TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 595.79 | Formula: C33H58NO6P
H donors: 4 H acceptors: 5 LogP: 8.79 Rotable bonds: 24
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCCCCCC(=O)N[C@@H](C(CP(=O)(O)O)O)Cc1ccc(cc1)OCC1CCCCC1
InChi: 1S/C33H58NO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-33(36)34-31(32(35)27-41(37,38)39)25-28-21-23-30(24-22-28)40-26-29-18-15-14-16-19-29/h21-24,29,31-32,35H,2-20,25-27H2,1H3,(H,34,36)(H2,37,38,39)/t31-,32?/m1/s1
InChiKey: BLVJISWLSIPUIP-XGDNGBMYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2014	0.4903
Schistosoma mansoni	tyrosinase precursor	0.0092	0.1008	0.2454
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0047	0.0425	0.0702
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0025	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0086	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Echinococcus multilocularis	jun protein	0.0082	0.0879	0.0879
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0104	0.1035
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.003	0.021	0.021
Brugia malayi	Steroid receptor seven-up type 2	0.0047	0.0425	0.0702
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0047	0.0425	0.0702
Onchocerca volvulus		0.0016	0.003	0.0296
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0104	0.0104
Loa Loa (eye worm)	DR-78	0.0022	0.0104	0.0173
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0021	0.0086	0.0142
Echinococcus granulosus	Ankyrin	0.0014	0.0002	0.0004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0047	0.0425	0.1034
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.003	0.021	0.0347
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Onchocerca volvulus		0.0022	0.0104	0.1035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Toxoplasma gondii	protease inhibitor PI2	0.0021	0.0086	0.0222
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0047	0.0425	0.0702
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.05	0.05
Loa Loa (eye worm)	MBCTL1	0.0053	0.05	0.0827
Loa Loa (eye worm)	hypothetical protein	0.008	0.085	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Brugia malayi	bZIP transcription factor family protein	0.0082	0.0879	0.1453
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0082	0.0879	0.2139
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0229
Echinococcus multilocularis	expressed protein	0.0021	0.0086	0.0086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0139	0.0229
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0047	0.0425	0.1034
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.000000010526	0.000000025621
Schistosoma mansoni	follistatin	0.0021	0.0086	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Loa Loa (eye worm)	tyrosinase 1	0.0092	0.1008	0.1667
Schistosoma mansoni	organic anion transporter	0.003	0.021	0.0511
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0021	0.0086	0.0142
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.003	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.0049
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0624	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0104	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Brugia malayi	hypothetical protein	0.0022	0.0104	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0003
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0452	0.7098
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Onchocerca volvulus		0.0016	0.003	0.0296
Brugia malayi	steroid hormone receptor	0.0047	0.0425	0.0702
Loa Loa (eye worm)	steroid hormone receptor	0.0047	0.0425	0.0702
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0104	0.0173
Brugia malayi	Protein kinase domain containing protein	0.0014	0.000000010526	0.000000017399
Onchocerca volvulus	Bile acid receptor homolog	0.0047	0.0425	0.4212
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0104	0.0173
Brugia malayi	ShTK domain containing protein	0.0092	0.1008	0.1667
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.003	0.0073
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0104	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0047	0.0425	0.0702
Brugia malayi	mbt repeat family protein	0.0046	0.0417	0.069
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0047	0.0425	0.0702
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0025	0.0139	0.0338
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.1408	0.3427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0047	0.0425	0.1034
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0104	0.0254
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0047	0.0425	0.0702
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0417	0.1016
Loa Loa (eye worm)	agrin synaptic family protein	0.0021	0.0086	0.0142
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0021	0.0086	0.0142
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0104	0.0254
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0417	0.0417
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0104	0.0254
Brugia malayi	sodium-independent organic anion transporter family protein	0.003	0.021	0.0347
Brugia malayi	hypothetical protein	0.003	0.021	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Schistosoma mansoni	coup transcription factor	0.0047	0.0425	0.1034
