TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 549.943 | Formula: C22H16ClF4NO5S2
H donors: 1 H acceptors: 5 LogP: 4.87 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(c(c1)S(=O)(=O)c1ccccc1F)S(=O)(=O)c1ccc(cc1)[C@@H](NC(=O)C(F)(F)F)C
InChi: 1S/C22H16ClF4NO5S2/c1-13(28-21(29)22(25,26)27)14-6-9-16(10-7-14)34(30,31)19-11-8-15(23)12-20(19)35(32,33)18-5-3-2-4-17(18)24/h2-13H,1H3,(H,28,29)/t13-/m0/s1
InChiKey: HCDXKFVDVPDYPB-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	g-protein coupled receptor	0.0055	0.0775	0.0664
Onchocerca volvulus		0.0055	0.0775	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0055	0.0775	0.2258
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0025	0.0147	0.1016
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.4368	0.4301
Echinococcus multilocularis	G protein coupled receptor 139	0.0055	0.0775	0.0664
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Leishmania major	pteridine reductase 1	0.0025	0.0147	0.1016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0055	0.0775	0.2258
Onchocerca volvulus		0.0055	0.0775	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0348	0.0319
Brugia malayi	Dopamine receptor protein 2	0.0055	0.0775	0.1245
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0147	0.0039
Schistosoma mansoni	amine GPCR	0.0055	0.0775	0.2258
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0348	0.8761
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	somatostatin receptor	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Onchocerca volvulus		0.0047	0.0593	0.7114
Onchocerca volvulus		0.0055	0.0775	1
Echinococcus multilocularis	serotonin receptor	0.0055	0.0775	0.0664
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	hypothetical protein	0.0228	0.4368	0.8066
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0348	0.0418
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0288	0.0321
Echinococcus granulosus	serotonin receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	neuropeptide receptor A26	0.05	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0025	0.0147	0.0141
Trypanosoma brucei	glucose transporter 1E	0.0033	0.031	0.6871
Schistosoma mansoni	amine GPCR	0.0055	0.0775	0.2258
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0348	0.0319
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0348	0.0418
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Schistosoma mansoni	histamine h1 receptor	0.0055	0.0775	0.2258
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Brugia malayi	putative neuropeptide receptor NPR1	0.0055	0.0775	0.1245
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0288	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0348	0.0436
Brugia malayi	putative neuropeptide receptor	0.0055	0.0775	0.1245
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.037	0.7313	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0775	0.0664
Toxoplasma gondii	ABC1 family protein	0.0035	0.0348	0.0319
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0118	0.2979
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0055	0.0775	0.1245
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0348	0.0418
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0397	0.0315
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Brugia malayi	Dopamine receptor	0.0055	0.0775	0.1245
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0348	0.0319
Echinococcus granulosus	orexin receptor type 2	0.0055	0.0775	0.0664
Leishmania major	oxidoreductase-like protein	0.0025	0.0147	0.1016
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0055	0.0775	0.0664
Brugia malayi	neuropeptide F receptor	0.0055	0.0775	0.1245
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0025	0.0147	0.0039
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0055	0.0775	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0141
Schistosoma mansoni	hypothetical protein	0.0164	0.3024	1
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0775	0.2258
Schistosoma mansoni	protein kinase	0.0033	0.0301	0.063
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0055	0.0775	0.0664
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0055	0.0775	0.2258
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0775	0.0664
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0348	0.0436
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.031	0.7803
Brugia malayi	Sugar transporter family protein	0.0106	0.1831	0.3251
Toxoplasma gondii	protein kinase, putative	0.03	0.5857	0.7976
Schistosoma mansoni	hypothetical protein	0.0106	0.1831	0.5895
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0301	0.0336
Echinococcus granulosus	allatostatin A receptor	0.0055	0.0775	0.0664
Loa Loa (eye worm)	TYRA-2 protein	0.0055	0.0775	0.1245
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.037	0.7313	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	allatostatin A receptor	0.0055	0.0775	0.0664
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0348	0.0418
Schistosoma mansoni	myosin xvIII	0.0055	0.0775	0.2258
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0302	0.0207
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0775	0.2258
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0025	0.0147	0.1016
Leishmania major	glucose transporter, lmgt2	0.0033	0.031	0.6871
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0055	0.0775	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0288	0.0321
Echinococcus multilocularis	General substrate transporter	0.0091	0.1521	0.142
