TDR Targets

Basic information

Technical information

TDR Targets ID: 43015
Name: 4-(3-trimethylsilylpropylamino)benzoic acid
MW: 251.397 | Formula: C13H21NO2Si
H donors: 2 H acceptors: 2 LogP: 3.98 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)c1ccc(cc1)NCCC[Si](C)(C)C
InChi: 1S/C13H21NO2Si/c1-17(2,3)10-4-9-14-12-7-5-11(6-8-12)13(15)16/h5-8,14H,4,9-10H2,1-3H3,(H,15,16)
InChiKey: RZBZSKCOVIGVSY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Toxoplasma gondii	hypothetical protein	0.0069	0.0906	0.5
Echinococcus multilocularis	GA binding protein alpha chain	0.0076	0.1098	0.1098
Echinococcus granulosus	GA binding protein alpha chain	0.0076	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0122	0.2347	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0329	0.7939	0.7939
Loa Loa (eye worm)	hypothetical protein	0.0405	1	1
Schistosoma mansoni	zinc finger protein	0.0155	0.3241	0.3186
Loa Loa (eye worm)	nuclear hormone receptor	0.0155	0.3241	0.3161
Entamoeba histolytica	hypothetical protein	0.0038	0.0081	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0155	0.3241	0.3241
Schistosoma mansoni	lipoxygenase	0.0059	0.0634	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0329	0.7939	0.7922
Echinococcus multilocularis	nuclear receptor nhr 48	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.016	0.3368	0.3289
Brugia malayi	steroid hormone receptor	0.0329	0.7939	0.7939
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0405	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0329	0.7939	0.7939
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0329	0.7939	0.7939
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.0798
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0087	0.1396	0.5947
Brugia malayi	Nuclear hormone receptor-like 1	0.0329	0.7939	0.7939
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0841	0.0841
Brugia malayi	hypothetical protein	0.0155	0.3241	0.3241
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0174	0.3744	0.3744
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0329	0.7939	0.7915
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0069	0.0906	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2308	0.2217
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0405	1	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0069	0.0906	0.0906
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0117	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0155	0.3241	0.3161
Brugia malayi	hypothetical protein	0.0069	0.0906	0.0906
Brugia malayi	Ets-domain containing protein	0.0076	0.1098	0.1098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0329	0.7939	0.7939
Brugia malayi	photoreceptor-specific nuclear receptor	0.0329	0.7939	0.7939
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0841	0.0841
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0069	0.0906	0.0832
Brugia malayi	Ets-domain containing protein	0.0076	0.1098	0.1098
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0172	0.3685	0.3685
Brugia malayi	hypothetical protein	0.0174	0.3744	0.3744
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0329	0.7939	0.7922
Onchocerca volvulus		0.0069	0.0906	0.0906
Plasmodium vivax	hypothetical protein, conserved	0.0069	0.0906	0.5
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Schistosoma mansoni	hypothetical protein	0.0139	0.2816	0.2757
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0329	0.7939	0.7939
Brugia malayi	Cytochrome P450 family protein	0.0081	0.1236	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Entamoeba histolytica	hypothetical protein	0.0038	0.0081	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0329	0.7939	0.7922
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.0906
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0329	0.7939	0.7922
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3744	0.367
Loa Loa (eye worm)	hypothetical protein	0.0167	0.3557	0.3481
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3744	0.367
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0329	0.7939	0.7915
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0069	0.0906	0.0832
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0059	0.0634	0.0634
Brugia malayi	nuclear hormone receptor	0.0329	0.7939	0.7939
Brugia malayi	hypoxia-induced factor 1	0.0147	0.3033	0.3033
Schistosoma mansoni	nuclear receptor	0.0155	0.3241	0.3186
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0329	0.7939	0.7939
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0329	0.7939	0.7939
Schistosoma mansoni	nuclear receptor	0.0155	0.3241	0.3186
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0147	0.3033	0.295
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0055	0.0524	0.2231
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0841	0.0733
Schistosoma mansoni	nuclear receptor nhr-48	0.0155	0.3241	0.3186
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0343	0.0343
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0329	0.7939	0.7939
Brugia malayi	nuclear receptor RXR	0.0174	0.3744	0.3744
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0343	0.0264
Brugia malayi	tailless protein	0.0155	0.3241	0.3241
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0076	0.1098	0.0993
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0329	0.7939	0.7939
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0329	0.7939	0.7922
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0155	0.3241	0.3241
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0069	0.0906	0.0832
Brugia malayi	Cytochrome P450 family protein	0.004	0.0117	0.0117
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0155	0.3241	0.3241
Onchocerca volvulus	Protein ultraspiracle homolog	0.0329	0.7939	0.7939
Loa Loa (eye worm)	hypothetical protein	0.0405	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0405	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Onchocerca volvulus	Bile acid receptor homolog	0.0329	0.7939	0.7939
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.5
Onchocerca volvulus		0.0135	0.2689	0.2689
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0069	0.0906	0.0832
