TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 485.49 | Formula: C23H27N5O7
H donors: 0 H acceptors: 5 LogP: 1.57 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1n(CCCCOc2cc3N=C[C@H]4N(C(=O)c3cc2OC)CCC4)nnc1C(=O)OC
InChi: 1S/C23H27N5O7/c1-32-17-11-15-16(24-13-14-7-6-8-27(14)21(15)29)12-18(17)35-10-5-4-9-28-20(23(31)34-3)19(25-26-28)22(30)33-2/h11-14H,4-10H2,1-3H3/t14-/m0/s1
InChiKey: IPQQIEQZDFZGGL-AWEZNQCLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0063	0.0187	0.0261
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Echinococcus granulosus	solute carrier family 22	0.0063	0.0187	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Brugia malayi	Sugar transporter family protein	0.0447	0.2242	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0137	0.0584	0.0404
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.01	0.0385	0.6491
Brugia malayi	major facilitator superfamily protein	0.0063	0.0187	0.0813
Echinococcus granulosus	General substrate transporter	0.0384	0.1906	0.2657
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0063	0.0187	0.1361
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1899	1	1
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0105	0.0139
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.3125
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0063	0.0187	0.5
Echinococcus multilocularis	solute carrier family 22	0.0063	0.0187	0.0254
Trichomonas vaginalis	glucose transporter, putative	0.0139	0.0593	0.2492
Schistosoma mansoni	hypothetical protein	0.0447	0.2242	0.312
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0806
Schistosoma mansoni	glucose transporter	0.0063	0.0187	0.0254
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0137	0.0584	0.0579
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0139	0.0593	0.8526
Echinococcus granulosus	solute carrier family 22	0.0063	0.0187	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0137	0.0584	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0177
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0023	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Schistosoma mansoni	glucose transport protein	0.0447	0.2242	0.312
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0023	0.0032
Schistosoma mansoni	hypothetical protein	0.0032	0.0023	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0222	0.0967
Onchocerca volvulus		0.0063	0.0187	0.1698
Echinococcus multilocularis	solute carrier family 22	0.0063	0.0187	0.0254
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Onchocerca volvulus		0.0063	0.0187	0.1698
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.01	0.0385	1
Toxoplasma gondii	protein kinase, putative	0.1264	0.6607	1
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0187	0.0647
Onchocerca volvulus		0.0063	0.0187	0.1698
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.312
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Leishmania major	protein kinase, putative	0.0137	0.0583	0.838
Trypanosoma cruzi	sugar transporter, putative	0.0063	0.0187	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Onchocerca volvulus		0.0063	0.0187	0.1698
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0137	0.0584	0.0579
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Toxoplasma gondii	transporter, major facilitator family protein	0.0063	0.0187	0.0275
Echinococcus multilocularis	General substrate transporter	0.0384	0.1906	0.2651
Chlamydia trachomatis	lysine--tRNA ligase	0.01	0.0385	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0806
Onchocerca volvulus		0.0063	0.0187	0.1698
Onchocerca volvulus		0.0063	0.0187	0.1698
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0569	0.2517
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0583	0.2583
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0137	0.0583	0.838
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0137	0.0583	0.2583
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0134	0.0569	0.2382
Onchocerca volvulus		0.0036	0.0045	0.0369
Schistosoma mansoni	sugar transporter	0.0063	0.0187	0.0254
Echinococcus multilocularis	solute carrier family 22	0.0063	0.0187	0.0254
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0394	0.1735
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0088	0.0319	0.1247
Onchocerca volvulus		0.0063	0.0187	0.1698
Leishmania major	glucose transporter, lmgt3	0.0139	0.0593	0.8526
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0105	0.0446
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0063	0.0187	0.1361
Leishmania major	glucose transporter, lmgt2	0.0139	0.0593	0.8526
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Onchocerca volvulus		0.0036	0.0045	0.0369
Trypanosoma brucei	glucose transporter 1E	0.0139	0.0593	0.8526
Loa Loa (eye worm)	hypothetical protein	0.01	0.0385	0.1696
Schistosoma mansoni	hypothetical protein	0.0032	0.0023	0.0024
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0187	0.2215
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0134	0.0569	0.9568
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Plasmodium falciparum	protein kinase 7	0.1264	0.6607	0.6542
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0045	0.004
