Detailed information for compound 439134

Basic information

Technical information
  • TDR Targets ID: 439134
  • Name: 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxypyrrol idin-1-yl]-2-oxoethyl]-2-oxo-3,4-dihydroquino lin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxami de
  • MW: 488.944 | Formula: C22H21ClN4O5S
  • H donors: 4 H acceptors: 5 LogP: 1.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1CN(C[C@@H]1O)C(=O)CN1C(=O)C(NC(=O)c2cc3c([nH]2)sc(c3)Cl)Cc2c1cccc2
  • InChi: 1S/C22H21ClN4O5S/c23-18-7-12-6-13(25-21(12)33-18)20(31)24-14-5-11-3-1-2-4-15(11)27(22(14)32)10-19(30)26-8-16(28)17(29)9-26/h1-4,6-7,14,16-17,25,28-29H,5,8-10H2,(H,24,31)/t14?,16-,17+
  • InChiKey: AROCOBNDRMAFQI-ZXFUBFMLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-oxo-ethyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxy-1-pyrrolidinyl]-2-oxoethyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxypyrrolidino]-2-keto-ethyl]-2-keto-3,4-dihydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-oxoethyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[3,2-d]pyrrole-5-carboxamide
  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-oxo-ethyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[3,2-d]pyrrole-5-carboxamide
  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxy-1-pyrrolidinyl]-2-oxoethyl]-2-oxo-3,4-dihydroquinolin-3-yl]-6H-thieno[3,2-d]pyrrole-5-carboxamide
  • 2-chloro-N-[1-[2-[(3R,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-keto-ethyl]-2-keto-3,4-dihydroquinolin-3-yl]-6H-thieno[3,2-d]pyrrole-5-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen, liver Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0035 0.0623 0.0593
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0623 0.0786
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0161 0.0434
Schistosoma mansoni biogenic amine receptor 0.001 0.0037 0.0015
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0032 0.0081
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0614 0.1867
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Schistosoma mansoni glycogen phosphorylase 0.013 0.2833 0.7736
Brugia malayi Phospholipase A2 family protein 0.0092 0.1949 0.5633
Echinococcus granulosus hypothetical protein 0.001 0.0037 0.0096
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0376 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0623 0.1632
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0037 0.0096
Echinococcus multilocularis GPCR, family 2 0.0015 0.0161 0.0434
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0161 0.0434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1885 0.1883
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0037 0.0096
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0246 0.0516
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0935 0.2702
Echinococcus multilocularis cysteine protease atg4b 0.0059 0.1179 0.3222
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0623 0.1899
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0623 0.1899
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.1113 0.3695
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.0015
Onchocerca volvulus 0.0035 0.0623 0.0593
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0037 0.0035
Entamoeba histolytica glycogenphosphorylase, putative 0.0056 0.1113 0.3695
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0032 0.0081
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0037 0.0096
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0161 0.0434
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Echinococcus granulosus orexin receptor type 2 0.001 0.0037 0.0096
Onchocerca volvulus 0.001 0.0037 0.0005
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0037 0.0096
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.2833 0.7754
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0161 0.0158
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.2833 1
Schistosoma mansoni hypothetical protein 0.0033 0.0577 0.1504
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0614 0.4869
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Schistosoma mansoni cpg binding protein 0.0029 0.0486 0.1254
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.006 0.0156
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0037 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0032 0.0081
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0037 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0623 0.4947
Echinococcus multilocularis allatostatin A receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0032 0.003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5043 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Onchocerca volvulus Phospholipase A2 homolog 0.0439 1 1
Schistosoma mansoni hypothetical protein 0.0015 0.0161 0.0356
Echinococcus granulosus dna polymerase eta 0.0019 0.0246 0.0666
Brugia malayi nuclear receptor NHR-88 0.001 0.0032 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0079 0.0076
Echinococcus granulosus neuropeptide receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0108 0.0268
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0037 0.0096
Echinococcus granulosus g-protein coupled receptor 0.001 0.0037 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1885 0.5157
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0032 0.0081
Onchocerca volvulus 0.0028 0.0449 0.0418
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Mycobacterium ulcerans beta-lactamase 0.0035 0.0623 0.5262
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0037 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0093
Leishmania major DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0037 0.0096
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.0015
Brugia malayi G protein-coupled receptor 0.001 0.0037 0.0108
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0037 0.0096
