Detailed information for compound 507138

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.391 | Formula: C19H23NO3
  • H donors: 1 H acceptors: 1 LogP: 2.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1CC[C@@]23c4c(C1)ccc(c4O[C@H]3C[C@H](C=C2)O)OC
  • InChi: 1S/C19H23NO3/c1-3-9-20-10-8-19-7-6-14(21)11-16(19)23-18-15(22-2)5-4-13(12-20)17(18)19/h3-7,14,16,21H,1,8-12H2,2H3/t14-,16-,19-/m0/s1
  • InChiKey: BQESVZIPHFRYNG-QOKNQOGYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Electrophorus electricus Acetylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 576 aa 23.4 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   633 aa 690 aa 32.3 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 517 aa 25.1 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   633 aa 576 aa 28.8 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   633 aa 622 aa 24.9 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   633 aa 549 aa 30.4 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   633 aa 690 aa 31.7 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 597 aa 25.1 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 620 aa 28.4 %
Onchocerca volvulus Acetylcholinesterase   633 aa 648 aa 25.3 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   633 aa 507 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0043 0.0345
Brugia malayi Carboxylesterase family protein 0.0082 0.1234 0.4729
Echinococcus multilocularis cysteine protease 0.0016 0.0043 0.0345
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0586 1
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.1234 1
Brugia malayi hypothetical protein 0.0035 0.0388 0.1485
Mycobacterium ulcerans methionine aminopeptidase 0.0033 0.0352 0.0352
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.038 0.308
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0095 0.0767
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0163
Brugia malayi hypoxia-induced factor 1 0.0145 0.2388 0.9151
Onchocerca volvulus 0.0059 0.0813 1
Echinococcus multilocularis acetylcholinesterase 0.0082 0.1234 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.261 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0813 0.3115
Brugia malayi hypothetical protein 0.0158 0.261 1
Leishmania major cathepsin L-like protease 0.0062 0.0867 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0628 0.7101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Leishmania major cathepsin L-like protease 0.0062 0.0867 1
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0043 0.0163
Brugia malayi Methionine aminopeptidase protein type I 0.0049 0.0644 0.2469
Schistosoma mansoni lipoxygenase 0.0019 0.0095 0.0767
Mycobacterium tuberculosis Probable methyltransferase 0.0059 0.0813 0.091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Leishmania major methionine aminopeptidase 2, putative 0.0046 0.0586 0.6594
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.077 0.8825
Onchocerca volvulus 0.0016 0.0043 0.0523
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0049 0.0644 0.522
Schistosoma mansoni o-methyltransferase 0.0059 0.0813 0.6587
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.2388 0.9151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Echinococcus granulosus acetylcholinesterase 0.0082 0.1234 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0043 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1234 0.4729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Toxoplasma gondii methionine aminopeptidase 0.0033 0.0352 0.4014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0813 0.659
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0049 0.0644 1
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0033 0.0352 0.0393
Schistosoma mansoni rab6-interacting 0.0019 0.0095 0.0767
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0602 0.4875
Leishmania major cathepsin L-like protease 0.0062 0.0867 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0043 0.0012
Plasmodium vivax vivapain-2 0.0016 0.0043 0.0012
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0043 0.0012
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.6349
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0388 0.3141
Toxoplasma gondii cathepsin CPL 0.0016 0.0043 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Entamoeba histolytica methionine aminopeptidase, putative 0.0046 0.0586 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0867 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0813 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0095 0.0877
Schistosoma mansoni polycystin 1-related 0.0019 0.0095 0.0767
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0813 0.9347
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0755 0.6114
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0813 0.091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0755 0.8635
Onchocerca volvulus 0.0035 0.038 0.4676
Onchocerca volvulus 0.0016 0.0043 0.0523
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0033 0.0352 0.0352
Echinococcus granulosus RUN 0.0019 0.0095 0.0767
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.1234 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0033 0.0352 0.2848
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0033 0.0352 0.0393
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0867 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Schistosoma mansoni o-methyltransferase 0.0059 0.0813 0.6587
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0867 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0043 0.0163
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0813 0.659
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0755 0.6114
Brugia malayi hypothetical protein 0.0019 0.0095 0.0363
Mycobacterium tuberculosis Probable catechol-O-methyltransferase 0.0506 0.8936 1
Onchocerca volvulus 0.0059 0.0813 1
Mycobacterium ulcerans methyltransferase 0.0059 0.0813 0.0813
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0163
Plasmodium vivax vivapain-2 0.0016 0.0043 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0867 1
Schistosoma mansoni hypothetical protein 0.0019 0.0095 0.0767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0813 0.659
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0755 0.0755
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0755 0.0755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0687 0.2632
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0009
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0009
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0046 0.0586 0.721
Mycobacterium leprae PROBABLE METHYLTRANSFERASE 0.0059 0.0813 1
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0049 0.0644 1
Echinococcus granulosus single minded 2 0.0035 0.038 0.308
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0043 0.0345
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.6349
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0043 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Schistosoma mansoni hypothetical protein 0.0035 0.0388 0.3141
Plasmodium vivax methionine aminopeptidase 2, putative 0.0046 0.0586 0.9034
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0043 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0033 0.0352 0.2848
