Detailed information for compound 509724

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.392 | Formula: C20H13F6N3O2S
  • H donors: 1 H acceptors: 3 LogP: 5.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@](NC(=O)c1ccc(cc1)SC(F)(F)F)(COc1cc(C#N)ccc1C(F)(F)F)C
  • InChi: 1S/C20H13F6N3O2S/c1-18(10-28,11-31-16-8-12(9-27)2-7-15(16)19(21,22)23)29-17(30)13-3-5-14(6-4-13)32-20(24,25)26/h2-8H,11H2,1H3,(H,29,30)/t18-/m0/s1
  • InChiKey: WTERNLDOAPYGJD-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.0139
Echinococcus multilocularis lamin dm0 0.0029 0.0141 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0111 0.044
Loa Loa (eye worm) dihydrofolate reductase 0.0045 0.0317 0.1255
Schistosoma mansoni hypothetical protein 0.0052 0.0396 0.0674
Echinococcus granulosus intermediate filament protein 0.0029 0.0141 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0111 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0111 0.044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0111 0.044
Onchocerca volvulus 0.0031 0.0162 0.0531
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0111 0.0189
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0111 0.044
Toxoplasma gondii ABC1 family protein 0.0072 0.0627 0.1752
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0439 0.1738
Trichomonas vaginalis esterase, putative 0.0072 0.0627 0.5896
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0627 0.1752
Brugia malayi TAR-binding protein 0.0063 0.0528 0.2091
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0653 0.2587
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0111 0.0111
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0149 0.1518 0.601
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0111 0.0111
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0111 0.0189
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0138 0.1127
Echinococcus granulosus carbonic anhydrase 0.0055 0.0439 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0627 0.3966
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.5077 1
Mycobacterium tuberculosis Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2) 0.0118 0.1154 0.2239
Loa Loa (eye worm) thymidylate synthase 0.011 0.1065 0.4218
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0141 0.0557
Leishmania major carbonic anhydrase-like protein 0.0149 0.1518 0.9603
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0528 0.2091
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0139
Brugia malayi thymidylate synthase 0.011 0.1065 0.4218
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0149 0.1518 0.2587
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0149 0.1518 0.601
Schistosoma mansoni hypothetical protein 0.0527 0.5869 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1048 1
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0527 0.5869 1
Echinococcus multilocularis geminin 0.0527 0.5869 0.5869
Mycobacterium leprae Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1) 0.0319 0.3473 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0138 0.1127
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0111 0.0189
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0111 0.0111
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0296 0.2663
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0138 0.1127
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.2484
Mycobacterium tuberculosis Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1) 0.0319 0.3473 0.6827
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0138 0.0335
Echinococcus multilocularis chromobox protein 1 0.0071 0.0621 0.0621
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0111 0.0189
Schistosoma mansoni coup transcription factor 0.0027 0.0111 0.0189
Schistosoma mansoni ets-related 0.0225 0.2388 0.4068
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0528 0.09
Echinococcus granulosus lamin 0.0029 0.0141 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0138 0.1127
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0111 0.044
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0627 0.3966
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0111 0.044
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0149 0.1518 0.601
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0138 0.0335
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0439 0.1738
Trypanosoma brucei carbonic anhydrase-like protein 0.0149 0.1518 0.9603
Schistosoma mansoni carbonic anhydrase 0.0055 0.0439 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0001 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0627 0.1196
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1048 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0155 0.1581 0.4515
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0528 0.2091
Echinococcus multilocularis musashi 0.0029 0.0141 0.0141
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0439 0.0439
Onchocerca volvulus 0.011 0.1065 1
Brugia malayi nuclear receptor NHR-88 0.0027 0.0111 0.044
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1048 0.415
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0111 0.044
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0155 0.1581 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0599 0.2371
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.0911
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.011 0.1065 0.2063
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0111 0.044
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1048 1
Mycobacterium ulcerans B12-dependent methionine synthase 0.0118 0.1154 0.3322
Chlamydia trachomatis bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase 0.0319 0.3473 1
Brugia malayi intermediate filament protein 0.0029 0.0141 0.0557
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0111 0.0189
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0039
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0599 0.2371
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0138 0.1127
Mycobacterium tuberculosis Conserved protein 0.0072 0.0627 0.1196
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1048 0.1048
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1048 1
Brugia malayi 6-phosphofructokinase 0.0108 0.1048 0.415
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 0.0319 0.3473 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0261 0.157
Echinococcus multilocularis dihydrofolate reductase 0.0045 0.0317 0.0317
Brugia malayi Fli-1 protein 0.0225 0.2388 0.9453
Echinococcus multilocularis lamin 0.0029 0.0141 0.0141
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1048 0.3016
Loa Loa (eye worm) hypothetical protein 0.0055 0.0439 0.1738
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0138 0.0335
Mycobacterium ulcerans hypothetical protein 0.0072 0.0627 0.1804
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0111 0.044
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0621 0.5835
Echinococcus granulosus lamin dm0 0.0029 0.0141 0.024
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0149 0.1518 0.2587
Onchocerca volvulus 0.0029 0.0141 0.0311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1048 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1048 0.6629
