Detailed information for compound 559547

Basic information

Technical information
  • TDR Targets ID: 559547
  • Name: 1,1,2,2,3,3,3-heptafluoro-N,N-bis(1,1,2,2,3,3 ,3-heptafluoropropyl)propan-1-amine
  • MW: 521.069 | Formula: C9F21N
  • H donors: 0 H acceptors: 0 LogP: 7.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: FC(C(C(F)(F)F)(F)F)(N(C(C(C(F)(F)F)(F)F)(F)F)C(C(C(F)(F)F)(F)F)(F)F)F
  • InChi: 1S/C9F21N/c10-1(11,4(16,17)18)7(25,26)31(8(27,28)2(12,13)5(19,20)21)9(29,30)3(14,15)6(22,23)24
  • InChiKey: JAJLKEVKNDUJBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,1,2,2,3,3,3-heptafluoro-N,N-bis(1,1,2,2,3,3,3-heptafluoropropyl)-1-propanamine
  • tris(1,1,2,2,3,3,3-heptafluoropropyl)amine
  • perfluorotripropylamine
  • 338-83-0
  • CHEBI:38850
  • 1,1,2,2,3,3,3-heptafluoro-N,N-bis(heptafluoropropyl)-1-propanamine
  • 1-Propanamine, 1,1,2,2,3,3,3-heptafluoro-N,N-bis(heptafluoropropyl)-
  • EINECS 206-420-2
  • HSDB 7102
  • Heneicosafluorotripropylamine
  • Heptafluoro-N,N-bis(heptafluoropropyl)-1-propanamine
  • Perfluamina [Spanish]
  • Perfluamine
  • Perfluamine [BAN:INN]
  • Perfluaminum [Latin]
  • F-tripropylamine
  • FTPA
  • 1,1,2,2,3,3,3-heptafluoro-N,N-bis(heptafluoropropyl)propan-1-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0068 0.0738
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0027 0.0051
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0035 0.007
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0035 0.0081
Plasmodium vivax sulfate transporter, putative 0.0032 0.0197 0.2279
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0189
Mycobacterium tuberculosis Probable adenine glycosylase MutY 0.0014 0.0048 0.0053
Echinococcus multilocularis endonuclease III protein 1 0.0014 0.0048 0.0113
Echinococcus multilocularis Chromo domain 0.0011 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0201 0.1597 0.6414
Schistosoma mansoni hypothetical protein 0.0011 0.0021 0.0036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0082
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0074 0.0053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0094 0.0111
Brugia malayi SET domain containing protein 0.0012 0.0027 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0371 0.4348
Schistosoma mansoni cpg binding protein 0.003 0.0176 0.041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0082
Echinococcus multilocularis geminin 0.0509 0.416 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0388 0.1555
Schistosoma mansoni hypothetical protein 0.0081 0.0601 0.1433
Mycobacterium leprae Probable transmembrane transport protein 0.0234 0.1877 0.3165
Entamoeba histolytica endonuclease III, putative 0.0014 0.0048 0.0065
Brugia malayi hypothetical protein 0.0012 0.003 0.012
Plasmodium vivax DNA repair endonuclease, putative 0.0076 0.0561 0.6602
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0847 0.2035
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0246 0.0226
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.2312 0.5557
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.016
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1935 0.465
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0502 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0847 0.3402
Leishmania major carbonic anhydrase-like protein 0.0149 0.1165 0.283
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0021 0.0049
Onchocerca volvulus Protein patched homolog 0.0012 0.003 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.1211 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Brugia malayi Patched protein homolog 1 0.0012 0.003 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0847 0.726
Leishmania major endonuclease III, putative 0.0014 0.0048 0.0104
Onchocerca volvulus 0.0111 0.0847 0.3347
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0847 0.3405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0847 0.2026
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.0116
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0068 0.015
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0134 0.1524
Echinococcus multilocularis DNA excision repair protein ERCC 1 0.0107 0.0819 0.1966
Trichomonas vaginalis nuclease Rad1 0.0076 0.0561 0.0541
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0601 0.1443
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0094 0.0073
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0847 0.1058
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0021 0.0189
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0416 0.1003
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0479 0.3913 0.491
Brugia malayi hypothetical protein 0.0012 0.0025 0.0102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.005 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Plasmodium vivax ERCC1 nucleotide excision repair protein, putative 0.0107 0.0819 0.9662