Mycobacterium ulcerans hypothetical protein 0.0035 0.0623 0.5262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0246 0.0243
Mycobacterium ulcerans lipase LipD 0.0035 0.0623 0.5262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Trypanosoma brucei unspecified product 0.0013 0.0108 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0037 0.0096
Echinococcus granulosus glycogen phosphorylase 0.013 0.2833 0.7754
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0339 0.2368
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0614 0.1867
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0032 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Schistosoma mansoni hypothetical protein 0.0166 0.3652 1
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0037 0.0035
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0037 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Schistosoma mansoni cpg binding protein 0.0029 0.0486 0.1254
Brugia malayi carbohydrate phosphorylase 0.013 0.2833 0.8185
Brugia malayi neuropeptide F receptor 0.001 0.0037 0.0108
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0037 0.0015
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.1179 0.3936
Brugia malayi Cytochrome P450 family protein 0.0012 0.0079 0.0227
Schistosoma mansoni biogenic amine receptor 0.001 0.0037 0.0015
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.1113 0.1807
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0037 0.0096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0037 0.0096
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0105 0.0238
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0032 0.003
Entamoeba histolytica peptidase, C54 family 0.0023 0.0339 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0037 0.0035
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0246 0.059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0161 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0108 0.0268
Echinococcus multilocularis fmrfamide receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0376 0.0373
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.3461 0.9474
Schistosoma mansoni opsin-like receptor 0.001 0.0037 0.0015
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.0015
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.3461 0.9474
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0105 0.0238
Mycobacterium tuberculosis Conserved protein 0.0035 0.0623 0.0786
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0623 0.0786
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0037 0.0015
Schistosoma mansoni glycogen phosphorylase 0.0056 0.1113 0.2985
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0614 0.1867
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0037 0.0096
Echinococcus granulosus neuropeptide s receptor 0.001 0.0037 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0246 0.1615
Trypanosoma brucei unspecified product 0.0013 0.0108 0.0268
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0246 0.1518
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0376 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.2833 1
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0037 0.0096
Onchocerca volvulus 0.001 0.0037 0.0005
Onchocerca volvulus 0.001 0.0037 0.0005
Brugia malayi Dopamine receptor protein 2 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0093
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0623 0.1632
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0037 0.0108
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0037 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0032 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Entamoeba histolytica peptidase, C54 family 0.0023 0.0339 0.0859
Onchocerca volvulus 0.001 0.0037 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Echinococcus multilocularis serotonin receptor 0.001 0.0037 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0614 0.1867
Echinococcus granulosus neuropeptide receptor 0.001 0.0037 0.0096
Leishmania major hypothetical protein, conserved 0.0035 0.0623 0.4947
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0376 0.27
Echinococcus granulosus g protein coupled receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0246 0.0243
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0037 0.0015
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0059 0.1179 0.3167
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0614 0.3995
Echinococcus multilocularis g protein coupled receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0614 0.1867
Brugia malayi Serotonin receptor 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0623 0.5262
Schistosoma mansoni glycogen phosphorylase 0.013 0.2833 0.7736
Echinococcus multilocularis Peptidase C54 0.0059 0.1179 0.3222
Brugia malayi neuropeptide F receptor 0.001 0.0037 0.0108
Schistosoma mansoni hypothetical protein 0.0166 0.3652 1
Brugia malayi G-protein coupled receptor 0.001 0.0037 0.0108
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0033 0.0577 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0108 0.0268
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0037 0.0108
Echinococcus multilocularis neuropeptide receptor 0.001 0.0037 0.0096
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.1113 0.3695
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0037 0.0096
Echinococcus multilocularis serotonin receptor 0.001 0.0037 0.0096
Schistosoma mansoni biogenic amine receptor 0.001 0.0037 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0037 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Schistosoma mansoni adenoreceptor 0.001 0.0037 0.0015
Mycobacterium tuberculosis Conserved protein 0.0035 0.0623 0.0786
Brugia malayi Melatonin receptor type 1A 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0161 0.0158
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0037 0.0096