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0055	0.0775	0.2258
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0775	0.2258
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0288	0.0171
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0348	0.0418
Trichomonas vaginalis	hypothetical protein	0.037	0.7313	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trypanosoma brucei	pteridine reductase 1	0.0025	0.0147	0.1016
Schistosoma mansoni	adenoreceptor	0.0055	0.0775	0.2258
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0302	0.0255
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0896	0.2678
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0775	0.0664
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0775	0.2258
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0055	0.0775	0.2258
Echinococcus granulosus	hypothetical protein	0.0055	0.0775	0.0664
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0025	0.0147	0.0098
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0055	0.0775	0.1245
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.037	0.7313	0.8113
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0348	0.0436
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0348	0.0791
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0025	0.0147	0.1548
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0348	0.0418
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0301	0.0347
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0055	0.0775	0.0664
Echinococcus multilocularis	neuropeptide s receptor	0.05	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0164	0.0086
Mycobacterium tuberculosis	Probable oxidoreductase	0.0025	0.0147	0.0141
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0025	0.0147	0.0032
Onchocerca volvulus		0.0035	0.0348	0.3208
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0025	0.0147	0.0039
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.4368	0.4301
Echinococcus multilocularis	dro:myosuppressin receptor	0.0055	0.0775	0.0664
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	Dopamine receptor protein 1	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0025	0.0147	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0147	0.0054
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0172	0.319	0.4269
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.031	0.0348
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	beta-lactamase family protein	0.0035	0.0348	0.0436
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0288	0.0335
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.031	0.6871
Schistosoma mansoni	amine GPCR	0.0055	0.0775	0.2258
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0775	0.0664
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.031	0.6871
Echinococcus granulosus	neuropeptide receptor A26	0.05	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Onchocerca volvulus		0.0055	0.0775	1
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0775	0.0664
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0302	0.0207
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0775	0.2258
Leishmania major	glucose transporter, lmgt1	0.0033	0.031	0.6871
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0025	0.0147	0.3692
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0055	0.0775	0.1245
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Brugia malayi	Serotonin receptor	0.0055	0.0775	0.1245
Leishmania major	glucose transporter, lmgt3	0.0033	0.031	0.6871
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Echinococcus granulosus	7tm_1 domain containing protein	0.0055	0.0775	0.0664
Brugia malayi	RE15519p	0.0055	0.0775	0.1245
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0397	0.0315
Brugia malayi	beta-lactamase family protein	0.0035	0.0348	0.0436
Echinococcus multilocularis	g protein coupled receptor	0.0055	0.0775	0.0664
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0288	0.0583
Chlamydia trachomatis	oxoacy-ACP reductase	0.0025	0.0147	0.0039
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0141
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0775	0.1245
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Brugia malayi	G-protein coupled receptor	0.0055	0.0775	0.1245
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0301	0.0185
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0593	0.1635
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0348	0.0259
Onchocerca volvulus		0.0035	0.0348	0.3208
Echinococcus granulosus	G protein coupled receptor 139	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0055	0.0775	0.2258
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0775	0.0664
Schistosoma mansoni	hypothetical protein	0.0055	0.0775	0.2258
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0896	0.1477
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0055	0.0775	0.0664
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.031	0.7803
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0118	0.0102
Schistosoma mansoni	hypothetical protein	0.0055	0.0775	0.2258
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0348	0.0436
Echinococcus granulosus	neuropeptide receptor	0.0055	0.0775	0.0664
Schistosoma mansoni	protein kinase	0.0033	0.0301	0.063
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0348	0.0418
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.031	0.0348
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	geminin	0.0164	0.3024	0.2941
