TDR Targets

Basic information

Technical information

TDR Targets ID: 43763
Name: N-(7-phenyl-1,6-naphthyridin-5-yl)propane-1,3 -diamine
MW: 278.352 | Formula: C17H18N4
H donors: 2 H acceptors: 2 LogP: 3.07 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NCCCNc1nc(cc2c1cccn2)c1ccccc1
InChi: 1S/C17H18N4/c18-9-5-11-20-17-14-8-4-10-19-16(14)12-15(21-17)13-6-2-1-3-7-13/h1-4,6-8,10,12H,5,9,11,18H2,(H,20,21)
InChiKey: RXBLOPKSKORQAR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-aminopropyl-(7-phenyl-1,6-naphthyridin-5-yl)amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	spleen tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	ko:K05855 spleen tyrosine kinase, putative	Get druggable targets OG5_131855	All targets in OG5_131855
Schistosoma japonicum	ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus granulosus	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0013	0.0133	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0188	0.4393	1
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0013	0.0133	0.0133
Loa Loa (eye worm)	subtilase	0.0013	0.0133	0.0154
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.004	0.0784	0.0784
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0527	0.061
Loa Loa (eye worm)	hypothetical protein	0.003	0.0533	0.0617
Echinococcus multilocularis	geminin	0.0177	0.4111	0.4111
Schistosoma mansoni	hypothetical protein	0.0013	0.0135	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0093	0.0108
Schistosoma mansoni	furin-1 (S08 family)	0.0135	0.309	0.309
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0527	0.061
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0093	0.0093
Schistosoma mansoni	inositol transporter	0.004	0.0784	0.0784
Echinococcus multilocularis		0.025	0.5891	0.5891
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0093	0.0093
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0533	0.0732
Schistosoma mansoni	cpg binding protein	0.0031	0.0567	0.0567
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0188	0.4393	0.4393
Brugia malayi	hypothetical protein	0.003	0.0533	0.0617
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0188	0.4393	0.4393
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0093	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0013	0.0133	0.5
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0013	0.0133	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0093	0.0093
Echinococcus granulosus	solute carrier family 5	0.004	0.0784	0.0784
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0093	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0363	0.8631	1
Brugia malayi	celfurPC protein	0.025	0.5891	0.6826
Schistosoma mansoni	tyrosine kinase	0.0264	0.6239	0.6239
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0073	0.1591	0.3423
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0093	0.0093
Brugia malayi	Subtilase family protein	0.0013	0.0133	0.0154
Echinococcus granulosus	Furin 1	0.0073	0.1591	0.1591
Echinococcus granulosus	cpg binding protein	0.0031	0.0567	0.0567
Giardia lamblia	High cysteine membrane protein Group 2	0.0115	0.2612	1
Schistosoma mansoni	cpg binding protein	0.0029	0.0527	0.0527
Schistosoma mansoni	high-affinity choline transporter	0.0363	0.8631	0.8631
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0073	0.1591	0.3423
Echinococcus granulosus	tyrosine protein kinase shark	0.0264	0.6239	0.6239
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0093	0.0093
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0093	0.0093
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.004	0.0784	0.0784
Onchocerca volvulus		0.0012	0.0093	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2768	0.3207
Onchocerca volvulus		0.004	0.0784	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0135	0.0135
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0093	0.0093
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0093	0.1189
Echinococcus granulosus	sodium:glucose cotransporter 2	0.004	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.004	0.0784	0.0908
Brugia malayi	Nuclear hormone receptor-like 1	0.028	0.6615	0.7665
Brugia malayi	GH02984p	0.0363	0.8631	1
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.006	0.1269	0.2667
Onchocerca volvulus		0.0029	0.0527	0.6716
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0093	0.0093
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0093	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0093	0.0108
Brugia malayi	Nuclear hormone receptor-like 1	0.028	0.6615	0.7665
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0093	0.1189
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0093	0.0108
Echinococcus granulosus	sodium:myo inositol cotransporter	0.004	0.0784	0.0784
Schistosoma mansoni	sodium/solute symporter	0.004	0.0784	0.0784
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0093	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0093	0.0108
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0013	0.0133	0.5
Onchocerca volvulus		0.0013	0.0133	0.1701
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0093	0.0108
Schistosoma mansoni	hypothetical protein	0.0177	0.4111	0.4111
Schistosoma mansoni	tyrosine kinase	0.0258	0.6091	0.6091
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0093	0.0093
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0013	0.0133	0.0133
Brugia malayi	Nuclear hormone receptor-like 1	0.0285	0.6749	0.7819
Schistosoma mansoni	hypothetical protein	0.006	0.1269	0.1269
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0008	0	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0533	1
Echinococcus multilocularis	high affinity choline transporter 1	0.0363	0.8631	0.8631
Echinococcus granulosus	sodium:glucose cotransporter	0.004	0.0784	0.0784
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0188	0.4393	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0032	0.0038
Brugia malayi	steroid hormone receptor	0.0012	0.0093	0.0108
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.006	0.1269	0.2667
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0073	0.1591	0.3423
Loa Loa (eye worm)	hypothetical protein	0.031	0.7349	0.8515
Schistosoma mansoni	hypothetical protein	0.0419	1	1
Loa Loa (eye worm)	proprotein convertase 2	0.0073	0.1591	0.1844
Brugia malayi	neuroendocrine convertase 1 precursor	0.0195	0.4548	0.527
Brugia malayi	ecdysteroid receptor	0.0012	0.0093	0.0108
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0093	0.0093
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0093	0.0108
Schistosoma mansoni	hypothetical protein	0.0177	0.4111	0.4111
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0093	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Echinococcus granulosus	furin	0.031	0.7349	0.7349
