Detailed information for compound 545953

Basic information

Technical information
  • TDR Targets ID: 545953
  • Name: nitrite hydrate
  • MW: 64.0208 | Formula: H2NO3-
  • H donors: 1 H acceptors: 3 LogP: -1.31 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]N=O.O
  • InChi: 1S/HNO2.H2O/c2-1-3;/h(H,2,3);1H2/p-1
  • InChiKey: SWEOMYFEYPLQII-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • Peroxynitrous Acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0574 0.0534
Echinococcus granulosus epidermal growth factor receptor 0.0079 0.1212 0.1212
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0574 0.0433
Echinococcus multilocularis malate dehydrogenase 0.0232 0.3813 0.3813
Schistosoma mansoni DNA helicase recq1 0.001 0.0043 0.0043
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0192 0.0192
Leishmania major UDP-galactopyranose mutase 0.0041 0.0574 0.0488
Echinococcus multilocularis lactate dehydrogenase a 0.0596 1 1
Brugia malayi MH2 domain containing protein 0.0139 0.2244 0.2244
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0068 0.1027 0.1396
Schistosoma mansoni hypothetical protein 0.0036 0.0493 0.0493
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0574 0.0534
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.236 0.236
Echinococcus multilocularis geminin 0.0165 0.2683 0.2683
Loa Loa (eye worm) hypothetical protein 0.0596 1 1
Plasmodium falciparum malate dehydrogenase 0.0596 1 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.334 0.334
Plasmodium falciparum lactate dehydrogenase, putative 0.0232 0.3813 0.3787
Loa Loa (eye worm) hypothetical protein 0.0041 0.0574 0.0574
Trypanosoma cruzi malate dehydrogenase, putative 0.0232 0.3813 1
Loa Loa (eye worm) matrix metalloproteinase 0.0056 0.0821 0.0821
Schistosoma mansoni malate dehydrogenase 0.0232 0.3813 0.3813
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0049 0.0049
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0232 0.3813 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0228 0.0186
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0043 0.0043
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0049 0.0049
Brugia malayi Muscleblind-like protein 0.0146 0.2351 0.2351
Schistosoma mansoni tyrosine kinase 0.0047 0.0671 0.0671
Plasmodium vivax lactate dehydrogenase 0.0596 1 1
Leishmania major glycosomal malate dehydrogenase 0.0232 0.3813 0.3756
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0574 0.0433
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0574 0.0433
Loa Loa (eye worm) RecQ helicase 0.0023 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0041 0.0574 0.0574
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0049 0.0049
Schistosoma mansoni amine oxidase 0.0041 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0118 0.1879 0.1879
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0574 0.1506
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0049 0.0049
Echinococcus granulosus lactate dehydrogenase protein 0.0596 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0049 0.0049
Brugia malayi N-terminal motif family protein 0.0204 0.334 0.334
Echinococcus granulosus Smad4 0.0009 0.004 0.004
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.004 0.004
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0232 0.3813 0.3813
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0068 0.1027 0.0533
Schistosoma mansoni tyrosine kinase 0.0078 0.1198 0.1198
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0091 0.0238
Schistosoma mansoni smad1 5 8 and 0.0009 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0493 0.0493
Schistosoma mansoni dep domain containing protein 0.001 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0036 0.0493 0.0493
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.2244 0.2244
Onchocerca volvulus Matrilysin homolog 0.0123 0.1969 0.5896
Echinococcus multilocularis smad 0.0009 0.004 0.004
Brugia malayi hypothetical protein 0.001 0.0049 0.0049
Echinococcus multilocularis muscleblind protein 0.0146 0.2351 0.2351
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.1207 0.1207
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.004 0.004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0582 0.9759 1
Schistosoma mansoni DNA helicase recq5 0.001 0.0043 0.0043
Brugia malayi Matrixin family protein 0.0056 0.0821 0.0821
Mycobacterium ulcerans hydrolase 0.0068 0.1027 0.0492
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0049 0.0049
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0043 0.0043
Echinococcus multilocularis GPCR, family 2 0.0036 0.0493 0.0493
Echinococcus granulosus cytosolic malate dehydrogenase 0.0232 0.3813 0.3813
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0049 0.0049
Echinococcus multilocularis 0.0045 0.0647 0.0647
Toxoplasma gondii lactate dehydrogenase LDH1 0.0596 1 1
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0232 0.3813 0.3815
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0574 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0493 0.0493
Onchocerca volvulus 0.0079 0.1215 0.3638
Schistosoma mansoni tyrosine kinase 0.0078 0.1198 0.1198
Chlamydia trachomatis malate dehydrogenase 0.0232 0.3813 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0144 0.0102
Echinococcus granulosus GPCR family 2 0.0036 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0146 0.2351 0.2351
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0232 0.3813 1
Schistosoma mansoni tyrosine kinase 0.0079 0.1212 0.1212
Loa Loa (eye worm) hypothetical protein 0.0056 0.0821 0.0821
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0202 0.3306 0.3306
Echinococcus granulosus geminin 0.0165 0.2683 0.2683