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.2833 0.7754
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0623 0.5262
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1885 0.5446
Schistosoma mansoni hypothetical protein 0.0011 0.006 0.0076
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0037 0.0096
Onchocerca volvulus 0.0035 0.0623 0.0593
Brugia malayi follicle stimulating hormone receptor 0.001 0.0037 0.0108
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.3461 0.3459
Brugia malayi beta-lactamase family protein 0.0035 0.0623 0.18
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0161 0.0434
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0614 0.4869
Brugia malayi sulfakinin receptor protein 0.001 0.0037 0.0108
Brugia malayi beta-lactamase family protein 0.0035 0.0623 0.18
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0037 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Schistosoma mansoni opsin-like receptor 0.001 0.0037 0.0015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0246 0.1518
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0037 0.0096
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.0015
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0037 0.0015
Echinococcus granulosus g protein coupled receptor 0.001 0.0037 0.0096
Brugia malayi hypothetical protein 0.0025 0.0376 0.1085
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus granulosus dna polymerase kappa 0.0019 0.0246 0.0666
Brugia malayi CXXC zinc finger family protein 0.0028 0.0449 0.1298
Brugia malayi larval opioid receptor 0.001 0.0037 0.0108
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0032 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Schistosoma mansoni myosin xvIII 0.001 0.0037 0.0015
Echinococcus multilocularis fmrfamide receptor 0.001 0.0037 0.0096
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0037 0.0096
Echinococcus multilocularis orexin receptor type 2 0.001 0.0037 0.0096
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0059 0.1179 0.3167
Schistosoma mansoni amine GPCR 0.001 0.0037 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0037 0.0096
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0623 0.062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.0096
Onchocerca volvulus 0.001 0.0037 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0093
Leishmania major hypothetical protein, conserved 0.0025 0.0376 0.27
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0037 0.0096
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0037 0.0015
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Onchocerca volvulus 0.0091 0.1918 0.1892
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus multilocularis dna polymerase eta 0.0019 0.0246 0.0666
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0032 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1885 0.5157
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0614 0.1867
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.0015
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0056 0.1113 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.1179 0.3936
Entamoeba histolytica peptidase, C54 family 0.0023 0.0339 0.0859
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0037 0.0035
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0037 0.0096
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0037 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Loa Loa (eye worm) hypothetical protein 0.0035 0.0623 0.062
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0059 0.1179 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1885 0.5157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0081
Loa Loa (eye worm) beta-lactamase 0.0035 0.0623 0.062
Schistosoma mansoni DNA polymerase eta 0.0019 0.0246 0.059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0081
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0161 0.0465
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0032 0.0093
Trypanosoma brucei glucosidase, putative 0.0035 0.0614 0.4869
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0614 0.1867
Brugia malayi Cytochrome P450 family protein 0.0012 0.0079 0.0227
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0037 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0623 0.1899
Echinococcus multilocularis g protein coupled receptor 0.001 0.0037 0.0096
Schistosoma mansoni amine GPCR 0.001 0.0037 0.0015
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0246 0.0666
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.2833 0.281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0032 0.003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0037 0.0108
Trypanosoma brucei unspecified product 0.0019 0.0246 0.1518
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Brugia malayi RE15519p 0.001 0.0037 0.0108
Brugia malayi Peptidase family C54 containing protein 0.0059 0.1179 0.3405
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0037 0.0015
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0037 0.0096
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0623 0.1699
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Echinococcus granulosus cpg binding protein 0.0029 0.0486 0.1325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0037 0.0096
Echinococcus granulosus somatostatin receptor 0.001 0.0037 0.0096
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0339 0.2368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0032 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0032 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0037 0.0015
Mycobacterium tuberculosis Conserved protein 0.0035 0.0623 0.0786
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0577 0.1667
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0093
Brugia malayi Serotonin receptor 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.0035 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0035 0.0623 0.062
