Detailed information for compound 547044

Basic information

Technical information
  • TDR Targets ID: 547044
  • Name: 2-[2-[2-[2-[bis(carboxymethyl)amino]-5-[(E)-2 -(3-ethyl-1,3-benzothiazol-3-ium-2-yl)vinyl]p henoxy]ethoxy]-N-(carboxymethyl)-4-methyl-ani lino]acetic acid iodide
  • MW: 805.633 | Formula: C34H36IN3O10S
  • H donors: 4 H acceptors: 8 LogP: 6.6 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[n+]1c(C=Cc2ccc(c(c2)OCCOc2cc(C)ccc2N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O)sc2c1cccc2.[I-]
  • InChi: 1S/C34H35N3O10S.HI/c1-3-37-26-6-4-5-7-29(26)48-30(37)13-10-23-9-12-25(36(20-33(42)43)21-34(44)45)28(17-23)47-15-14-46-27-16-22(2)8-11-24(27)35(18-31(38)39)19-32(40)41;/h4-13,16-17H,3,14-15,18-21H2,1-2H3,(H3-,38,39,40,41,42,43,44,45);1H
  • InChiKey: AJICOSVECOHRCM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[2-[2-[bis(carboxymethyl)amino]-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)vinyl]phenoxy]ethoxy]-N-(carboxymethyl)-4-methylanilino]acetic acid iodide
  • 2-[[2-[2-[2-[bis(carboxymethyl)amino]-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)ethenyl]phenoxy]ethoxy]-4-methyl-phenyl]-(carboxymethyl)amino]ethanoic acid iodide
  • 2-[2-[2-[2-[bis(carboxymethyl)amino]-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)ethenyl]phenoxy]ethoxy]-N-(carboxymethyl)-4-methylanilino]acetic acid iodide
  • 1-(5-(2-(2-N-ethylbenzothiazolinium)ethenyl)-2-aminophenoxy)-2-(2-amino-5-methylphenoxy)ethane-N,N,N',N'-tetraacetic acid
  • 2-[[2-[2-[2-(bis(carboxymethyl)amino)-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)ethenyl]phenoxy]ethoxy]-4-methylphenyl]-(carboxymethyl)amino]acetic acid iodide
  • 2-[[2-[2-[2-(bis(carboxymethyl)amino)-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)vinyl]phenoxy]ethoxy]-4-methyl-phenyl]-(carboxymethyl)amino]acetic acid iodide
  • 2-[[2-[2-[2-(bis(carboxymethyl)amino)-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)vinyl]phenoxy]ethoxy]-4-methylphenyl]-(carboxymethyl)amino]acetic acid iodide
  • 2-[[2-[2-[2-(bis(carboxymethyl)amino)-5-[(E)-2-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)ethenyl]phenoxy]ethoxy]-4-methyl-phenyl]-(carboxymethyl)amino]ethanoic acid iodide
  • 150669-69-5
  • STBT