Loa Loa (eye worm) matrixin family protein 0.0123 0.1969 0.1969
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0232 0.3813 0.3721
Plasmodium vivax malate dehydrogenase, putative 0.0596 1 1
Mycobacterium ulcerans malate dehydrogenase 0.0232 0.3813 0.3526
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0091 0.0091
Leishmania major mitochondrial malate dehydrogenase 0.0232 0.3813 0.3756
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0043 0.0043
Schistosoma mansoni smad 0.0009 0.004 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0232 0.3813 1
Brugia malayi MH1 domain containing protein 0.0009 0.004 0.004
Echinococcus granulosus smad 0.0009 0.004 0.004
Schistosoma mansoni Smad4 0.0009 0.004 0.004
Loa Loa (eye worm) malate dehydrogenase 0.0232 0.3813 0.3813
Brugia malayi Smad1 0.0009 0.004 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Toxoplasma gondii lactate dehydrogenase LDH2 0.0596 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0493 0.0493
Schistosoma mansoni tyrosine kinase 0.0146 0.236 0.236
Toxoplasma gondii hypothetical protein 0.001 0.0049 0.0006
Schistosoma mansoni hypothetical protein 0.0165 0.2683 0.2683
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0049 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0146 0.2351 0.2351
Loa Loa (eye worm) hypothetical protein 0.0078 0.1207 0.1207
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0079 0.1212 0.1212
Loa Loa (eye worm) hypothetical protein 0.0041 0.0574 0.0574
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0232 0.3813 0.3813
Brugia malayi MH2 domain containing protein 0.0009 0.004 0.004
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.0574 0.0534
Schistosoma mansoni malate dehydrogenase 0.0232 0.3813 0.3813
Echinococcus granulosus malate dehydrogenase 0.0232 0.3813 0.3813
Loa Loa (eye worm) hypothetical protein 0.0115 0.1822 0.1822
Loa Loa (eye worm) matrixin family protein 0.0134 0.2158 0.2158
Echinococcus multilocularis lactate dehydrogenase a 0.0596 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.236 0.236
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0049 0.0049
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0596 1 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0068 0.1027 0.1027
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0049 0.0146
Schistosoma mansoni hypothetical protein 0.0165 0.2683 0.2683
Schistosoma mansoni malate dehydrogenase 0.0596 1 1
Brugia malayi SWIRM domain containing protein 0.0041 0.0574 0.0574
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0574 0.0534
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0043 0.0043
Plasmodium falciparum L-lactate dehydrogenase 0.0596 1 1
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0049 0.0049
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0232 0.3813 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.004 0.004
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0043 0.0043
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0232 0.3813 1
Echinococcus multilocularis lactate dehydrogenase protein 0.0596 1 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0232 0.3813 0.3813
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0493 0.0493
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0574 0.0574
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0091 0.0238
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0493 0.0493
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0232 0.3813 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0821 0.0821
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0049 0.0049
Brugia malayi MH1 domain containing protein 0.0009 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0821 0.0821
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0202 0.3306 0.3306
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0276 0.0724
Onchocerca volvulus 0.0041 0.0574 0.172
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0049 0.0049
Schistosoma mansoni malate dehydrogenase 0.0232 0.3813 0.3813
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Onchocerca volvulus 0.0056 0.0821 0.2459
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.0671 0.0671
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.004 0.004
Echinococcus granulosus malate dehydrogenase 0.0232 0.3813 0.3813
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0232 0.3813 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.004 0.004
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0049 0.0049
Echinococcus granulosus L lactate dehydrogenase 0.0365 0.6066 0.6066
Echinococcus multilocularis L lactate dehydrogenase 0.0365 0.6066 0.6066
Leishmania major malate dehydrogenase 0.0232 0.3813 0.3756
Brugia malayi Matrixin family protein 0.0056 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0068 0.1027 0.1027
Trypanosoma brucei glycosomal malate dehydrogenase 0.0232 0.3813 1
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0276 0.0276
Brugia malayi hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni tyrosine kinase 0.0047 0.0671 0.0671
Toxoplasma gondii malate dehydrogenase MDH 0.0596 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.0671 0.0671
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0574 0.1506
Schistosoma mansoni dishevelled 0.001 0.0049 0.0049
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0232 0.3813 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0232 0.3813 1
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2351 0.2351
Leishmania major malate dehydrogenase, putative 0.0596 1 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0232 0.3813 0.3813
Brugia malayi Matrixin family protein 0.0134 0.2158 0.2158
