TDR Targets

Basic information

Technical information

TDR Targets ID: 551616
Name: 4-methyl-1-(1-phenylcyclohexyl)piperidine hyd rochloride
MW: 293.875 | Formula: C18H28ClN
H donors: 0 H acceptors: 0 LogP: 5.44 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)C1(CCCCC1)c1ccccc1.Cl
InChi: 1S/C18H27N.ClH/c1-16-10-14-19(15-11-16)18(12-6-3-7-13-18)17-8-4-2-5-9-17;/h2,4-5,8-9,16H,3,6-7,10-15H2,1H3;1H
InChiKey: RSMMAQCKCNQZQX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1934-50-5
2201-42-5
Piperidine, 4-methyl-1-(1-phenylcyclohexyl)-, hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	prolyl endopeptidase	0.0923	0.5765	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0038	0.0169
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0045	0.0074
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0038	0.0169
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0019	0.0008	0.0014
Plasmodium falciparum	plasmepsin VI	0.0019	0.0008	0.0156
Toxoplasma gondii	hypothetical protein	0.0097	0.0505	0.0872
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0045	0.0074
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0097	0.0505	0.0872
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0097	0.0505	0.0863
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0097	0.0505	0.995
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0097	0.0505	1
Plasmodium vivax	hypothetical protein, conserved	0.0097	0.0505	1
Plasmodium falciparum	plasmepsin III	0.0019	0.0008	0.0156
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0367	0.2226	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0038	0.0073
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0507	1
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0097	0.0505	0.0872
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0367	0.2226	0.3858
Brugia malayi	hypothetical protein	0.0019	0.0008	0.001
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0923	0.5765	1
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0097	0.0505	0.995
Loa Loa (eye worm)	prolyl oligopeptidase	0.0097	0.0505	0.0876
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0367	0.2226	0.3858
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0367	0.2226	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0038	0.0073
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0097	0.0505	0.0872
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0507	0.0505
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0154	0.3022
Plasmodium falciparum	peptidase, putative	0.0097	0.0505	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0019	0.0008	0.001
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0161	0.0917	0.159
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0154	0.0152
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0097	0.0505	1
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0097	0.0505	0.0872
Plasmodium vivax	aspartyl proteinase, putative	0.0019	0.0008	0.0156
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0019	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0214	0.0371
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0045	0.0074
Plasmodium falciparum	plasmepsin VII	0.0019	0.0008	0.0156
Trypanosoma cruzi	hypothetical protein, conserved	0.0097	0.0505	0.0872
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0097	0.0505	0.0503
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Onchocerca volvulus		0.0023	0.0038	0.0052
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0045	0.0074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0172	0.0294
Schistosoma mansoni	alzheimer's disease beta-amyloid related	0.0121	0.0656	0.1135
Toxoplasma gondii	prolyl endopeptidase	0.0923	0.5765	1
Loa Loa (eye worm)	prolyl oligopeptidase	0.0097	0.0505	0.0876
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0019	0.0008	0.0006
Trypanosoma brucei	prolyl endopeptidase	0.0923	0.5765	1
Brugia malayi	prolyl oligopeptidase family protein	0.0923	0.5765	1
Schistosoma mansoni	hypothetical protein	0.004	0.0145	0.0247
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0023	0.0036
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0172	0.0294
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0923	0.5765	1
Schistosoma mansoni	hypothetical protein	0.004	0.0145	0.0247
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0038	0.0169
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0367	0.2226	0.3858
Plasmodium falciparum	plasmepsin IV	0.0019	0.0008	0.0156
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0264	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0923	0.5765	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0097	0.0505	0.0872
Entamoeba histolytica	dipeptidyl-peptidase, putative	0.0097	0.0505	0.995
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0172	0.0294
Entamoeba histolytica	hypothetical protein, conserved	0.0097	0.0505	0.995
Plasmodium vivax	aspartyl protease, putative	0.0019	0.0008	0.0156
Loa Loa (eye worm)	hypothetical protein	0.014	0.078	0.1353
Plasmodium falciparum	plasmepsin II	0.0019	0.0008	0.0156
Loa Loa (eye worm)	hypothetical protein	0.007	0.0334	0.0579
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0097	0.0505	1
Brugia malayi	Pepsin A precursor	0.0019	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0505	0.0876
Echinococcus multilocularis	prolyl endopeptidase	0.0923	0.5765	0.5764
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0517	0.0893
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0264	0.0262
Mycobacterium tuberculosis	Probable peptidase	0.0367	0.2226	0.4323
Plasmodium falciparum	plasmepsin V	0.0019	0.0008	0.0156
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0264	0.0454
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0367	0.2226	0.4323
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0097	0.0505	0.0872
Brugia malayi	prolyl oligopeptidase family protein	0.0097	0.0505	0.0872
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0038	0.0169
Trypanosoma cruzi	prolyl endopeptidase	0.0923	0.5765	1
Loa Loa (eye worm)	hypothetical protein	0.0261	0.1548	0.2685
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0038	0.0065
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Trypanosoma cruzi	oligopeptidase b	0.0367	0.2226	0.3858
Plasmodium falciparum	plasmepsin VIII, putative	0.0019	0.0008	0.0156
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0367	0.2226	0.3858
Schistosoma mansoni	cathepsin D (A01 family)	0.0019	0.0008	0.001
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0097	0.0505	0.0872
Toxoplasma gondii	aspartyl protease	0.0019	0.0008	0.001
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0019	0.0008	0.001
Plasmodium vivax	aspartyl protease, putative	0.0019	0.0008	0.0156
Plasmodium vivax	aspartyl proteinase, putative	0.0019	0.0008	0.0156
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0264	0.0454
Plasmodium vivax	aspartyl protease, putative	0.0019	0.0008	0.0156
