major cathepsin L-like protease 0.0013 0.0251 0.0863
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0519 0.0518
Brugia malayi Protein kinase domain containing protein 0.0011 0.0144 0.0144
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0519 0.0519
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0519 0.0519
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0642 0.0642
Brugia malayi conserved hypotetical protein 0.0018 0.0519 0.0519
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.167 0.2262
Onchocerca volvulus 0.0037 0.167 0.6723
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.2386 1
Brugia malayi bZIP transcription factor family protein 0.0066 0.3302 0.3302
Echinococcus granulosus Ankyrin 0.0011 0.0149 0.0243
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.167 0.2108
Plasmodium vivax vivapain-2 0.0013 0.0251 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0642 0.0689
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0519 0.0518
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.002 0.0642 0.0642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Brugia malayi nuclear receptor RXR 0.002 0.0642 0.0642
Echinococcus granulosus cathepsin l1 0.0013 0.0251 0.0409
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0642 0.0642
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0181 1 1
Onchocerca volvulus 0.0013 0.0251 0.1011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.167 0.167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.167 0.2108
Schistosoma mansoni ankyrin 23/unc44 0.0011 0.0144 0.0195
Schistosoma mansoni hypothetical protein 0.0053 0.2588 0.3506
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0519 0.0519
Brugia malayi nuclear hormone receptor 0.0018 0.0519 0.0519
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.167 0.2262
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0066 0.3302 0.5375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.167 0.2262
Schistosoma mansoni zinc finger protein 0.0018 0.0519 0.0703
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.167 0.2262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Loa Loa (eye worm) cysteine protease 0.0013 0.0251 0.0251
Brugia malayi nuclear receptor NHR-67 0.0018 0.0519 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Brugia malayi hypothetical protein 0.002 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0098 0.5203 0.6991
Schistosoma mansoni thyroid hormone receptor 0.0136 0.7381 1
Onchocerca volvulus Cathepsin F homolog 0.0013 0.0251 0.1011
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.167 0.2718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Echinococcus granulosus FTZ F1 alpha 0.0037 0.167 0.2718
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Echinococcus multilocularis cathepsin L cysteine protease 0.0013 0.0251 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0519 0.0845
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.167 0.167
Leishmania major cathepsin L-like protease 0.005 0.2386 1
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0519 0.0845
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0519 0.0845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Schistosoma mansoni hypothetical protein 0.0011 0.0144 0.0195
Echinococcus granulosus jun protein 0.0066 0.3302 0.5375
Brugia malayi Cathepsin L-like precursor 0.0013 0.0251 0.0251
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0011 0.0144 0.0144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.167 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.167 0.167
Brugia malayi nuclear receptor NHR-88 0.0018 0.0519 0.0519
Schistosoma mansoni netrin receptor unc5 0.0011 0.0144 0.0195
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0251 0.0251
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.167 0.167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0642 0.087
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.2386 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0149 0.0149
Leishmania major cathepsin L-like protease 0.0013 0.0251 0.0863
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0251 1
Brugia malayi hypothetical protein 0.0051 0.2483 0.2483
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0013 0.0251 0.0251
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0519 0.0519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0519 0.0703
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0251 0.034
Brugia malayi steroid hormone receptor 0.0037 0.167 0.167
Schistosoma mansoni coup transcription factor 0.0037 0.167 0.2262
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.2386 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Echinococcus multilocularis cysteine protease 0.0013 0.0251 0.0148
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.167 0.2108
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0011 0.0144 0.0234
Schistosoma mansoni nuclear hormone receptor 0.0037 0.167 0.2262
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.167 0.167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.167 0.167
Brugia malayi hypothetical protein 0.002 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Leishmania major cathepsin L-like protease 0.005 0.2386 1
Onchocerca volvulus 0.0013 0.0251 0.1011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.167 0.2718
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.167 0.2108
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Echinococcus granulosus death domain containing protein 0.0011 0.0144 0.0234
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.167 0.2718
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0011 0.0144 0.000000052255
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.167 0.2108
Brugia malayi nuclear hormone receptor 0.0037 0.167 0.167
Brugia malayi Cytochrome P450 family protein 0.001 0.005 0.005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.167 0.6723
Loa Loa (eye worm) hypothetical protein 0.002 0.0642 0.0642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.005 0.005
Onchocerca volvulus 0.0013 0.0251 0.1011
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0519 0.0518
Toxoplasma gondii cathepsin CPL 0.0013 0.0251 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.167 0.167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.167 0.167
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0642 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0642 0.0642
Leishmania major cathepsin L-like protease 0.0013 0.0251 0.0863
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.167 0.2718
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.1766 0.7348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0251 0.0148
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0098 0.5203 0.8471
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0519 0.0518
Brugia malayi Death domain containing protein 0.0011 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.167 0.2262
Brugia malayi ecdysone receptor 0.0018 0.0519 0.0519
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0095 0.4992 0.6698
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) CYP4Cod1 0.001 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Echinococcus multilocularis Ankyrin 0.0011 0.0149 0.0008
Brugia malayi Cytochrome P450 family protein 0.001 0.005 0.005
Onchocerca volvulus 0.0013 0.0251 0.1011
Echinococcus granulosus netrin receptor unc 5 0.0011 0.0144 0.0234
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0642 0.087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0519 0.0703
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0013 0.0251 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.005 0.005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0519 0.2089
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0519 0.0519
Schistosoma mansoni jun-related protein 0.0053 0.2588 0.3506
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.167 0.167
Brugia malayi ecdysteroid receptor 0.0037 0.167 0.167
Leishmania major cathepsin L-like protease 0.0013 0.0251 0.0863
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.167 0.2108
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0519 0.0845
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.167 0.6723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Onchocerca volvulus Cathepsin L homolog 0.0013 0.0251 0.1011
Onchocerca volvulus 0.0013 0.0251 0.1011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0114 0.6142 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.167 0.167
Brugia malayi Cathepsin L-like precursor 0.0013 0.0251 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Entamoeba histolytica cysteine protease, putative 0.0013 0.0251 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.167 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0013 0.0251 0.0409
Loa Loa (eye worm) ctsf protein 0.0013 0.0251 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.167 0.2718
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.167 0.167
Brugia malayi Cathepsin L-like precursor 0.0013 0.0251 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0519 0.0703
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0519 0.0519
Onchocerca volvulus 0.0018 0.0519 0.2089
Brugia malayi nuclear receptor RXR 0.0018 0.0519 0.0519
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0011 0.0149 0.0202
Schistosoma mansoni retinoic acid receptor RXR 0.0114 0.6142 0.8321
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0057 0.2833 0.3715
Brugia malayi nuclear receptor NHR-88 0.0037 0.167 0.167
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Echinococcus granulosus cathepsin L cysteine proteinase 0.0013 0.0251 0.0409
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.2386 1
Brugia malayi tailless protein 0.0018 0.0519 0.0519
Plasmodium vivax vivapain-2 0.0013 0.0251 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.167 0.167
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0251 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.3197 0.3197
Schistosoma mansoni thyroid hormone receptor 0.0136 0.7381 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.167 0.2718
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.167 0.2262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.167 0.167
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0251 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0519 0.0519
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0519 0.2089
Brugia malayi Uncoordinated protein 44 0.0011 0.0144 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0251 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0144 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.2386 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0642 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.167 0.167
Leishmania major cathepsin L-like protease 0.0013 0.0251 0.0863

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 Inhibition of 5-LO activity in ionophore A23187 and arachidonic-stimulated human intact PMNL ChEMBL. 17461565

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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