Detailed information for compound 520542

Basic information

Technical information
  • TDR Targets ID: 520542
  • Name: 4-[(E)-2-[4-[6-(3-fluoropropoxy)-1,3-benzothi azol-2-yl]phenyl]ethenyl]-N,N-dimethylaniline
  • MW: 432.553 | Formula: C26H25FN2OS
  • H donors: 0 H acceptors: 1 LogP: 7.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCCCOc1ccc2c(c1)sc(n2)c1ccc(cc1)/C=C/c1ccc(cc1)N(C)C
  • InChi: 1S/C26H25FN2OS/c1-29(2)22-12-8-20(9-13-22)5-4-19-6-10-21(11-7-19)26-28-24-15-14-23(18-25(24)31-26)30-17-3-16-27/h4-15,18H,3,16-17H2,1-2H3/b5-4+
  • InChiKey: JJKIBQVSZODQDV-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(E)-2-[4-[6-(3-fluoropropoxy)-1,3-benzothiazol-2-yl]phenyl]vinyl]-N,N-dimethyl-aniline
  • 4-[(E)-2-[4-[6-(3-fluoropropoxy)-1,3-benzothiazol-2-yl]phenyl]vinyl]-N,N-dimethylaniline
  • 4-[(E)-2-[4-[6-(3-fluoropropoxy)-1,3-benzothiazol-2-yl]phenyl]ethenyl]-N,N-dimethyl-aniline
  • [4-[(E)-2-[4-[6-(3-fluoropropoxy)-1,3-benzothiazol-2-yl]phenyl]vinyl]phenyl]-dimethyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0717 0.3708 0.5609
Schistosoma mansoni hypothetical protein 0.0072 0.0229 0.0285
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0099 0.0375 0.1544
Plasmodium vivax lysine--tRNA ligase, putative 0.0099 0.0375 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0177 0.0645
Loa Loa (eye worm) sugar transporter 0.0444 0.2234 0.4943
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus multilocularis chromobox protein 1 0.0067 0.0204 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0586 0.3989
Toxoplasma gondii protein kinase, putative 0.1253 0.6604 1
Plasmodium falciparum hexose transporter 0.0444 0.2234 0.2094
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0136 0.0574 0.0565
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0177 0.0371
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0104 0.0401 0.0518
Onchocerca volvulus 0.0036 0.0035 0.0296
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0024 0.0054
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2899
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0035 0.0033
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0062 0.0177 0.2235
Echinococcus granulosus solute carrier family 22 0.0062 0.0177 0.0226
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0136 0.0574 0.0855
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0062 0.0177 0.2235
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0133 0.0559 0.1217
Echinococcus multilocularis lysyl tRNA synthetase 0.0099 0.0375 0.0476
Leishmania major glucose transporter/membrane transporter D2, putative 0.0138 0.0583 0.3969
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0059 0.0111
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0338 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0177 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0044 0.004
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus granulosus microtubule associated protein 2 0.1453 0.7684 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0044 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0062 0.0193
Trypanosoma brucei glucose transporter 2A 0.0138 0.0583 0.3969
Echinococcus multilocularis solute carrier family 22 0.0062 0.0177 0.0218
Loa Loa (eye worm) hypothetical protein 0.0104 0.0401 0.0888
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0204 0.0766
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.1415 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Trypanosoma brucei glucose transporter 1E 0.0138 0.0583 0.3969
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Onchocerca volvulus 0.0042 0.0069 0.0584
Brugia malayi chromobox protein homolog 3 0.0038 0.0044 0.0076
Schistosoma mansoni hypothetical protein 0.0104 0.0401 0.051
Trichomonas vaginalis glucose transporter, putative 0.0062 0.0177 0.0645
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0035 0.0056
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2899
Brugia malayi Pre-SET motif family protein 0.0219 0.1021 0.2243
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1184 0.5227
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0059 0.0111
Schistosoma mansoni microtubule-associated protein tau 0.1453 0.7684 1
Leishmania major glucose transporter, lmgt2 0.0138 0.0583 0.3969
Plasmodium falciparum lysine--tRNA ligase 0.0099 0.0375 0.0201
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0133 0.0559 0.957
Schistosoma mansoni glucose transporter 0.0062 0.0177 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus granulosus General substrate transporter 0.0381 0.1898 0.2466
