Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | Enoyl-[acyl-carrier-protein] reductase [NADH] | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0055 | 1 |
Mycobacterium leprae | PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) (DIHYDRODIPICOLINATE SYNTHETASE) | 0.0113 | 0.0439 | 0.0439 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0055 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0.0055 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Chlamydia trachomatis | 4-hydroxy-tetrahydrodipicolinate synthase | 0.0113 | 0.0439 | 0.4716 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0055 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.0931 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0055 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Mycobacterium ulcerans | dihydrodipicolinate synthase | 0.0113 | 0.0439 | 0.0439 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0055 | 0.0591 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0055 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.0931 | 1 |
Mycobacterium tuberculosis | Probable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase) | 0.0113 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0027 | 0.0055 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0.0055 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2253 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0.0055 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0027 | 0.0055 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0027 | 0.0055 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0027 | 0.0055 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.0931 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0027 | 0.0055 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0027 | 0.0055 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0027 | 0.0055 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.0931 | 0.0931 |
Schistosoma mansoni | carbonic anhydrase | 0.0027 | 0.0055 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0027 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0055 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0027 | 0.0055 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.0931 | 0.0931 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0055 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0027 | 0.0055 | 1 |
Mycobacterium ulcerans | dihydrodipicolinate synthase DapA | 0.0113 | 0.0439 | 0.0439 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.0931 | 0.0931 |
Toxoplasma gondii | dihydrodipicolinate synthase | 0.0113 | 0.0439 | 0.4716 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0027 | 0.0055 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrodipicolinate synthase | 0.0113 | 0.0439 | 0.4716 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0027 | 0.0055 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0027 | 0.0055 | 0.0591 |
Mycobacterium ulcerans | malate synthase G | 0.2253 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.0931 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.0931 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.0931 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.8 uM | Inhibition of Bacillus anthracis Enoyl ACP reductase | ChEMBL. | 18499454 |
IC50 (binding) | = 1.8 uM | Inhibition of Bacillus anthracis Enoyl ACP reductase | ChEMBL. | 18499454 |
MIC (functional) | > 80 ug ml-1 | Antibacterial activity against Bacillus anthracis dANR | ChEMBL. | 18499454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.