Schistosoma mansoni	cathepsin D (A01 family)	0.0019	0.0008	0.001
Brugia malayi	aspartic protease BmAsp-2, identical	0.0019	0.0008	0.001
Schistosoma mansoni	hypothetical protein	0.004	0.0145	0.0247
Entamoeba histolytica	hypothetical protein	0.0025	0.0045	0.0841
Echinococcus granulosus	expressed conserved protein	0.0091	0.047	0.0811
Brugia malayi	CHE-14 protein	0.0042	0.0154	0.0264
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0045	0.0074
Schistosoma mansoni	memapsin-2 (A01 family)	0.0466	0.2858	0.4955
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0019	0.0008	0.0111
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0264	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0507	0.088
Plasmodium falciparum	plasmepsin IX	0.0019	0.0008	0.0156
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0019	0.0008	0.0014
Plasmodium vivax	plasmepsin IV, putative	0.0019	0.0008	0.0156
Echinococcus multilocularis	protein patched	0.0042	0.0154	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0023	0.004
Schistosoma mansoni	hypothetical protein	0.004	0.0145	0.0247
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0923	0.5765	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0038	0.0169
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0172	0.0298
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0045	0.0042
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0154	0.0264
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0038	0.0169
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0097	0.0505	0.995
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0038	0.07
Brugia malayi	hypothetical protein	0.0019	0.0008	0.001
Brugia malayi	Amyloid A4 extracellular domain containing protein	0.0331	0.1994	0.3456
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0097	0.0505	0.0872
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0038	0.0061
Echinococcus multilocularis	expressed conserved protein	0.0091	0.047	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.0505	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0154	0.0268
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0038	0.0061
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Brugia malayi	prolyl oligopeptidase family protein	0.0097	0.0505	0.0872
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0097	0.0505	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0008	0.0014
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0002	0.0004
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0038	0.0061
Schistosoma mansoni	patched 1	0.0042	0.0154	0.0264
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.0773	0.0771
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0192	0.0189
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0045	0.0074
Trypanosoma brucei	oligopeptidase b	0.0367	0.2226	0.3858
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0264	0.0513
Leishmania major	oligopeptidase b	0.0367	0.2226	0.3858
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0264	0.1187
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0264	0.0454
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0826	0.5149	1
Toxoplasma gondii	aspartyl protease ASP1	0.0019	0.0008	0.001
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0507	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0008	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0505	0.0876
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0097	0.0505	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0038	0.0061
Trypanosoma cruzi	hypothetical protein, conserved	0.0097	0.0505	0.0872
Brugia malayi	aspartic protease BmAsp-1, identical	0.0019	0.0008	0.001
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0154	0.0268
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0097	0.0505	0.0872
Trypanosoma cruzi	oligopeptidase b	0.0367	0.2226	0.3858
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0038	0.0169
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0002	0.0004
Brugia malayi	Angiotensin-converting enzyme family protein	0.0161	0.0917	0.1587
Plasmodium falciparum	plasmepsin I	0.0019	0.0008	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0008	0.0014
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0154	0.0264
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0264	0.1187
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0097	0.0505	0.0872
Toxoplasma gondii	aspartyl protease ASP3	0.0019	0.0008	0.001
Plasmodium falciparum	plasmepsin X	0.0019	0.0008	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0038	0.0065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0045	0.0845
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0097	0.0505	0.0503
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0097	0.0505	0.0872
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0172	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0038	0.0065
Entamoeba histolytica	prolyl oligopeptidase family protein	0.0097	0.0505	0.995
Brugia malayi	prolyl oligopeptidase family protein	0.0097	0.0505	0.0872
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0038	0.07
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0264	0.0454
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0019	0.0008	0.001
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0038	0.0061
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0097	0.0505	0.0872
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0172	0.0294
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0172	0.0294
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0923	0.5765	1
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0367	0.2226	0.3858
Loa Loa (eye worm)	aspartyl protease 6	0.0019	0.0008	0.0014
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0172	0.0169
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0097	0.0505	0.0872
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0019	0.0008	0.001
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0038	0.0061
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0038	0.0169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0172	0.0294
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0038	0.07
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.0773	0.1337
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0097	0.0505	0.0503
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0	0.5
Brugia malayi	prolyl oligopeptidase family protein	0.0097	0.0505	0.0872
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0507	0.0877
Plasmodium vivax	plasmepsin V, putative	0.0019	0.0008	0.0156
Echinococcus granulosus	acylamino acid releasing enzyme	0.0097	0.0505	0.0872

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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PubChem: 121544

Bibliographic References

No literature references available for this target.

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Detailed information for compound 551616