Detailed information for compound 500353

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.427 | Formula: C23H20F7N5O
  • H donors: 1 H acceptors: 3 LogP: 3.37 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCn2c([C@H]1Cc1ccc(cc1)F)nc(n2)C(F)(F)F
  • InChi: 1S/C23H20F7N5O/c24-14-3-1-12(2-4-14)7-19-21-32-22(23(28,29)30)33-35(21)6-5-34(19)20(36)10-15(31)8-13-9-17(26)18(27)11-16(13)25/h1-4,9,11,15,19H,5-8,10,31H2/t15-,19-/m1/s1
  • InChiKey: ILWOOGUHZKNTQQ-DNVCBOLYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Brugia malayi Sugar transporter family protein 0.0014 0.009 0.009
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0064 0.2232 0.2232
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0464 0.0464
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0464 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0824 0.1973
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0196 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0196 0.5
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0196 0.0196
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0464 0.0464
Trypanosoma cruzi oligopeptidase b 0.0017 0.0196 0.044
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0464 0.0464
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0196 0.5
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0196 0.0196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0464 0.0464
Trypanosoma cruzi oligopeptidase b 0.0017 0.0196 0.044
Echinococcus granulosus solute carrier family 22 0.0014 0.009 0.009
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0464 0.0464
Brugia malayi ecdysteroid receptor 0.0023 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0824 0.1973
Schistosoma mansoni glucose transport protein 0.01 0.3814 0.3814
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0464 0.0464
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0244 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0464 0.0464
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0464 0.0464
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0824 0.3025
Leishmania major glucose transporter, lmgt1 0.0031 0.0824 0.3025
Brugia malayi prolyl oligopeptidase family protein 0.007 0.2518 0.2518
Brugia malayi nuclear hormone receptor 0.0023 0.0464 0.0464
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0196 1
Echinococcus granulosus solute carrier family 22 0.0014 0.009 0.009
Brugia malayi Sugar transporter family protein 0.0014 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Leishmania major glucose transporter, lmgt2 0.0031 0.0824 0.3025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0464 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0824 0.1973
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.2518 0.2518
Schistosoma mansoni dopamine-beta-monooxygenase 0.0129 0.5067 0.5067
Toxoplasma gondii hypothetical protein 0.0017 0.0196 0.0287
Loa Loa (eye worm) hypothetical protein 0.0017 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0464 0.0464
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0196 0.0196
Schistosoma mansoni sugar transporter 0.0014 0.009 0.009
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.009 0.009
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0196 0.0287
Loa Loa (eye worm) hypothetical protein 0.0129 0.5067 0.5067
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0464 0.0464
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0824 0.1973
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.009 0.009
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0464 0.0444
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0196 0.044
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.2518 0.2518
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0464 0.0464
Schistosoma mansoni coup transcription factor 0.0023 0.0464 0.0464
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.8516 0.8516
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Schistosoma mansoni peptidylglycine monooxygenase 0.0129 0.5067 0.5067
Plasmodium falciparum hexose transporter 0.01 0.3814 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.2518 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0824 0.1973
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0464 0.0464
Trypanosoma cruzi hexose transporter 0.0031 0.0824 0.3025
Schistosoma mansoni glucose transporter 0.0014 0.009 0.009
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0464 0.0464
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0196 0.0196
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0464 0.0464
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0196 0.0196
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0464 0.0464
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0464 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0464 0.0464
Trypanosoma brucei glucose transporter 1E 0.0031 0.0824 0.3025
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0196 0.0196
Leishmania major oligopeptidase b 0.0017 0.0196 0.044
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0196 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.01 0.3814 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0196 0.044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0464 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0464 0.0464
Brugia malayi major facilitator superfamily protein 0.0014 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0017 0.0196 0.0196
Echinococcus granulosus solute carrier family 22 0.0014 0.009 0.009
Plasmodium falciparum peptidase, putative 0.0017 0.0196 0.0287
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0464 0.0464
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.8516 0.8516
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0464 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0196 0.044
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0464 0.0464
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.009 0.009
Onchocerca volvulus 0.0023 0.0464 0.0444
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0196 0.044
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0196 0.044
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0824 0.3025
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0464 0.0464
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0129 0.5067 0.5067
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0244 1 1
Echinococcus granulosus General substrate transporter 0.0086 0.3205 0.3205
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Brugia malayi hypothetical protein 0.0014 0.009 0.009
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.2518 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Leishmania major glucose transporter, lmgt3 0.0031 0.0824 0.3025
Echinococcus multilocularis solute carrier family 22 0.0014 0.009 0.009
Trypanosoma brucei oligopeptidase b 0.0017 0.0196 0.044
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.009 0.009
Brugia malayi steroid hormone receptor 0.0023 0.0464 0.0464
Plasmodium vivax hexose transporter 0.01 0.3814 1
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0464 0.0444