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0481	0.605	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.05	0.05
Loa Loa (eye worm)	STAT protein	0.0481	0.605	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.1008	0.1667
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.003	0.0073
Onchocerca volvulus		0.0092	0.1008	1
Brugia malayi	follicle stimulating hormone receptor	0.0228	0.2774	0.4584
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0021	0.0086	0.0222
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0047	0.0425	0.1034
Onchocerca volvulus	Putative organic anion transporter	0.003	0.021	0.2082
Echinococcus multilocularis	FTZ F1 alpha	0.0047	0.0425	0.0425
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0624	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Echinococcus multilocularis	agrin	0.0021	0.0086	0.0086
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0104	0.0254
Schistosoma mansoni	jun-related protein	0.0067	0.068	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0047	0.0425	0.0702
Plasmodium vivax	vivapain-2	0.0016	0.003	0.5
Schistosoma mansoni	nuclear receptor	0.0022	0.0104	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0417	0.069
Schistosoma mansoni	retinoic acid receptor RXR	0.0143	0.167	0.4064
Onchocerca volvulus		0.0046	0.0417	0.4139
Leishmania major	cathepsin L-like protease	0.0062	0.0624	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0047	0.0425	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0104	0.0173
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0554	0.8824
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Brugia malayi	sodium-independent organic anion transporter family protein	0.003	0.021	0.0347
Onchocerca volvulus	Protein ultraspiracle homolog	0.0047	0.0425	0.4212
Entamoeba histolytica	cysteine protease, putative	0.0016	0.003	0.5
Plasmodium vivax	vivapain-2	0.0016	0.003	0.5
Brugia malayi	hypothetical protein	0.0022	0.0104	0.0173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0047	0.0425	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0086	0.0142
Brugia malayi	Nuclear hormone receptor-like 1	0.0047	0.0425	0.0702
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.05	0.1218
Onchocerca volvulus		0.0022	0.0104	0.1035
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.003	0.0049
Onchocerca volvulus	Putative organic anion transporter	0.003	0.021	0.2082
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0104	0.0173
Onchocerca volvulus		0.0064	0.0651	0.6458
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0182	0.2179	0.5303
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0047	0.0425	0.1034
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0118	0.1349	0.1349
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0104	0.0173
Echinococcus granulosus	FTZ F1 alpha	0.0047	0.0425	0.1034
Onchocerca volvulus		0.0016	0.003	0.0296
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0417	0.1016
Onchocerca volvulus		0.0092	0.1008	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0104	0.0254
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0047	0.0425	0.0425
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.003	0.5
Leishmania major	cathepsin L-like protease	0.0062	0.0624	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0002	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.003	0.5
Schistosoma mansoni	hypothetical protein	0.0331	0.4109	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.05	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0104	0.0173
Schistosoma mansoni	nuclear hormone receptor	0.0047	0.0425	0.1034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Onchocerca volvulus		0.0016	0.003	0.0296
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0143	0.167	0.4064
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Onchocerca volvulus		0.003	0.021	0.2082
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0047	0.0425	0.1034
Brugia malayi	tailless protein	0.0022	0.0104	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0053	0.05	0.0827
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Brugia malayi	hypothetical protein	0.0064	0.0651	0.1076
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.003	0.0073
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0228	0.2774	0.4584
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0047	0.0425	0.0702
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0047	0.0425	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0086	0.0142
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.003	0.021	0.021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.003	0.0296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0104	0.0254
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0624	1
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.021	0.254	1
Onchocerca volvulus		0.003	0.021	0.2082
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0104	0.1035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Schistosoma mansoni	organic anion transporter	0.003	0.021	0.0511
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0104	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0229