Schistosoma mansoni DNA repair endonuclease xp-f / mei-9 / rad1 0.0076 0.0561 0.1338
Schistosoma mansoni excision repair cross-complementing 1 ercc1 0.0107 0.0819 0.1957
Brugia malayi CXXC zinc finger family protein 0.0028 0.0162 0.0652
Schistosoma mansoni hypothetical protein 0.0509 0.416 1
Schistosoma mansoni cpg binding protein 0.0028 0.0162 0.0378
Onchocerca volvulus 0.0011 0.0021 0.000000057912
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0021 0.0086
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.0116
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0847 0.2035
Onchocerca volvulus 0.0012 0.003 0.0034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.0152
Brugia malayi Patched family protein 0.0012 0.003 0.012
Echinococcus multilocularis protein patched 0.0086 0.0644 0.1547
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0388 0.092
Loa Loa (eye worm) carbonic anhydrase 3 0.0149 0.1165 0.4679
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0697 0.1675
Trichomonas vaginalis esterase, putative 0.0111 0.0847 0.0828
Onchocerca volvulus 0.0012 0.003 0.0034
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0149 0.1165 0.2791
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0601 0.1443
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0388 0.093
Trypanosoma cruzi 8-oxoguanine DNA glycosylase, putative 0.0014 0.0048 0.0367
Brugia malayi beta-lactamase family protein 0.0111 0.0847 0.3405
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus granulosus geminin 0.0509 0.416 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0055 0.0388 0.1555
Loa Loa (eye worm) hypothetical protein 0.0038 0.0246 0.0987
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0134 0.1577
Echinococcus granulosus carbonic anhydrase 0.0055 0.0388 0.093
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0644 0.2587
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1935 0.465
Schistosoma mansoni hypothetical protein 0.0175 0.1381 0.3311
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0094 0.0178
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0388 0.1558
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Brugia malayi Patched family protein 0.0012 0.003 0.012
Mycobacterium ulcerans hypothetical protein 0.0111 0.0847 0.0803
Loa Loa (eye worm) hypothetical protein 0.003 0.0178 0.0711
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0094 0.109
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0154 0.0133
Trypanosoma cruzi 8-oxoguanine DNA glycosylase, putative 0.0014 0.0048 0.0367
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.2053 0.8251
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0021 0.0189
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0021 0.0047
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0697 0.274
Entamoeba histolytica A/G-specific adenine glycosylase, putative 0.0014 0.0048 0.0065
Trypanosoma cruzi endonuclease III, putative 0.0014 0.0048 0.0367
Brugia malayi beta-lactamase 0.0111 0.0847 0.3405
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0149 0.1165 0.2791
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0046 0.0025
Onchocerca volvulus 0.0012 0.003 0.0034
Brugia malayi Patched family protein 0.0012 0.003 0.012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0601 0.1443
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0094 0.0378
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0309 0.0288
Brugia malayi Helix-hairpin-helix motif family protein 0.0061 0.0434 0.1743
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0847 0.1058
Loa Loa (eye worm) hypothetical protein 0.0256 0.2053 0.8251
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0847 0.3402
Schistosoma mansoni ap endonuclease 0.002 0.0094 0.0213
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0068 0.016
Brugia malayi chromobox protein homolog 3 0.0038 0.0246 0.0991
Loa Loa (eye worm) ERCC4 domain-containing protein 0.0009 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0241 0.1935 0.7775
Entamoeba histolytica carbonic anhydrase, putative 0.0502 0.4102 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0021 0.0196
Toxoplasma gondii patched family protein 0.0012 0.003 0.0288
Onchocerca volvulus 0.0308 0.2489 1
Onchocerca volvulus 0.0111 0.0847 0.3347
Schistosoma mansoni hypothetical protein 0.0011 0.0021 0.0038
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0388 0.093
Brugia malayi ERCC4 domain containing protein 0.0009 0.0005 0.0022
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0496 0.1989
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0697 0.1675
Echinococcus multilocularis chromobox protein 1 0.0068 0.0496 0.119
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.2312 0.5557
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0094 0.0764
