Detailed information for compound 458512

Basic information

Technical information
  • TDR Targets ID: 458512
  • Name: (2R)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluo roethyl]amino]-N-(1-cyanocyclopropyl)-3-methy lsulfinylpropanamide
  • MW: 452.289 | Formula: C16H17BrF3N3O2S
  • H donors: 2 H acceptors: 3 LogP: 2.74 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@@H](N[C@H](C(F)(F)F)c1ccc(cc1)Br)C[S+](C)[O-]
  • InChi: 1S/C16H17BrF3N3O2S/c1-26(25)8-12(14(24)23-15(9-21)6-7-15)22-13(16(18,19)20)10-2-4-11(17)5-3-10/h2-5,12-13,22H,6-8H2,1H3,(H,23,24)/t12-,13-,26?/m0/s1
  • InChiKey: WKOXXQWORKCMDZ-GXXHEZNASA-N  


Substructure search Similarity search

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Synonyms

  • (2R)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfinyl-propanamide
  • (2R)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]amino]-N-(1-cyanocyclopropyl)-3-methylsulfinyl-propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum exodeoxyribonuclease (exoA) 0.0013 0.035 0.5
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Plasmodium vivax unspecified product 0.002 0.0739 0.1022
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.2996 0.2996
Trypanosoma cruzi cysteine protease, putative 0.0047 0.2278 0.1998
Toxoplasma gondii cathepsin CPC1 0.002 0.0739 0.0928
Giardia lamblia Hypothetical protein 0.002 0.0739 0.1194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.2278 0.2278
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0739 0.1022
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Plasmodium vivax unspecified product 0.0027 0.1132 0.1953
Loa Loa (eye worm) hypothetical protein 0.002 0.0739 0.0739
Onchocerca volvulus 0.0086 0.4536 1
Echinococcus multilocularis cathepsin b 0.0181 1 1
Onchocerca volvulus 0.0086 0.4536 1
Echinococcus granulosus cathepsin b 0.0181 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.035 0.035
Giardia lamblia Cathepsin B precursor 0.002 0.0739 0.1194
Onchocerca volvulus Cathepsin L homolog 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0739 0.1022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0548 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Plasmodium falciparum serine repeat antigen 7 0.002 0.0739 0.1022
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0.035 0.5
Brugia malayi Cathepsin L-like precursor 0.0059 0.2996 0.2996
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.2278 0.4606
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0739 0.1194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0739 0.0928
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0739 0.1022
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.4536 1
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.4536 0.4337
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.4536 0.4536
Echinococcus granulosus cathepsin l1 0.0086 0.4536 0.4536
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.4536 0.4536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.4536 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0739 0.0928
Brugia malayi Cathepsin L-like precursor 0.0086 0.4536 0.4536
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0086 0.4536 0.4536
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0739 0.0739
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0027 0.1132 0.1132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0017 0.0548 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0739 0.1022
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0739 0.1194
Giardia lamblia Cathepsin B precursor 0.002 0.0739 0.1194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0739 0.0928
Onchocerca volvulus 0.0086 0.4536 1
Plasmodium falciparum serine repeat antigen 9 0.002 0.0739 0.1022
Onchocerca volvulus 0.0059 0.2996 0.6606
Loa Loa (eye worm) hypothetical protein 0.0059 0.2996 0.2996
Giardia lamblia Cathepsin L precursor 0.002 0.0739 0.1194
Loa Loa (eye worm) hypothetical protein 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Schistosoma mansoni hypothetical protein 0.0119 0.6417 0.6417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Echinococcus multilocularis cysteine protease 0.0086 0.4536 0.4536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0739 0.1022
Entamoeba histolytica hypothetical protein 0.002 0.0739 0.0928
Toxoplasma gondii cathepsin B 0.007 0.3603 0.7771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.1132 0.081
Loa Loa (eye worm) hypothetical protein 0.002 0.0739 0.0739
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.2996 0.6322
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0739 0.1022
Plasmodium falciparum serine repeat antigen 2 0.002 0.0739 0.1022
Echinococcus multilocularis cathepsin L 0.002 0.0739 0.0739
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0739 0.1022
Schistosoma mansoni ap endonuclease 0.0013 0.035 0.035
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.2278 0.2278
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.2278 0.2278
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0548 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.4536 0.4536
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.2278 0.4606
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0548 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0013 0.035 0.1822
Loa Loa (eye worm) hypothetical protein 0.0012 0.0306 0.0306
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.4536 0.4536
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0027 0.1132 0.1132
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Plasmodium falciparum serine repeat antigen 1 0.002 0.0739 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.035 0.0104
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0739 0.0928
Giardia lamblia Cathepsin B precursor 0.002 0.0739 0.1194
Giardia lamblia Cathepsin B precursor 0.007 0.3603 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.035 0.035
Giardia lamblia Cysteine protease 0.002 0.0739 0.1194
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.2278 0.1998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.4536 1
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.2278 0.1998
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.2278 0.1998
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1132 0.081
Echinococcus multilocularis cathepsin b 0.0181 1 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0739 0.0739
