Detailed information for compound 553671

Basic information

Technical information
  • TDR Targets ID: 553671
  • Name: (5-fluoro-3-pyridyl)methanol
  • MW: 127.116 | Formula: C6H6FNO
  • H donors: 1 H acceptors: 2 LogP: 0.07 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cc(F)cnc1
  • InChi: 1S/C6H6FNO/c7-6-1-5(4-9)2-8-3-6/h1-3,9H,4H2
  • InChiKey: GGGJYJXAFSEWNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5-fluoropyridin-3-yl)methanol
  • 5-fluoronicotinyl alcohol
  • 22620-32-2
  • 3-Pyridinemethanol, 5-fluoro-
  • 5-Fluoro-3-hydroxymethylpyridine
  • 5-Fluoro-3-pyridinemethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0424 0.089
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.3409 0.3358
Trichomonas vaginalis esterase, putative 0.0037 0.0469 0.1028
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0424 0.089
Loa Loa (eye worm) hypothetical protein 0.0098 0.1929 0.1867
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0053 0.0834 0.2458
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0449 0.0855
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0053 0.0834 0.2147
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0493 0.0982
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0493 0.1034
Schistosoma mansoni transient receptor potential channel 0.0098 0.1929 0.5201
Onchocerca volvulus 0.0037 0.0469 0.0174
Onchocerca volvulus 0.0037 0.0469 0.0174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0469 0.0316
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0469 0.1028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0469 0.0149
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0159 0.3394 1
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0053 0.0834 0.1985
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0053 0.0834 0.1247
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0029 0.0273 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0066 0.115 0.2913
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0301 0.0145
Schistosoma mansoni alpha glucosidase 0.0035 0.0424 0.0782
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0493 0.11
Loa Loa (eye worm) inositol-1 0.0038 0.0493 0.042
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0469 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0747 0.0676
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.0396
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.3409 0.9549
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0053 0.0834 0.2147
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.115 0.1008
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0469 0.0149
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0424 0.089
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0301 0.0226
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0424 0.0271
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0424 0.1251
Brugia malayi intermediate filament protein 0.003 0.0301 0.0145
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0469 0.0914
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0493 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0424 0.0782
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.3409 0.3303
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0053 0.0834 0.2458
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0053 0.0834 0.2458
Schistosoma mansoni lamin 0.003 0.0301 0.0418
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0053 0.0834 0.1985
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0424 0.089
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.1131 0.2858
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0226
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0493 0.1452
Loa Loa (eye worm) hypothetical protein 0.012 0.2457 0.2399
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0053 0.0834 0.2458
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.0396
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0159 0.3394 1
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0159 0.3394 1
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0053 0.0834 0.2458
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0159 0.3394 0.3343
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.0396
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0493 0.11
Brugia malayi TAR-binding protein 0.0066 0.115 0.1008
Schistosoma mansoni alpha-glucosidase 0.0138 0.2875 0.798
Schistosoma mansoni intermediate filament proteins 0.003 0.0301 0.0418
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0424 0.0782
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0493 0.0982
Schistosoma mansoni hypothetical protein 0.0033 0.0376 0.0639
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0469 0.0962
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.115 0.1082
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0053 0.0834 0.1985
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0424 0.089
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0469 0.1028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.0396
Loa Loa (eye worm) hypothetical protein 0.0053 0.0834 0.0764
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0469 0.0149
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0493 0.1452
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0424 0.089
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0053 0.0834 0.2147
Entamoeba histolytica hypothetical protein 0.0024 0.0158 0.0073
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0053 0.0834 0.0687
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.1929 0.5201
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0424 0.0351
Leishmania major hypothetical protein, conserved 0.0037 0.0469 0.1383
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0449 0.0855
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0469 0.1028
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0053 0.0834 0.2089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0747 0.0598
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0053 0.0834 0.1985
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.1929 0.5201
Loa Loa (eye worm) hypothetical protein 0.0033 0.0376 0.0302
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0053 0.0834 0.1985
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0469 0.1383
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0493 1
Brugia malayi beta-lactamase 0.0037 0.0469 0.0316
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0158 0.0073
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0023 0.0134 0.0396
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0053 0.0834 0.1985
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0469 0.0149
Brugia malayi hypothetical protein 0.012 0.2457 0.2336
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0213
Echinococcus granulosus lamin dm0 0.003 0.0301 0.0418
Brugia malayi RNA binding protein 0.0066 0.115 0.1008
Echinococcus multilocularis tar DNA binding protein 0.0066 0.115 0.2913
Trichomonas vaginalis DNA polymerase II, putative 0.0053 0.0834 0.2147
Schistosoma mansoni hypothetical protein 0.0166 0.3562 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0273 0.0198
Brugia malayi DNA polymerase family B containing protein 0.0053 0.0834 0.0687
Echinococcus granulosus intermediate filament protein 0.003 0.0301 0.0418
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0053 0.0834 0.2089
