TDR Targets

Basic information

Technical information

TDR Targets ID: 437918
Name: tert-butyl 2-[[6-cyano-1-[(3-methylimidazol-4 -yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(1- methylimidazole-4-carbonyl)amino]acetate
MW: 489.569 | Formula: C26H31N7O3
H donors: 0 H acceptors: 5 LogP: 1.97 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc2c(c1)CC(CN2Cc1cncn1C)N(C(=O)c1ncn(c1)C)CC(=O)OC(C)(C)C
InChi: 1S/C26H31N7O3/c1-26(2,3)36-24(34)15-33(25(35)22-14-30(4)17-29-22)20-9-19-8-18(10-27)6-7-23(19)32(12-20)13-21-11-28-16-31(21)5/h6-8,11,14,16-17,20H,9,12-13,15H2,1-5H3
InChiKey: AMJSRHMOGWRDHI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[[6-cyano-1-[(3-methyl-4-imidazolyl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-[(1-methyl-4-imidazolyl)-oxomethyl]amino]acetic acid tert-butyl ester
tert-butyl 2-[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(1-methylimidazol-4-yl)carbonyl-amino]ethanoate
2-[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(1-methylimidazole-4-carbonyl)amino]acetic acid tert-butyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0149	0.0202
Schistosoma mansoni	retinoic acid receptor RXR	0.0142	0.6142	0.8321
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0071	0.2833	0.3715
Brugia malayi	nuclear receptor NHR-88	0.0046	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Plasmodium vivax	vivapain-2	0.0016	0.0251	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0251	0.0409
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2386	1
Brugia malayi	tailless protein	0.0022	0.0519	0.0519
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.167	0.167
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0251	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.167	0.167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.167	0.2262
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.167	0.2718
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Schistosoma mansoni	thyroid hormone receptor	0.0168	0.7381	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.3197	0.3197
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0251	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0251	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0519	0.2089
Brugia malayi	Uncoordinated protein 44	0.0014	0.0144	0.0144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0642
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.167	0.167
Leishmania major	cathepsin L-like protease	0.0016	0.0251	0.0863
Onchocerca volvulus		0.0016	0.0251	0.1011
Echinococcus multilocularis	Ankyrin	0.0014	0.0149	0.0008
Brugia malayi	Cytochrome P450 family protein	0.0012	0.005	0.005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0519	0.0703
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0144	0.0234
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0025	0.0642	0.087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0251	0.0148
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0519	0.2089
Schistosoma mansoni	jun-related protein	0.0066	0.2588	0.3506
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0519	0.0519
Brugia malayi	ecdysteroid receptor	0.0046	0.167	0.167
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.167	0.167
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.005	0.005
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.167	0.6723
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0519	0.0845
Leishmania major	cathepsin L-like protease	0.0016	0.0251	0.0863
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.167	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0251	0.1011
Onchocerca volvulus		0.0016	0.0251	0.1011
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0142	0.6142	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.167	0.167
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0251	0.0251
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0251	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.167	0.167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Loa Loa (eye worm)	ctsf protein	0.0016	0.0251	0.0251
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0251	0.0409
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.167	0.2718
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.167	0.167
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0251	0.0251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Onchocerca volvulus		0.0022	0.0519	0.2089
Brugia malayi	nuclear receptor RXR	0.0022	0.0519	0.0519
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0519	0.0703
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0519	0.0519
Brugia malayi	nuclear hormone receptor	0.0046	0.167	0.167
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0144	0.000000052255
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.167	0.2108
Brugia malayi	Cytochrome P450 family protein	0.0012	0.005	0.005
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.167	0.6723
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.005	0.005
Onchocerca volvulus		0.0016	0.0251	0.1011
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0519	0.0518
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0642
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.167	0.167
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.167	0.167
Toxoplasma gondii	cathepsin CPL	0.0016	0.0251	0.5
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0025	0.0642	0.1045
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.167	0.167
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.1766	0.7348
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0642
Leishmania major	cathepsin L-like protease	0.0016	0.0251	0.0863
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.167	0.2718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0519	0.0519
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0251	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0519	0.0518
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.5203	0.8471
Brugia malayi	ecdysone receptor	0.0022	0.0519	0.0519
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0117	0.4992	0.6698
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.167	0.2262
Brugia malayi	Death domain containing protein	0.0014	0.0144	0.0144
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.167	0.167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0251	0.0251
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0251	1
Brugia malayi	hypothetical protein	0.0064	0.2483	0.2483
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0519	0.0519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0519	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0251	0.034
Brugia malayi	steroid hormone receptor	0.0046	0.167	0.167
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2386	1
Schistosoma mansoni	coup transcription factor	0.0046	0.167	0.2262
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Echinococcus multilocularis	cysteine protease	0.0016	0.0251	0.0148
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.167	0.2108
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0144	0.0234
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.167	0.167
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.167	0.2262
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.167	0.167
Brugia malayi	hypothetical protein	0.0025	0.0642	0.0642
Leishmania major	cathepsin L-like protease	0.0062	0.2386	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Onchocerca volvulus		0.0016	0.0251	0.1011
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.167	0.2718
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.167	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.167	0.2718
Echinococcus granulosus	death domain containing protein	0.0014	0.0144	0.0234
Brugia malayi	hypothetical protein	0.0025	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.167	0.2718