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0847 0.2026
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.1597 0.6415
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Brugia malayi Patched family protein 0.0012 0.003 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0697 0.1689
Trypanosoma brucei endonuclease III, putative 0.0014 0.0048 0.0367
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0338 0.1358
Schistosoma mansoni hypothetical protein 0.0509 0.416 1
Brugia malayi Patched family protein 0.0012 0.003 0.012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0094 0.0375
Echinococcus granulosus carbonic anhydrase II 0.0149 0.1165 0.2799
Echinococcus granulosus dnaJ subfamily B 0.04 0.3258 0.7831
Leishmania major carbonic anhydrase family protein, putative 0.0502 0.4102 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0094 1
Onchocerca volvulus 0.0111 0.0847 0.3347
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0644 0.0624
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0847 0.0828
Chlamydia trachomatis sulfate transporter 0.0032 0.0197 1
Brugia malayi hypothetical protein 0.0016 0.0061 0.0245
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0847 0.0828
Onchocerca volvulus Protein patched homolog 0.0012 0.003 0.0034
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0271 0.025
Onchocerca volvulus 0.0012 0.003 0.0034
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0496 0.0475
Trypanosoma brucei DNA repair protein, putative 0.0046 0.0314 0.2658
Entamoeba histolytica DNA repair endonuclease, putative 0.0076 0.0561 0.1323
Schistosoma mansoni hypothetical protein 0.0081 0.0601 0.1433
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0416 0.037
Loa Loa (eye worm) hypothetical protein 0.0111 0.0847 0.3402
Brugia malayi Heterochromatin protein 1 0.0068 0.0496 0.1992
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.1597 0.3836
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0082
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0271 0.025
Plasmodium falciparum endonuclease III homologue, putative 0.0014 0.0048 0.0523
Trypanosoma cruzi DNA repair protein, putative 0.0046 0.0314 0.2658
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0246 0.0226
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.0116
Toxoplasma gondii helix-hairpin-helix motif domain-containing protein 0.0014 0.0048 0.0506
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0197 0.2359
Brugia malayi Patched family protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus granulosus carbonic anhydrase 0.0055 0.0388 0.093
Echinococcus multilocularis crossover junction endonuclease mus81 0.0009 0.0005 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0847 0.726
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.2053 0.8251
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0094 0.0764
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0644 0.1547
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0197 0.1655
Plasmodium falciparum carbonic anhydrase 0.0055 0.0388 0.4699
Plasmodium vivax endonuclease III homologue, putative 0.0014 0.0048 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0154 0.0133
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0068 0.016
Brugia malayi hypothetical protein 0.0308 0.2489 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Brugia malayi protein C24B5.3 0.0012 0.003 0.012
Trypanosoma brucei 8-oxoguanine DNA glycosylase, putative 0.0014 0.0048 0.0367
Schistosoma mansoni hypothetical protein 0.0055 0.0388 0.092
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0021 0.0086
Brugia malayi Patched family protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0111 0.0847 0.3402
Loa Loa (eye worm) helix-hairpin-helix domain-containing protein family protein 0.0107 0.0819 0.3288
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0021 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0082
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0068 0.0536
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0388 0.1558
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0388 0.1558
Schistosoma mansoni hypothetical protein 0.04 0.3258 0.7828
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.016
Brugia malayi hypothetical protein 0.0241 0.1935 0.7776
Onchocerca volvulus Endonuclease III homolog 0.0014 0.0048 0.0108
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0094 0.0046
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0257 0.2066 0.2589
Brugia malayi Patched family protein 0.0012 0.003 0.012
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0847 0.0828
Mycobacterium tuberculosis Conserved protein 0.0111 0.0847 0.1058
Brugia malayi Patched family protein 0.0012 0.003 0.012
Echinococcus granulosus carbonic anhydrase 0.0055 0.0388 0.093