Brugia malayi DNA polymerase delta catalytic subunit 0.0159 0.3394 0.3287
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0469 0.0149
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0076 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0066 0.115 0.2913
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0424 0.089
Echinococcus multilocularis Protein lozenge 0.0055 0.0881 0.2124
Brugia malayi beta-lactamase family protein 0.0037 0.0469 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0066 0.115 0.2913
Loa Loa (eye worm) hypothetical protein 0.0029 0.0273 0.0198
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.1131 0.2858
Loa Loa (eye worm) hypothetical protein 0.0062 0.1053 0.0984
Echinococcus multilocularis geminin 0.0166 0.3562 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0469 0.0914
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0469 0.1383
Loa Loa (eye worm) beta-lactamase 0.0037 0.0469 0.0396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0424 0.089
Mycobacterium leprae Probable lipase LipE 0.0037 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.0435 1 1
Onchocerca volvulus 0.0037 0.0469 0.0174
Schistosoma mansoni transient receptor potential channel 0.0065 0.1131 0.2858
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.185 0.497
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0158 0.0073
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0159 0.3394 0.3189
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0159 0.3394 1
Loa Loa (eye worm) runx1 0.0055 0.0881 0.0811
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0023 0.0134 0.0058
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.1929 0.5201
Schistosoma mansoni lozenge 0.0055 0.0881 0.2124
Brugia malayi beta-lactamase family protein 0.0037 0.0469 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0058
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0159 0.3394 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.115 0.1082
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0424 0.1251
Schistosoma mansoni tar DNA-binding protein 0.0066 0.115 0.2913
Toxoplasma gondii DNA polymerase 0.0159 0.3394 1
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0053 0.0834 0.055
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.185 0.497
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0424 0.089
Echinococcus granulosus lamin 0.003 0.0301 0.0418
Onchocerca volvulus DNA polymerase homolog 0.0053 0.0834 0.055
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0053 0.0834 0.1985
Schistosoma mansoni inositol monophosphatase 0.0038 0.0493 0.0982
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0053 0.0834 0.055
Schistosoma mansoni alpha-glucosidase 0.0138 0.2875 0.798
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0424 0.089
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0493 0.11
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0493 0.1452
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0747 0.0598
Loa Loa (eye worm) hypothetical protein 0.012 0.2457 0.2399
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0449 0.0296
Schistosoma mansoni inositol monophosphatase 0.0038 0.0493 0.0982
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0053 0.0834 0.2147
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0053 0.0834 0.2147
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0469 0.0149
Echinococcus multilocularis lamin dm0 0.003 0.0301 0.0418
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.3409 0.9549
Loa Loa (eye worm) hypothetical protein 0.0049 0.0747 0.0676
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0493 0.11
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0469 0.0149
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0023 0.0134 0.0396
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0469 0.1028
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0159 0.3394 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.1131 0.2858
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0469 0.0914
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0029 0.0273 0.0426
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.5298 1
Onchocerca volvulus 0.0435 1 1
Echinococcus granulosus geminin 0.0166 0.3562 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0469 0.0149
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0493 0.11
Loa Loa (eye worm) intermediate filament protein 0.003 0.0301 0.0226
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0053 0.0834 0.1247
Trypanosoma brucei glucosidase, putative 0.0035 0.0424 0.0823
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.013 0.2694 0.7938
Schistosoma mansoni transient receptor potential channel 0.0065 0.1131 0.2858
Loa Loa (eye worm) hypothetical protein 0.0037 0.0449 0.0376
Onchocerca volvulus 0.0092 0.1792 0.1537
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0159 0.3394 0.9504
Onchocerca volvulus Huntingtin homolog 0.012 0.2457 0.2224
Brugia malayi DNA polymerase alpha catalytic subunit 0.0053 0.0834 0.0687
Loa Loa (eye worm) hypothetical protein 0.0435 1 1
Plasmodium vivax DNA polymerase alpha, putative 0.0053 0.0834 0.1247
Loa Loa (eye worm) RNA binding protein 0.0066 0.115 0.1082
Onchocerca volvulus Huntingtin homolog 0.012 0.2457 0.2224
Schistosoma mansoni hypothetical protein 0.0166 0.3562 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.1131 0.2858
Toxoplasma gondii DNA polymerase family B protein 0.0053 0.0834 0.2147
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0424 0.089
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0159 0.3394 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.3409 0.9549
Echinococcus multilocularis lamin 0.003 0.0301 0.0418
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0469 0.0396
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0159 0.3394 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0469 0.1028
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0159 0.3394 0.9504
Mycobacterium tuberculosis Conserved protein 0.0037 0.0469 0.0149
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0053 0.0834 0.2089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0469 0.0396
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0053 0.0834 0.1985
Echinococcus granulosus tar DNA binding protein 0.0066 0.115 0.2913
Echinococcus multilocularis musashi 0.003 0.0301 0.0418
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0029 0.0273 0.0426
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0424 0.089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0469 0.0914
Brugia malayi Inositol-1 0.0038 0.0493 0.034
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0424 0.1251
Loa Loa (eye worm) hypothetical protein 0.0033 0.0371 0.0297
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0159 0.3394 0.9504
Mycobacterium tuberculosis Conserved protein 0.0037 0.0469 0.0149
Toxoplasma gondii ABC1 family protein 0.0037 0.0469 0.1028
Schistosoma mansoni tar DNA-binding protein 0.0066 0.115 0.2913
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0158 0.0466
Schistosoma mansoni lamin 0.003 0.0301 0.0418
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0376 0.0221
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0053 0.0834 0.1985

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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