Detailed information for compound 542995

Basic information

Technical information
  • TDR Targets ID: 542995
  • Name: N2-(4-methoxyphenyl)-3-phenyl-6-(trifluoromet hyl)quinoxaline-2,8-diamine
  • MW: 410.392 | Formula: C22H17F3N4O
  • H donors: 2 H acceptors: 2 LogP: 4.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Nc1nc2c(N)cc(cc2nc1c1ccccc1)C(F)(F)F
  • InChi: 1S/C22H17F3N4O/c1-30-16-9-7-15(8-10-16)27-21-19(13-5-3-2-4-6-13)28-18-12-14(22(23,24)25)11-17(26)20(18)29-21/h2-12H,26H2,1H3,(H,27,29)
  • InChiKey: CQKCOXZIDJJZCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [8-amino-3-phenyl-6-(trifluoromethyl)quinoxalin-2-yl]-(4-methoxyphenyl)amine
  • 2-N-(4-methoxyphenyl)-3-phenyl-6-(trifluoromethyl)quinoxaline-2,8-diamine
  • N-(4-methoxyphenyl)-3-phenyl-6-(trifluoromethyl)quinoxaline-2,8-diamine
  • AIDS-138414
  • AIDS138414
  • NSC645169
  • N~2~-(4-Methoxyphenyl)-3-phenyl-6-(trifluoromethyl)-2,8-quinoxalinediamine
  • NCI60_015375

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0203 0.4525 0.6543
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.2064 0.2046
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0305 0.0675
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1289 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0211 0.0305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.4099 0.5928
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0595 0.1271
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.018 0.026
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.056 0.2528
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0655 0.0962
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.4099 0.5868
Schistosoma mansoni glucose transport protein 0.0104 0.2215 0.3171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0352 0.0508
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Brugia malayi hypothetical protein 0.0015 0.0153 0.0339
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1277 0.1828
Brugia malayi RNA binding protein 0.0063 0.1277 0.2822
Echinococcus multilocularis transcription factor Dp 1 0.0118 0.2541 0.3675
Plasmodium falciparum protein kinase 7 0.0293 0.6595 0.6588
Schistosoma mansoni hypothetical protein 0.0016 0.018 0.0257
Toxoplasma gondii sugar transporter ST1 0.0015 0.0153 0.0199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.018 0.026
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0023 0.0033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0585 0.125
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0481 0.0697
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0551 0.053
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0153 0.029
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0305 0.0628
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0352 0.0777
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0352 0.033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.051
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0595 0.0861
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2215 0.3204
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0595 0.1315
Giardia lamblia Sugar-proton symporter 0.0015 0.0153 0.2282
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0595 0.452
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0023 0.0103
Toxoplasma gondii sugar transporter ST3 0.0015 0.0153 0.0199
Echinococcus multilocularis solute carrier family 22 0.0015 0.0153 0.0222
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0023 0.0033
Toxoplasma gondii thioredoxin reductase 0.0097 0.2064 0.3106
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0551 0.0804
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0595 0.1271
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0023 0.0033
Brugia malayi Thioredoxin reductase 0.0097 0.2064 0.4562
Echinococcus granulosus glutamate synthase 0.0009 0.0023 0.0033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796
Leishmania major glucose transporter, lmgt1 0.0032 0.056 0.1194
Loa Loa (eye worm) hypothetical protein 0.0034 0.0602 0.087
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.2064 0.2985
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0153 0.029
Schistosoma mansoni ran 0.0021 0.0305 0.0437
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0551 0.1173
Schistosoma mansoni glucose transport protein 0.0104 0.2215 0.3171
Mycobacterium tuberculosis Probable oxidoreductase 0.0246 0.5517 1
Echinococcus granulosus snurportin 1 0.0306 0.6915 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0153 0.0692
Echinococcus granulosus transcription factor Dp 1 0.0118 0.2541 0.3675
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2215 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0211 0.0305
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0536 0.0775
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0775
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0551 0.053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.4099 0.906
Echinococcus granulosus solute carrier family 22 0.0015 0.0153 0.0222
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0023 0.0033
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0305 0.0283
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0595 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0655 0.0634
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0153 0.0339
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0585 0.125
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Echinococcus multilocularis General substrate transporter 0.0089 0.1878 0.2716
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.4945 0.8958
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0352 0.2597
Onchocerca volvulus 0.0015 0.0153 0.2621
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0073 0.0106
Leishmania major protein kinase, putative 0.0032 0.0551 0.1173
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Onchocerca volvulus 0.0009 0.0023 0.039
Brugia malayi Cam kinase protein 1 0.0032 0.0551 0.1217
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0049 0.0108
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1277 0.1847
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0505 0.0731
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.2064 0.4535
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0536 0.1184
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0595 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0305 0.0442