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0329	0.7939	0.7939
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Brugia malayi	Nuclear hormone receptor E75	0.0155	0.3241	0.3241
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0174	0.3744	0.367
Schistosoma mansoni	thyroid hormone receptor	0.0329	0.7939	0.7922
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0059	0.0634	0.0634
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0069	0.0906	0.0906
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0087	0.1396	1
Echinococcus granulosus	serotonin transporter	0.0405	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.0906
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.0906
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0329	0.7939	0.7939
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0329	0.7939	0.7939
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Brugia malayi	nuclear hormone receptor family member odr-7	0.0155	0.3241	0.3241
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0329	0.7939	0.7915
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0329	0.7939	0.7922
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0062	0.0729	0.3105
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0155	0.3241	0.3241
Brugia malayi	bZIP transcription factor family protein	0.0172	0.3685	0.3685
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0069	0.0906	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0329	0.7939	0.7939
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0069	0.0906	0.0906
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0329	0.7939	0.7939
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0335	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0155	0.3241	0.3186
Schistosoma mansoni	nuclear hormone receptor	0.0155	0.3241	0.3186
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0184	0.4029	0.5
Echinococcus multilocularis	jun protein	0.0172	0.3685	0.3685
Treponema pallidum	sodium- and chloride- dependent transporter	0.0405	1	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0841	0.0766
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0343	0.0264
Brugia malayi	ecdysone receptor	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Schistosoma mansoni	thyroid hormone receptor	0.0329	0.7939	0.7922
Schistosoma mansoni	jun-related protein	0.0139	0.2816	0.2757
Brugia malayi	Nuclear hormone receptor-like 1	0.0174	0.3744	0.3744
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0841	0.0733
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0155	0.3241	0.3241
Entamoeba histolytica	hypothetical protein	0.0038	0.0081	0.5
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0081	0.0081
Schistosoma mansoni	sodium/chloride dependent transporter	0.0069	0.0906	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Brugia malayi	nuclear hormone receptor	0.0155	0.3241	0.3241
Onchocerca volvulus		0.0405	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0155	0.3241	0.3241
Echinococcus multilocularis	serotonin transporter	0.0405	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0329	0.7939	0.7939
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0329	0.7939	0.7915
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0343	0.0343
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0841	0.0766
Onchocerca volvulus		0.0329	0.7939	0.7939
Loa Loa (eye worm)	DR-78	0.0155	0.3241	0.3161
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0841	0.0766
Entamoeba histolytica	hypothetical protein	0.0038	0.0081	0.5
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3744	0.367
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0343	0.0343
Trichomonas vaginalis	aldehyde oxidase, putative	0.0184	0.4029	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0117	0.5
Echinococcus granulosus	jun protein	0.0172	0.3685	0.3685
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0155	0.3241	0.3241
Onchocerca volvulus		0.0069	0.0906	0.0906
Brugia malayi	Cytochrome P450 family protein	0.004	0.0117	0.0117
Schistosoma mansoni	coup transcription factor	0.0329	0.7939	0.7922
Echinococcus granulosus	nuclear receptor nhr 48	0.0155	0.3241	0.3241
Brugia malayi	Nuclear hormone receptor-like 1	0.0174	0.3744	0.3744
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0329	0.7939	0.7915
Loa Loa (eye worm)	cytochrome P450 family protein	0.0081	0.1236	0.1132
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0155	0.3241	0.3241
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0184	0.4029	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0329	0.7939	0.7939
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0329	0.7939	0.7939
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0069	0.0906	0.0832
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0069	0.0906	0.0906
Brugia malayi	hypothetical protein	0.016	0.3368	0.3368
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0174	0.3744	0.3693
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0841	0.0766
Brugia malayi	Nuclear hormone receptor E75	0.0155	0.3241	0.3241
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0329	0.7939	0.7939
Plasmodium falciparum	amino acid transporter, putative	0.0069	0.0906	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0343	0.0264
Loa Loa (eye worm)	steroid hormone receptor	0.0329	0.7939	0.7915
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0329	0.7939	0.7939
Brugia malayi	Fli-1 protein	0.023	0.5275	0.5275
Echinococcus multilocularis	ecdysone induced protein 78C	0.0329	0.7939	0.7939
Plasmodium vivax	amine transporter, putative	0.0069	0.0906	0.5
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Brugia malayi	nuclear receptor NHR-88	0.0155	0.3241	0.3241
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0329	0.7939	0.7922
Brugia malayi	orphan nuclear receptor NR2E1	0.0155	0.3241	0.3241
Brugia malayi	hypothetical protein	0.0285	0.675	0.675
Brugia malayi	nuclear receptor NHR-88	0.0329	0.7939	0.7939
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0329	0.7939	0.7939
Schistosoma mansoni	single-minded	0.0048	0.0335	0.0256
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0841	0.0733
Brugia malayi	nuclear receptor NHR-67	0.0155	0.3241	0.3241