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0078
Schistosoma mansoni protein kinase 0.0136 0.0573 0.0734
Loa Loa (eye worm) hypothetical protein 0.0099 0.0375 0.0829
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0024 0.0027
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Schistosoma mansoni lysyl-tRNA synthetase 0.0099 0.0375 0.0476
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0133 0.0559 0.1236
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.1415 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1415 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.067 0.6048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0099 0.0199
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0078
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0133 0.0559 0.0715
Entamoeba histolytica protein kinase, putative 0.0136 0.0573 1
Brugia malayi Cam kinase protein 1 0.0136 0.0573 0.125
Loa Loa (eye worm) hypothetical protein 0.0133 0.0559 0.1236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0024 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0097
Plasmodium falciparum mitogen-activated protein kinase 2 0.0717 0.3708 0.3595
Brugia malayi beta-lactamase family protein 0.0036 0.0035 0.0056
Onchocerca volvulus 0.0062 0.0177 0.1494
Onchocerca volvulus 0.0062 0.0177 0.1494
Onchocerca volvulus 0.0062 0.0177 0.1494
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Mycobacterium ulcerans sugar transporter 0.0062 0.0177 0.2235
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0155 0.0678 0.4656
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2904
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Onchocerca volvulus 0.0062 0.0177 0.1494
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0643 0.3309 0.4299
Onchocerca volvulus 0.0062 0.0177 0.1494
Echinococcus granulosus synaptic vesicle 2 protein 0.0062 0.0177 0.0226
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2899
Brugia malayi hypothetical protein 0.0062 0.0177 0.0371
Brugia malayi jmjC domain containing protein 0.0092 0.0338 0.0728
Plasmodium vivax CDK-related protein kinase 6, putative 0.1883 1 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0246 0.153
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2904
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Onchocerca volvulus 0.0062 0.0177 0.1494
Toxoplasma gondii lysine-tRNA ligase 0.0099 0.0375 0.0553
Trypanosoma brucei THT1 - hexose transporter, putative 0.0138 0.0583 0.3969
Trypanosoma brucei sugar transporter, putative 0.0062 0.0177 0.1028
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Schistosoma mansoni protein kinase 0.0136 0.0573 0.0734
Echinococcus granulosus solute carrier family 22 0.0062 0.0177 0.0226
Trypanosoma cruzi hexose transporter, putative 0.0138 0.0583 0.3969
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0044 0.0371
Onchocerca volvulus 0.0062 0.0177 0.1494
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0155 0.0678 0.4656
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0078
Plasmodium falciparum protein kinase 7 0.1253 0.6604 0.6542
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0104 0.0401 0.051
Echinococcus multilocularis solute carrier family 22 0.0062 0.0177 0.0218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0035 0.0041
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0059 0.0502
Trichomonas vaginalis sugar transport protein, putative 0.0062 0.0177 0.0645
Giardia lamblia Lysyl-tRNA synthetase 0.0099 0.0375 0.5182
Brugia malayi lysyl-tRNA synthetase 0.0099 0.0375 0.0809
Loa Loa (eye worm) sugar transporter 0.0062 0.0177 0.0391
Plasmodium vivax hexose transporter 0.0444 0.2234 0.2227
Giardia lamblia Prolyl-tRNA synthetase 0.0133 0.0559 1
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0229 0.0285
Schistosoma mansoni lysyl-tRNA synthetase 0.0099 0.0375 0.0476
Onchocerca volvulus 0.0062 0.0177 0.1494
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0177 0.0645
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0177 0.0371
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2904
Toxoplasma gondii sugar transporter ST2 0.0062 0.0177 0.0254
Brugia malayi beta-lactamase 0.0036 0.0035 0.0056
Echinococcus granulosus chromobox protein 1 0.0067 0.0204 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0583 0.249
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0136 0.0573 0.1268
Trypanosoma cruzi hexose transporter 0.0138 0.0583 0.3969
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0084 0.0294 0.2469