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0739 0.0739
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4536 0.4337
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0306 0.0306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0548 0.0472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 1 1
Giardia lamblia Cysteine protease 0.002 0.0739 0.1194
Leishmania major cysteine peptidase A (CPA) 0.0086 0.4536 1
Onchocerca volvulus Cathepsin F homolog 0.0086 0.4536 1
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0548 0.0548
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0739 0.0739
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0739 0.0928
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0548 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.4536 0.4536
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0739 0.0928
Onchocerca volvulus 0.002 0.0739 0.1629
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0739 0.0928
Onchocerca volvulus 0.0086 0.4536 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0739 0.1194
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.4536 0.4536
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.2278 0.4606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0739 0.0739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0739 0.0928
Brugia malayi Cathepsin L-like precursor 0.0027 0.1132 0.1132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0548 0.5
Loa Loa (eye worm) cathepsin B 0.007 0.3603 0.3603
Giardia lamblia Cysteine protease 0.002 0.0739 0.1194
Entamoeba histolytica cysteine protease, putative 0.002 0.0739 0.0928
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.3603 0.3603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0739 0.0402
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.4536 1
Giardia lamblia Cathepsin B precursor 0.002 0.0739 0.1194
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.1132 0.1132
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0739 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Loa Loa (eye worm) fibroinase 0.0086 0.4536 0.4536
Echinococcus granulosus geminin 0.0119 0.6417 0.6417
Brugia malayi Cathepsin L-like precursor 0.0086 0.4536 0.4536
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0739 0.0402
Onchocerca volvulus 0.0086 0.4536 1
Giardia lamblia Cathepsin L precursor 0.002 0.0739 0.1194
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.4536 0.4536
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.002 0.0739 0.1194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Giardia lamblia Cathepsin L-like protease 0.002 0.0739 0.1194
Onchocerca volvulus 0.0086 0.4536 1
Echinococcus multilocularis cysteine protease 0.0086 0.4536 0.4536
Entamoeba histolytica cysteine protease, putative 0.002 0.0739 0.0928
Loa Loa (eye worm) hypothetical protein 0.0012 0.0306 0.0306
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0739 0.1022
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Loa Loa (eye worm) cysteine protease 0.0086 0.4536 0.4536
Toxoplasma gondii cathepsin CPL 0.0086 0.4536 1
Plasmodium falciparum serine repeat antigen 3 0.002 0.0739 0.1022
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Giardia lamblia Cathepsin B precursor 0.007 0.3603 1
Giardia lamblia Cathepsin L precursor 0.002 0.0739 0.1194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.2278 0.4606
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.4536 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.2278 0.4606
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.2996 0.2742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.0739 0.1629
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.2278 0.4606
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0739 0.1022
Echinococcus granulosus cathepsin b 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.0181 1 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.4536 1
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.4536 0.4536
Plasmodium falciparum serine repeat antigen 8 0.002 0.0739 0.1022
Brugia malayi Cathepsin L-like precursor 0.0086 0.4536 0.4536
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.4536 0.4536
Giardia lamblia Cathepsin L-like protease 0.002 0.0739 0.1194
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.3603 0.7771
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.1132 0.1132
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0548 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2996 0.6322
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine proteinase 2 0.0047 0.2278 0.4606
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0739 0.0739
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0739 0.0739
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4536 0.4337
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0739 0.0739
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.3603 0.3371
Giardia lamblia Cathepsin L precursor 0.002 0.0739 0.1194
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.2278 0.4606
Echinococcus granulosus cysteine protease 0.0047 0.2278 0.2278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.4536 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0548 0.0472
Echinococcus multilocularis cathepsin L 0.0047 0.2278 0.2278
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.4536 0.4536
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0739 0.1022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0548 0.0548
Plasmodium vivax vivapain-2 0.0086 0.4536 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0739 0.0739
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0739 0.0739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.2278 0.1998
Entamoeba histolytica acyl-coA synthetase, putative 0.0017 0.0548 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2996 0.6322
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0548 1
Brugia malayi cathepsin L precursor 0.002 0.0739 0.0739
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.2996 0.2996
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.2278 0.2278
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4536 0.4337
Mycobacterium ulcerans hypothetical protein 0.0017 0.0548 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0306 0.139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0739 0.0928