Echinococcus granulosus	ecdysone induced protein 78C	0.0329	0.7939	0.7939
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0069	0.0906	0.0906
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0155	0.3241	0.3161
Brugia malayi	conserved hypotetical protein	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0329	0.7939	0.7939
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0174	0.3744	0.3693
Brugia malayi	TAR-binding protein	0.0066	0.0841	0.0841
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0329	0.7939	0.7939
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Brugia malayi	hypothetical protein	0.0038	0.0081	0.0081
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0069	0.0906	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0329	0.7939	0.7922
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0329	0.7939	0.7915
Brugia malayi	Steroid receptor seven-up type 2	0.0329	0.7939	0.7939
Loa Loa (eye worm)	serotonin transporter b	0.0405	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0329	0.7939	0.7939
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0069	0.0906	0.0906
Brugia malayi	hypothetical protein	0.0155	0.3241	0.3241
Brugia malayi	RNA binding protein	0.0066	0.0841	0.0841
Schistosoma mansoni	sodium/chloride dependent transporter	0.0069	0.0906	0.0832
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0343	0.0343
Echinococcus granulosus	thyroid hormone receptor alpha	0.0155	0.3241	0.3241
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0343	0.0343
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0841	0.0841
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0172	0.3685	0.3685
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0329	0.7939	0.7939
Brugia malayi	ecdysteroid receptor	0.0329	0.7939	0.7939
Onchocerca volvulus		0.0069	0.0906	0.0906
Trypanosoma brucei	cytochrome P450, putative	0.004	0.0117	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0329	0.7939	0.7939
Loa Loa (eye worm)	norepinephrine transporter	0.0405	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0174	0.3744	0.3744
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0062	0.0729	0.3105
Brugia malayi	hypothetical protein	0.0135	0.2689	0.2689
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0329	0.7939	0.7939
Echinococcus granulosus	sodium and chloride dependent glycine	0.0069	0.0906	0.0906
Schistosoma mansoni	RAR-like nuclear receptor	0.0329	0.7939	0.7922
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.5
Echinococcus granulosus	sodium and chloride dependent glycine	0.0069	0.0906	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0329	0.7939	0.7939
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0329	0.7939	0.7939
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0069	0.0906	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3744	0.367
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3744	0.367
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0069	0.0906	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Schistosoma mansoni	gabp alpha	0.0076	0.1098	0.1025
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0841	0.0766
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0069	0.0906	0.0832
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0329	0.7939	0.7939
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7939	0.7915
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0069	0.0906	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0155	0.3241	0.3186
Brugia malayi	nuclear receptor RXR	0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3241	0.3161
Onchocerca volvulus		0.0155	0.3241	0.3241
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0906	0.0798
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.004	0.0117	0.0499
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0343	0.0228
Toxoplasma gondii	hypothetical protein	0.0069	0.0906	0.5
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0069	0.0906	0.0906
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0329	0.7939	0.7922
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0155	0.3241	0.3241
Brugia malayi	PAS domain containing protein	0.0048	0.0335	0.0335
Schistosoma mansoni	nuclear hormone receptor	0.0155	0.3241	0.3186
Schistosoma mansoni	ets-related	0.023	0.5275	0.5237
Loa Loa (eye worm)	fli-1 protein	0.023	0.5275	0.5219
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0155	0.3241	0.3241
Echinococcus granulosus	FTZ F1 alpha	0.0329	0.7939	0.7939
Onchocerca volvulus		0.0155	0.3241	0.3241
Leishmania major	cytochrome p450-like protein	0.004	0.0117	0.5
Brugia malayi	hypothetical protein	0.0174	0.3744	0.3744
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0087	0.1396	0.5947
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0329	0.7939	0.7915
Plasmodium falciparum	transporter, putative	0.0069	0.0906	0.5
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0069	0.0906	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0801	0.0692
Schistosoma mansoni	sodium/chloride dependent transporter	0.0405	1	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0069	0.0906	0.0832

Activities

Activity type	Activity value	Assay description	Source	Reference
Diet (functional)	< 47 %	In vivo Triglyceride lowering activity at a dose of 0.10 % of the diet	ChEMBL.	6604818
Diet (functional)	< 58 %	In vivo Triglyceride lowering activity at dose as 0.03 % of the diet	ChEMBL.	6604818
Diet (functional)	< 69 %	In vivo Triglyceride lowering activity at dose as 0.01 % of the diet	ChEMBL.	6604818
Diet (functional)	< 82 %	In vivo sterol lowering activity at dose of 0.10 % of the diet	ChEMBL.	6604818
Diet (functional)	= 90 %	In vivo sterol lowering activity, dosed as 0.03 % of the diet	ChEMBL.	6604818
Diet (functional)	= 100 %	In vivo Sterol lowering activity at dose as 0.01% of the diet	ChEMBL.	6604818
Inhibition (binding)	= 12 %	In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase	ChEMBL.	6604818
Inhibition (binding)	= 12 %	In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase	ChEMBL.	6604818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL286745
PubChem: 13884865

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 43015