Detailed information for compound 568147

Basic information

Technical information
  • TDR Targets ID: 568147
  • Name: Org 2305
  • MW: 264.365 | Formula: C18H20N2
  • H donors: 0 H acceptors: 0 LogP: 3.84 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC2N(C1)c1ccccc1Cc1c2cccc1
  • InChi: 1S/C18H20N2/c1-19-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)20(18)13-19/h2-9,18H,10-13H2,1H3
  • InChiKey: BNRNHNFZHLZLQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 53245-50-4
  • 1,2,3,4,4a,9-Hexahydro-2-methyldibenzo(c,f)pyrimido(1,6a)azepine
  • Dibenzo(c,f)pyrimido(1,6-a)azepine, 1,2,3,4,4a,9-hexahydro-2-methyl-
  • Org-2305

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.0532 0.0513
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0161 0.0151
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0024 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.002 0.002
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.001
Echinococcus granulosus tar DNA binding protein 0.0193 0.0828 0.2123
Echinococcus granulosus lamin 0.0028 0.0061 0.0132
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.216 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0843 0.3862 1
Echinococcus multilocularis dna polymerase eta 0.002 0.0024 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.002 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0138 0.0128
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0161 0.1835
Echinococcus granulosus dna polymerase eta 0.002 0.0024 0.0035
Schistosoma mansoni hypothetical protein 0.0305 0.1353 0.1344
Loa Loa (eye worm) hypothetical protein 0.0037 0.0103 0.117
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0691
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0161 0.0151
Schistosoma mansoni hypothetical protein 0.0076 0.0284 0.0274
Trypanosoma brucei protein kinase, putative 0.0055 0.0188 0.0169
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.0532 0.1355
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.216 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0188 0.0463
Leishmania major DNA polymerase kappa, putative 0.002 0.0024 0.0004
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0843 0.3862 1
Leishmania major dihydroorotate dehydrogenase 0.216 1 1
Schistosoma mansoni dihydroorotate dehydrogenase 0.216 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.002 0.0226
Echinococcus multilocularis lamin dm0 0.0028 0.0061 0.0132
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.216 1 1
Entamoeba histolytica hypothetical protein 0.0076 0.0284 0.0688
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0843 0.3862 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.216 1 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0268
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0188 0.0169
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0188 0.0463
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0188 0.0169
Giardia lamblia DINP protein human, muc B family 0.002 0.0024 0.022
Echinococcus multilocularis tar DNA binding protein 0.0193 0.0828 0.2123
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.002 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0066 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0284 0.0712
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0193 0.0183
Loa Loa (eye worm) TAR-binding protein 0.0193 0.0828 0.9429
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0138 0.0128
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0843 0.3862 1
Brugia malayi mbt repeat family protein 0.005 0.0161 0.0161
Echinococcus multilocularis musashi 0.0028 0.0061 0.0132
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0188 0.0169
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0188 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0066 0.0056
Echinococcus granulosus lamin dm0 0.0028 0.0061 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0188 0.0178
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.0859 0.2203
Brugia malayi MAP kinase sur-1 0.0055 0.0188 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0066 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0284 0.0274
Brugia malayi intermediate filament protein 0.0028 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0024 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0188 0.0438
Brugia malayi RNA recognition motif domain containing protein 0.0193 0.0828 0.0828
Loa Loa (eye worm) MBCTL1 0.0056 0.0193 0.2199
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0188 0.0169
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0024 0.001
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0843 0.3862 1
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0532 0.0522
Schistosoma mansoni lamin 0.0028 0.0061 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0066 0.0056
Brugia malayi Zinc finger, C2H2 type family protein 0.0843 0.3862 0.3862
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0161 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0161 0.1835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0138 0.0333
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0843 0.3862 0.385
Plasmodium falciparum dihydroorotate dehydrogenase 0.216 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0193 0.0828 0.9429
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0843 0.3862 1
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0188 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0183 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0066 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0061 0.0691
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.0532 0.0513
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0183 0.0183
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.216 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0103 0.0093
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0161 0.0392
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0035
Brugia malayi Pre-SET motif family protein 0.0029 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Entamoeba histolytica hypothetical protein 0.0076 0.0284 0.0688
Schistosoma mansoni ap endonuclease 0.0019 0.002 0.001
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0193 0.0475
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.216 1 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0193 0.0475
Brugia malayi hypothetical protein 0.0076 0.0284 0.0284
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.001 0.001
Echinococcus multilocularis lamin 0.0028 0.0061 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0828 0.0819
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0188 0.0438
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0843 0.3862 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0024 0.0014
Entamoeba histolytica hypothetical protein 0.0076 0.0284 0.0688
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0183 0.2081
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0188 0.0169
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.0859 0.2203
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0004
Echinococcus granulosus intermediate filament protein 0.0028 0.0061 0.0132
Brugia malayi TAR-binding protein 0.0193 0.0828 0.0828
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0843 0.3862 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0188 0.2144
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.216 1 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0061 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0058 0.0664
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Echinococcus granulosus dna polymerase kappa 0.002 0.0024 0.0035
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0024 0.0014
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0161 0.1059
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0828 0.0819
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0004
Onchocerca volvulus 0.005 0.0161 0.1059
Plasmodium vivax SET domain protein, putative 0.0029 0.0066 0.0046
Leishmania major DNA polymerase eta, putative 0.002 0.0024 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0161 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0066 0.0145
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0843 0.3862 1
Brugia malayi RNA binding protein 0.0193 0.0828 0.0828
Brugia malayi mbt repeat family protein 0.005 0.0161 0.0161
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0161 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0828 0.0819
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0061 0.0061
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0188 0.0169
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0024 0.0268
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0828 0.0819
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0113
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.216 1 1
Onchocerca volvulus 0.0231 0.1009 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0024 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0532 0.0513
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0188 0.0438
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0188 0.0463
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0188 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0193 0.0475
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0004
Echinococcus multilocularis dna polymerase kappa 0.002 0.0024 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0138 0.0333
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0188 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0066 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0532 0.0513
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0193 0.0475
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.001 0.0113
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0066 0.0145
Brugia malayi Pre-SET motif family protein 0.0203 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0056 0.0193 0.2199
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.0532 0.0513
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0193 0.0193
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.0532 0.1355
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.216 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0024 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0017 0.001 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0061 0.0691
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0004
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.216 1 1
Onchocerca volvulus 0.0029 0.0066 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0024 0.001
Schistosoma mansoni tar DNA-binding protein 0.0193 0.0828 0.0819
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0138 0.0128
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1009 0.2574
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0284 0.0712
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.002 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0138 0.1576
Loa Loa (eye worm) hypothetical protein 0.0054 0.0183 0.2081
Trypanosoma brucei unspecified product 0.002 0.0024 0.0004
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0138 0.0333
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.216 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0843 0.3862 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0024 0.0014
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0843 0.3862 1
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0161 0.0392
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0024 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0061 0.0132
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0188 0.0463
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0878 1
Loa Loa (eye worm) RNA binding protein 0.0193 0.0828 0.9429
Entamoeba histolytica hypothetical protein 0.0076 0.0284 0.0688
Loa Loa (eye worm) hypothetical protein 0.0029 0.0066 0.0752
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0138 0.0333
Schistosoma mansoni lamin 0.0028 0.0061 0.0051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0024 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0138 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0532 0.0513
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0103 0.0103
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0532 0.0522

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.