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0536 0.0767
Leishmania major pyruvate kinase 0.0033 0.0585 0.125
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0353 0.0779
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0153 0.0692
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0352 0.073
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.056 0.1194
Trypanosoma cruzi hexose transporter 0.0032 0.056 0.1194
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0023 0.0103
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0023 0.0033
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0585 0.2642
Loa Loa (eye worm) hypothetical protein 0.005 0.0966 0.1397
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Entamoeba histolytica hypothetical protein 0.0023 0.0352 0.0777
Echinococcus granulosus solute carrier family 22 0.0015 0.0153 0.0222
Brugia malayi hypothetical protein 0.0015 0.0153 0.0339
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0203 0.4525 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.018 0.026
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0536 0.1184
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0585 0.0564
Echinococcus multilocularis pyruvate kinase 0.0033 0.0585 0.0846
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0305 0.0628
Trichomonas vaginalis sugar transporter, putative 0.0032 0.056 0.2528
Brugia malayi RNA, U transporter 1 0.0082 0.1707 0.3773
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0023 0.0103
Schistosoma mansoni hypothetical protein 0.0009 0.0023 0.0033
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0585 0.2642
Echinococcus granulosus solute carrier family 22 0.0015 0.0153 0.0222
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0481 0.1018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0775
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Loa Loa (eye worm) hypothetical protein 0.0033 0.0585 0.0846
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0551 0.053
Plasmodium vivax hexose transporter 0.0104 0.2215 0.2198
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Brugia malayi Importin beta-1 subunit 0.0029 0.0481 0.1063
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0112 0.0161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.4099 0.5928
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0352 0.05
Schistosoma mansoni glutamate synthase 0.0009 0.0023 0.0033
Schistosoma mansoni hypothetical protein 0.0034 0.0602 0.0862
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0595 1
Schistosoma mansoni ran 0.0021 0.0305 0.0437
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0595 0.0871
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.2064 0.3716
Trichomonas vaginalis glucose transporter, putative 0.0032 0.056 0.2528
Trichomonas vaginalis ran, putative 0.0021 0.0305 0.1379
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0585 0.125
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3693 0.3679
Trichomonas vaginalis sugar transporter, putative 0.0032 0.056 0.2528
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0023 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1277 0.1847
Onchocerca volvulus 0.0015 0.0153 0.2621
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0023 0.0033
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0388 0.0858
Schistosoma mansoni hypothetical protein 0.0016 0.018 0.0257
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0595 0.0852
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0305 0.4938
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.4099 0.5868
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0352 0.5745
Entamoeba histolytica disulphide oxidoreductase, putative 0.0009 0.0023 0.005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0595 0.0574
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.4945 0.8958
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.039 0.0368
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0595 0.1271
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0305 0.0283
Trypanosoma cruzi hexose transporter, putative 0.0032 0.056 0.1194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0271 0.0452
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.1289 0.2813
Echinococcus multilocularis geminin 0.017 0.3747 0.5418
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0023 0.0103
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0352 0.0503
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.007 0.083
Echinococcus multilocularis pyruvate kinase 0.0017 0.0211 0.0305
Giardia lamblia Pyruvate kinase 0.0033 0.0585 0.9829
Schistosoma mansoni importin beta-1 0.0029 0.0481 0.0689
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0023 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0153 0.0692
Schistosoma mansoni hypothetical protein 0.017 0.3747 0.5363
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0023 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0551 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0153 0.0692
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.6915 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.4099 0.5928
Leishmania major trypanothione reductase 0.0097 0.2064 0.4535
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0481 0.0696
Loa Loa (eye worm) hypothetical protein 0.0009 0.0023 0.0033
Leishmania major GTP-binding protein, putative 0.0021 0.0305 0.0628
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0595 0.452
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0203 0.4525 0.6477
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0585 0.1024
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0023 0.0033
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0153 0.0692
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0602 0.133
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0153 0.0222
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0595 0.0574
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0203 0.4525 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0153 0.0339
Trypanosoma cruzi hexose transporter, putative 0.0032 0.056 0.1194
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0655 0.1405
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.1289 0.1845
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0153 0.0131
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0352 0.5745
Echinococcus multilocularis solute carrier family 22 0.0015 0.0153 0.0222