Schistosoma mansoni	opsin-like receptor	0.0055	0.0775	0.2258
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0025	0.0147	0.1016
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0775	0.0664
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0147	0.0039
Echinococcus multilocularis	neuropeptide receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0775	0.0664
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0302	0.0207
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0775	0.1245
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0055	0.0775	0.0664
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0301	0.0347
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0147	0.0039
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0025	0.0147	0.0039
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	beta-lactamase	0.0035	0.0348	0.0436
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0775	0.0664
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0025	0.0147	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0025	0.0147	0.0141
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0775	0.2258
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.031	0.0348
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0775	0.2258
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.026	0.0143
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0302	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0025	0.0147	0.0141
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0348	0.0436
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0397	0.0388
Onchocerca volvulus		0.0055	0.0775	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0301	0.0347
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0172	0.319	0.3464
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0025	0.0147	0.0141
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0147	0.0039
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0896	0.1477
Schistosoma mansoni	glucose transport protein	0.0106	0.1831	0.5895
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0055	0.0775	0.0664
Schistosoma mansoni	opsin-like receptor	0.0055	0.0775	0.2258
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0055	0.0775	0.0664
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0348	0.0418
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.031	0.0348
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0118	0.0084
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.031	0.7803
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0288	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Onchocerca volvulus		0.0055	0.0775	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0302	0.0207
Schistosoma mansoni	glucose transport protein	0.0106	0.1831	0.5895
Echinococcus granulosus	neuropeptide FF receptor 2	0.0055	0.0775	0.0664
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0025	0.0147	0.0039
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0896	0.2678
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0302	0.0255
Schistosoma mansoni	neuropeptide f receptor 76f	0.0055	0.0775	0.2258
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0397	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0301	1
Echinococcus granulosus	fmrfamide receptor	0.0055	0.0775	0.0664
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Mycobacterium tuberculosis	Possible oxidoreductase	0.0025	0.0147	0.0141
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0025	0.0147	0.0029
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0775	0.0664
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0025	0.0147	0.0141
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Leishmania major	hypothetical protein, conserved	0.0035	0.0348	0.8235
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0896	0.2678
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0397	1
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.1831	0.2445
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0025	0.0147	0.1016
Schistosoma mansoni	hypothetical protein	0.0164	0.3024	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.031	0.6871
Plasmodium vivax	hexose transporter	0.0106	0.1831	0.1932
Schistosoma mansoni	amine GPCR	0.0055	0.0775	0.2258
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0025	0.0147	0.0054
Schistosoma mansoni	amine GPCR	0.0055	0.0775	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0288	0.0317
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0775	0.2258
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0348	0.0436
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0302	0.0207
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0055	0.0775	0.2258
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0288	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0055	0.0775	0.1245
Brugia malayi	neuropeptide F receptor	0.0055	0.0775	0.1245
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0775	0.2258
Mycobacterium ulcerans	oxidoreductase	0.0025	0.0147	0.0039
Onchocerca volvulus		0.0055	0.0775	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0055	0.0775	0.2258
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0896	0.1477
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0775	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0348	0.0436
Echinococcus granulosus	dro:myosuppressin receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0775	0.0664