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0073	0.1591	0.3423
Loa Loa (eye worm)	endoprotease bli-4	0.031	0.7349	0.8515
Echinococcus multilocularis	tyrosine protein kinase shark	0.0264	0.6239	0.6239
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0093	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0093	0.0108
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0093	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0093	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1329	0.1329
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0073	0.1591	0.3423
Schistosoma mansoni	coup transcription factor	0.0012	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0019	0.0277	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0093	0.0108
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0093	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0093	0.0093
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0073	0.1591	0.1591
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0093	0.0108
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0013	0.0133	0.0133
Leishmania major	hypothetical protein, conserved	0.003	0.0533	1
Loa Loa (eye worm)	hypothetical protein	0.0279	0.6599	0.7646
Echinococcus multilocularis	cpg binding protein	0.0031	0.0567	0.0567
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0013	0.0133	0.5
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.004	0.0784	0.0784
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0093	0.0093
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0013	0.0133	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0093	0.0093
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1166	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0093	0.0108
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0093	0.0108
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0093	0.0108
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0135	0.0135
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0093	0.0093
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0533	1
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0533	0.3866
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0013	0.0133	0.0133
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0093	0.0108
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0093	0.0093
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0013	0.0133	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0533	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0567	0.0567
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0013	0.0133	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0533	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0093	0.0108
Echinococcus multilocularis	neuroendocrine convertase 2	0.0195	0.4548	0.4548
Brugia malayi	nuclear hormone receptor	0.0012	0.0093	0.0108
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0013	0.0133	0.5
Schistosoma mansoni	inositol transporter	0.004	0.0784	0.0784
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0093	0.1189
Brugia malayi	proprotein convertase 2	0.0195	0.4548	0.527
Mycobacterium leprae	Possible secreted protease	0.0013	0.0133	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0093	0.0093
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0093	0.0093
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0032	0.0032
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0093	0.0093
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0093	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0093	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0093	0.0108
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0093	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Echinococcus granulosus	high affinity choline transporter 1	0.0363	0.8631	0.8631
Trichomonas vaginalis	hypothetical protein	0.006	0.1269	0.2667
Trypanosoma brucei	RNA helicase, putative	0.0238	0.559	1
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0533	1
Echinococcus multilocularis	Furin 1	0.0073	0.1591	0.1591
Echinococcus multilocularis	solute carrier family 5	0.004	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0133	0.0154
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Brugia malayi	Sodium:solute symporter family protein	0.004	0.0784	0.0908
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0093	0.0108
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0093	0.0093
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.006	0.1269	0.2667
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.028	0.6615	0.7665
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0093	0.0093
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.004	0.0784	0.6297
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0093	0.0093
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0093	0.0093
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0093	0.0093
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0093	0.0093
Echinococcus multilocularis	dnaJ subfamily B	0.0419	1	1
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0013	0.0133	0.0154
Echinococcus granulosus	neuroendocrine convertase 2	0.0195	0.4548	0.4548
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.004	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.031	0.7349	0.7349
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0032	0.0032
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0013	0.0133	0.0133
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0073	0.1591	0.3423
Schistosoma mansoni	hypothetical protein	0.0238	0.559	0.559
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.1269	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0093	0.0108
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.003	0.0034
Echinococcus granulosus	geminin	0.0177	0.4111	0.4111
Brugia malayi	endoprotease bli-4 precursor	0.031	0.7349	0.8515
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0013	0.0133	0.5
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0013	0.0133	0.0133
Echinococcus granulosus	membrane bound transcription factor site 1	0.0013	0.0133	0.0133
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0013	0.0133	0.0154

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 410 nM	Inhibition of recombinant Syk	ChEMBL.	19254842
IC50 (binding)	= 0.14 uM	Inhibitory activity against spleen tyrosine kinase (SYK)	ChEMBL.	12668002
IC50 (binding)	= 0.14 uM	Inhibitory activity against spleen tyrosine kinase (SYK)	ChEMBL.	12668002
IC50 (binding)	= 0.41 uM	Inhibition of spleen tyrosine kinase (unknown origin)	ChEMBL.	23917087

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL281696
PubChem: 10214743

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 43763