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0023 0.0103
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0551 0.053
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0595 0.0871
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0153 0.0692
Plasmodium vivax sugar transporter, putative 0.0015 0.0153 0.0131
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0023 0.0033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Echinococcus multilocularis glutamate synthase 0.0009 0.0023 0.0033
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.039 0.0368
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0352 0.1587
Schistosoma mansoni glucose transport protein 0.0104 0.2215 0.3171
Echinococcus multilocularis GPCR, family 2 0.0016 0.018 0.026
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0153 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0153 0.0692
Schistosoma mansoni pyruvate kinase 0.0017 0.0211 0.0302
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0655 0.1405
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.039 0.0815
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0203 0.4525 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1277 0.1828
Schistosoma mansoni sugar transporter 0.0015 0.0153 0.022
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.1289 0.2849
Schistosoma mansoni protein kinase 0.0032 0.0551 0.0788
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0203 0.4525 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Trypanosoma brucei sugar transporter, putative 0.0015 0.0153 0.029
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0153 0.0222
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0655 0.1405
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1289 1
Echinococcus granulosus General substrate transporter 0.0089 0.1878 0.2716
Brugia malayi TAR-binding protein 0.0063 0.1277 0.2822
Schistosoma mansoni hypothetical protein 0.0104 0.2215 0.3171
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.056 0.1194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0153 0.0238
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0585 0.1294
Leishmania major importin beta-1 subunit, putative 0.0023 0.0355 0.0738
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0353 0.051
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0023 0.005
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0352 0.0508
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Entamoeba histolytica protein kinase, putative 0.0032 0.0551 0.1217
Onchocerca volvulus 0.0015 0.0153 0.2621
Brugia malayi Latrophilin receptor protein 2 0.0016 0.018 0.0397
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0271 0.0452
Schistosoma mansoni hypothetical protein 0.0016 0.018 0.0257
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Toxoplasma gondii protein kinase, putative 0.0293 0.6595 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0551 0.053
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0023 0.0033
Plasmodium vivax importin-beta 2, putative 0.0029 0.0481 0.0459
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0551 0.053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0246 0.5517 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0153 0.0222
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0966 0.2134
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0023 0.0103
Onchocerca volvulus Putative transporter 0.0015 0.0153 0.2621
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0153 0.2282
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0551 0.053
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0551 0.0796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.4099 0.5868
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Leishmania major glucose transporter, lmgt3 0.0032 0.056 0.1194
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Onchocerca volvulus 0.0015 0.0153 0.2621
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.018 0.026
Onchocerca volvulus 0.0015 0.0153 0.2621
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0023 0.0103
Loa Loa (eye worm) sugar transporter 0.0015 0.0153 0.0222
Brugia malayi major facilitator superfamily protein 0.0015 0.0153 0.0339
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1277 0.1847
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0211 0.0189
Schistosoma mansoni protein kinase 0.0032 0.0551 0.0788
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.039 0.0558
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Chlamydia trachomatis pyruvate kinase 0.0033 0.0585 0.9829
Brugia malayi glutathione reductase 0.0097 0.2064 0.4562
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1277 0.1828
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0023 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0966 0.1397
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0023 0.0103
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1277 0.2822
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0023 0.0103
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0536 0.0767
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0153 0.1031
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0585 0.0846
Leishmania major hypothetical protein, conserved 0.0025 0.039 0.0815
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0655 0.1405
Schistosoma mansoni glutamate synthase 0.0009 0.0023 0.0033
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0595 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0286 0.1289
Brugia malayi hypothetical protein 0.0015 0.0153 0.0339
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0203 0.4525 0.6543
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0203 0.4525 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.039 0.0563
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0153 0.0339
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0023 0.0103
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0023 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1277 0.1828
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0536 0.1184
Onchocerca volvulus 0.0015 0.0153 0.2621
Onchocerca volvulus 0.0015 0.0153 0.2621
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.4945 0.8958
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0595 0.1271
Onchocerca volvulus 0.0015 0.0153 0.2621
Loa Loa (eye worm) hypothetical protein 0.0025 0.0401 0.058
Mycobacterium ulcerans sugar transporter 0.0015 0.0153 0.1031
