Detailed information for compound 43210

Basic information

Technical information
  • TDR Targets ID: 43210
  • Name: 1-(1-phenylcyclohexyl)piperidine chloride
  • MW: 278.84 | Formula: C17H25ClN-
  • H donors: 0 H acceptors: 0 LogP: 5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)(N1CCCCC1)c1ccccc1.[Cl-]
  • InChi: 1S/C17H25N.ClH/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18;/h1,4-5,10-11H,2-3,6-9,12-15H2;1H/p-1
  • InChiKey: BUAJNGPDPGKBGV-UHFFFAOYSA-M  

Network

Hover on a compound node to display the structore

Synonyms

  • Phencyclidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0923 0.5765 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0038 0.0169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0172 0.0298
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.004
Echinococcus multilocularis protein patched 0.0042 0.0154 0.0152
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0019 0.0008 0.0014
Plasmodium vivax plasmepsin IV, putative 0.0019 0.0008 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0505 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.047 0.0468
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0331 0.1994 0.3456
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0097 0.0505 0.0872
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0061
Brugia malayi hypothetical protein 0.0019 0.0008 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0038 0.07
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0045 0.0042
Entamoeba histolytica prolyl oligopeptidase family protein 0.0097 0.0505 0.995
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0154 0.0264
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0038 0.0169
Brugia malayi CHE-14 protein 0.0042 0.0154 0.0264
Echinococcus granulosus expressed conserved protein 0.0091 0.047 0.0811
Plasmodium falciparum plasmepsin IX 0.0019 0.0008 0.0156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0264 0.0454
Loa Loa (eye worm) hypothetical protein 0.0097 0.0507 0.088
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0019 0.0008 0.0111
Schistosoma mansoni memapsin-2 (A01 family) 0.0466 0.2858 0.4955
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0045 0.0074
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0264 0.0513
Trypanosoma brucei oligopeptidase b 0.0367 0.2226 0.3858
Leishmania major oligopeptidase b 0.0367 0.2226 0.3858
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0045 0.0074
Echinococcus multilocularis protein dispatched 1 0.0048 0.0192 0.0189
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0773 0.0771
Schistosoma mansoni patched 1 0.0042 0.0154 0.0264
Loa Loa (eye worm) hypothetical protein 0.0097 0.0505 0.0876
Toxoplasma gondii aspartyl protease ASP1 0.0019 0.0008 0.001
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0507 0.0877
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0264 0.1187
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0826 0.5149 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0264 0.0454
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0154 0.0268
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0038 0.0061
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0061
Echinococcus granulosus Dipeptidyl peptidase 9 0.0097 0.0505 0.0872
Brugia malayi prolyl oligopeptidase family protein 0.0097 0.0505 0.0872
Plasmodium falciparum plasmepsin X 0.0019 0.0008 0.0156
Toxoplasma gondii aspartyl protease ASP3 0.0019 0.0008 0.001
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0097 0.0505 0.0872
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0264 0.1187
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0097 0.0505 0.0872
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0172 0.0169
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0065
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0097 0.0505 0.0503
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0045 0.0845
Brugia malayi aspartic protease BmAsp-1, identical 0.0019 0.0008 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.0505 0.0872
Giardia lamblia Alanyl dipeptidyl peptidase 0.0097 0.0505 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0038 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0014
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0154 0.0264
Plasmodium falciparum plasmepsin I 0.0019 0.0008 0.0156
Brugia malayi Angiotensin-converting enzyme family protein 0.0161 0.0917 0.1587
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0002 0.0004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0154 0.0268
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0097 0.0505 0.0872
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0038 0.0169
Trypanosoma cruzi oligopeptidase b 0.0367 0.2226 0.3858
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0097 0.0505 0.0872
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0038 0.0061
Trypanosoma brucei prolyl oligopeptidase, putative 0.0367 0.2226 0.3858
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0172 0.0169
Loa Loa (eye worm) aspartyl protease 6 0.0019 0.0008 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0172 0.0294
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0923 0.5765 1
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0507 0.0877
Brugia malayi prolyl oligopeptidase family protein 0.0097 0.0505 0.0872
Plasmodium vivax plasmepsin V, putative 0.0019 0.0008 0.0156
Echinococcus granulosus acylamino acid releasing enzyme 0.0097 0.0505 0.0872
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0038 0.07
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0773 0.1337
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0097 0.0505 0.0503
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0038 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0172 0.0294
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0038 0.07
Brugia malayi prolyl oligopeptidase family protein 0.0097 0.0505 0.0872
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Entamoeba histolytica prolyl oligopeptidase family protein 0.0097 0.0505 0.995
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0097 0.0505 0.0872
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0172 0.0294
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0264 0.0454
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0019 0.0008 0.001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0038 0.0061
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0097 0.0505 0.0872
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0507 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0367 0.2226 0.3858
Plasmodium falciparum plasmepsin III 0.0019 0.0008 0.0156
Plasmodium vivax hypothetical protein, conserved 0.0097 0.0505 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0367 0.2226 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0038 0.0073