Onchocerca volvulus		0.0055	0.0775	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0896	0.2678
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0301	0.063
Schistosoma mansoni	hypothetical protein	0.0055	0.0775	0.2258
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0348	0.04
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.031	0.6871
Schistosoma mansoni	hypothetical protein	0.0047	0.0593	0.1635
Brugia malayi	GnHR receptor homolog	0.0055	0.0775	0.1245
Schistosoma mansoni	neuropeptide F-like receptor	0.0055	0.0775	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0348	0.0436
Brugia malayi	ORL1-like opioid receptor	0.0055	0.0775	0.1245
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0025	0.0147	0.0039
Brugia malayi	RNA binding protein	0.0061	0.0896	0.1477
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0348	0.0418
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0348	0.0418
Loa Loa (eye worm)	G-protein coupled receptor	0.0055	0.0775	0.1245
Echinococcus granulosus	g protein coupled receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0348	0.0233
Onchocerca volvulus		0.0055	0.0775	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0288	0.0583
Schistosoma mansoni	growth hormone secretagogue receptor	0.0055	0.0775	0.2258
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0278	0.5387	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0348	0.0418
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0055	0.0775	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0302	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0301	0.6561
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0397	1
Onchocerca volvulus		0.0055	0.0775	1
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.037	0.7313	1
Schistosoma mansoni	dihydropteridine reductase	0.0025	0.0147	0.0098
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0348	0.0418
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0896	0.1477
Brugia malayi	G protein-coupled receptor F59B2.13	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0141
Brugia malayi	larval opioid receptor	0.0055	0.0775	0.1245
Loa Loa (eye worm)	neuropeptide F receptor	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	sugar transporter	0.0106	0.1831	0.3251
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Brugia malayi	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	sulfakinin receptor protein	0.0055	0.0775	0.1245
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0025	0.0147	0.0039
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0348	0.0791
Echinococcus multilocularis	fmrfamide receptor	0.0055	0.0775	0.0664
Brugia malayi	Serotonin receptor	0.0055	0.0775	0.1245
Echinococcus multilocularis	orexin receptor type 2	0.0055	0.0775	0.0664
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0025	0.0147	0.0032
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0055	0.0775	0.0664
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0348	0.04
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0348	0.8761
Echinococcus granulosus	geminin	0.0164	0.3024	0.2941
Onchocerca volvulus		0.0055	0.0775	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0055	0.0775	0.1245
Loa Loa (eye worm)	melatonin receptor type 1A	0.0055	0.0775	0.1245
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0055	0.0775	0.1245
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.031	0.0348
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0025	0.0147	0.3692
Echinococcus multilocularis	neuropeptides capa receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0775	0.0664
Schistosoma mansoni	opsin-like receptor	0.0055	0.0775	0.2258
Echinococcus multilocularis	serotonin receptor	0.0055	0.0775	0.0664
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0302	0.0207
Schistosoma mansoni	hypothetical protein	0.0055	0.0775	0.2258
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0896	0.0787
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0025	0.0147	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.031	0.0348
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0055	0.0775	0.2258
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0348	0.04
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0025	0.0147	0.3692
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0288	0.9253
Echinococcus multilocularis	sex peptide receptor	0.0055	0.0775	0.0664
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0397	1
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0775	0.0664
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0593	0.0901
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.4239	0.5771
Onchocerca volvulus		0.0055	0.0775	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Echinococcus granulosus	tm gpcr rhodopsin	0.0055	0.0775	0.0664
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0055	0.0775	0.1245
Entamoeba histolytica	protein kinase, putative	0.0033	0.0301	1
Schistosoma mansoni	neuropeptide receptor	0.0055	0.0775	0.2258
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Echinococcus granulosus	biogenic amine 5HT receptor	0.0055	0.0775	0.0664
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0055	0.0775	0.0664
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0775	0.0664
Trichomonas vaginalis	esterase, putative	0.0035	0.0348	0.04
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0348	0.04
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trypanosoma brucei	glucose transporter 2A	0.0033	0.031	0.6871
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.037	0.7313	1