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0136 0.0574 0.0565
Schistosoma mansoni sugar transporter 0.0062 0.0177 0.0218
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0136 0.0574 0.0855
Trichomonas vaginalis sugar transporter, putative 0.0138 0.0583 0.249
Brugia malayi Sugar transporter family protein 0.0062 0.0177 0.0371
Schistosoma mansoni chromobox protein 0.0067 0.0204 0.0253
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0099 0.0375 0.2461
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0177 0.0645
Trypanosoma cruzi hexose transporter, putative 0.0138 0.0583 0.3969
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0136 0.0574 0.0855
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0734
Brugia malayi major facilitator superfamily protein 0.0062 0.0177 0.0371
Onchocerca volvulus Putative transporter 0.0062 0.0177 0.1494
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0052 0.0055
Echinococcus multilocularis calcium dependent protein kinase 0.0127 0.0528 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0078
Leishmania major lysyl-tRNA synthetase, putative 0.0099 0.0375 0.2461
Brugia malayi latrophilin 2 splice variant baaae 0.0225 0.1052 0.2311
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.1021 0.2259
Brugia malayi jmjC domain containing protein 0.0034 0.0024 0.0032
Echinococcus multilocularis GPCR, family 2 0.0104 0.0401 0.051
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0155 0.0678 0.4656
Brugia malayi Heterochromatin protein 1 0.0067 0.0204 0.043
Echinococcus granulosus chromobox protein 1 0.0067 0.0204 0.026
Toxoplasma gondii sugar transporter ST1 0.0062 0.0177 0.0254
Plasmodium vivax sugar transporter, putative 0.0062 0.0177 0.0167
Onchocerca volvulus 0.0249 0.1184 1
Trichomonas vaginalis sugar transporter, putative 0.0138 0.0583 0.249
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0717 0.3708 0.3702
Schistosoma mansoni glucose transport protein 0.0444 0.2234 0.2899
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1415 1
Schistosoma mansoni chromobox protein 0.0067 0.0204 0.0253
Echinococcus multilocularis solute carrier family 22 0.0062 0.0177 0.0218
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0062 0.0193
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0062 0.0177 0.1352
Onchocerca volvulus 0.0036 0.0035 0.0296
Echinococcus multilocularis microtubule associated protein 2 0.1453 0.7684 1
Loa Loa (eye worm) hypothetical protein 0.0867 0.452 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.1052 0.2327
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0155 0.0678 0.4656
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1084 1
Toxoplasma gondii hypothetical protein 0.0047 0.0094 0.0128
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Treponema pallidum prolyl-tRNA synthetase 0.0047 0.0094 0.5
Mycobacterium ulcerans integral membrane transport protein 0.0062 0.0177 0.2235
Onchocerca volvulus 0.0036 0.0035 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0583 0.249
Plasmodium falciparum calcium-dependent protein kinase 4 0.0136 0.0574 0.0404
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0643 0.3309 0.4303
Echinococcus multilocularis synaptic vesicle 2 protein 0.0062 0.0177 0.0218
Echinococcus granulosus calcium dependent protein kinase 0.0127 0.0528 0.0683
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0035 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0328 0.1613 0.3568
Echinococcus granulosus solute carrier family 22 0.0062 0.0177 0.0226
Brugia malayi hypothetical protein 0.0062 0.0177 0.0371
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0154 0.0341
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.0177 0.0254
Brugia malayi hypothetical protein 0.0072 0.0229 0.0485
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0133 0.0559 0.238
Onchocerca volvulus 0.0062 0.0177 0.1494
Leishmania major glucose transporter, lmgt1 0.0138 0.0583 0.3969
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0204 0.045
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0444 0.2234 0.2899
Echinococcus granulosus GPCR family 2 0.0104 0.0401 0.0518
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0062 0.0177 0.0218
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0099 0.0375 0.5351
Trichomonas vaginalis glucose transporter, putative 0.0138 0.0583 0.249
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0742
Schistosoma mansoni hypothetical protein 0.0048 0.0099 0.0117
Trypanosoma cruzi hexose transporter, putative 0.0138 0.0583 0.3969