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0246 0.0666
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0037 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0623 0.1899
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0059 0.1179 0.1176
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0023 0.0339 0.2368
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0623 1
Brugia malayi G-protein coupled receptor 0.001 0.0037 0.0108
Schistosoma mansoni autophagin-1 (C54 family) 0.0059 0.1179 0.3167
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0614 0.0612
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0037 0.0015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.3461 0.9474
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0037 0.0108
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0037 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0037 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1885 0.5117
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0246 0.071
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0037 0.0015
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0614 0.4869
Echinococcus granulosus Peptidase C54 0.0059 0.1179 0.3222
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.2833 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0376 0.27
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0037 0.0096
Toxoplasma gondii ABC1 family protein 0.0035 0.0623 0.412
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0623 0.0786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0032 0.003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0093
Schistosoma mansoni amine GPCR 0.001 0.0037 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0105 0.0303
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0037 0.0096
Onchocerca volvulus 0.001 0.0037 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1028 1
Schistosoma mansoni hypothetical protein 0.0015 0.0161 0.0356
Brugia malayi hypothetical protein 0.0016 0.0172 0.0498
Schistosoma mansoni alpha glucosidase 0.0035 0.0614 0.1608
Schistosoma mansoni alpha-glucosidase 0.0135 0.2951 0.8063
Mycobacterium leprae Probable lipase LipE 0.0035 0.0623 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1174 0.3155
Echinococcus granulosus sex peptide receptor 0.001 0.0037 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0614 0.1867
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0032 0.0093
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0059 0.1179 1
Trichomonas vaginalis esterase, putative 0.0035 0.0623 0.1899
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus granulosus GPCR family 2 0.0015 0.0161 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0023 0.0339 0.2368
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0032 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0049 0.0935 0.0933
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0623 0.062
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0105 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Brugia malayi putative neuropeptide receptor 0.001 0.0037 0.0108
Giardia lamblia Glycogen phosphorylase 0.013 0.2833 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0623 0.0786
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0037 0.0015
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0037 0.0015
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0079 0.0076
Echinococcus granulosus FTZ F1 alpha 0.001 0.0032 0.0081
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.3461 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.1179 0.3936
Echinococcus granulosus g protein coupled receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Brugia malayi beta-lactamase 0.0035 0.0623 0.18
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0614 0.1867
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.0015
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0037 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Echinococcus multilocularis cpg binding protein 0.0029 0.0486 0.1325
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0059 0.1179 1
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.2833 0.2831
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0081
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.006 0.0156
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0105 0.0238
Brugia malayi GnHR receptor homolog 0.001 0.0037 0.0108
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0037 0.0015
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.1179 0.3936
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0935 0.0933
Onchocerca volvulus Phospholipase A2 homolog 0.0092 0.1949 0.1923
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0623 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0032 0.0093
Echinococcus granulosus allatostatin A receptor 0.001 0.0037 0.0096
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0081
Schistosoma mansoni neuropeptide receptor 0.001 0.0037 0.0015
Onchocerca volvulus 0.001 0.0037 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0246 0.0516
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0059 0.1179 0.3936
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0623 0.4947
Schistosoma mansoni hypothetical protein 0.0015 0.0161 0.0356
Schistosoma mansoni amine GPCR 0.001 0.0037 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0376 0.053
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0623 0.0786
Leishmania major DNA polymerase eta, putative 0.0019 0.0246 0.1518
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0105 0.0073
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0037 0.0015
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.0092 0.1949 0.1947
Echinococcus multilocularis glycogen phosphorylase 0.013 0.2833 0.7754
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0623 0.1699