Mycobacterium ulcerans carbonic anhydrase 0.0502 0.4102 0.4073
Brugia malayi hypothetical protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0105 0.0805 0.3234
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0416 0.0999
Brugia malayi Patched family protein 0.0012 0.003 0.012
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0388 0.1558
Echinococcus granulosus dna repair endonuclease xpf 0.0076 0.0561 0.1347
Onchocerca volvulus 0.0012 0.003 0.0034
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0021 0.0196
Schistosoma mansoni hypothetical protein 0.0083 0.0619 0.1476
Brugia malayi protein C24B5.3 0.0012 0.003 0.012
Echinococcus granulosus DNA excision repair protein ERCC 1 0.0107 0.0819 0.1966
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0021 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0074 0.0053
Toxoplasma gondii DNA repair protein rad10 subfamily protein 0.0107 0.0819 0.9662
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0847 0.1058
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0697 0.5968
Echinococcus granulosus Chromobox protein 3 0.0011 0.0021 0.0049
Schistosoma mansoni kinase 0.0047 0.0319 0.0755
Trichomonas vaginalis excision repair cross-complementing 1 ercc1, putative 0.0107 0.0819 0.0799
Toxoplasma gondii endonuclease III family 1 protein 0.0014 0.0048 0.0506
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0074 0.0053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0416 0.0516
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0388 0.092
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0068 0.0738
Mycobacterium ulcerans beta-lactamase 0.0111 0.0847 0.0803
Toxoplasma gondii ERCC4 domain-containing protein 0.0076 0.0561 0.6602
Echinococcus multilocularis chromobox protein 2 0.0011 0.0021 0.0049
Entamoeba histolytica endonuclease III, putative 0.0014 0.0048 0.0065
Brugia malayi hypothetical protein 0.0025 0.0134 0.0538
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.1381 0.555
Loa Loa (eye worm) hypothetical protein 0.0111 0.0847 0.3402
Leishmania major hypothetical protein, conserved 0.0025 0.0134 0.0313
Loa Loa (eye worm) hypothetical protein 0.0025 0.0134 0.0534
Schistosoma mansoni chromobox protein 0.0011 0.0021 0.0038
Onchocerca volvulus Putative sulfate transporter 0.0203 0.1616 0.6462
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0094 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0068 0.0764
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0021 0.0189
Echinococcus multilocularis dna repair endonuclease xpf 0.0076 0.0561 0.1347
Schistosoma mansoni patched 1 0.0086 0.0644 0.1538
Schistosoma mansoni chromobox protein 0.0011 0.0021 0.0038
Schistosoma mansoni chromobox protein 0.0068 0.0496 0.118
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0388 0.092
Brugia malayi Protein cec-1. 0.0011 0.0021 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0055 0.0388 0.1555
Brugia malayi beta-lactamase family protein 0.0111 0.0847 0.3405
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0309 0.0288
Brugia malayi Patched related family protein 4 0.0012 0.003 0.012
Echinococcus multilocularis expressed conserved protein 0.0188 0.1495 0.3593
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.1597 0.386
Plasmodium vivax patched family protein, putative 0.0012 0.003 0.0288
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0496 0.0475
Loa Loa (eye worm) hypothetical protein 0.0086 0.0644 0.2587
Loa Loa (eye worm) ERCC4 domain-containing protein 0.0076 0.0561 0.2252
Brugia malayi isocitrate dehydrogenase 0.0017 0.0068 0.0272
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0601 0.2415
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0416 0.037
Brugia malayi hypothetical protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus granulosus chromobox protein 1 0.0068 0.0496 0.119
Toxoplasma gondii hypothetical protein 0.0012 0.003 0.0288
Mycobacterium ulcerans lipase LipD 0.0111 0.0847 0.0803
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0111 0.0847 0.3402
Schistosoma mansoni hypothetical protein 0.0083 0.0619 0.1476
Trypanosoma cruzi DNA repair protein, putative 0.0046 0.0314 0.2658
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0021 0.0196
Brugia malayi Patched family protein 0.0012 0.003 0.012
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0021 0.0086
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0134 0.1106
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0035 0.0136
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0706 0.5798 0.7278
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Onchocerca volvulus 0.0012 0.003 0.0034
Brugia malayi ERCC4 domain containing protein 0.0076 0.0561 0.2255
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0967 0.7964 1
Entamoeba histolytica DNA excision repair protein, putative 0.0107 0.0819 0.1954