Mycobacterium leprae PROBABLE DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) 0.0118 0.1154 0.2653
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0001 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0111 0.044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0111 0.0189
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0599 0.0599
Onchocerca volvulus 0.0072 0.0627 0.541
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.2484
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0653 0.1113
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0111 0.0189
Onchocerca volvulus 0.0072 0.0627 0.541
Leishmania major methionine synthase, putative 0.0118 0.1154 0.7301
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0023
Echinococcus granulosus chromobox protein 1 0.0071 0.0621 0.1058
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1048 0.2028
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0439 0.0439
Echinococcus granulosus acetylcholinesterase 0.0069 0.0599 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0127 0.1015
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0599 0.0599
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0111 0.0189
Loa Loa (eye worm) fli-1 protein 0.0225 0.2388 0.9453
Schistosoma mansoni chromobox protein 0.0071 0.0621 0.1058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0111 0.0111
Mycobacterium tuberculosis Hypothetical protein 0.0052 0.0403 0.0752
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0296 0.1936
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0627 0.1804
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0627 0.1069
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0138 0.0335
Onchocerca volvulus 0.0072 0.0627 0.541
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0627 0.5896
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0111 0.0189
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 0.5
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0296 0.2663
Loa Loa (eye worm) carboxylesterase 0.0069 0.0599 0.2371
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0111 0.0189
Loa Loa (eye worm) hypothetical protein 0.0055 0.0439 0.1738
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0111 0.044
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0138 0.1127
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1048 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Brugia malayi Carboxylesterase family protein 0.0069 0.0599 0.2371
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0403 0.3706
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0627 0.0984
Mycobacterium ulcerans lipase LipD 0.0072 0.0627 0.1804
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0599 0.102
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0599 0.102
Brugia malayi Ets-domain containing protein 0.0074 0.0653 0.2587
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0149 0.1518 0.9603
Loa Loa (eye worm) hypothetical protein 0.004 0.0261 0.1033
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0627 0.5896
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1048 0.415
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.2484
Schistosoma mansoni lamin 0.0029 0.0141 0.024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0627 0.1069
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0054 0.0429 0.1697
Echinococcus granulosus carbonic anhydrase II 0.0149 0.1518 0.2587
Brugia malayi RNA binding protein 0.0063 0.0528 0.2091
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0528 0.09
Schistosoma mansoni hypothetical protein 0.0037 0.023 0.0392
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1048 0.415
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0111 0.044
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.2484
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0045 0.0317 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0261 0.2323
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0439 0.0748
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.009
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0155 0.1581 1
Brugia malayi nuclear hormone receptor 0.0027 0.0111 0.044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0111 0.0189
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0621 0.5835
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.011 0.1065 0.1815
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0138 0.0335
Mycobacterium ulcerans dihydropteroate synthase 1 FolP1 0.0319 0.3473 1
Brugia malayi dihydrofolate reductase family protein 0.0045 0.0317 0.1255
Brugia malayi Heterochromatin protein 1 0.0071 0.0621 0.2459
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0155 0.1581 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1048 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0627 0.1196
Echinococcus granulosus carbonic anhydrase 0.0055 0.0439 0.0748
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.2484
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0439 0.1738
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1048 0.2316
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0127 0.1015
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0627 0.1804
Plasmodium falciparum carbonic anhydrase 0.0055 0.0439 0.1206
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0111 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0261 0.2323
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0111 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0528 0.09
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0627 0.5896
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0627 0.5896
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0111 0.0189
Brugia malayi steroid hormone receptor 0.0027 0.0111 0.044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0141 0.0557
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0111 0.0111
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0528 0.0528
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0627 0.1196
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0138 1
Schistosoma mansoni gabp alpha 0.0074 0.0653 0.1113
Schistosoma mansoni lamin 0.0029 0.0141 0.024
Brugia malayi 6-phosphofructokinase 0.0108 0.1048 0.415
Schistosoma mansoni chromobox protein 0.0071 0.0621 0.1058
Schistosoma mansoni intermediate filament proteins 0.0029 0.0141 0.024
Chlamydia trachomatis dihydrofolate reductase 0.0045 0.0317 0.0535
Mycobacterium leprae Probable lipase LipE 0.0072 0.0627 0.0984
Brugia malayi ecdysteroid receptor 0.0027 0.0111 0.044
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0138 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0627 0.3966
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0627 0.2484
Loa Loa (eye worm) beta-lactamase 0.0072 0.0627 0.2484
Echinococcus multilocularis thymidylate synthase 0.011 0.1065 0.1065
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0111 0.0189
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0052 0.0403 0.2545
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0653 0.0653
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0111 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0111 0.044
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0138 0.0335