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1097	0.4881
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0137	0.0584	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0023	0.0077
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.024	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.3125
Echinococcus multilocularis	solute carrier family 22	0.0063	0.0187	0.0254
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.312
Echinococcus granulosus	lysyl tRNA synthetase	0.01	0.0385	0.0537
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.024	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0177
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.0394	0.1735
Onchocerca volvulus		0.0063	0.0187	0.1698
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.01	0.0385	0.529
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.3125
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0045	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0023	0.0032
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Brugia malayi	Sugar transporter family protein	0.0063	0.0187	0.0813
Schistosoma mansoni	protein kinase	0.0137	0.0583	0.0806
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0156	0.0688	0.1033
Echinococcus granulosus	solute carrier family 22	0.0063	0.0187	0.0261
Echinococcus multilocularis	lysyl tRNA synthetase	0.01	0.0385	0.0529
Trypanosoma cruzi	glucose transporter, putative	0.0063	0.0187	0.2215
Echinococcus multilocularis	microtubule associated protein 2	0.137	0.7175	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0137	0.0584	0.0876
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0187	0.0647
Toxoplasma gondii	facilitative glucose transporter GT1	0.0447	0.2242	0.3388
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0085	0.0305	0.2481
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0187	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Toxoplasma gondii	sugar transporter ST1	0.0063	0.0187	0.0275
Schistosoma mansoni	protein kinase	0.0137	0.0583	0.0806
Schistosoma mansoni	lysyl-tRNA synthetase	0.01	0.0385	0.0529
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Brugia malayi	Sugar transporter family protein	0.0063	0.0187	0.0813
Schistosoma mansoni	microtubule-associated protein tau	0.137	0.7175	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0137	0.0584	0.0404
Plasmodium vivax	proline--tRNA ligase, putative	0.0156	0.0688	0.0682
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0139	0.0593	0.8526
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0063	0.0187	0.4187
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0063	0.0187	0.4187
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0063	0.0187	0.0813
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0137	0.0584	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.1097	0.1529
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0063	0.0187	0.0254
Toxoplasma gondii	lysine-tRNA ligase	0.01	0.0385	0.0575
Echinococcus multilocularis	calcium dependent protein kinase	0.0129	0.0538	0.0743
Onchocerca volvulus		0.0229	0.1077	1
Trichomonas vaginalis	glucose transporter, putative	0.0139	0.0593	0.2492
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0045	0.0055
Entamoeba histolytica	hypothetical protein	0.01	0.0385	0.4216
Brugia malayi	Pre-SET motif family protein	0.0201	0.0928	0.4123
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.1077	0.4694
Schistosoma mansoni	sugar transporter	0.0063	0.0187	0.0254
Brugia malayi	beta-lactamase	0.0036	0.0045	0.0177
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.0394	0.1735
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0045	0.0055
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.0394	0.1735
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0134	0.0569	0.0785
Trypanosoma brucei	glucose transporter 2A	0.0139	0.0593	0.8526
Leishmania major	myo-inositol/proton symporter (MIT)	0.0063	0.0187	0.2215
Trichomonas vaginalis	sugar transporter, putative	0.0139	0.0593	0.2492
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0006	0.0008
Echinococcus granulosus	synaptic vesicle 2 protein	0.0063	0.0187	0.0261
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0134	0.0569	0.2517
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0156	0.0688	1
Onchocerca volvulus		0.0063	0.0187	0.1698
Mycobacterium ulcerans	sugar transporter	0.0063	0.0187	0.4187
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0156	0.0688	1
Trichomonas vaginalis	conserved hypothetical protein	0.0447	0.2242	1
Brugia malayi	major facilitator superfamily protein	0.0063	0.0187	0.0813
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0139	0.0593	0.8526
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0177
Giardia lamblia	Prolyl-tRNA synthetase	0.0134	0.0569	1
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Mycobacterium ulcerans	integral membrane transport protein	0.0063	0.0187	0.4187
Onchocerca volvulus		0.0063	0.0187	0.1698
Brugia malayi	hypothetical protein	0.0063	0.0187	0.0813
Brugia malayi	hypothetical protein	0.0063	0.0187	0.0813
Plasmodium falciparum	lysine--tRNA ligase	0.01	0.0385	0.0201
Trypanosoma cruzi	hexose transporter, putative	0.0076	0.0257	0.3292
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0187	0.0647