Brugia malayi	Cam kinase protein 1	0.0033	0.0301	0.0347
Plasmodium falciparum	protein kinase 7	0.03	0.5857	0.6471
Plasmodium falciparum	enoyl-acyl carrier reductase	0.037	0.7313	0.8113
Echinococcus granulosus	neuropeptide Y receptor	0.0055	0.0775	0.0664
Mycobacterium ulcerans	lipase LipD	0.0035	0.0348	0.0319
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0896	0.2678
Brugia malayi	TAR-binding protein	0.0061	0.0896	0.1477
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0348	0.0319
Onchocerca volvulus		0.0055	0.0775	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0302	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	G protein-coupled receptor	0.0055	0.0775	0.1245
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0348	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Schistosoma mansoni	protein kinase	0.0033	0.0301	0.063
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0451	0.8986	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0055	0.0775	0.0664
Loa Loa (eye worm)	oxidoreductase	0.0025	0.0147	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Brugia malayi	Melatonin receptor type 1A	0.0055	0.0775	0.1245
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0055	0.0775	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.026	0.0143
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.1831	0.1734
Echinococcus granulosus	sex peptide receptor	0.0055	0.0775	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.037	0.7313	1
Brugia malayi	follicle stimulating hormone receptor	0.0278	0.5387	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0301	0.0185
Leishmania major	protein kinase, putative	0.0033	0.0301	0.6561
Trypanosoma brucei	glucose transporter, putative	0.0033	0.031	0.6871
Onchocerca volvulus		0.0055	0.0775	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0025	0.0147	0.0054
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0055	0.0775	0.0664
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0896	0.0787
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0055	0.0775	0.0664
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0025	0.0147	0.0039
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.1831	0.1734
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0172	0.319	0.3464
Loa Loa (eye worm)	hypothetical protein	0.0228	0.4368	0.8066
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0025	0.0147	0.0029
Onchocerca volvulus		0.0055	0.0775	1
Trypanosoma brucei	oxidoreductase-like protein	0.0025	0.0147	0.1016
Echinococcus granulosus	neuropeptides capa receptor	0.0055	0.0775	0.0664
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0302	0.0255
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0348	0.8235
Brugia malayi	G-protein coupled receptor	0.0055	0.0775	0.1245
Echinococcus granulosus	7TM GPCR rhodopsin	0.0055	0.0775	0.0664
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0055	0.0775	0.0664
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0025	0.0147	0.0039
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0348	0.0436
Echinococcus granulosus	g-protein coupled receptor	0.0055	0.0775	0.0664
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0055	0.0775	0.2258
Schistosoma mansoni	glucose transport protein	0.0106	0.1831	0.5895
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0025	0.0147	0.0054
Trypanosoma cruzi	hexose transporter	0.0033	0.031	0.7803
Onchocerca volvulus		0.0035	0.0348	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0301	0.0347
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.031	0.0348
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0055	0.0775	0.1245
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.1831	0.2381
Onchocerca volvulus		0.0055	0.0775	1
Plasmodium falciparum	hexose transporter	0.0106	0.1831	0.1932
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0055	0.0775	0.0664
Echinococcus granulosus	somatostatin receptor	0.0055	0.0775	0.0664
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0397	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0055	0.0775	0.0664
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.037	0.7313	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0348	0.04
Echinococcus granulosus	General substrate transporter	0.0091	0.1521	0.142
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0775	0.1245
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0055	0.0775	0.1245
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Echinococcus granulosus	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Onchocerca volvulus		0.0055	0.0775	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0055	0.0775	0.0664
Plasmodium falciparum	protein kinase 6	0.0451	0.8986	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0055	0.0775	0.0664
Brugia malayi	AKH receptor	0.0055	0.0775	0.1245
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0288	0.0171
Schistosoma mansoni	biogenic amine receptor	0.0055	0.0775	0.2258
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0055	0.0775	0.2258
Mycobacterium ulcerans	short chain dehydrogenase	0.0025	0.0147	0.0039

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 3.7 nM	Binding affinity to CB1 receptor	ChEMBL.	17466519
Ki (binding)	= 3.7 nM	Binding affinity to CB1 receptor	ChEMBL.	17466519
Ratio Ki (binding)	= 784	Selectivity for CB1 receptor over CB2 receptor	ChEMBL.	17466519

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL396368

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 456334