TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 581.454 | Formula: C28H27BrF2N6O
H donors: 1 H acceptors: 3 LogP: 4.43 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Brc1ccc(cc1)/C=N/c1ccc(cc1)N1CCN(CC1)CC(c1ccc(cc1F)F)(Cn1ncnc1)O
InChi: 1S/C28H27BrF2N6O/c29-22-3-1-21(2-4-22)16-33-24-6-8-25(9-7-24)36-13-11-35(12-14-36)17-28(38,18-37-20-32-19-34-37)26-10-5-23(30)15-27(26)31/h1-10,15-16,19-20,38H,11-14,17-18H2/b33-16+
InChiKey: DCPRHRQPOYXLOS-MHDJOFBISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	coup transcription factor	0.001	0.0124	0.0124
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0021	0.039	0.0919
Toxoplasma gondii	exonuclease III APE	0.0022	0.0407	0.2808
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0124	0.0521
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.208	0.208
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0013	0.0056
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0124	0.0124
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0124	0.0124
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0148	0.3413	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0124	0.0521
Brugia malayi	nuclear hormone receptor	0.001	0.0124	0.0521
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0407	0.097
Mycobacterium ulcerans	hypothetical protein	0.0148	0.3413	1
Mycobacterium tuberculosis	Probable aminotransferase	0.0148	0.3413	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0407	1
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.039	0.039
Schistosoma mansoni	hypothetical protein	0.0033	0.0676	0.0676
Schistosoma mansoni	cpg binding protein	0.0032	0.064	0.064
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0124	0.0521
Echinococcus granulosus	Aminotransferase class III	0.0021	0.039	0.039
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0084	0.0355
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0407	1
Echinococcus multilocularis	dnaJ subfamily B	0.0424	1	1
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0021	0.039	0.0919
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0021	0.039	0.0919
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0084	0.0355
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0124	0.0521
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0109	0.0109
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0109	0.0109
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0124	0.0124
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0013	0.0013
Loa Loa (eye worm)	CYP4Cod1	0.0008	0.0084	0.0355
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0124	0.0521
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0148	0.3413	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0124	0.0521
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0676	0.0676
Schistosoma mansoni	hypothetical protein	0.0071	0.159	0.159
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.208	0.8754
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0021	0.039	0.5
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0407	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0676	0.0676
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0013	0.0013
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0124	0.0124
Echinococcus multilocularis	Aminotransferase class III	0.0021	0.039	0.039
Echinococcus multilocularis		0.0008	0.0084	0.0084
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0109	0.0459
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0676	0.2846
Schistosoma mansoni	hypothetical protein	0.0033	0.0676	0.0676
Echinococcus granulosus	cpg binding protein	0.0032	0.064	0.064
Onchocerca volvulus		0.001	0.0124	0.2064
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0124	0.0124
Brugia malayi	Cytochrome P450 family protein	0.0052	0.1135	0.4776
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.2376	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0124	0.2064
Brugia malayi	cytochrome P450	0.0008	0.0084	0.0355
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.208	0.208
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.2376	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0407	0.1714
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0407	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0013	0.0056
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1395	0.1395
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0124	0.0124
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0124	0.0521
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0124	0.0124
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0124	0.0124
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0124	0.0521
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0021	0.039	0.0919
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0066	0.0066
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0124	0.0124
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0021	0.039	0.0919
Echinococcus multilocularis	cpg binding protein	0.0032	0.064	0.064
Schistosoma mansoni	hypothetical protein	0.0033	0.0676	0.0676
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0021	0.039	0.0919
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0013	0.0056
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0124	0.0124
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.1135	0.4776
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0676	0.2846
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0599	0.2522
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0124	0.0124
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0066	0.0066
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0407	0.1714
Brugia malayi	nuclear receptor RXR	0.0005	0.0013	0.0056
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.039	0.039
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0407	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0124	0.0521
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0021	0.039	0.0919
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0407	0.0407
Schistosoma mansoni	hypothetical protein	0.0424	1	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0013	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0013	0.0056
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0124	0.0124
Brugia malayi	steroid hormone receptor	0.001	0.0124	0.0521
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0148	0.3413	1
Onchocerca volvulus		0.003	0.0599	1
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0124	0.0124
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0124	0.0124
Schistosoma mansoni	cpg binding protein	0.0032	0.064	0.064
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0124	0.0124