Leishmania major glucose transporter, lmgt3 0.0138 0.0583 0.3969
Schistosoma mansoni glucose transport protein 0.0444 0.2234 0.2899
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0099 0.0375 0.5351
Onchocerca volvulus 0.0062 0.0177 0.1494
Schistosoma mansoni sugar transporter 0.0062 0.0177 0.0218
Entamoeba histolytica protein kinase, putative 0.0136 0.0573 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0138 0.0583 0.3969
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Schistosoma mansoni hypothetical protein 0.0104 0.0401 0.051
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0338 0.0428
Schistosoma mansoni sugar transporter 0.0062 0.0177 0.0218
Echinococcus multilocularis solute carrier family 22 0.0062 0.0177 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0867 0.452 1
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1111 0.1441
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0035 0.0078
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0136 0.0573 0.0742
Loa Loa (eye worm) beta-lactamase 0.0036 0.0035 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Schistosoma mansoni hypothetical protein 0.0225 0.1052 0.1358
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0099 0.0375 0.2461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0742
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0055 0.0135 0.0299
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0444 0.2234 0.2904
Brugia malayi major facilitator superfamily protein 0.0062 0.0177 0.0371
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trypanosoma cruzi glucose transporter, putative 0.0062 0.0177 0.1028
Brugia malayi Sugar transporter family protein 0.0444 0.2234 0.4932
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0024 0.0019
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0236 0.0295
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0062 0.0193
Onchocerca volvulus 0.0062 0.0177 0.1494
Loa Loa (eye worm) hypothetical protein 0.0136 0.0573 0.1268
Plasmodium falciparum calcium-dependent protein kinase 3 0.0136 0.0574 0.0404
Brugia malayi beta-lactamase family protein 0.0036 0.0035 0.0056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0104 0.0401 0.0888
Onchocerca volvulus 0.0062 0.0177 0.1494
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0229 0.0285
Toxoplasma gondii sugar transporter ST3 0.0062 0.0177 0.0254
Brugia malayi Sugar transporter family protein 0.0062 0.0177 0.0371
Echinococcus multilocularis General substrate transporter 0.0381 0.1898 0.246
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0052 0.0063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0586 0.3989
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0062 0.0193
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.011 0.0544
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Toxoplasma gondii ABC1 family protein 0.0036 0.0035 0.0038
Toxoplasma gondii facilitative glucose transporter GT1 0.0444 0.2234 0.3373
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0573 0.0734
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0734
Schistosoma mansoni protein kinase 0.0136 0.0573 0.0734
Echinococcus granulosus Sugar transporter ERD6 protein 0.0062 0.0177 0.0226
Leishmania major protein kinase, putative 0.0136 0.0573 0.3901
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0742
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Trichomonas vaginalis sugar transporter, putative 0.0138 0.0583 0.249
Schistosoma mansoni hypothetical protein 0.0444 0.2234 0.2899
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0136 0.0573 0.3901
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0177 0.0645
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0047 0.0094 0.0929
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0024 0.0019
Schistosoma mansoni sugar transporter 0.0062 0.0177 0.0218
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0133 0.0559 0.0715
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Brugia malayi Calcitonin receptor-like protein seb-1 0.0328 0.1613 0.3554
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0177 0.0391
Onchocerca volvulus 0.0062 0.0177 0.1494
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.0223
Onchocerca volvulus 0.0062 0.0177 0.1494
Brugia malayi hypothetical protein 0.0235 0.1111 0.2441
Plasmodium falciparum calcium-dependent protein kinase 5 0.0136 0.0574 0.0404
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0204 0.0766