Brugia malayi	conserved hypotetical protein	0.0022	0.0104	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0047	0.0425	0.0702
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0104	0.0254
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Brugia malayi	Common central domain of tyrosinase family protein	0.0092	0.1008	0.1667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0047	0.0425	0.0702
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0417	0.0417
Toxoplasma gondii	transporter, major facilitator family protein	0.003	0.021	0.0717
Schistosoma mansoni	hypothetical protein	0.0281	0.3459	0.842
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0086	0.0142
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0047	0.0425	0.1034
Onchocerca volvulus		0.0092	0.1008	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.05	0.0827
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Brugia malayi	prostaglandin transporter	0.003	0.021	0.0347
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0104	0.0173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.003	0.0073
Onchocerca volvulus		0.0016	0.003	0.0296
Brugia malayi	ecdysone receptor	0.0022	0.0104	0.0173
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0047	0.0425	0.0425
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.1408	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0229
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0229
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0139	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0047	0.0425	0.0702
Brugia malayi	sodium-independent organic anion transporter family protein	0.003	0.021	0.0347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0047	0.0425	0.0702
Onchocerca volvulus		0.0016	0.003	0.0296
Echinococcus multilocularis	cysteine protease	0.0016	0.003	0.003
Loa Loa (eye worm)	fibroinase	0.0016	0.003	0.0049
Brugia malayi	nuclear hormone receptor	0.0022	0.0104	0.0173
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.1008	0.1667
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0047	0.0425	0.0702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1008	0.1667
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0104	0.0254
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0049
Schistosoma mansoni	zinc finger protein	0.0022	0.0104	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Echinococcus granulosus	cathepsin l1	0.0016	0.003	0.0073
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0047	0.0425	0.1034
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0104	0.0173
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0417	0.4139
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Onchocerca volvulus		0.0021	0.0086	0.085
Brugia malayi	Uncoordinated protein 44	0.0014	0.000000010526	0.000000017399
Onchocerca volvulus		0.0092	0.1008	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0049
Brugia malayi	hypothetical protein	0.003	0.021	0.0347
Echinococcus granulosus	ecdysone induced protein 78C	0.0047	0.0425	0.1034
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0021	0.0086	0.0222
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0748	0.1822
Onchocerca volvulus	Putative organic anion transporter	0.003	0.021	0.2082
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0624	1
Echinococcus granulosus	Solute carrier organic anion transporter family	0.003	0.021	0.0511
Schistosoma mansoni	RAR-like nuclear receptor	0.0047	0.0425	0.1034
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0417	0.069
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0047	0.0425	0.0425
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.003	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0047	0.0425	0.0702
Schistosoma mansoni	hypothetical protein	0.0331	0.4109	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0049
Echinococcus granulosus	geminin	0.0331	0.4109	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1008	0.1667
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0748	0.0748
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0021	0.0086	0.0222
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.1008	0.1667
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0047	0.0425	0.0425
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0425	0.0702
Onchocerca volvulus		0.003	0.021	0.2082
Echinococcus multilocularis	ecdysone induced protein 78C	0.0047	0.0425	0.0425
Schistosoma mansoni	hypothetical protein	0.0123	0.1408	0.3427
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0049
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2014	0.4903
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0047	0.0425	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Echinococcus multilocularis	Ankyrin	0.0014	0.0002	0.0002
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0104	0.0173
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0021	0.0086	0.0142
Brugia malayi	nuclear receptor RXR	0.0025	0.0139	0.0229
Brugia malayi	nuclear hormone receptor	0.0047	0.0425	0.0702
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0092	0.1008	0.1667
Brugia malayi	nuclear receptor RXR	0.0022	0.0104	0.0173
Brugia malayi	nuclear receptor NHR-88	0.0047	0.0425	0.0702
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0417	0.1016