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0595 0.452
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0551 0.0804
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0595 0.2686
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.2064 0.2985
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.4945 0.8958
Entamoeba histolytica thioredoxin reductase, putative 0.0009 0.0023 0.005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0305 0.043
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Entamoeba histolytica Ran family GTPase 0.0021 0.0305 0.0675
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0153 0.022
Giardia lamblia Pyruvate kinase 0.0017 0.0211 0.3286
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0246 0.5517 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0203 0.4525 0.6543
Plasmodium falciparum thioredoxin reductase 0.0097 0.2064 0.2046
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0352 0.0503
Schistosoma mansoni hypothetical protein 0.017 0.3747 0.5363
Echinococcus granulosus solute carrier family 22 0.0015 0.0153 0.0222
Entamoeba histolytica hypothetical protein 0.0023 0.0355 0.0785
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Echinococcus granulosus pyruvate kinase 0.0033 0.0585 0.0846
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0536 0.0934
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.4099 0.5928
Brugia malayi hypothetical protein 0.0016 0.0186 0.0412
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Echinococcus multilocularis pyruvate kinase 0.0026 0.0423 0.0612
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0551 0.0804
Onchocerca volvulus 0.0015 0.0153 0.2621
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796
Echinococcus multilocularis pyruvate kinase 0.0017 0.0211 0.0305
Mycobacterium tuberculosis Probable reductase 0.0221 0.4945 0.8958
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0023 0.005
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0551 0.1217
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.1289 0.2305
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0023 0.0103
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0023 0.0033
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.119 0.1721
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0352 0.0508
Leishmania major hypothetical protein, conserved 0.0015 0.0153 0.029
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0585 0.1024
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0595 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.056 0.2528
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0595 0.1271
Onchocerca volvulus 0.0015 0.0153 0.2621
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.007 0.0375
Echinococcus multilocularis solute carrier family 22 0.0015 0.0153 0.0222
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0153 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0023 0.0033
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0153 0.1031
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0305 0.0442
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3693 0.5585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0966 0.2134
Onchocerca volvulus 0.0015 0.0153 0.2621
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0305 0.0628
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0595 0.1271
Treponema pallidum NADH oxidase 0.0034 0.0595 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.1277 0.1847
Brugia malayi major facilitator superfamily protein 0.0015 0.0153 0.0339
Onchocerca volvulus 0.0015 0.0153 0.2621
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0655 0.1405
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0595 0.1042
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0073 0.0106
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3693 0.3679
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0585 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2215 0.3336
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0655 0.0634
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0352 0.2597
Trypanosoma brucei glucose transporter 1E 0.0032 0.056 0.1194
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0153 0.0222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0595 0.1271
Plasmodium falciparum glutathione reductase 0.0034 0.0595 0.0574
Trichomonas vaginalis glucose transporter, putative 0.0032 0.056 0.2528
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0536 0.0775
Schistosoma mansoni glutamate synthase 0.0009 0.0023 0.0033
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0153 0.1031
Toxoplasma gondii sugar transporter ST2 0.0015 0.0153 0.0199
Brugia malayi hypothetical protein 0.0025 0.039 0.0861
Trypanosoma brucei glucose transporter 2A 0.0032 0.056 0.1194
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0355 0.1603
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0505 0.0731
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0551 0.053
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Plasmodium falciparum importin beta, putative 0.0029 0.0481 0.0459
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0352 0.073
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2215 0.3204
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.056 0.1194
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0023 0.0033
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.039 0.0368
Schistosoma mansoni sugar transporter 0.0015 0.0153 0.022
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0153 0.0238
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Schistosoma mansoni pyruvate kinase 0.0033 0.0585 0.0838
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0585 1
Echinococcus granulosus GPCR family 2 0.0016 0.018 0.026
Echinococcus granulosus importin subunit beta 1 0.0029 0.0481 0.0696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.4099 0.5928
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0153 0.029
Plasmodium falciparum thioredoxin reductase 0.0034 0.0595 0.0574
Schistosoma mansoni hypothetical protein 0.0011 0.0073 0.0105
Plasmodium falciparum hexose transporter 0.0104 0.2215 0.2198
Echinococcus granulosus geminin 0.017 0.3747 0.5418
Brugia malayi glutamate synthase 0.0009 0.0023 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.018 0.026
Echinococcus granulosus pyruvate kinase 0.0017 0.0211 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0481 0.0696
