Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0041 | 0.0365 | 0.0365 |
Echinococcus granulosus | serotonin transporter | 0.0241 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0241 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0041 | 0.0365 | 0.0365 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.5721 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.4017 | 0.4017 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0241 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.5721 | 0.5559 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0743 | 0.0743 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0041 | 0.0365 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0743 | 0.0743 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0241 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.5721 | 0.5559 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0743 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0041 | 0.0365 | 0.0365 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0777 | 0.0777 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0041 | 0.0365 | 0.0365 |
Plasmodium falciparum | transporter, putative | 0.0041 | 0.0365 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.5721 | 0.5559 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.5721 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.4017 | 0.4017 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0.0365 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.5721 | 0.5559 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.5721 | 0.5721 |
Loa Loa (eye worm) | serotonin transporter b | 0.0241 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Brugia malayi | Hint module family protein | 0.0049 | 0.0777 | 0.0777 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0241 | 1 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0041 | 0.0365 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0041 | 0.0365 | 0.0365 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Plasmodium falciparum | amino acid transporter, putative | 0.0041 | 0.0365 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0041 | 0.0365 | 0.0365 |
Echinococcus multilocularis | hedgehog | 0.0182 | 0.7165 | 0.7058 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.5721 | 0.5559 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.0365 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.5721 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0041 | 0.0392 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0.0365 | 0.5 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0365 | 0.0365 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.5721 | 0.5721 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.5721 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.4783 | 0.4783 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0777 | 0.0777 |
Onchocerca volvulus | 0.0241 | 1 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.4017 | 0.4017 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0041 | 0.0365 | 0.0365 |
Echinococcus granulosus | Desert hedgehog protein | 0.0182 | 0.7165 | 0.7058 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.5721 | 0.5559 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0041 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0743 | 0.0743 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0365 | 0.5 |
Brugia malayi | Hint module family protein | 0.0049 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.