Schistosoma mansoni	hypothetical protein	0.0008	0.0084	0.0084
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0021	0.039	0.0919
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.159	0.6689
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0124	0.0124
Schistosoma mansoni	ap endonuclease	0.0022	0.0407	0.0407
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0106	0.0447
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0407	0.097
Brugia malayi	Cytochrome P450 family protein	0.0008	0.0084	0.0355
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0407	0.0407
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0124	0.0124
Echinococcus granulosus	GPCR family 2	0.0033	0.0676	0.0676
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0013	0.0056
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.208	0.8754
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0407	1
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0124	0.2064
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0124	0.0124
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0124	0.0124
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1234	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0013	0.0013
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0407	0.5
Schistosoma mansoni	cytochrome P450	0.0008	0.0084	0.0084
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0407	0.1062
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.208	0.208
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0124	0.0521
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0148	0.3413	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2376	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0066	0.0066
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0124	0.0521
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0021	0.039	0.039
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0021	0.039	0.1643
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0407	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0676	0.0676
Echinococcus granulosus	ornithine aminotransferase	0.0021	0.039	0.039
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0676	0.2846
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0124	0.0521
Loa Loa (eye worm)	cytochrome P450	0.0008	0.0084	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0013	0.0056
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.208	0.208
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0124	0.0521
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0124	0.0521
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0124	0.0521
Echinococcus granulosus	cytochrome P450 2K1	0.0008	0.0084	0.0084
Brugia malayi	ecdysteroid receptor	0.001	0.0124	0.0521
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0124	0.0521
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Brugia malayi	hypothetical protein	0.0005	0.0013	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0013	0.0056
Brugia malayi	CXXC zinc finger family protein	0.003	0.0599	0.2522
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0066	0.0066
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0407	0.1062
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0124	0.2064
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0676	0.2846
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0124	0.0124
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0021	0.039	0.0919
Brugia malayi	hypothetical protein	0.0005	0.0013	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0124	0.0521
Loa Loa (eye worm)	cytochrome P450 family protein	0.0008	0.0084	0.0355
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0124	0.0521
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.2376	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0124	0.0521
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.039	0.0919
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0124	0.0521
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0124	0.0521
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Loa Loa (eye worm)	cytochrome P450 family protein	0.0008	0.0084	0.0355
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0013	0.0013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.208	0.208
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0124	0.0124
Mycobacterium ulcerans	L-lysine aminotransferase	0.0021	0.039	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0071	0.159	0.6689
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0407	1
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.039	0.0919
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0124	0.0521
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0676	0.0676
Loa Loa (eye worm)	hypothetical protein	0.001	0.0124	0.0521
Brugia malayi	nuclear receptor NHR-88	0.001	0.0124	0.0521
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0124	0.0521
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0021	0.039	0.2661
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.208	0.208
Schistosoma mansoni	cpg binding protein	0.003	0.0599	0.0599
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0124	0.0124
Schistosoma mansoni	ap endonuclease	0.0022	0.0407	0.0407
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0124	0.0521
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0124	0.0124
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0676	0.0676
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.208	0.208
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0407	1
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0021	0.039	0.0919
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0676	0.0676

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC80 (functional)	= 2 ug ml-1	Antifungal activity against Candida parapsilosis ATCC22019 by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	= 8 ug ml-1	Antifungal activity against Candida krusei ATCC6258 by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	= 32 ug ml-1	Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	= 32 ug ml-1	Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	= 64 ug ml-1	Antifungal activity against Candida albicans after 24 hrs by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	> 64 ug ml-1	Antifungal activity against Candida tropicalis by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	> 64 ug ml-1	Antifungal activity against Torulopsis glabrata by microbroth dilution method	ChEMBL.	17184885
MIC80 (functional)	= 64 ug ml-1	Antifungal activity against Candida albicans after 24 hrs by microbroth dilution method	ChEMBL.	17184885

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL244517

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 435163