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine receptor 0.0017 0.0508 0.1687
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0508 0.095
Echinococcus granulosus somatostatin receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) hepatopoietin HPO2 0.0068 0.5351 0.5351
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.5351 0.5
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.5351 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.1912 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0508 0.095
Leishmania major cytochrome p450-like protein 0.0051 0.3769 0.54
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0508 0.095
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0508 0.1687
Schistosoma mansoni histamine h1 receptor 0.0017 0.0508 0.1687
Onchocerca volvulus 0.0017 0.0508 0.5
Brugia malayi neuropeptide F receptor 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.5351 1
Brugia malayi G-protein coupled receptor 0.0017 0.0508 0.0508
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.5351 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.1912 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.1912 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Leishmania major hypothetical protein, conserved 0.0068 0.5351 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.1912 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.3769 1
Schistosoma mansoni cytochrome P450 0.0032 0.1912 0.6348
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0508 0.095
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.242 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0508 0.095
Brugia malayi Dopamine receptor 0.0017 0.0508 0.0508
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0508 0.1687
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0508 0.095
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.2667 0.4985
Brugia malayi larval opioid receptor 0.0017 0.0508 0.0508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0508 0.095
Schistosoma mansoni hypothetical protein 0.0017 0.0508 0.1687
Brugia malayi sulfakinin receptor protein 0.0017 0.0508 0.0508
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0508 0.095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Schistosoma mansoni amine GPCR 0.0017 0.0508 0.1687
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0508 0.095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0508 0.0508
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0508 0.095
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0508 0.095
Schistosoma mansoni amine GPCR 0.0017 0.0508 0.1687
Brugia malayi Dopamine receptor protein 2 0.0017 0.0508 0.0508
Onchocerca volvulus 0.0017 0.0508 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.5351 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.1912 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.1912 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0508 0.095
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.1912 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0508 0.095
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi Cytochrome P450 family protein 0.0051 0.3769 0.3769
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0032 0.1912 0.6348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus fmrfamide receptor 0.0017 0.0508 0.095
Trypanosoma brucei cytochrome P450, putative 0.0051 0.3769 0.54
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0508 0.1687
Mycobacterium leprae putative cytochrome p450 0.0032 0.1912 0.5
Onchocerca volvulus 0.0017 0.0508 0.5
Echinococcus granulosus hypothetical protein 0.0017 0.0508 0.095
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.1912 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.2667 0.2667
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0508 0.095
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0508 0.095
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.1912 0.5
Echinococcus granulosus orexin receptor type 2 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Schistosoma mansoni opsin-like receptor 0.0017 0.0508 0.1687
Echinococcus granulosus g protein coupled receptor 0.0017 0.0508 0.095
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.3769 0.54
Onchocerca volvulus 0.0017 0.0508 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.1912 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0508 0.0508
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0508 0.095
Schistosoma mansoni adenoreceptor 0.0017 0.0508 0.1687
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Loa Loa (eye worm) cytochrome P450 0.0032 0.1912 0.1912
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Schistosoma mansoni opsin-like receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0508 0.095
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0508 0.095
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.1912 0.5
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.3769 0.3769
Schistosoma mansoni biogenic amine receptor 0.0017 0.0508 0.1687
Schistosoma mansoni biogenic amine receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0068 0.5351 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi Cytochrome P450 family protein 0.0032 0.1912 0.1912
Echinococcus granulosus sex peptide receptor 0.0017 0.0508 0.095
Brugia malayi Dopamine receptor protein 1 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0034 0.2171 0.2171
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0508 0.0508
Echinococcus granulosus serotonin receptor 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0508 0.095
Brugia malayi Serotonin receptor 0.0017 0.0508 0.0508
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.1912 0.5
Schistosoma mansoni myosin xvIII 0.0017 0.0508 0.1687
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0508 0.0508
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.2667 0.4985
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Brugia malayi GnHR receptor homolog 0.0017 0.0508 0.0508
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0508 0.095
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0508 0.0508
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0508 0.1687
Echinococcus multilocularis serotonin receptor 0.0017 0.0508 0.095
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0508 0.095
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0508 0.095
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0508 0.095
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0508 0.1687
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0508 0.095
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Brugia malayi RE15519p 0.0017 0.0508 0.0508
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0508 0.095
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0508 0.095
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Schistosoma mansoni neuropeptide receptor 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.002 0.0769 0.0769
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus allatostatin A receptor 0.0017 0.0508 0.095
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.1912 0.3573
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.1912 0.5
Onchocerca volvulus 0.0017 0.0508 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.3769 0.54
Brugia malayi Cytochrome P450 family protein 0.0051 0.3769 0.3769
Onchocerca volvulus 0.0017 0.0508 0.5
Schistosoma mansoni neuropeptide receptor 0.0017 0.0508 0.1687
Brugia malayi AKH receptor 0.0017 0.0508 0.0508
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.5351 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.1912 0.5
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0508 0.0508
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.3012 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0508 0.1687
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0508 0.1687
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0508 0.1687
Schistosoma mansoni amine GPCR 0.0017 0.0508 0.1687
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0508 0.095
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0508 0.095
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0508 0.095
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0508 0.095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus g protein coupled receptor 0.0017 0.0508 0.095
Brugia malayi cytochrome P450 0.0032 0.1912 0.1912
Loa Loa (eye worm) CYP4Cod1 0.0051 0.3769 0.3769
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi ORL1-like opioid receptor 0.0017 0.0508 0.0508
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0508 0.095
Brugia malayi neuropeptide F receptor 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.3769 0.3769
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0508 0.095
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0508 0.095
Echinococcus multilocularis serotonin receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) cytochrome P450 family protein 0.0117 1 1
Onchocerca volvulus 0.0017 0.0508 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0508 0.095
Brugia malayi G-protein coupled receptor 0.0017 0.0508 0.0508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0508 0.0508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0508 0.1687
Schistosoma mansoni neuropeptide receptor 0.0017 0.0508 0.1687
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.1912 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0508 0.0508
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0508 0.1687
Onchocerca volvulus 0.0017 0.0508 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi Melatonin receptor type 1A 0.0017 0.0508 0.0508
Brugia malayi G protein-coupled receptor 0.0017 0.0508 0.0508
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0508 0.095
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0508 0.095
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0508 0.095
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0508 0.095
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0508 0.095
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.1912 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Schistosoma mansoni neuropeptide receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.2667 0.2667
Echinococcus granulosus neuropeptide receptor 0.0017 0.0508 0.095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.1912 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Echinococcus granulosus neuropeptide receptor 0.0017 0.0508 0.095
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Onchocerca volvulus 0.0017 0.0508 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0508 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0508 0.0508
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Onchocerca volvulus 0.0017 0.0508 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.1912 0.5
Brugia malayi Serotonin receptor 0.0017 0.0508 0.0508
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis somatostatin receptor 0.0017 0.0508 0.095
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Brugia malayi putative neuropeptide receptor 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0508 0.095
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0508 0.095
Echinococcus multilocularis 0.0032 0.1912 0.3573
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0508 0.1687
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0068 0.5351 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0508 0.095
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0508 0.095
Echinococcus granulosus g protein coupled receptor 0.0017 0.0508 0.095
Onchocerca volvulus 0.0017 0.0508 0.5
Brugia malayi Augmenter of liver regeneration 0.0068 0.5351 0.5351
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0508 0.095
Brugia malayi hypothetical protein 0.0017 0.0508 0.0508
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0508 0.095
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0508 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0508 0.095
Schistosoma mansoni opsin-like receptor 0.0017 0.0508 0.1687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Echinococcus multilocularis sex peptide receptor 0.0017 0.0508 0.095
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.1912 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0508 0.095
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0508 0.1687
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0508 0.1687
Schistosoma mansoni amine GPCR 0.0017 0.0508 0.1687
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.1912 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0508 0.1687
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0508 0.0508
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.5351 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0508 0.1687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.3012 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0508 0.095
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.242 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0508 0.0508
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.1912 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0508 0.095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0508 0.095
Schistosoma mansoni amine GPCR 0.0017 0.0508 0.1687
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.5351 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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