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0548 0.0472
Brugia malayi Cathepsin L-like precursor 0.0086 0.4536 0.4536
Echinococcus granulosus cathepsin l1 0.0059 0.2996 0.2996
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.035 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Schistosoma mansoni cathepsin C 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0739 0.0928
Entamoeba histolytica cysteine protease, putative 0.002 0.0739 0.0928
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0548 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0739 0.1022
Loa Loa (eye worm) ctsf protein 0.0086 0.4536 0.4536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Giardia lamblia Cysteine protease 0.002 0.0739 0.1194
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.1132 0.1132
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0739 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0548 0.0472
Loa Loa (eye worm) hypothetical protein 0.002 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0059 0.2996 0.2996
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Plasmodium falciparum serine repeat antigen 4 0.002 0.0739 0.1022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Giardia lamblia Hypothetical protein 0.002 0.0739 0.1194
Loa Loa (eye worm) hypothetical protein 0.0012 0.0306 0.0306
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.2278 0.2278
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0739 0.0928
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0739 0.0928
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 1 1
Schistosoma mansoni ap endonuclease 0.0013 0.035 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.2278 0.4606
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.035 0.035
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0012 0.0306 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.4536 0.4536
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0548 0.0472
Entamoeba histolytica cysteine protease, putative 0.002 0.0739 0.0928
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.4536 1
Plasmodium falciparum serine repeat antigen 5 0.002 0.0739 0.1022
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0739 0.0928
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0739 0.0928
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0017 0.0548 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0739 0.0739
Giardia lamblia Cathepsin L precursor 0.002 0.0739 0.1194
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.3603 0.7771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0739 0.0928
Onchocerca volvulus 0.0017 0.0548 0.1208
Leishmania major cathepsin L-like protease 0.0086 0.4536 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0548 0.0548
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.2278 0.2278
Plasmodium vivax vivapain-2 0.0086 0.4536 1
Echinococcus granulosus cathepsin L 0.002 0.0739 0.0739
Toxoplasma gondii cathepsin CPC2 0.002 0.0739 0.0928
Giardia lamblia Encystation-specific protease 0.002 0.0739 0.1194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Giardia lamblia Cathepsin B precursor 0.002 0.0739 0.1194
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0739 0.0739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0739 0.0928
Loa Loa (eye worm) hypothetical protein 0.0027 0.1132 0.1132
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0017 0.0548 1
Plasmodium vivax vivapain-1 0.0047 0.2278 0.4662
Schistosoma mansoni hypothetical protein 0.0119 0.6417 0.6417
Giardia lamblia Cathepsin B precursor 0.007 0.3603 1
Onchocerca volvulus Cathepsin L homolog 0.0086 0.4536 1
Brugia malayi fibroinase precursor 0.002 0.0739 0.0739
Brugia malayi Cathepsin L-like precursor 0.0059 0.2996 0.2996
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0739 0.0739
Plasmodium vivax vivapain-3 0.0047 0.2278 0.4662
Plasmodium vivax unspecified product 0.0047 0.2278 0.4662
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0548 0.0548
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.2278 0.4662
Loa Loa (eye worm) hypothetical protein 0.0059 0.2996 0.2996
Schistosoma mansoni cathepsin s 0.0027 0.1132 0.1132
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0739 0.0928
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0739 0.0739
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0739 0.1022
Echinococcus granulosus cathepsin L 0.0047 0.2278 0.2278
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.2278 0.4606
Onchocerca volvulus 0.0086 0.4536 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.035 0.2958
Plasmodium falciparum serine repeat antigen 6 0.002 0.0739 0.1022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.4536 1
Echinococcus multilocularis geminin 0.0119 0.6417 0.6417
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.4536 0.4337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.4536 1
Giardia lamblia Cathepsin L precursor 0.002 0.0739 0.1194
Brugia malayi cathepsin L-like precursor 0.0059 0.2996 0.2996
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0739 0.0739
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.4536 0.4536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.4536 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.3603 0.7771
Loa Loa (eye worm) hypothetical protein 0.0012 0.0306 0.0306
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0548 0.0548
Brugia malayi Cathepsin L-like precursor 0.0086 0.4536 0.4536
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0739 0.1022
Entamoeba histolytica cysteine protease, putative 0.0047 0.2278 0.4606
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0739 0.1022
Loa Loa (eye worm) hypothetical protein 0.002 0.0739 0.0739

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 639 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 639 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 2173 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 2173 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 8029 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 8029 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) > 10000 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) > 10000 nM Inhibition of human cathepsin L ChEMBL. 17590332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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