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0813
Brugia malayi	Major Facilitator Superfamily protein	0.0063	0.0187	0.0813
Giardia lamblia	Lysyl-tRNA synthetase	0.01	0.0385	0.5182
Trichomonas vaginalis	myo-inositol transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0063	0.0187	0.0813
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0187	0.0647
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0139	0.0593	0.8526
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Onchocerca volvulus		0.0063	0.0187	0.1698
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Brugia malayi	Major Facilitator Superfamily protein	0.0063	0.0187	0.0813
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0045	0.0177
Onchocerca volvulus		0.0063	0.0187	0.1698
Schistosoma mansoni	hypothetical protein	0.0048	0.0105	0.0139
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.01	0.0385	0.529
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0023	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0045	0.0177
Brugia malayi	Major Facilitator Superfamily protein	0.0063	0.0187	0.0813
Entamoeba histolytica	protein kinase, putative	0.0137	0.0583	1
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0023	0.0077
Leishmania major	lysyl-tRNA synthetase, putative	0.01	0.0385	0.529
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0434	0.1915
Brugia malayi	Cam kinase protein 1	0.0137	0.0583	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0047	0.0105	0.175
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0137	0.0583	0.2583
Schistosoma mansoni	lysyl-tRNA synthetase	0.01	0.0385	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0569	0.2517
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.312
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0137	0.0584	0.0579
Trichomonas vaginalis	CAMK family protein kinase	0.0137	0.0583	0.245
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0045	0.0055
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0137	0.0584	0.0404
Toxoplasma gondii	ABC1 family protein	0.0036	0.0045	0.006
Loa Loa (eye worm)	sugar transporter	0.0063	0.0187	0.0813
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0085	0.0305	0.2481
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0085	0.0305	0.4954
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0063	0.0187	0.2215
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0063	0.0187	0.0254
Leishmania major	hypothetical protein, conserved	0.0063	0.0187	0.2215
Entamoeba histolytica	protein kinase, putative	0.0137	0.0583	1
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Schistosoma mansoni	sugar transporter	0.0063	0.0187	0.0254
Trypanosoma cruzi	hexose transporter, putative	0.0139	0.0593	0.8526
Echinococcus granulosus	GPCR family 2	0.0032	0.0023	0.0032
Brugia malayi	hypothetical protein	0.0073	0.024	0.1049
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0156	0.0688	1
Onchocerca volvulus		0.0063	0.0187	0.1698
Onchocerca volvulus	Putative transporter	0.0063	0.0187	0.1698
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0723	0.3715	0.3712
Echinococcus granulosus	microtubule associated protein 2	0.137	0.7175	1
Trichomonas vaginalis	sugar transporter, putative	0.0139	0.0593	0.2492
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0156	0.0688	1
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Plasmodium falciparum	proline--tRNA ligase	0.0156	0.0688	0.051
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0045	0.0177
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0447	0.2242	0.3125
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0723	0.3715	0.3595
Brugia malayi	beta-lactamase family protein	0.0036	0.0045	0.0177
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0063	0.0187	0.0254
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.0928	0.4123
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trichomonas vaginalis	sugar transport protein, putative	0.0063	0.0187	0.0647
Schistosoma mansoni	hypothetical protein	0.0032	0.0023	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Brugia malayi	lysyl-tRNA synthetase	0.01	0.0385	0.1696
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.109	1
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Echinococcus granulosus	solute carrier family 22	0.0063	0.0187	0.0261
Trypanosoma cruzi	hexose transporter, putative	0.0139	0.0593	0.8526
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0134	0.0569	0.0785
Plasmodium vivax	hexose transporter	0.0447	0.2242	0.2238
Trypanosoma cruzi	hexose transporter	0.0139	0.0593	0.8526
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0813
Brugia malayi	hypothetical protein	0.0063	0.0187	0.0813
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0222	0.0967
Schistosoma mansoni	glucose transport protein	0.0447	0.2242	0.312
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.01	0.0385	0.1546
Plasmodium vivax	lysine--tRNA ligase, putative	0.01	0.0385	0.038
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0593	0.2492
Onchocerca volvulus		0.0063	0.0187	0.1698
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Treponema pallidum	prolyl-tRNA synthetase	0.0047	0.0105	0.5
Schistosoma mansoni	protein kinase	0.0137	0.0583	0.0806
