Detailed information for compound 561310

Basic information

Technical information
  • TDR Targets ID: 561310
  • Name: 2-diethylaminoethyl (2S,5R,6R)-3,3-dimethyl-7 -oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabi cyclo[3.2.0]heptane-2-carboxylate hydroiodide
  • MW: 561.477 | Formula: C22H32IN3O4S
  • H donors: 1 H acceptors: 3 LogP: 3.26 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(CCOC(=O)[C@@H]1N2C(=O)[C@H]([C@H]2SC1(C)C)NC(=O)Cc1ccccc1)CC.I
  • InChi: 1S/C22H31N3O4S.HI/c1-5-24(6-2)12-13-29-21(28)18-22(3,4)30-20-17(19(27)25(18)20)23-16(26)14-15-10-8-7-9-11-15;/h7-11,17-18,20H,5-6,12-14H2,1-4H3,(H,23,26);1H/t17-,18+,20-;/m1./s1
  • InChiKey: XWRCFDRXQPRCCO-FLQNVMKHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenylethyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 2-diethylaminoethyl ester hydroiodide
  • 2-diethylaminoethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylethanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydroiodide
  • (2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 2-diethylaminoethyl ester hydroiodide
  • penethamate hydroiodide
  • 3689-73-4
  • 808-71-9
  • beta-Diethylaminoethyl benzylpenicillinate hydriodide
  • Deripen
  • 2-Diethylaminoethyl (6R)-6-(2-phenylacetamido)penicillanate hydriodide
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, 2-(diethylamino)ethyl ester, monohydriodide
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-, (2S,5R,6R)-, 2-(diethylamino)ethyl ester, monohydriodide
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, 2-(diethylamino)ethyl ester, monohydriodide
  • Alivin
  • Benzylpenicillin beta-diethylaminoethyl ester hydriodide
  • Bronchocillin
  • Bronchopen
  • Broncopen
  • Diethyl(2-(6-(2-phenylacetamido)penicillanoyloxy)ethyl)ammonium iodide
  • Diethylaminoethyl ester penicillin hydriodide
  • EINECS 212-367-6
  • Eficillin
  • Ephicillin hydriodide
  • Estopen
  • Leocillin
  • Neo-Penil
  • Neopenil
  • Penethacillin
  • Penethamate Hydriodide
  • Penethamate hydriodide [BAN]
  • Penicillin G diethylaminoethyl ester hydriodide
  • Penicillin G, 2-(diethylamino)ethyl ester, hydriodide
  • Penicillin, 2-(diethylamino)ethyl ester, hydriodide
  • Pulmaxil N
  • Pulmo 500