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0047	0.0425	0.1034
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.000000010526	0.000000025621
Echinococcus multilocularis	cysteine protease	0.0016	0.003	0.003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0624	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0104	0.0104
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0047	0.0425	0.1034
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0182	0.2179	0.2179
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0104	0.0254
Loa Loa (eye worm)	ShTK domain-containing protein	0.0092	0.1008	0.1667
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0021	0.0086	0.0222
Brugia malayi	ecdysteroid receptor	0.0047	0.0425	0.0702
Echinococcus granulosus	jun protein	0.0082	0.0879	0.2139
Leishmania major	cathepsin L-like protease	0.0062	0.0624	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0047	0.0425	0.0702
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.003	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.003	0.5
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0092	0.1008	0.1667
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0049
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0417	0.1016
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.000000010526	0.000000010526
Echinococcus granulosus	agrin	0.0021	0.0086	0.0209
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0104	0.0104
Onchocerca volvulus		0.003	0.021	0.2082
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0047	0.0425	0.0702
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.003	0.0049
Echinococcus multilocularis	thyroid hormone receptor alpha	0.017	0.2014	0.2014
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0047	0.0425	0.4212
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0047	0.0425	0.1034
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0047	0.0425	0.0702
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0104	0.0104
Brugia malayi	secreted modular calcium-binding protein 1	0.0021	0.0086	0.0142
Brugia malayi	mbt repeat family protein	0.0046	0.0417	0.069
Trypanosoma cruzi	MFS transporter, putative	0.003	0.021	0.3029
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.003	0.021	0.0347
Onchocerca volvulus		0.0047	0.0425	0.4212
Onchocerca volvulus		0.003	0.021	0.2082
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0025	0.0139	0.0229
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.003	0.021	0.0511
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0021	0.0086	0.0142
Echinococcus multilocularis	follistatin	0.0021	0.0086	0.0086
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0139	0.0338
Brugia malayi	SPARC precursor	0.0021	0.0086	0.0142
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.003	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0139	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0104	0.0173
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.05	0.1218
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0047	0.0425	0.1034
Brugia malayi	hypothetical protein	0.0025	0.0139	0.0229
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.003	0.0296
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0047	0.0425	0.0702
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.003	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0082	0.0879	0.0879
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0047	0.0425	0.0702
Schistosoma mansoni	nuclear receptor	0.0022	0.0104	0.0254
Onchocerca volvulus		0.0016	0.003	0.0296
Echinococcus granulosus	follistatin	0.0021	0.0086	0.0209
Schistosoma mansoni	hypothetical protein	0.0067	0.068	0.1656
Loa Loa (eye worm)	cysteine protease	0.0016	0.003	0.0049
Schistosoma mansoni	agrin	0.0021	0.0086	0.0209
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0025	0.0139	0.0338
Echinococcus multilocularis	geminin	0.0331	0.4109	0.4109
Brugia malayi	Death domain containing protein	0.0014	0.000000010526	0.000000017399
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	0.5
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0417	0.1016
Loa Loa (eye worm)	ctsf protein	0.0016	0.003	0.0049
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.003	0.003
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0047	0.0425	0.0425
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.003	0.003
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0104	0.0173
Schistosoma mansoni	tyrosinase precursor	0.0092	0.1008	0.2454

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 67 %	Inhibition of human recombinant ATX at 100 uM after 16 hrs	ChEMBL.	17257836
Inhibition (binding)	= 67 %	Inhibition of human recombinant ATX at 100 uM after 16 hrs	ChEMBL.	17257836
Inhibition (binding)	= 80 %	Inhibition of human recombinant ATX at 10 uM after 16 hrs	ChEMBL.	17257836
Inhibition (binding)	= 80 %	Inhibition of human recombinant ATX at 10 uM after 16 hrs	ChEMBL.	17257836
Inhibition (binding)	= 84 %	Inhibition of human recombinant ATX at 1 uM after 16 hrs	ChEMBL.	17257836
Inhibition (binding)	= 84 %	Inhibition of human recombinant ATX at 1 uM after 16 hrs	ChEMBL.	17257836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230060

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 429369