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0097 0.0505 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0097 0.0505 0.0872
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0507 0.0505
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0038 0.0073
Loa Loa (eye worm) prolyl oligopeptidase 0.0097 0.0505 0.0876
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0367 0.2226 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0367 0.2226 0.3858
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0097 0.0505 0.995
Brugia malayi hypothetical protein 0.0019 0.0008 0.001
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0923 0.5765 1
Plasmodium falciparum plasmepsin VI 0.0019 0.0008 0.0156
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0019 0.0008 0.0014
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0038 0.0169
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0038 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0045 0.0074
Echinococcus granulosus prolyl endopeptidase 0.0923 0.5765 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0097 0.0505 0.0863
Entamoeba histolytica prolyl oligopeptidase family protein 0.0097 0.0505 0.995
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0097 0.0505 0.0872
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0045 0.0074
Toxoplasma gondii hypothetical protein 0.0097 0.0505 0.0872
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Onchocerca volvulus 0.0023 0.0038 0.0052
Echinococcus multilocularis acylamino acid releasing enzyme 0.0097 0.0505 0.0503
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.0505 0.0872
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0045 0.0074
Plasmodium falciparum plasmepsin VII 0.0019 0.0008 0.0156
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0121 0.0656 0.1135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0172 0.0294
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0045 0.0074
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0019 0.0008 0.001
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0161 0.0917 0.159
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0154 0.0152
Plasmodium falciparum peptidase, putative 0.0097 0.0505 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0154 0.3022
Loa Loa (eye worm) hypothetical protein 0.0051 0.0214 0.0371
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0097 0.0505 0.0872
Plasmodium vivax aspartyl proteinase, putative 0.0019 0.0008 0.0156
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0019 0.0008 0.001
Giardia lamblia Alanyl dipeptidyl peptidase 0.0097 0.0505 1
Plasmodium vivax aspartyl protease, putative 0.0019 0.0008 0.0156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0172 0.0294
Entamoeba histolytica hypothetical protein, conserved 0.0097 0.0505 0.995
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0097 0.0505 0.0872
Loa Loa (eye worm) hypothetical protein 0.0923 0.5765 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0097 0.0505 0.995
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0264 0.1187
Echinococcus multilocularis prolyl endopeptidase 0.0923 0.5765 0.5764
Mycobacterium tuberculosis Probable peptidase 0.0367 0.2226 0.4323
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0517 0.0893
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0264 0.0262
Loa Loa (eye worm) hypothetical protein 0.0097 0.0505 0.0876
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0097 0.0505 1
Brugia malayi Pepsin A precursor 0.0019 0.0008 0.001
Plasmodium falciparum plasmepsin II 0.0019 0.0008 0.0156
Loa Loa (eye worm) hypothetical protein 0.014 0.078 0.1353
Loa Loa (eye worm) hypothetical protein 0.007 0.0334 0.0579
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0023 0.0036
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0247
Trypanosoma brucei prolyl endopeptidase 0.0923 0.5765 1
Brugia malayi prolyl oligopeptidase family protein 0.0923 0.5765 1
Toxoplasma gondii prolyl endopeptidase 0.0923 0.5765 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0097 0.0505 0.0876
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0019 0.0008 0.0006
Plasmodium falciparum plasmepsin IV 0.0019 0.0008 0.0156
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0367 0.2226 0.3858
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0247
Mycobacterium ulcerans hypothetical protein 0.0023 0.0038 0.0169
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0172 0.0294
Onchocerca volvulus Prolyl endopeptidase homolog 0.0923 0.5765 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0264 0.0454
Plasmodium vivax aspartyl protease, putative 0.0019 0.0008 0.0156
Plasmodium vivax aspartyl proteinase, putative 0.0019 0.0008 0.0156
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0097 0.0505 0.0872
Brugia malayi Eukaryotic aspartyl protease family protein 0.0019 0.0008 0.001
Toxoplasma gondii aspartyl protease 0.0019 0.0008 0.001
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0367 0.2226 0.3858
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.004 0.0145 0.0247
Brugia malayi aspartic protease BmAsp-2, identical 0.0019 0.0008 0.001
Entamoeba histolytica hypothetical protein 0.0025 0.0045 0.0841
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0008 0.001
Plasmodium vivax aspartyl protease, putative 0.0019 0.0008 0.0156
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0097 0.0505 0.0872
Brugia malayi prolyl oligopeptidase family protein 0.0097 0.0505 0.0872
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0038 0.0169
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0264 0.0454
Plasmodium falciparum plasmepsin V 0.0019 0.0008 0.0156
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0367 0.2226 0.4323
Plasmodium falciparum plasmepsin VIII, putative 0.0019 0.0008 0.0156
Trypanosoma cruzi oligopeptidase b 0.0367 0.2226 0.3858
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0065
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0261 0.1548 0.2685
Trypanosoma cruzi prolyl endopeptidase 0.0923 0.5765 1

Activities

Activity type Activity value Assay description Source Reference
Damage score (functional) = 1.06 Tested for its effect on hippocampal neuronal damage in gerbils activity ChEMBL. 2170646
Damage score (functional) < 1.14 Tested for its effect on Hypoxia induced neuronal damage ChEMBL. 2170646
IC50 (functional) = 270 nM Inhibitory concentration of the compound for [3H]-PCP binding to rat brain homogenate relative to PCP ChEMBL. 7310819
Relative potency (functional) = 1 Ability of the compound to displace 7.0 nM [3H]-PCP binding to rat brain homogenate relative to PCP (IC50= 270 nM) ChEMBL. 7310819
Relative potency (functional) = 1 Relative potency of the compound was determined in the rat discriminative stimulus assay, expressed as mg of PCP (= 1.0 mg of compound) ChEMBL. 7310819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.