Echinococcus multilocularis solute carrier family 22 0.0014 0.009 0.009
Schistosoma mansoni glucose transport protein 0.01 0.3814 0.3814
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0196 0.0287
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0464 0.0464
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0196 0.044
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0464 0.0464
Loa Loa (eye worm) sugar transporter 0.01 0.3814 0.3814
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0464 0.0464
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.2518 0.652
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0196 0.044
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.8516 0.8516
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.2518 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0196 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0464 0.0464
Schistosoma mansoni sugar transporter 0.0014 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0054 0.1802 0.1802
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.8516 0.8516
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.009 0.009
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0244 1 1
Brugia malayi hypothetical protein 0.0054 0.1802 0.1802
Loa Loa (eye worm) hypothetical protein 0.0244 1 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0196 1
Schistosoma mansoni sugar transporter 0.0014 0.009 0.009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0464 0.0464
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0824 0.3025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0464 0.0464
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0464 0.0464
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.8516 0.8516
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0196 0.5
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0017 0.0196 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0464 0.0464
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.009 0.009
Brugia malayi nuclear receptor NHR-88 0.0023 0.0464 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0464 0.0464
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.0196 0.0127
Echinococcus multilocularis solute carrier family 22 0.0014 0.009 0.009
Echinococcus multilocularis General substrate transporter 0.0086 0.3205 0.3205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0464 0.0464
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0464 0.0464
Schistosoma mansoni glucose transport protein 0.01 0.3814 0.3814
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0464 0.0464
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0464 0.0464
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0196 0.0196
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0215 0.0516
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0464 0.0464
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0066 0.2316 0.2316
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0196 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0464 0.0464
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0824 0.1973
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0464 0.0444
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0196 0.0287
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0464 0.0464
Trypanosoma brucei glucose transporter 2A 0.0031 0.0824 0.3025
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.8516 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.2518 1
Toxoplasma gondii facilitative glucose transporter GT1 0.01 0.3814 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0464 0.0464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0023 0.0464 0.0464
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0464 0.0464
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0196 0.0196
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0464 0.0464
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0824 0.3025
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0196 0.044
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0196 0.044
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0196 0.5
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.2518 0.2518
Brugia malayi hypothetical protein 0.0014 0.009 0.009
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.009 0.009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0196 0.5
Brugia malayi major facilitator superfamily protein 0.0014 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0464 0.0464
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0196 0.044
Brugia malayi Sugar transporter family protein 0.01 0.3814 0.3814
Loa Loa (eye worm) hypothetical protein 0.0017 0.0196 0.0196
Brugia malayi hypothetical protein 0.0014 0.009 0.009
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0196 0.044
Echinococcus granulosus solute carrier family 22 0.0014 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0464 0.0464
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0196 0.0287
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0824 0.3025
Loa Loa (eye worm) sugar transporter 0.0014 0.009 0.009
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.009 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0196 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0464 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0464 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0824 0.1973
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0196 0.0287
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.01 0.3814 0.3814
Echinococcus multilocularis solute carrier family 22 0.0014 0.009 0.009
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0196 0.5
Trypanosoma brucei glucose transporter, putative 0.0031 0.0824 0.3025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0464 0.0464
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.01 0.3814 0.3814
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0824 0.3025
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.2518 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.009
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.01 0.3814 0.3814
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0824 0.3025
Schistosoma mansoni sugar transporter 0.0014 0.009 0.009

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 0.146 uM.hr.Kg/mg Normalized AUC in rat ChEMBL. 17827003
CL (ADMET) = 76 ml/min.kg Plasma clearance in rat ChEMBL. 17827003
F (ADMET) = 32 % Oral bioavailability in rat ChEMBL. 17827003
IC50 (binding) = 4 nM Inhibition of DPP4 ChEMBL. 17827003
IC50 (binding) = 4 nM Inhibition of DPP4 ChEMBL. 17827003
IC50 (binding) = 25000 nM Inhibition of DPP8 ChEMBL. 17827003
IC50 (binding) = 25000 nM Inhibition of DPP8 ChEMBL. 17827003
IC50 (binding) = 27000 nM Inhibition of DPP9 ChEMBL. 17827003
IC50 (binding) = 27000 nM Inhibition of DPP9 ChEMBL. 17827003
IC50 (binding) = 60000 nM Inhibition of QPP ChEMBL. 17827003
IC50 (binding) = 60000 nM Inhibition of QPP ChEMBL. 17827003
t1/2 (ADMET) = 2.7 hr Half life in rat ChEMBL. 17827003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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