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0271 0.101
Trypanosoma brucei carbonic anhydrase-like protein 0.0149 0.1165 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0847 0.1058
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0094 0.0224
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0847 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.1211 1 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0068 0.0272
Onchocerca volvulus 0.0203 0.1616 0.6462
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0162 0.0649
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0021 0.0038
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0021 0.0038
Plasmodium falciparum DNA repair endonuclease, putative 0.0067 0.0484 0.5888
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0074 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Toxoplasma gondii patched family protein 0.0012 0.003 0.0288
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0094 0.0224
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0388 0.093
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0149 0.1165 1
Mycobacterium ulcerans integral membrane transporter 0.0032 0.0197 0.015
Schistosoma mansoni endonuclease III 0.0014 0.0048 0.0102
Loa Loa (eye worm) hypothetical protein 0.0081 0.0601 0.2412
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0847 0.1058
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0021 0.0049
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0847 0.726
Brugia malayi Patched family protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus granulosus chromobox protein 2 0.0011 0.0021 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0134 0.1106
Echinococcus granulosus Chromo domain 0.0011 0.0021 0.0049
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0068 0.0536
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0416 0.0999
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0094 0.0216
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0094 0.0073
Schistosoma mansoni carbonic anhydrase 0.0502 0.4102 0.986
Plasmodium falciparum ERCC1 nucleotide excision repair protein, putative 0.0107 0.0819 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0068 0.0738
Trypanosoma brucei polo-like protein kinase 0.0092 0.0697 0.5968
Brugia malayi CHD4 protein 0.0013 0.0035 0.014
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0601 0.2412
Schistosoma mansoni hypothetical protein 0.0081 0.0601 0.1433
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0697 0.28
Echinococcus granulosus GPCR family 2 0.0081 0.0601 0.1443
Schistosoma mansoni hypothetical protein 0.0049 0.0338 0.08
Schistosoma mansoni cpg binding protein 0.003 0.0176 0.041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0074 0.0053
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0068 0.0078
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0197 0.2279
Brugia malayi hypothetical protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.1597 0.3836
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0416 0.488
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0197 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0134 0.1577
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0021 0.0038
Loa Loa (eye worm) beta-lactamase 0.0111 0.0847 0.3402
Brugia malayi Patched related family protein 10 0.0012 0.003 0.012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0601 0.1443
Schistosoma mansoni chromobox protein 0.0068 0.0496 0.118
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0094 0.0764
Echinococcus granulosus crossover junction endonuclease mus81 0.0009 0.0005 0.0011
Onchocerca volvulus 0.0028 0.0162 0.0571
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0094 0.1281
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0697 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Schistosoma mansoni hypothetical protein 0.0083 0.0619 0.1476
Loa Loa (eye worm) patched family protein 0.0012 0.003 0.0116
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0424 0.1008
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0388 0.1558
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0021 0.0189
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0847 0.0803
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0416 0.0989
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0149 0.1165 0.4681
Echinococcus multilocularis protein dispatched 1 0.0098 0.0746 0.179
Echinococcus multilocularis cpg binding protein 0.003 0.0176 0.042
Schistosoma mansoni hypothetical protein 0.0081 0.0601 0.1433
Toxoplasma gondii patched family protein 0.0012 0.003 0.0288
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Onchocerca volvulus 0.0012 0.0027 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0847 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0338 0.08