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.5203	0.6991
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0251	0.1011
Schistosoma mansoni	thyroid hormone receptor	0.0168	0.7381	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.167	0.2718
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0251	0.0148
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0519	0.0845
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0519	0.0845
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Leishmania major	cathepsin L-like protease	0.0062	0.2386	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.167	0.167
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0519	0.0845
Schistosoma mansoni	hypothetical protein	0.0014	0.0144	0.0195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0251	0.0251
Echinococcus granulosus	jun protein	0.0081	0.3302	0.5375
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0144	0.0144
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.167	0.2262
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.167	0.167
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0144	0.0195
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0519	0.0519
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0251	0.0251
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.2386	1
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.167	0.167
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0642	0.087
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0149	0.0149
Leishmania major	cathepsin L-like protease	0.0016	0.0251	0.0863
Plasmodium vivax	vivapain-2	0.0016	0.0251	0.5
Echinococcus granulosus	Ankyrin	0.0014	0.0149	0.0243
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.167	0.2108
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0025	0.0642	0.0689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	nuclear receptor RXR	0.0025	0.0642	0.0642
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0519	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0642
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0025	0.0642	0.0642
Onchocerca volvulus		0.0016	0.0251	0.1011
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.167	0.167
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.167	0.2108
Echinococcus granulosus	cathepsin l1	0.0016	0.0251	0.0409
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0144	0.0195
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0519	0.0519
Schistosoma mansoni	hypothetical protein	0.0066	0.2588	0.3506
Brugia malayi	nuclear hormone receptor	0.0022	0.0519	0.0519
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.167	0.2262
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0081	0.3302	0.5375
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.167	0.2262
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.167	0.2262
Schistosoma mansoni	zinc finger protein	0.0022	0.0519	0.0703
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Loa Loa (eye worm)	cysteine protease	0.0016	0.0251	0.0251
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0519	0.0519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.167	0.167
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0071	0.2833	0.4612
Onchocerca volvulus		0.0016	0.0251	0.1011
Onchocerca volvulus		0.0064	0.2483	1
Echinococcus multilocularis	cysteine protease	0.0016	0.0251	0.0148
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0251	0.0251
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0519	0.0845
Echinococcus multilocularis	jun protein	0.0081	0.3302	0.4363
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.167	0.6723
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0251	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0519	0.0703
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0168	0.7381	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.005	0.5
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0251	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0519	0.0519
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.167	0.2718
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.167	0.167
Loa Loa (eye worm)	fibroinase	0.0016	0.0251	0.0251
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0251	0.0148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0519	0.0519
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0251	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.167	0.167
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0519	0.0519
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0519	0.0845
Schistosoma mansoni	hypothetical protein	0.0122	0.5203	0.7049
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0519	0.0519
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0519	0.0519
Leishmania major	cathepsin L-like protease	0.0016	0.0251	0.0863
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0144	0.0144
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0519	0.0518
Brugia malayi	conserved hypotetical protein	0.0022	0.0519	0.0519
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.167	0.2262
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0642	0.0642
Onchocerca volvulus		0.0046	0.167	0.6723
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.2386	1
Brugia malayi	bZIP transcription factor family protein	0.0081	0.3302	0.3302
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.167	0.167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0642
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.167	0.167
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.167	0.167
Onchocerca volvulus		0.0016	0.0251	0.1011
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0144	0.0579
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.167	0.2262
Schistosoma mansoni	nuclear receptor	0.0022	0.0519	0.0703
Brugia malayi	hypothetical protein	0.0022	0.0519	0.0519
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.2135	0.8925
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0081	0.3302	0.4363
Schistosoma mansoni	nuclear receptor	0.0022	0.0519	0.0703
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0144	0.0144
Brugia malayi	hypothetical protein	0.0022	0.0519	0.0519
Loa Loa (eye worm)	DR-78	0.0022	0.0519	0.0519
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0251	0.034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0251	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0251	0.0251
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.167	0.2108
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.167	0.2108
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0251	0.0251
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0251	0.1011
Leishmania major	cathepsin L-like protease	0.0062	0.2386	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0251	0.5
Onchocerca volvulus		0.0022	0.0519	0.2089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.2386	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0519	0.0703
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0251	0.0251
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0519	0.0518
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.167	0.167
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0251	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	> 5000 nM	Antimalarial activity against Plasmodium falciparum 3D7	ChEMBL.	17722901
ED50 (functional)	> 5000 nM	Antimalarial activity against Plasmodium falciparum K1	ChEMBL.	17722901
ED50 (functional)	> 5000 nM	Antimalarial activity against Plasmodium falciparum 3D7	ChEMBL.	17722901
ED50 (functional)	> 5000 nM	Antimalarial activity against Plasmodium falciparum K1	ChEMBL.	17722901
IC50 (binding)	> 50 nM	Inhibition of plasmodium falciparum protein farnesyltransferase by scintillation proximity assay	ChEMBL.	17722901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL233496
PubChem: 17759645

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 437918