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1048 1
Mycobacterium ulcerans thymidylate synthase 0.011 0.1065 0.3066
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0155 0.1581 0.4515
Echinococcus granulosus geminin 0.0527 0.5869 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0528 0.2091
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0111 0.044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0155 0.1581 0.4515
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0111 0.044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0135 0.0533
Leishmania major hypothetical protein, conserved 0.0072 0.0627 0.3966
Echinococcus granulosus chromobox protein 1 0.0071 0.0621 0.1058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0111 0.044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0111 0.044
Echinococcus granulosus carbonic anhydrase 0.0055 0.0439 0.0748
Echinococcus granulosus tar DNA binding protein 0.0063 0.0528 0.09
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0111 0.0189
Brugia malayi phosphofructokinase 0.0108 0.1048 0.415
Brugia malayi chromobox protein homolog 3 0.004 0.0261 0.1033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0111 0.0111
Brugia malayi Cytochrome P450 family protein 0.0017 0.0001 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0627 0.1196
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.0557
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0627 0.1196
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0599 0.0599
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.009
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0141 0.0557
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.023 0.0911
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0627 0.1069
Loa Loa (eye worm) hypothetical protein 0.0069 0.0599 0.2371
Echinococcus granulosus dihydrofolate reductase 0.0045 0.0317 0.054
Echinococcus granulosus thymidylate synthase 0.011 0.1065 0.1815
Schistosoma mansoni dihydrofolate reductase 0.0045 0.0317 0.054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0429 0.1697
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1048 0.6629
Echinococcus granulosus acetylcholinesterase 0.0069 0.0599 0.102
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0528 0.09
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0439 0.1738
Loa Loa (eye worm) hypothetical protein 0.0063 0.053 0.2098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0139
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0111 0.0111
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0621 0.2459
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0627 0.1196
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0138 0.1127
Brugia malayi Ets-domain containing protein 0.0074 0.0653 0.2587
Loa Loa (eye worm) hypothetical protein 0.0031 0.0162 0.064
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1048 0.1786
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1048 0.6629
Brugia malayi Cytochrome P450 family protein 0.0017 0.0001 0.0003
Onchocerca volvulus 0.0029 0.0141 0.0311
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0439 0.0439
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.011 0.1065 0.2371
Brugia malayi beta-lactamase family protein 0.0072 0.0627 0.2484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0111 0.044
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0439 0.1738
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0149 0.1518 0.9603
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0045 0.0317 0.091
Brugia malayi beta-lactamase family protein 0.0072 0.0627 0.2484
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0627 0.2484
Loa Loa (eye worm) carbonic anhydrase 3 0.0149 0.1518 0.601
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0111 0.0189
Mycobacterium tuberculosis Conserved protein 0.0072 0.0627 0.1196
Echinococcus multilocularis carbonic anhydrase II 0.0149 0.1518 0.1518
Brugia malayi follicle stimulating hormone receptor 0.0237 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.044
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0627 0.1196
Toxoplasma gondii dihydropteroate synthase 0.0319 0.3473 1
Brugia malayi hypothetical protein 0.0052 0.0403 0.1595
Toxoplasma gondii hypothetical protein 0.0055 0.0439 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0111 0.044
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0111 0.0189
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0139
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1048 0.1786
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0429 0.1697
Brugia malayi beta-lactamase 0.0072 0.0627 0.2484
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0111 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0138 0.1127
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1048 0.1786
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0111 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0111 0.044
Brugia malayi Dihydrofolate reductase 0.0045 0.0317 0.1255
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0055 0.0439 0.1738
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0439 0.0748
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0439 0.0748
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0627 0.0627
Loa Loa (eye worm) RNA binding protein 0.0063 0.0528 0.2091
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0138 0.1127
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0111 0.0111
Plasmodium vivax hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative 0.0319 0.3473 1
Echinococcus multilocularis chromobox protein 1 0.0071 0.0621 0.0621
Mycobacterium ulcerans dihydropteroate synthase 2 FolP2 0.0118 0.1154 0.3322
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0627 0.5896
Mycobacterium ulcerans beta-lactamase 0.0072 0.0627 0.1804
Brugia malayi Carboxylesterase family protein 0.0069 0.0599 0.2371
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0111 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0528 0.09
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0111 0.044
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.0072 0.0627 0.2484
Schistosoma mansoni hypothetical protein 0.0055 0.0439 0.0748
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0111 0.044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.2526 1
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0627 0.1196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0429 0.1697
Mycobacterium leprae Probable 5-methyltetrahydrofolate--homocystein methyltransferase MetH (Methionine synthase, vitamin-B12 dependent isozyme) (MS) 0.0118 0.1154 0.2653
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0439 0.1738

Activities

Activity type Activity value Assay description Source Reference
EC100 (functional) = 0.0032 ppm Anthelmintic activity against benzimidazole-resistant Haemonchus contortus isolate by larva development assay ChEMBL. 18400497
EC100 (functional) = 0.01 ppm Anthelmintic activity against levamisole-resistant Trichostrongylus colubriformis isolate by larva development assay ChEMBL. 18400497

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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