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.2053 0.8251
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0094 0.1053
Brugia malayi Myosin head containing protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0416 0.0989
Toxoplasma gondii ABC1 family protein 0.0111 0.0847 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0697 0.1657
Loa Loa (eye worm) hypothetical protein 0.0308 0.2489 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0697 0.1666
Onchocerca volvulus 0.0012 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0175 0.1381 0.5548
Echinococcus multilocularis GPCR, family 2 0.0081 0.0601 0.1443
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Echinococcus multilocularis chromobox protein 1 0.0068 0.0496 0.119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0074 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Trypanosoma cruzi endonuclease III, putative 0.0014 0.0048 0.0367
Loa Loa (eye worm) hypothetical protein 0.0055 0.0388 0.1555
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.003 0.0298
Schistosoma mansoni ap endonuclease 0.002 0.0094 0.0213
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0697 0.5968
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0134 0.1106
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0035 0.0081
Echinococcus granulosus endonuclease III protein 1 0.0014 0.0048 0.0113
Toxoplasma gondii patched family protein 0.0012 0.003 0.0288
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0149 0.1165 1
Echinococcus multilocularis carbonic anhydrase II 0.0149 0.1165 0.2799
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0068 0.0268
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0197 0.1655
Onchocerca volvulus 0.0049 0.0338 0.1283
Echinococcus granulosus expressed conserved protein 0.0188 0.1495 0.3593
Loa Loa (eye worm) hypothetical protein 0.0111 0.0847 0.3402
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.1622 0.3892
Onchocerca volvulus 0.003 0.0178 0.0634
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0134 0.1524
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.0536
Echinococcus multilocularis dnaJ subfamily B 0.04 0.3258 0.7831
Trypanosoma cruzi A/G-specific adenine glycosylase, putative 0.0014 0.0048 0.0367
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0847 0.1058
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.0536
Echinococcus granulosus chromobox protein 1 0.0068 0.0496 0.119
Toxoplasma gondii hypothetical protein 0.0055 0.0388 0.454
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0847 0.1058
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0644 0.1547
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0697 0.0678
Brugia malayi Patched related family protein 12 0.0012 0.003 0.012
Mycobacterium tuberculosis Conserved protein 0.0111 0.0847 0.1058
Schistosoma mansoni DNA glycosylase 0.0014 0.0048 0.0102
Brugia malayi Patched family protein 0.0012 0.003 0.012
Leishmania major hypothetical protein, conserved 0.0111 0.0847 0.2055
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0197 0.015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.016
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0197 0.1655
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0847 0.0828
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0644 0.1547
Brugia malayi Patched family protein 0.0012 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Loa Loa (eye worm) helicase 0.0011 0.0021 0.0082
Schistosoma mansoni hypothetical protein 0.0083 0.0619 0.1476
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Echinococcus granulosus cpg binding protein 0.003 0.0176 0.042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0074 0.0053
Toxoplasma gondii exonuclease III APE 0.002 0.0094 0.1053
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0416 0.037
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0847 0.0803
Brugia malayi CHE-14 protein 0.0086 0.0644 0.2589
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0021 0.0189
Schistosoma mansoni carbonic anhydrase 0.0055 0.0388 0.092
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0149 0.1165 0.4679
Brugia malayi Patched family protein 0.0012 0.003 0.012
Giardia lamblia Kinase, PLK 0.0092 0.0697 1
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0234 0.1877 0.2352
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0847 0.1058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0601 0.2415
Brugia malayi Endonuclease III-like protein 1 0.0014 0.0048 0.0193
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0149 0.1165 0.4681
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0246 0.0912
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0074 0.0053

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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