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0299 0.0336
Trichomonas vaginalis set domain proteins, putative 0.023 0.0821 0.2349
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0035 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0707 0.209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0834 0.0946
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0085 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Schistosoma mansoni glutaminase 0.0855 0.3367 0.3834
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0137 0.0395
Brugia malayi MH2 domain containing protein 0.0133 0.0426 0.1255
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0461 0.3977
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0085 0.0438
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0097 0.0275
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0061 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Onchocerca volvulus 0.0049 0.0085 0.0994
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0061 0.0066
Brugia malayi Pre-SET motif family protein 0.0202 0.0707 0.209
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0077 0.0113
Onchocerca volvulus 0.0052 0.0097 0.1131
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0039 0.2741
Loa Loa (eye worm) hypothetical protein 0.0126 0.0399 0.1175
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Loa Loa (eye worm) hypothetical protein 0.0126 0.0399 0.1175
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0039 0.297
Plasmodium vivax importin-beta 2, putative 0.0058 0.0121 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0056 0.0051
Brugia malayi RNA, U transporter 1 0.0164 0.0553 0.1632
Mycobacterium ulcerans transcriptional regulator 0.1346 0.5364 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0039 0.0007
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0461 0.3977
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0056 0.0063
Brugia malayi hypothetical protein 0.0036 0.0035 0.0092
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0061 0.0169
Echinococcus multilocularis protein patched 0.0043 0.0061 0.0057
Onchocerca volvulus Huntingtin homolog 0.0126 0.0399 0.4841
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.1103 1
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0035 0.2407
Schistosoma mansoni microtubule-associated protein tau 0.2184 0.8775 1
Loa Loa (eye worm) glutaminase 2 0.0855 0.3367 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.0834 0.2468
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0085 0.0241
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0008 0.0316
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1101 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0039 0.0044
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0034 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0085 0.0094
Schistosoma mansoni hypothetical protein 0.0615 0.2388 0.2718
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0293 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0055
Echinococcus granulosus expressed conserved protein 0.0094 0.0268 0.0306
Echinococcus granulosus snurportin 1 0.0615 0.2388 0.2722
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0057 0.0173
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0059 0.4696
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.0347
Leishmania major importin beta-1 subunit, putative 0.0047 0.0077 0.0355
Schistosoma mansoni ran 0.0042 0.0059 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.0834 0.2468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.0834 0.0951
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.0834 0.083
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0008 0.0011
Brugia malayi CHE-14 protein 0.0043 0.0061 0.0169
Schistosoma mansoni patched 1 0.0043 0.0061 0.0065
Mycobacterium ulcerans hypothetical protein 0.0157 0.0526 0.0921
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0059 0.4696
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0284 0.0324
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0077 0.0355
Brugia malayi Bromodomain containing protein 0.003 0.0008 0.0011
Schistosoma mansoni ap endonuclease 0.0037 0.0039 0.004
Echinococcus granulosus importin subunit beta 1 0.0058 0.0121 0.0138
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0085 0.0094
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0095 0.0525
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0293 0.2414
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0121 0.0117
Schistosoma mansoni ap endonuclease 0.0037 0.0039 0.004
Brugia malayi Importin beta-1 subunit 0.0058 0.0121 0.0347
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0467
Brugia malayi jmjC domain containing protein 0.0036 0.0034 0.0087
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1101 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Loa Loa (eye worm) hypothetical protein 0.01 0.0293 0.0859
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0526 0.0935
Echinococcus granulosus microtubule associated protein 2 0.2184 0.8775 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0269
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.0912 0.2698
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1101 1
Brugia malayi glutaminase DH11.1 0.0855 0.3367 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0834 0.0946
Schistosoma mansoni survival motor neuron protein 0.0052 0.0097 0.0105
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0559 0.6798
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0166 0.0563 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0895 0.2649
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0121 0.0772
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0163
Trichomonas vaginalis glutaminase, putative 0.0855 0.3367 1
Schistosoma mansoni hypothetical protein 0.0036 0.0035 0.0035
Leishmania major GTP-binding protein, putative 0.0042 0.0059 0.019
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0008 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.019
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0481 0.0837
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0085 0.0471
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0034 0.0087
Onchocerca volvulus Alhambra homolog 0.003 0.0008 0.0045
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0481 0.0749
Mycobacterium ulcerans TetR family transcriptional regulator 0.1346 0.5364 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.0912 0.2698
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0481 0.0851
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Plasmodium falciparum importin beta, putative 0.0058 0.0121 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0035 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0426 0.1255
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0061 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Echinococcus multilocularis snurportin 1 0.0615 0.2388 0.2385
Mycobacterium ulcerans glutaminase 0.0855 0.3367 0.6252
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0834 0.0946
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0467 0.0463
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0426 0.1255
Echinococcus multilocularis protein dispatched 1 0.0049 0.0086 0.0081
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0895 0.2649
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0035 0.2646
Onchocerca volvulus Huntingtin homolog 0.0126 0.0399 0.4841
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.019
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0039 0.0103
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0077 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0085 0.0241
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0461 0.3977
Echinococcus granulosus geminin 0.034 0.127 0.1447
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0085 0.0109
Brugia malayi jmjC domain containing protein 0.0098 0.0284 0.0832
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1101 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0059 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0085 0.0438
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Brugia malayi PHD-finger family protein 0.003 0.0008 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.0916 0.1044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0035 0.0031
Trichomonas vaginalis ran, putative 0.0042 0.0059 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0039 0.0036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0057 0.0173
Schistosoma mansoni hypothetical protein 0.0052 0.0097 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0595 0.1672
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0023 0.0055
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0615 0.2388 0.709
Entamoeba histolytica hypothetical protein 0.0047 0.0077 0.0389
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0039 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0121 0.0772
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.019
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0008 0.0009
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0061 0.007
Plasmodium vivax hypothetical protein, conserved 0.003 0.0008 0.0316
Schistosoma mansoni ran 0.0042 0.0059 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0085 0.0471
Onchocerca volvulus 0.023 0.0821 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0057 0.0173
Schistosoma mansoni hypothetical protein 0.034 0.127 0.1443
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0085 0.0094
Brugia malayi hypothetical protein 0.0126 0.0399 0.1175
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0085 0.0109
Echinococcus granulosus peregrin 0.003 0.0008 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0039 0.5
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.02 0.0699 0.2067
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Echinococcus multilocularis peregrin 0.003 0.0008 0.0004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1103 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.0916 0.2712
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0595 0.1672
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0085 0.0241
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0166 0.0563 0.0559
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.4523
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0241
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0284 0.028
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.1103 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0039 0.0035
Echinococcus multilocularis geminin 0.034 0.127 0.1266
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0008 0.0316
Echinococcus multilocularis expressed conserved protein 0.0094 0.0268 0.0264
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0202 0.0226
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0039 0.0283
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.0699 0.2067
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0293 0.0859
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0039 0.0103
Schistosoma mansoni hypothetical protein 0.034 0.127 0.1443
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0085 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.0834 0.083
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0004 0.0005
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1103 1
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.0916 0.0912
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0085 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0467 0.0533
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1346 0.5364 1
Toxoplasma gondii hypothetical protein 0.0048 0.0082 0.6699
Brugia malayi hypothetical protein 0.0253 0.0916 0.2712
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0059 0.0055
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0034 0.0038
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0035 0.004
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.5364 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Loa Loa (eye worm) glutaminase 0.0855 0.3367 1
Entamoeba histolytica Ran family GTPase 0.0042 0.0059 0.0224
Loa Loa (eye worm) hypothetical protein 0.0052 0.01 0.0285
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0057 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0085 0.0438
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0086 0.0243
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Mycobacterium ulcerans hypothetical protein 0.0049 0.0085 0.0094
Toxoplasma gondii exonuclease III APE 0.0037 0.0039 0.297
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0077 0.0113
Echinococcus multilocularis microtubule associated protein 2 0.2184 0.8775 0.8775
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0035 0.0015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0085 0.0094
Schistosoma mansoni importin beta-1 0.0058 0.0121 0.0133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0086 0.0243
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0033
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0008 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0085 0.0471
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.0834 0.0951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0241
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0293 0.0334
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0121 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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