Schistosoma mansoni	hypothetical protein	0.0073	0.024	0.0327
Onchocerca volvulus		0.0063	0.0187	0.1698
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.024	0.0327
Plasmodium vivax	sugar transporter, putative	0.0063	0.0187	0.0182
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0134	0.0569	1
Trichomonas vaginalis	sugar transporter, putative	0.0139	0.0593	0.2492
Trichomonas vaginalis	conserved hypothetical protein	0.0139	0.0593	0.2492
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0447	0.2242	0.312
Schistosoma mansoni	hypothetical protein	0.0032	0.0023	0.0024
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0723	0.3715	0.5619
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0156	0.0688	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0813
Schistosoma mansoni	sugar transporter	0.0063	0.0187	0.0254
Trypanosoma brucei	sugar transporter, putative	0.0063	0.0187	0.2215
Toxoplasma gondii	sugar transporter ST3	0.0063	0.0187	0.0275
Trichomonas vaginalis	glucose transporter, putative	0.0063	0.0187	0.0647
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0134	0.0569	0.0785
Echinococcus granulosus	calcium dependent protein kinase	0.0129	0.0538	0.075
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Toxoplasma gondii	sugar transporter ST2	0.0063	0.0187	0.0275
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0023	0.0077
Plasmodium falciparum	hexose transporter	0.0447	0.2242	0.2094
Brugia malayi	beta-lactamase family protein	0.0036	0.0045	0.0177
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0055	0.0146	0.0626
Loa Loa (eye worm)	sugar transporter	0.0447	0.2242	1
Onchocerca volvulus		0.0036	0.0045	0.0369
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0023	0.0024
Leishmania major	glucose transporter, lmgt1	0.0139	0.0593	0.8526
Schistosoma mansoni	hypothetical protein	0.0069	0.0222	0.0302
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0134	0.0569	0.2517
Trypanosoma brucei	glucose transporter, putative	0.0139	0.0593	0.8526
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0023	0.0024
Schistosoma mansoni	glucose transport protein	0.0447	0.2242	0.312
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0806
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0137	0.0583	0.2583
Onchocerca volvulus		0.0048	0.0105	0.0932
Onchocerca volvulus		0.0063	0.0187	0.1698
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.1097	0.1523
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.01	0.0385	1
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0187	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0187	0.0813
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0134	0.0569	0.0793
Schistosoma mansoni	serine/threonine protein kinase	0.0137	0.0583	0.0806
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0137	0.0584	0.0876
Trypanosoma cruzi	hexose transporter, putative	0.0139	0.0593	0.8526
Brugia malayi	hypothetical protein	0.0233	0.1097	0.4881
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0045	0.0177
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0137	0.0583	0.0806
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0137	0.0583	0.0813
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0137	0.0584	0.0876

Activities

Activity type	Activity value	Assay description	Source	Reference
deltaTm (binding)	= 0 degrees C	Binding affinity to calf thymus DNA assessed as helix melting temperature at 20 uM after 18 hrs	ChEMBL.	18207392
GI50 (functional)	= 0.13 uM	Growth inhibition of human A2780 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 0.13 uM	Growth inhibition of human A2780 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 0.21 uM	Growth inhibition of human Colo205 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 0.21 uM	Growth inhibition of human Colo205 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.04 uM	Growth inhibition of human SiHa cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.04 uM	Growth inhibition of human SiHa cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.12 uM	Growth inhibition of human Zr-75-1 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.12 uM	Growth inhibition of human Zr-75-1 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.24 uM	Growth inhibition of human DWD cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.36 uM	Growth inhibition of human KB cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.36 uM	Growth inhibition of human KB cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 2.39 uM	Growth inhibition of human Gurav cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 25.4 uM	Growth inhibition of human PC3 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 25.4 uM	Growth inhibition of human PC3 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 28.71 uM	Growth inhibition of human A549 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 28.71 uM	Growth inhibition of human A549 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 30.5 uM	Growth inhibition of human MCF7 cells by SRB method	ChEMBL.	18207392
GI50 (functional)	= 30.5 uM	Growth inhibition of human MCF7 cells by SRB method	ChEMBL.	18207392

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 520519