Schistosoma mansoni glucose transporter 0.0015 0.0153 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.039 0.0815
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Plasmodium vivax glutathione reductase, putative 0.0097 0.2064 0.2046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0023 0.0103
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0536 0.2419
Plasmodium falciparum glutathione reductase 0.0097 0.2064 0.2046
Brugia malayi Sugar transporter family protein 0.0015 0.0153 0.0339
Plasmodium falciparum pyruvate kinase 0.0033 0.0585 0.0564
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.007 0.083
Schistosoma mansoni hypothetical protein 0.0306 0.6915 0.9899
Schistosoma mansoni protein kinase 0.0032 0.0551 0.0788
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0023 0.0103
Loa Loa (eye worm) sugar transporter 0.0104 0.2215 0.3204
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0009 0.0023 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0271 0.0452
Loa Loa (eye worm) glutathione reductase 0.0097 0.2064 0.2985
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0595 0.1271
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0009 0.0023 0.005
Echinococcus granulosus pyruvate kinase 0.0017 0.0211 0.0305
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0223 0.0444
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1289 0.1864
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Echinococcus multilocularis snurportin 1 0.0306 0.6915 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0352 0.073
Echinococcus granulosus tar DNA binding protein 0.0063 0.1277 0.1847
Echinococcus granulosus pyruvate kinase 0.0033 0.0585 0.0846
Schistosoma mansoni pyruvate kinase 0.0033 0.0585 0.0838
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0246 0.5517 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0595 0.0574
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0355 0.1603
Onchocerca volvulus 0.0015 0.0153 0.2621
Trypanosoma brucei glucose transporter, putative 0.0032 0.056 0.1194
Brugia malayi Sugar transporter family protein 0.0015 0.0153 0.0339
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0023 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.056 0.1194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0009 0.0023 0.005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0355 0.0738
Echinococcus multilocularis solute carrier family 22 0.0015 0.0153 0.0222
Leishmania major pyruvate kinase 0.0033 0.0585 0.125
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0153 0.0199
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0551 0.053
Trypanosoma brucei trypanothione reductase 0.0097 0.2064 0.4535
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0585 0.0846
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0595 0.1271
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0222
Entamoeba histolytica protein kinase, putative 0.0032 0.0551 0.1217
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0585 0.1294
Brugia malayi Sugar transporter family protein 0.0104 0.2215 0.4897
Schistosoma mansoni sugar transporter 0.0015 0.0153 0.022
Onchocerca volvulus 0.0015 0.0153 0.2621
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0595 0.0861
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0305 0.0442
Loa Loa (eye worm) hypothetical protein 0.0032 0.0551 0.0796
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796
Schistosoma mansoni hypothetical protein 0.0016 0.018 0.0257
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0585 0.0856
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0585 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0481 0.1018
Onchocerca volvulus 0.0015 0.0153 0.2621
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0153 0.029
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0153 0.0692
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1277 0.1828
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0355 0.1603
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0585 0.125
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1289 0.1864
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0211 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.039 0.0815
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.2064 0.2985
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0023 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0032 0.056 0.2528
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0009 0.0023 0.005
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0585 0.4443
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0352 0.0598
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0221 0.4945 0.8958
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0585 0.0846
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0352 0.033
Giardia lamblia Hexose transporter 0.0015 0.0153 0.2282
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0551 0.0796
Trypanosoma cruzi hexose transporter, putative 0.0032 0.056 0.1194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.018 0.026
Schistosoma mansoni sugar transporter 0.0015 0.0153 0.022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0595 0.1271
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0536 0.8965
Leishmania major glucose transporter, lmgt2 0.0032 0.056 0.1194
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.018 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0551 0.2486
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0211 0.0189
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0595 0.2686
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Onchocerca volvulus 0.0015 0.0153 0.2621
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0153 0.0692
Plasmodium vivax CDK-related protein kinase 6, putative 0.0439 1 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0585 0.0846
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0388 0.0858
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.4945 0.8958
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0153 0.029
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0551 0.0796
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0203 0.4525 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0551 0.0796

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.772 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.425 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.157 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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