Schistosoma mansoni hypothetical protein 0.001 0.0037 0.0015
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0246 0.059
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0037 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1885 0.5117
Echinococcus granulosus fmrfamide receptor 0.001 0.0037 0.0096
Schistosoma mansoni amine GPCR 0.001 0.0037 0.0015
Entamoeba histolytica peptidase, C54 family 0.0023 0.0339 0.0859
Brugia malayi ecdysteroid receptor 0.001 0.0032 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0376 0.27
Loa Loa (eye worm) hypothetical protein 0.0035 0.0623 0.062
Echinococcus multilocularis g protein coupled receptor 0.001 0.0037 0.0096
Brugia malayi ORL1-like opioid receptor 0.001 0.0037 0.0108
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0623 0.18
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0246 0.0516
Echinococcus granulosus cysteine protease atg4b 0.0059 0.1179 0.3222
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0093
Brugia malayi Dopamine receptor 0.001 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus glycogen phosphorylase 0.013 0.2833 0.7754
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0623 0.4947
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0246 0.1615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1885 0.5117
Echinococcus multilocularis neuropeptide receptor 0.001 0.0037 0.0096
Echinococcus multilocularis geminin 0.0166 0.3652 1
Echinococcus granulosus serotonin receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Brugia malayi hypothetical protein 0.001 0.0037 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0081
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0623 0.0786
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0246 0.1518
Brugia malayi steroid hormone receptor 0.001 0.0032 0.0093
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.2833 1
Schistosoma mansoni hypothetical protein 0.0015 0.0161 0.0356
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0614 0.1775
Echinococcus multilocularis glycogen phosphorylase 0.013 0.2833 0.7754
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0037 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0246 0.071
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0623 0.062
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0449 0.0447
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0093
Schistosoma mansoni cpg binding protein 0.0028 0.0449 0.1152
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0037 0.0096
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0037 0.0015
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0037 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Entamoeba histolytica peptidase, C54 family 0.0059 0.1179 0.3936
Chlamydia trachomatis glycogen phosphorylase 0.013 0.2833 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Schistosoma mansoni opsin-like receptor 0.001 0.0037 0.0015
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0614 0.1676
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0614 0.1867
Echinococcus multilocularis somatostatin receptor 0.001 0.0037 0.0096
Schistosoma mansoni alpha-glucosidase 0.0135 0.2951 0.8063
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0246 0.0666
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.0096
Brugia malayi AKH receptor 0.001 0.0037 0.0108
Brugia malayi nuclear hormone receptor 0.001 0.0032 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0093
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0037 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0037 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0246 0.1518
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0614 0.1676
Echinococcus multilocularis sex peptide receptor 0.001 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0246 0.1518
Schistosoma mansoni histamine h1 receptor 0.001 0.0037 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0246 0.1518
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0037 0.0096
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0037 0.0096
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0037 0.0096
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0623 0.0786
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1885 0.5157
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0037 0.0035
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0037 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0623 0.1899
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0037 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0935 0.2702
Brugia malayi Dopamine receptor protein 1 0.001 0.0037 0.0108
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0246 0.1518
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0614 0.1867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0037 0.0015
Onchocerca volvulus 0.001 0.0037 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0037 0.0096
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0037 0.0005
Echinococcus granulosus geminin 0.0166 0.3652 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0037 0.0108
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0037 0.0096
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0037 0.0096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0081
Onchocerca volvulus 0.001 0.0037 0.0005

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.14 uM Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay ChEMBL. 17095214
IC50 (binding) = 0.14 uM Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme coupled assay ChEMBL. 17095214
Inhibition (functional) <= 30 % Inhibition of glucose output in glucagon challenged primary rat hepatocytes at 30 uM ChEMBL. 17095214
PPB (ADMET) = 2.35 % Plasma protein binding ChEMBL. 17095214
Solubility = 2.2 uM Solubility in water ChEMBL. 17095214

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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