Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0232 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0232 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0074 | 0.0974 | 0.0974 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.2231 | 0.2231 |
Brugia malayi | Tubulin beta chain | 0.0074 | 0.0974 | 0.0974 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.013 | 0.4188 | 0.4188 |
Trypanosoma brucei | beta tubulin | 0.013 | 0.4188 | 0.4188 |
Giardia lamblia | Alpha-tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.2231 | 0.2231 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0186 | 0.7363 | 0.6605 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0232 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Entamoeba histolytica | tubulin family protein | 0.0232 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.2231 | 0.2231 |
Echinococcus multilocularis | hypothetical protein | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0232 | 1 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0112 | 0.3175 | 0.3175 |
Echinococcus granulosus | tubulin epsilon chain | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Giardia lamblia | Alpha-tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.2231 | 0.2231 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0186 | 0.7363 | 0.7363 |
Brugia malayi | Tubulin alpha-2 chain | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.013 | 0.4149 | 0.4149 |
Trypanosoma brucei | beta tubulin | 0.0232 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.013 | 0.4188 | 0.4188 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.4149 | 0.4149 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0232 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0057 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | tubulin subunit beta | 0.0232 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.2231 | 0.2231 |
Trypanosoma brucei | epsilon tubulin | 0.013 | 0.4188 | 0.4188 |
Entamoeba histolytica | tubulin family protein | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha | 0.013 | 0.4188 | 0.4188 |
Plasmodium falciparum | tubulin beta chain | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | tubulin subunit beta | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0112 | 0.3175 | 0.3175 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | tubulin beta chain | 0.0232 | 1 | 1 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.7363 | 0.7363 |
Plasmodium vivax | tubulin gamma chain, putative | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.013 | 0.4188 | 0.4188 |
Giardia lamblia | Beta tubulin | 0.0232 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0232 | 1 | 1 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0057 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0074 | 0.0974 | 0.0974 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0074 | 0.0974 | 0.0974 |
Trypanosoma cruzi | beta tubulin, putative | 0.0232 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Brugia malayi | Tubulin alpha-2 chain | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0232 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.2231 | 0.2231 |
Mycobacterium leprae | cell division protein FtsZ | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit epsilon | 0.013 | 0.4188 | 0.4188 |
Treponema pallidum | cell division protein FtsZ | 0.0057 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0074 | 0.0974 | 0.0974 |
Trypanosoma brucei | tubulin gamma chain | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0232 | 1 | 1 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0096 | 0.2231 | 1 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0074 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | alpha-tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0232 | 1 | 1 |
Leishmania major | gamma-tubulin | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.013 | 0.4149 | 0.4149 |
Schistosoma mansoni | tubulin subunit beta | 0.0232 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0232 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.0096 | 0.2231 | 0.2231 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0232 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.2231 | 0.2231 |
Schistosoma mansoni | tubulin subunit beta | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.7363 | 0.7363 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.013 | 0.4149 | 0.4149 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0232 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.013 | 0.4188 | 0.4188 |
Plasmodium falciparum | alpha tubulin 1 | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.013 | 0.4149 | 0.4149 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.2231 | 0.2231 |
Trypanosoma cruzi | tubulin gamma chain | 0.013 | 0.4188 | 0.4188 |
Plasmodium falciparum | tubulin gamma chain | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.7363 | 0.7363 |
Giardia lamblia | Beta tubulin | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.013 | 0.4188 | 0.4188 |
Echinococcus granulosus | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | beta tubulin | 0.0232 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.2231 | 0.2231 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0186 | 0.7363 | 0.6605 |
Trypanosoma brucei | beta tubulin | 0.0232 | 1 | 1 |
Brugia malayi | Tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | beta tubulin | 0.0232 | 1 | 1 |
Brugia malayi | alpha-tubulin | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | tubulin subunit gamma | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0074 | 0.0974 | 0.0974 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | tubulin alpha | 0.013 | 0.4188 | 0.4188 |
Echinococcus granulosus | tubulin subunit TubB | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Brugia malayi | tubulin alpha chain - mouse | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma brucei | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma brucei | alpha tubulin, putative | 0.0074 | 0.0974 | 0.0974 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | BEN-1 protein | 0.0232 | 1 | 1 |
Echinococcus multilocularis | tubulin epsilon chain | 0.013 | 0.4188 | 0.4188 |
Entamoeba histolytica | tubulin gamma chain | 0.013 | 0.4188 | 0.2518 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.7363 | 0.7363 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | tubulin gamma chain | 0.013 | 0.4188 | 0.4188 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Giardia lamblia | Gamma tubulin | 0.013 | 0.4188 | 0.4188 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0186 | 0.7363 | 0.7363 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3175 | 0.3175 |
Brugia malayi | Tubulin gamma chain | 0.013 | 0.4188 | 0.4188 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.013 | 0.4188 | 0.4188 |
Trichomonas vaginalis | tubulin, putative | 0.0074 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0232 | 1 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0186 | 0.7363 | 0.7363 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Leishmania major | epsilon tubulin, putative | 0.013 | 0.4188 | 0.4188 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0232 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.2231 | 0.2231 |
Brugia malayi | tubulin alpha-2 chain | 0.0186 | 0.7363 | 0.7363 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.7363 | 0.7363 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.013 | 0.4188 | 0.4188 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Schistosoma mansoni | tubulin subunit beta | 0.0232 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0186 | 0.7363 | 0.7363 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.013 | 0.4188 | 0.4188 |
Echinococcus multilocularis | beta tubulin | 0.0232 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0232 | 1 | 1 |
Leishmania major | beta tubulin | 0.0232 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0186 | 0.7363 | 0.7363 |
Trypanosoma brucei | epsilon tubulin | 0.013 | 0.4188 | 0.4188 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0186 | 0.7363 | 0.7363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Antimycobacterial activity against Mycobacterium bovis BCG at 100 ug/mL by microplate Alamar blue assay | ChEMBL. | 17602465 |
Inhibition (functional) | = 0 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 100 ug/mL by microplate Alamar blue assay | ChEMBL. | 17602465 |
Inhibition (functional) | = 0 % | Antimycobacterial activity against Mycobacterium avium ATCC 25291 at 100 ug/mL by microplate Alamar blue assay | ChEMBL. | 17602465 |
Inhibition (functional) | = 0 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 100 ug/mL by microplate Alamar blue assay | ChEMBL. | 17602465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.