Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.0976 | 0.389 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0034 | 0.047 | 0.0384 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0169 | 0.0172 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0991 | 0.091 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.146 | 0.1383 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0.047 | 0.4219 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0034 | 0.047 | 0.0384 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0175 | 0.0738 |
Brugia malayi | RNA binding protein | 0.0074 | 0.146 | 0.2992 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2217 | 0.2083 |
Plasmodium vivax | amine transporter, putative | 0.0034 | 0.047 | 0.0485 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0034 | 0.047 | 0.0384 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.009 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0022 | 0.0175 | 0.0086 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.2759 | 0.3401 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0202 | 0.467 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0034 | 0.047 | 0.0384 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.011 | 0.2368 | 0.2299 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.0307 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.0175 | 0.0086 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.011 | 0.2368 | 0.2299 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0724 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.467 | 0.4578 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0332 | 0.7939 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0724 | 0.064 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.011 | 0.2368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2217 | 0.2083 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.146 | 0.2992 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.0991 | 0.4187 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.2759 | 0.3401 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0034 | 0.047 | 0.0384 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0034 | 0.047 | 0.0384 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0019 | 0.009 | 0.0379 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.146 | 0.1383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.011 | 0.2368 | 0.2299 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Brugia malayi | glutathione reductase | 0.0055 | 0.0991 | 0.1969 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0373 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0724 | 0.064 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0175 | 0.0738 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0332 | 0.7939 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.4219 |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0.0175 | 0.0373 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.4219 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0019 | 0.009 | 0.0379 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.0991 | 0.1969 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.011 | 0.2368 | 0.2237 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0373 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.0991 | 0.0837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.014 | 0.3111 | 0.3848 |
Echinococcus multilocularis | dna polymerase eta | 0.0022 | 0.0175 | 0.0086 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0034 | 0.047 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0034 | 0.047 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Leishmania major | trypanothione reductase | 0.0055 | 0.0991 | 0.3958 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0175 | 0.0108 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0724 | 0.064 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.011 | 0.2368 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.0175 | 0.0006 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.0175 | 0.0086 |
Loa Loa (eye worm) | serotonin transporter b | 0.0202 | 0.467 | 0.4578 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.0831 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.014 | 0.3111 | 0.3848 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0724 | 0.0565 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0202 | 0.467 | 0.4621 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.047 | 0.0485 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0724 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.2759 | 0.3401 |
Onchocerca volvulus | 0.0093 | 0.1945 | 0.3513 | |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.009 | 0.0379 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.0991 | 0.1149 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.0175 | 0.0373 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0202 | 0.467 | 0.4578 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0724 | 0.064 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.0991 | 0.3958 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.0175 | 0.0086 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Plasmodium falciparum | amino acid transporter, putative | 0.0034 | 0.047 | 0.0485 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0175 | 0.0186 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.0175 | 0.0373 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0175 | 0.0086 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.0175 | 0.0373 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.2217 | 0.2146 |
Schistosoma mansoni | kinase | 0.0056 | 0.1013 | 0.0931 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0175 | 0.0186 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.146 | 0.1383 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0035 | 0.0479 | 0.0393 |
Echinococcus multilocularis | serotonin receptor | 0.0414 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.011 | 0.2368 | 0.452 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.011 | 0.2368 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.0991 | 0.1149 |
Onchocerca volvulus | 0.0202 | 0.467 | 1 | |
Trypanosoma brucei | polo-like protein kinase | 0.011 | 0.2368 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.0991 | 0.1149 |
Echinococcus multilocularis | serotonin receptor | 0.0414 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0175 | 0.0738 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.2217 | 0.2146 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.0991 | 0.1149 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.2759 | 0.3401 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0175 | 0.0006 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0034 | 0.047 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.0175 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 1 | 1 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0332 | 0.7939 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0414 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0175 | 0.0108 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.146 | 0.1383 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Echinococcus granulosus | serotonin transporter | 0.0202 | 0.467 | 0.4621 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0034 | 0.047 | 0.0831 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.0831 |
Treponema pallidum | hypothetical protein | 0.0332 | 0.7939 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0724 | 0.064 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.009 | 0.0379 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0175 | 0.0108 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0.0175 | 0.0738 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.011 | 0.2368 | 0.4975 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.014 | 0.3111 | 0.0678 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0373 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.0175 | 0.0738 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0034 | 0.047 | 0.0384 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0373 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.0831 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.0991 | 0.1149 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0202 | 0.467 | 0.4578 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0054 | 0.0976 | 0.389 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0175 | 0.0086 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.467 | 0.4578 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.3111 | 0.3848 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0332 | 0.7939 | 1 |
Giardia lamblia | Kinase, PLK | 0.011 | 0.2368 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0202 | 0.467 | 0.4621 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.146 | 0.2992 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0202 | 0.467 | 0.4621 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.011 | 0.2368 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0175 | 0.0108 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.146 | 0.1314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.146 | 0.1383 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.467 | 0.4578 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0202 | 0.467 | 0.5835 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0034 | 0.047 | 0.0384 |
Brugia malayi | Trypsin family protein | 0.0104 | 0.2217 | 0.4644 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.0175 | 0.0086 |
Plasmodium falciparum | transporter, putative | 0.0034 | 0.047 | 0.0485 |
Echinococcus granulosus | dna polymerase eta | 0.0022 | 0.0175 | 0.0086 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.4219 |
Brugia malayi | hypothetical protein | 0.0034 | 0.047 | 0.0831 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0332 | 0.7939 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.146 | 0.1383 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.146 | 0.1383 |
Onchocerca volvulus | 0.0104 | 0.2217 | 0.4159 | |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0034 | 0.047 | 0.0384 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.146 | 0.1314 |
Toxoplasma gondii | hypothetical protein | 0.0034 | 0.047 | 0.4219 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.0991 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.146 | 0.1314 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0738 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0034 | 0.047 | 0.0384 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.2759 | 0.3401 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0034 | 0.047 | 0.0384 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0034 | 0.047 | 0.0384 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.0175 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.047 | 0.0307 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.2759 | 0.3401 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0991 | 0.091 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0034 | 0.047 | 0.0307 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0724 | 0.064 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0175 | 0.0373 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.009 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.0991 | 0.0837 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.2368 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.