Mycobacterium ulcerans putative regulatory protein 0.0035 0.038 0.038
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0095 0.0767
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0049 0.0644 0.522
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0163
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0755 0.2891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0043 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0009
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0046 0.0586 0.6594
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.6349
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0813 0.0813
Loa Loa (eye worm) carboxylesterase 0.0082 0.1234 0.4729
Treponema pallidum methionine aminopeptidase (map) 0.0033 0.0352 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0717 0.5807
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0163
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0095 0.0767
Brugia malayi O-methyltransferase family protein 0.0059 0.0813 0.3115
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0049 0.0644 0.7299
Echinococcus multilocularis RUN 0.0019 0.0095 0.0767
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0046 0.0586 0.6594
Onchocerca volvulus 0.0016 0.0043 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0033 0.0352 0.4014
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0033 0.0352 0.5141
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0755 0.0844
Brugia malayi O-methyltransferase family protein 0.0059 0.0813 0.3115
Schistosoma mansoni rab6-interacting 0.0019 0.0095 0.0767
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0043 0.0345
Schistosoma mansoni single-minded 0.0047 0.0602 0.4875
Brugia malayi PAS domain containing protein 0.0047 0.0602 0.2306
Schistosoma mansoni loxhd1 0.0019 0.0095 0.0767
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0095 0.0877
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0586 1
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0049 0.0644 0.7299
Onchocerca volvulus 0.0019 0.0095 0.1164
Brugia malayi O-methyltransferase 0.0059 0.0813 0.3115
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0717 0.5807
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0043 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0755 0.6114
Schistosoma mansoni o-methyltransferase 0.0059 0.0813 0.6587
Schistosoma mansoni o-methyltransferase 0.0059 0.0813 0.6587
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0043 0.0523
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0033 0.0352 0.5141
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0046 0.0586 0.7055
Brugia malayi Doublecortin family protein 0.0019 0.0095 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0043 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Loa Loa (eye worm) methionine aminopeptidase type I 0.0049 0.0644 0.2469
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0813 0.0813
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0043 0.0523
Loa Loa (eye worm) fibroinase 0.0016 0.0043 0.0163
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0095 0.0767
Echinococcus granulosus cathepsin l1 0.0016 0.0043 0.0345
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0046 0.0586 0.6594
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0043 0.0726
Echinococcus multilocularis acetylcholinesterase 0.0082 0.1234 1
Brugia malayi Carboxylesterase family protein 0.0082 0.1234 0.4729
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0043 0.0163
Loa Loa (eye worm) initiation factor 2-associated protein 0.0046 0.0586 0.2246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Giardia lamblia Methionine aminopeptidase 0.0046 0.0586 0.5
Loa Loa (eye worm) O-methyltransferase 0.0059 0.0813 0.3115
Loa Loa (eye worm) cysteine protease 0.0016 0.0043 0.0163
Echinococcus granulosus carboxylesterase 5A 0.0082 0.1234 1
Chlamydia trachomatis methionine aminopeptidase 0.0033 0.0352 0.5
Onchocerca volvulus 0.0016 0.0043 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0043 0.0345
Toxoplasma gondii methionine aminopeptidase 0.0049 0.0644 0.7809
Plasmodium falciparum methionine aminopeptidase 2 0.0046 0.0586 0.9034
Echinococcus multilocularis cysteine protease 0.0016 0.0043 0.0345
Trypanosoma brucei methionine aminopeptidase, putative 0.0049 0.0644 0.7299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0095 0.0767
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0043 0.0726
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0644 0.7299
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0813 1
Entamoeba histolytica hypothetical protein 0.0035 0.0388 0.6349
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0813 0.659
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0586 1
Onchocerca volvulus 0.0019 0.0095 0.1164
Brugia malayi hypothetical protein 0.0019 0.0095 0.0363
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0388 0.3141
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0095 0.0767
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.1234 0.4729
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0033 0.0352 0.2848
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0046 0.0586 1
Onchocerca volvulus 0.0016 0.0043 0.0523
Leishmania major cathepsin L-like protease 0.0016 0.0043 0.0009
Brugia malayi bHLH-PAS transcription factor 0.0035 0.038 0.1457
Wolbachia endosymbiont of Brugia malayi O-methyltransferase 0.0059 0.0813 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0043 0.0523
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0043 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0095 0.0363
Schistosoma mansoni lipoxygenase 0.0053 0.0717 0.5807
Onchocerca volvulus 0.0016 0.0043 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0043 0.0726
Brugia malayi Cathepsin L-like precursor 0.0016 0.0043 0.0163
Echinococcus multilocularis methionyl aminopeptidase 2 0.0046 0.0586 0.4749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0363
Brugia malayi O-methyltransferase family protein 0.0059 0.0813 0.3115
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0049 0.0644 0.7299
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0046 0.0586 0.6594
Echinococcus granulosus acetylcholinesterase 0.0082 0.1234 1
Onchocerca volvulus 0.0016 0.0043 0.0523
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0043 0.0009
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0049 0.0644 0.7299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0388 0.3141
Echinococcus granulosus methionyl aminopeptidase 2 0.0046 0.0586 0.4749
Brugia malayi initiation factor 2-associated protein. 0.0046 0.0586 0.2246
Loa Loa (eye worm) hypothetical protein 0.0082 0.1234 0.4729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0043 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0867 1
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0046 0.0586 0.4749

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.18 uM Inhibition of electric eel acetylcholineesterase ChEMBL. 18356045
IC50 (binding) = 0.18 uM Inhibition of electric eel acetylcholineesterase ChEMBL. 18356045

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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