Onchocerca volvulus Matrix metalloproteinase homolog 0.0123 0.1969 0.5896
Entamoeba histolytica malate dehydrogenase, putative 0.0596 1 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0276 0.0276
Echinococcus granulosus bloom syndrome protein 0.0023 0.0276 0.0276
Brugia malayi hypothetical protein 0.0041 0.0574 0.0574
Brugia malayi Matrixin family protein 0.0056 0.0821 0.0821
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0541 0.9063 1
Schistosoma mansoni L-lactate dehydrogenase 0.0232 0.3813 0.3813
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1822 0.1822
Brugia malayi MH2 domain containing protein 0.0009 0.004 0.004
Echinococcus granulosus insulin receptor 0.0047 0.0671 0.0671
Schistosoma mansoni tyrosine kinase 0.0078 0.1198 0.1198
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0596 1 0.5
Schistosoma mansoni hypothetical protein 0.0078 0.1207 0.1207
Echinococcus granulosus lactate dehydrogenase a 0.0596 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0049 0.0049
Echinococcus granulosus L lactate dehydrogenase B chain 0.0596 1 1
Brugia malayi DIX domain containing protein 0.001 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0036 0.0493 0.0493
Echinococcus granulosus muscleblind protein 0.0146 0.2351 0.2351
Schistosoma mansoni hypothetical protein 0.0079 0.1215 0.1215
Brugia malayi Protein kinase domain containing protein 0.0047 0.0671 0.0671
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0041 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0041 0.0574 0.0574
Entamoeba histolytica malate dehydrogenase, putative 0.0232 0.3813 0.3813
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0574 0.0574
Brugia malayi Matrixin family protein 0.0056 0.0821 0.0821
Loa Loa (eye worm) malate dehydrogenase 0.0232 0.3813 0.3813
Trypanosoma brucei cytosolic malate dehydrogenase 0.0232 0.3813 1
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.236 0.236
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0276 0.0724
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0049 0.0049
Onchocerca volvulus Matrilysin homolog 0.0056 0.0821 0.2459
Echinococcus multilocularis lactate dehydrogenase a 0.0596 1 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0041 0.0574 0.0574
Echinococcus multilocularis 0.0041 0.0574 0.0574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0493 0.0493
Trypanosoma brucei malate dehydrogenase-related 0.0232 0.3813 1
Schistosoma mansoni L-lactate dehydrogenase 0.0596 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.004 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0113 0.1795 0.4708
Schistosoma mansoni dishevelled 0.001 0.0049 0.0049
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0574 0.0574
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.004 0.004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1822 0.1822
Echinococcus multilocularis epidermal growth factor receptor 0.0079 0.1212 0.1212
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.2244 0.2244
Echinococcus multilocularis Smad4 0.0009 0.004 0.004
Onchocerca volvulus 0.001 0.0049 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0493 0.0493
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0574 0.0574
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0574 0.0574
Echinococcus multilocularis malate dehydrogenase 0.0232 0.3813 0.3813
Schistosoma mansoni amine oxidase 0.0041 0.0574 0.0574
Echinococcus multilocularis insulin receptor 0.0047 0.0671 0.0671
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0574 0.0534
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0043 0.000000000075023
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0049 0.0049
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.1256 0.1256
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0493 0.0493
Leishmania major malate dehydrogenase, putative 0.0232 0.3813 0.3756
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0232 0.3813 0.3813
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Schistosoma mansoni regulator of G protein signaling 0.001 0.0049 0.0049
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0049 0.0049
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0056 0.0821 0.0821
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.334 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0574 0.0574
Trichomonas vaginalis malate dehydrogenase, putative 0.0113 0.1795 0.4708
Loa Loa (eye worm) hypothetical protein 0.001 0.0049 0.0049
Echinococcus granulosus cytosolic malate dehydrogenase 0.0232 0.3813 0.3813
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0232 0.3813 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0232 0.3813 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.004 0.004
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Giardia lamblia Malate dehydrogenase 0.0232 0.3813 1
Echinococcus granulosus lactate dehydrogenase a 0.0596 1 1
Loa Loa (eye worm) Smad1 0.0009 0.004 0.004
Schistosoma mansoni tyrosine kinase 0.0079 0.1212 0.1212
Leishmania major cytosolic malate dehydrogenase 0.0232 0.3813 0.3756
Brugia malayi Hemopexin family protein 0.0079 0.1215 0.1215
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0582 0.9759 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0232 0.3813 1
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.236 0.236
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0232 0.3813 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1822 0.1822
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0043 0.0043

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

23 literature references were collected for this gene.

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