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Mycobacterium ulcerans hypothetical protein 0.0154 0.067 1
Echinococcus granulosus solute carrier family 22 0.0062 0.0177 0.0226
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0586 0.3989
Plasmodium falciparum calcium-dependent protein kinase 1 0.0136 0.0574 0.0404
Chlamydia trachomatis lysine--tRNA ligase 0.0099 0.0375 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0069 0.0077
Entamoeba histolytica hypothetical protein 0.0099 0.0375 0.4238
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0177 0.0391
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0133 0.0559 1
Brugia malayi Latrophilin receptor protein 2 0.0104 0.0401 0.0868
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0062 0.0177 0.0218
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.0177 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0229 0.0293
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0155 0.0678 0.4656
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0136 0.0573 0.1268
Plasmodium vivax proline--tRNA ligase, putative 0.0155 0.0678 0.0668
Loa Loa (eye worm) hypothetical protein 0.0235 0.1111 0.2457
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0078
Schistosoma mansoni glucose transport protein 0.0444 0.2234 0.2899
Trichomonas vaginalis myo-inositol transporter, putative 0.0062 0.0177 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0087 0.0309 0.1245
Plasmodium falciparum proline--tRNA ligase 0.0155 0.0678 0.051
Onchocerca volvulus 0.0062 0.0177 0.1494
Leishmania major myo-inositol/proton symporter (MIT) 0.0062 0.0177 0.1028
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0155 0.0678 0.1013
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0062 0.0177 0.1028
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0177 0.1028
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0133 0.0559 0.1217
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0177 0.0371
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0084 0.0294 0.4949
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0035 0.0033
Plasmodium falciparum calcium-dependent protein kinase 2 0.0136 0.0574 0.0404
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0133 0.0559 0.0715
Onchocerca volvulus 0.0048 0.0099 0.084
Trypanosoma cruzi sugar transporter, putative 0.0062 0.0177 0.1028
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0136 0.0573 0.125
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0133 0.0559 0.0723
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0108 0.0424 0.0938
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0734
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0573 0.0734
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0136 0.0574 0.0565
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0084 0.0294 0.2469
Echinococcus multilocularis chromobox protein 1 0.0067 0.0204 0.0253
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Schistosoma mansoni hypothetical protein 0.0104 0.0401 0.051
Schistosoma mansoni hypothetical protein 0.0104 0.0401 0.051
Brugia malayi hypothetical protein 0.0062 0.0177 0.0371
Trichomonas vaginalis CAMK family protein kinase 0.0136 0.0573 0.2448
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Onchocerca volvulus 0.0062 0.0177 0.1494
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0099 0.0375 0.6488
Trichomonas vaginalis conserved hypothetical protein 0.0444 0.2234 1
Trypanosoma brucei glucose transporter, putative 0.0138 0.0583 0.3969
Trypanosoma brucei THT1 - hexose transporter, putative 0.0138 0.0583 0.3969
Leishmania major hypothetical protein, conserved 0.0062 0.0177 0.1028
Echinococcus granulosus lysyl tRNA synthetase 0.0099 0.0375 0.0483
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1111 0.1435
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0062 0.0177 0.1352
Trichomonas vaginalis glucose transporter, putative 0.0138 0.0583 0.249
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Schistosoma mansoni survival motor neuron protein 0.0048 0.0099 0.0117
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0104 0.0401 0.0868
Plasmodium vivax calcium-dependent protein kinase, putative 0.0136 0.0574 0.0565
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0177 0.0645
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.0391

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.12 nM Displacement of [125I]TZDM from beta amyloid protein 42 (unknown origin) ChEMBL. 18226893

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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