Detailed information for compound 560610

Basic information

Technical information
  • TDR Targets ID: 560610
  • Name: [4-(4-aminophenyl)sulfonylphenyl]urea
  • MW: 291.326 | Formula: C13H13N3O3S
  • H donors: 3 H acceptors: 3 LogP: 0.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)N
  • InChi: 1S/C13H13N3O3S/c14-9-1-5-11(6-2-9)20(18,19)12-7-3-10(4-8-12)16-13(15)17/h1-8H,14H2,(H3,15,16,17)
  • InChiKey: UPWPBIUUSLIWAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-(4-aminophenyl)sulfonylphenyl]urea
  • (4-sulfanilylphenyl)urea
  • 4-amino-p'-ureidodiphenylsulfone
  • 3569-77-5
  • Amidapsone (USAN)
  • 1-(4-(4-Sulfanilyl)phenyl)urea
  • Amidapsona [INN-Spanish]
  • Amidapsone [USAN:INN]
  • Amidapsonum [INN-Latin]
  • NSC 28120
  • Urea, (4-((4-aminophenyl)sulfonyl)phenyl)-
  • Urea, (p-sulfanilylphenyl)- (8CI)
  • AIDS-109612
  • AIDS109612
  • Amino-N-{4-[(4-aminophenyl)sulfonyl]phenyl}amide
  • (p-Sulfanilylphenyl)urea
  • 1-[4-(4-Sulfanilyl)phenyl]urea
  • 4-(N-Sulfanilyl)phenylurea
  • 4-Amino-4'-ureidodiphenyl sulfone
  • Amidapsone
  • NSC28120
  • Sulfacid
  • Sulfacide
  • Sulfone, p-aminophenyl p-ureidophenyl
  • Urea, (p-sulfanilylphenyl)-
  • Urea, [4-[(4-aminophenyl)sulfonyl]phenyl]-
  • p-Amino-p'-ureidodiphenyl sulfone
  • D02900

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0113
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0182 0.4111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0205 0.0606
Loa Loa (eye worm) hypothetical protein 0.004 0.0154 0.0143
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0415 0.3601 0.3601
Loa Loa (eye worm) hypothetical protein 0.0026 0.0029 0.0017
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0098 0.0112
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0188 0.0259
Schistosoma mansoni hypothetical protein 0.0176 0.1401 0.5274
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0289 0.0278
Leishmania major hypothetical protein, conserved 0.0037 0.0124 0.0124
Trichomonas vaginalis esterase, putative 0.0037 0.0124 0.2801
Brugia malayi hypothetical protein 0.0076 0.0481 0.0471
Brugia malayi intermediate filament protein 0.0055 0.0289 0.0278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0124 0.029
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0724 0.1129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0205 0.0287
Schistosoma mansoni hypothetical protein 0.0042 0.0174 0.0482
Mycobacterium ulcerans hypothetical protein 0.0037 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0289 0.0278
Loa Loa (eye worm) hypothetical protein 0.0044 0.0188 0.0177
Onchocerca volvulus 0.0102 0.0722 0.198
Loa Loa (eye worm) hypothetical protein 0.0051 0.0255 0.0243
Brugia malayi beta-lactamase family protein 0.0037 0.0124 0.0113
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0124 0.0582
Trypanosoma cruzi Emopamil binding protein, putative 0.0415 0.3601 0.3601
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0154 0.3479
Echinococcus multilocularis importin subunit beta 1 0.0029 0.005 0.0035
Schistosoma mansoni hypothetical protein 0.0042 0.0174 0.0482
Schistosoma mansoni survival motor neuron protein 0.0049 0.0233 0.0713
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.195 1
Trypanosoma brucei Emopamil binding protein, putative 0.0415 0.3601 0.3569
Echinococcus multilocularis protein dispatched 1 0.005 0.0245 0.0352
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.1126 0.1783
Brugia malayi CHE-14 protein 0.0044 0.0188 0.0177
Entamoeba histolytica hypothetical protein 0.0074 0.0467 0.6451
Leishmania major hypothetical protein, conserved 0.0415 0.3601 0.3601
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0255 0.0243
Schistosoma mansoni intermediate filament proteins 0.0055 0.0289 0.0934
Echinococcus granulosus intermediate filament protein 0.0055 0.0289 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0047 0.1051
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0106 0.0095
Echinococcus granulosus importin subunit beta 1 0.0029 0.005 0.0035
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0124 0.0582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0205 0.0287
Entamoeba histolytica hypothetical protein 0.0074 0.0467 0.6451
Mycobacterium tuberculosis Conserved protein 0.0037 0.0124 0.0582
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.0106 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0289 0.0278
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0724 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0124 0.1719
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.0269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0124 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0098 0.0112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0205 0.0287
Onchocerca volvulus 0.0055 0.0289 0.0774
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0154 0.0398
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0124 0.0155
Brugia malayi Heterochromatin protein 1 0.0072 0.0444 0.0433
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0444 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0124 0.0582
Entamoeba histolytica hypothetical protein 0.0074 0.0467 0.6451
Mycobacterium tuberculosis Conserved protein 0.0037 0.0124 0.0582
Onchocerca volvulus 0.0037 0.0124 0.0314
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0011 0.0011
Echinococcus granulosus geminin 0.0176 0.1401 0.2228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0205 0.0194
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0055 0.0044
Onchocerca volvulus 0.0415 0.3601 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0124 0.0113
Echinococcus multilocularis protein patched 0.0044 0.0188 0.0259
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0481 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0124 0.0582
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0481 0.0481
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0106 0.0095
Loa Loa (eye worm) hypothetical protein 0.0568 0.5006 0.5001
Brugia malayi hypothetical protein 0.0049 0.0235 0.0224
Onchocerca volvulus 0.0049 0.0233 0.0616
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0011 0.0157
Echinococcus multilocularis snurportin 1 0.0307 0.2611 0.4194
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0481 0.0434
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0011 0.0011
Echinococcus granulosus chromobox protein 1 0.0072 0.0444 0.0674
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.0471
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0205 0.0287
Brugia malayi beta-lactamase family protein 0.0037 0.0124 0.0113
Echinococcus granulosus lamin dm0 0.0055 0.0289 0.0423
Brugia malayi beta-lactamase 0.0037 0.0124 0.0113
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0738 0.2688
Mycobacterium ulcerans beta-lactamase 0.0037 0.0124 1
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0722 0.2625
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0055 0.0044
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0444 0.0433
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0124 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0124 0.0124
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0255 0.0243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0205 0.0606
Echinococcus multilocularis lamin 0.0055 0.0289 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0124 0.029
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.2611 0.2602
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0124 0.2801
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.1978 0.1968
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0481 1
Schistosoma mansoni chromobox protein 0.0072 0.0444 0.1537
Echinococcus multilocularis chromobox protein 1 0.0072 0.0444 0.0674
Brugia malayi hypothetical protein 0.0239 0.1978 0.1968
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0124 0.0124
Echinococcus multilocularis expressed conserved protein 0.0096 0.0667 0.1037
Brugia malayi follicle stimulating hormone receptor 0.024 0.1993 0.1984
Echinococcus granulosus chromobox protein 1 0.0072 0.0444 0.0674
Loa Loa (eye worm) hypothetical protein 0.0102 0.0724 0.0713
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1112 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0113
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0467 0.1628
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0124 0.0113
Mycobacterium leprae Probable lipase LipE 0.0037 0.0124 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0124 0.1719
Echinococcus multilocularis tumor protein p63 0.0697 0.6186 1
Brugia malayi chromobox protein homolog 3 0.004 0.0154 0.0143
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0124 1
Entamoeba histolytica hypothetical protein 0.0074 0.0467 0.6451
Brugia malayi hypothetical protein 0.0074 0.0467 0.0456
Schistosoma mansoni chromobox protein 0.0072 0.0444 0.1537
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0444 1
Schistosoma mansoni hypothetical protein 0.0042 0.0174 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0154 0.3479
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0011 0.0157
Onchocerca volvulus 0.0037 0.0124 0.0314
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0182 0.0476
Echinococcus multilocularis lamin dm0 0.0055 0.0289 0.0423
Echinococcus multilocularis chromobox protein 1 0.0072 0.0444 0.0674
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0724 0.1129
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0182 0.4111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0205 0.0606
Echinococcus granulosus lamin 0.0055 0.0289 0.0423
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0188 0.0177
Schistosoma mansoni hypothetical protein 0.0176 0.1401 0.5274
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0124 0.2801
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0188 0.4241
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0047 0.1051
Onchocerca volvulus 0.0055 0.0289 0.0774
Schistosoma mansoni hypothetical protein 0.0049 0.0233 0.0713
Echinococcus granulosus expressed conserved protein 0.0096 0.0667 0.1037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0467 0.0712
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0233 0.0221
Onchocerca volvulus 0.0031 0.0075 0.0176
Schistosoma mansoni lamin 0.0055 0.0289 0.0934
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0481 1
Echinococcus granulosus tumor protein p63 0.0697 0.6186 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0724 0.0713
Brugia malayi RNA, U transporter 1 0.0082 0.0538 0.0527
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1978 0.3165
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0289 0.0278
Loa Loa (eye worm) hypothetical protein 0.0102 0.0722 0.0712
Trypanosoma brucei C-8 sterol isomerase, putative 0.1112 1 1
Schistosoma mansoni lamin 0.0055 0.0289 0.0934
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.1126 0.1783
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0124 0.2801
Schistosoma mansoni hypothetical protein 0.0074 0.0467 0.1628
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0113
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0188 0.0259
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0124 0.0155
Leishmania major C-8 sterol isomerase-like protein 0.1112 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0124 0.0582
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0467 0.0712
Loa Loa (eye worm) hypothetical protein 0.1112 1 1
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0415 0.3601 0.3601
Echinococcus granulosus snurportin 1 0.0307 0.2611 0.4194
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0124 0.2801
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0205 0.0194
Trypanosoma cruzi Emopamil binding protein, putative 0.0415 0.3601 0.3601
Mycobacterium ulcerans lipase LipD 0.0037 0.0124 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0188 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0039
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0011 0.0157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0255 0.0243
Brugia malayi Importin beta-1 subunit 0.0029 0.005 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1978 0.3165
Loa Loa (eye worm) beta-lactamase 0.0037 0.0124 0.0113
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0124 0.0582
Leishmania major hypothetical protein, conserved 0.0076 0.0481 0.0481
Schistosoma mansoni hypothetical protein 0.0034 0.0098 0.0186
Schistosoma mansoni hypothetical protein 0.0042 0.0174 0.0482
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0113
Schistosoma mansoni patched 1 0.0044 0.0188 0.0539
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0124 0.0582
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0481 0.0481
Echinococcus multilocularis musashi 0.0055 0.0289 0.0423
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1993 0.1984
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0124 0.2801
Loa Loa (eye worm) hypothetical protein 0.0054 0.0279 0.0268
Schistosoma mansoni hypothetical protein 0.0307 0.2611 1
Onchocerca volvulus 0.0037 0.0124 0.0314
Echinococcus multilocularis geminin 0.0176 0.1401 0.2228
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0415 0.3601 0.3601
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0124 0.0075

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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